产品简要
公司名称 :
Immunoglobe
产品类型 :
抗体
产品名称 :
vasodilator stimulated phosphoprotein [VASP]
目录 :
0016-05
规格 :
100微升, 50微克
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
IE273
反应物种 :
人类, 牛
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
Immunoglobe 产品网页
文章摘录数: 44
参考文献
Mischnik M, Boyanova D, Hubertus K, Geiger J, Philippi N, Dittrich M, et al. A Boolean view separates platelet activatory and inhibitory signalling as verified by phosphorylation monitoring including threshold behaviour and integrin modulation. Mol Biosyst. 2013;9:1326-39 pubmed 出版商
Glenn J, White A, Iyu D, Heptinstall S. PGE(2) reverses G(s)-mediated inhibition of platelet aggregation by interaction with EP3 receptors, but adds to non-G(s)-mediated inhibition of platelet aggregation by interaction with EP4 receptors. Platelets. 2012;23:344-51 pubmed 出版商
Wangorsch G, Butt E, Mark R, Hubertus K, Geiger J, Dandekar T, et al. Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation. BMC Syst Biol. 2011;5:178 pubmed 出版商
Maruoka M, Sato M, Yuan Y, Ichiba M, Fujii R, Ogawa T, et al. Abl-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion. Biochem J. 2012;441:889-99 pubmed 出版商
Molins B, Pena E, de la Torre R, Badimon L. Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow. Cardiovasc Res. 2011;92:328-37 pubmed 出版商
Pena E, Padro T, Molins B, Vilahur G, Badimon L. Proteomic signature of thrombin-activated platelets after in vivo nitric oxide-donor treatment: coordinated inhibition of signaling (phosphatidylinositol 3-kinase-?, 14-3-3?, and growth factor receptor-bound protein 2) and cytoskeleton protein transl. Arterioscler Thromb Vasc Biol. 2011;31:2560-9 pubmed 出版商
Iyu D, Glenn J, White A, Fox S, Dovlatova N, Heptinstall S. P2Y?? and EP3 antagonists promote the inhibitory effects of natural modulators of platelet aggregation that act via cAMP. Platelets. 2011;22:504-15 pubmed 出版商
Aggarwal S, Gross C, Kumar S, Datar S, Oishi P, Kalkan G, et al. Attenuated vasodilatation in lambs with endogenous and exogenous activation of cGMP signaling: role of protein kinase G nitration. J Cell Physiol. 2011;226:3104-13 pubmed 出版商
Iyu D, Glenn J, White A, Fox S, Heptinstall S. Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist. Arterioscler Thromb Vasc Biol. 2011;31:416-22 pubmed 出版商
Iyu D, Jüttner M, Glenn J, White A, Johnson A, Fox S, et al. PGE1 and PGE2 modify platelet function through different prostanoid receptors. Prostaglandins Other Lipid Mediat. 2011;94:9-16 pubmed 出版商
Iyu D, Glenn J, White A, Fox S, van Giezen H, Nylander S, et al. Mode of action of P2Y(12 ) antagonists as inhibitors of platelet function. Thromb Haemost. 2011;105:96-106 pubmed 出版商
Tadokoro S, Nakazawa T, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, et al. A potential role for ?-actinin in inside-out ?IIb?3 signaling. Blood. 2011;117:250-8 pubmed 出版商
Geiger J, Brandmann T, Hubertus K, Tjahjadi B, Schinzel R, Walter U. A protein phosphorylation-based assay for screening and monitoring of drugs modulating cyclic nucleotide pathways. Anal Biochem. 2010;407:261-9 pubmed 出版商
Iyu D, Glenn J, White A, Johnson A, Fox S, Heptinstall S. The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. Platelets. 2010;21:329-42 pubmed 出版商
Wang Y, Dong H, Zhu M, Ou Y, Zhang J, Luo H, et al. Icariin exterts negative effects on human gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway. Eur J Pharmacol. 2010;635:40-8 pubmed 出版商
Mirone V, d Emmanuele di Villa Bianca R, Mitidieri E, Imbimbo C, Fusco F, Verze P, et al. Platelet cyclic guanosine monophosphate as a biomarker of phosphodiesterase type 5 inhibitor efficacy in the treatment of erectile dysfunction: a randomized placebo-controlled study. Eur Urol. 2009;56:1067-73 pubmed 出版商
Zhang D, Ouyang J, Wang N, Zhang Y, Bie J, Zhang Y. Promotion of PDGF-induced endothelial cell migration by phosphorylated VASP depends on PKA anchoring via AKAP. Mol Cell Biochem. 2010;335:1-11 pubmed 出版商
Dugina V, Zwaenepoel I, Gabbiani G, Clement S, Chaponnier C. Beta and gamma-cytoplasmic actins display distinct distribution and functional diversity. J Cell Sci. 2009;122:2980-8 pubmed 出版商
Zhang Y, Han G, Fan B, Zhou Y, Zhou X, Wei L, et al. Green tea (-)-epigallocatechin-3-gallate down-regulates VASP expression and inhibits breast cancer cell migration and invasion by attenuating Rac1 activity. Eur J Pharmacol. 2009;606:172-9 pubmed 出版商
Benz P, Blume C, Moebius J, Oschatz C, Schuh K, Sickmann A, et al. Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes. J Cell Biol. 2008;180:205-19 pubmed 出版商
Birschmann I, Mietner S, Dittrich M, Pfrang J, Dandekar T, Walter U. Use of functional highly purified human platelets for the identification of new proteins of the IPP signaling pathway. Thromb Res. 2008;122:59-68 pubmed
Zhang L, Wang T, Wen X, Wei Y, Peng X, Li H, et al. Effect of matrine on HeLa cell adhesion and migration. Eur J Pharmacol. 2007;563:69-76 pubmed
Warnholtz A, Ostad M, Velich N, Trautmann C, Schinzel R, Walter U, et al. A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Atherosclerosis. 2008;196:689-95 pubmed
Blume C, Benz P, Walter U, Ha J, Kemp B, Renne T. AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem. 2007;282:4601-12 pubmed
van der Ven P, Ehler E, Vakeel P, Eulitz S, Schenk J, Milting H, et al. Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP. Exp Cell Res. 2006;312:2154-67 pubmed
August M, Wingerter O, Oelze M, Wenzel P, Kleschyov A, Daiber A, et al. Mechanisms underlying dysfunction of carotid arteries in genetically hyperlipidemic rabbits. Nitric Oxide. 2006;15:241-51 pubmed
Galler A, Garcia Arguinzonis M, Baumgartner W, Kuhn M, Smolenski A, Simm A, et al. VASP-dependent regulation of actin cytoskeleton rigidity, cell adhesion, and detachment. Histochem Cell Biol. 2006;125:457-74 pubmed
Geiger J, Teichmann L, Grossmann R, Aktas B, Steigerwald U, Walter U, et al. Monitoring of clopidogrel action: comparison of methods. Clin Chem. 2005;51:957-65 pubmed
Lohmann S, Walter U. Tracking functions of cGMP-dependent protein kinases (cGK). Front Biosci. 2005;10:1313-28 pubmed
Dunkern T, Hatzelmann A. The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5. Cell Signal. 2005;17:331-9 pubmed
Gustavsson A, Yuan M, Fallman M. Temporal dissection of beta1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation. J Biol Chem. 2004;279:22893-901 pubmed
Mollnau H, Schulz E, Daiber A, Baldus S, Oelze M, August M, et al. Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells. Arterioscler Thromb Vasc Biol. 2003;23:615-21 pubmed
Wei L, Muller S, Ouyang J, Stoltz J, Wang X. Changes of vasodilator-stimulated phosphoprotein (VASP) and its phosphorylation in endothelial cells exposed to laminar flow. Clin Hemorheol Microcirc. 2003;28:113-20 pubmed
Anderson S, Behrendt B, Machesky L, Insall R, Nash G. Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton. Cell Motil Cytoskeleton. 2003;54:135-46 pubmed
Schulz E, Tsilimingas N, Rinze R, Reiter B, Wendt M, Oelze M, et al. Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment. Circulation. 2002;105:1170-5 pubmed
Mollnau H, Wendt M, Szocs K, LASSEGUE B, Schulz E, Oelze M, et al. Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Circ Res. 2002;90:E58-65 pubmed
Ibarra Alvarado C, Galle J, Melichar V, Mameghani A, Schmidt H. Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling. Mol Pharmacol. 2002;61:312-9 pubmed
Mülsch A, Oelze M, Kloss S, Mollnau H, Töpfer A, Smolenski A, et al. Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta. Circulation. 2001;103:2188-94 pubmed
Obergfell A, Judd B, del Pozo M, Schwartz M, Koretzky G, Shattil S. The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton. J Biol Chem. 2001;276:5916-23 pubmed
Oelze M, Mollnau H, Hoffmann N, Warnholtz A, Bodenschatz M, Smolenski A, et al. Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction. Circ Res. 2000;87:999-1005 pubmed
Smolenski A, Poller W, Walter U, Lohmann S. Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I. J Biol Chem. 2000;275:25723-32 pubmed
Bachmann C, Fischer L, Walter U, Reinhard M. The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation. J Biol Chem. 1999;274:23549-57 pubmed
Niebuhr K, Ebel F, Frank R, Reinhard M, Domann E, Carl U, et al. A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. EMBO J. 1997;16:5433-44 pubmed
Lambrechts A, Verschelde J, Jonckheere V, Goethals M, Vandekerckhove J, Ampe C. The mammalian profilin isoforms display complementary affinities for PIP2 and proline-rich sequences. EMBO J. 1997;16:484-94 pubmed
产品信息
目录号 :
0016-05
NAME (Link To Web Site) :
IE273
特异性 :
vasodilator stimulated phosphoprotein [VASP]
其他名称 :
vasodilator-stimulated phosphoprotein
UniProt数据库/Swiss Prot数据库# :
P50552, B2RBT9, Q6PIZ1, Q93035
CLONE/Poly-clonal :
单克隆, IE273
宿主物种 :
小鼠
抗体亚型 :
IgG1
反应物种 :
human, pig, bovine, sheep, rabbit; by inference (sequence idetity: cat, African elephant, manatee)
格式/CONJUGATES :
纯化
规格 :
100微升, 50微克
描述 :
comes with a free positive control: human platelet protein (lysate); antibody raised against full-length protein; detailed information on epitope available; works with formaldehyde fixed cells; the antibody recognizes both the 46 kDa (Ser-157 dephospho) and 50 kDa (Ser-157 phospho) form of VASP.
应用 :
WB - Western blot, immunoblot, IF - immunofluorescence, IHC - immuno-histochemistry, IP - immunoprecipitation, ELISA
SAMPLE APPLICATIONS :
Basic and Clinical Research Applications
SUGGESTED DILUTIONS :
WB: 1:2, 000 - 1:50, 000;IF:1:100-1:500;免疫沉淀
[Pubmed登录号;Pubmed登录号] :
21351102, 12529859, 16597505, 10438535, 18195108, 17931695, 17082196, 19638415, 15567064, 16267652, 20708596, 15817818, 22436052, 15044442, 11809855, 21591981, 21106949, 20941457, 20433310, 21095237, 9034331, 15769627, 22014333, 19781847, 23463387, 21859817, 12692005, 11884382, 11331261, 12652017, 9312002, 11113155, 11090544, 21836071, 11889009, 10851246, 20940419, 16631741, 20307526, 22034949, 17214996, 12652017, 19711176, 17343841, 19171136, 15567064
Updated :
3/1/15
更多信息或购买 :
Immunoglobe 产品网页
公司信息
Immunoglobe
info@immunoGlobe.com
www.immunoglobe.com
49-9364-81061-0