产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45.1 Monoclonal Antibody (A20), FITC, eBioscience™
目录 :
11-0453-82
规格 :
100微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
异硫氰酸荧光素
克隆名称 :
A20
反应物种 :
小鼠
应用 :
流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 78
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 1:500; 图 6g
Gang E, Kim H, Hsieh Y, Ruan Y, Ogana H, Lee S, et al. Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia. Blood. 2020;136:210-223 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3f
Lee L, Krupski C, Clark J, Wunderlich M, Lorsbach R, Grimley M, et al. High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy. Blood Adv. 2020;4:717-727 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2d
Tizian C, Lahmann A, Hölsken O, Cosovanu C, Kofoed Branzk M, Heinrich F, et al. c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells. elife. 2020;9: pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 1s1a
Koike T, Harada K, Horiuchi S, Kitamura D. The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets. elife. 2019;8: pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 s8c
Chorro L, Suzuki M, Chin S, Williams T, Snapp E, Odagiu L, et al. Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape. Nat Commun. 2018;9:5368 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1c
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s4a
Vo L, Kinney M, Liu X, Zhang Y, Barragan J, Sousa P, et al. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. 2018;553:506-510 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4b
Deniset J, Surewaard B, Lee W, Kubes P. Splenic Ly6Ghigh mature and Ly6Gint immature neutrophils contribute to eradication of S. pneumoniae. J Exp Med. 2017;214:1333-1350 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s2
Jacoby E, Nguyen S, Fountaine T, Welp K, Gryder B, Qin H, et al. CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. Nat Commun. 2016;7:12320 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4
McWilliams I, Rajbhandari R, Nozell S, BENVENISTE E, Harrington L. STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE. J Neuroinflammation. 2015;12:128 pubmed 出版商
  • 流式细胞仪; 小鼠
Jacque E, Schweighoffer E, Visekruna A, Papoutsopoulou S, Janzen J, Zillwood R, et al. IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. J Exp Med. 2014;211:2085-101 pubmed 出版商
  • 流式细胞仪; 小鼠
Hamada H, Garcia Hernandez M, Reome J, Misra S, Strutt T, McKinstry K, et al. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009;182:3469-81 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠
Schwickert T, Lindquist R, Shakhar G, Livshits G, Skokos D, Kosco Vilbois M, et al. In vivo imaging of germinal centres reveals a dynamic open structure. Nature. 2007;446:83-7 pubmed
Baptista A, Gola A, Huang Y, Milanez Almeida P, Torabi Parizi P, Urban J, et al. The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity. Immunity. 2019;50:1188-1201.e6 pubmed 出版商
Pyaram K, Kumar A, Kim Y, Noel S, Reddy S, Rabb H, et al. Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis. Cell Rep. 2019;27:699-707.e4 pubmed 出版商
Beneke V, Küster F, Neehus A, Hesse C, Lopez Rodriguez E, Haake K, et al. An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages. Sci Rep. 2018;8:16281 pubmed 出版商
Wang X, Dong F, Zhang S, Yang W, Yu W, Wang Z, et al. TGF-?1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells. Stem Cell Reports. 2018;11:274-287 pubmed 出版商
Schmidt K, Zhang Q, Tasdogan A, Petzold A, Dahl A, Arneth B, et al. The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice. elife. 2018;7: pubmed 出版商
Tang J, Frey J, Wilson C, Moncada Pazos A, Levet C, Freeman M, et al. Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation. Mol Cell Biol. 2018;38: pubmed 出版商
Maryanovich M, Zahalka A, Pierce H, Pinho S, Nakahara F, Asada N, et al. Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche. Nat Med. 2018;24:782-791 pubmed 出版商
Xia P, Wang S, Ye B, Du Y, Li C, Xiong Z, et al. A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. Immunity. 2018;48:688-701.e7 pubmed 出版商
Saranchova I, Han J, Zaman R, Arora H, Huang H, Fenninger F, et al. Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis. Sci Rep. 2018;8:2924 pubmed 出版商
Omodho B, Miao T, Symonds A, Singh R, Li S, Wang P. Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells. Immun Inflamm Dis. 2018;6:221-233 pubmed 出版商
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172:517-533.e20 pubmed 出版商
Wang Q, He H, Chen D, Wang C, Xu Y, Song W. Hepatic stroma-educated regulatory DCs suppress CD8+ T cell proliferation in mice. Oncotarget. 2017;8:93414-93425 pubmed 出版商
Vaeth M, Maus M, Klein Hessling S, Freinkman E, Yang J, Eckstein M, et al. Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming. Immunity. 2017;47:664-679.e6 pubmed 出版商
Zaid A, Hor J, Christo S, Groom J, Heath W, Mackay L, et al. Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation. J Immunol. 2017;199:2451-2459 pubmed 出版商
Strandt H, Pinheiro D, Kaplan D, Wirth D, GRATZ I, Hammerl P, et al. Neoantigen Expression in Steady-State Langerhans Cells Induces CTL Tolerance. J Immunol. 2017;199:1626-1634 pubmed 出版商
Miao T, Symonds A, Singh R, Symonds J, Ogbe A, Omodho B, et al. Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation. J Exp Med. 2017;214:1787-1808 pubmed 出版商
Saranchova I, Han J, Huang H, Fenninger F, Choi K, Munro L, et al. Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33. Sci Rep. 2016;6:30555 pubmed 出版商
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed 出版商
Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel M, et al. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016;7:292-305 pubmed 出版商
Mercier F, Sykes D, Scadden D. Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse. Stem Cell Reports. 2016;6:985-992 pubmed 出版商
Ghosh M, Shapiro L. In vitro Ag Cross-presentation and in vivo Ag Cross-presentation by Dendritic Cells in the Mouse. Bio Protoc. 2012;2:e305 pubmed
de Valle E, Grigoriadis G, O Reilly L, Willis S, Maxwell M, Corcoran L, et al. NF?B1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells. J Exp Med. 2016;213:621-41 pubmed 出版商
Torrisi J, Hespe G, Cuzzone D, Savetsky I, Nitti M, Gardenier J, et al. Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity. Sci Rep. 2016;6:19817 pubmed 出版商
Wu L, Li N, Zhang M, Xue S, Cassady K, Lin Q, et al. MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice. Proc Natl Acad Sci U S A. 2015;112:15994-9 pubmed 出版商
Abidin B, Owusu Kwarteng E, Heinonen K. Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal. J Immunol. 2015;195:2168-76 pubmed 出版商
Jacque E, Schweighoffer E, Tybulewicz V, Ley S. BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival. J Exp Med. 2015;212:883-92 pubmed 出版商
Xue J, Sharma V, Hsieh M, Chawla A, Murali R, Pandol S, et al. Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. Nat Commun. 2015;6:7158 pubmed 出版商
Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, et al. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Nat Commun. 2015;6:6353 pubmed 出版商
Bruns I, Lucas D, Pinho S, Ahmed J, Lambert M, Kunisaki Y, et al. Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion. Nat Med. 2014;20:1315-20 pubmed 出版商
Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211:2119-34 pubmed 出版商
Rodríguez Díez E, Quereda V, Bellutti F, Prchal Murphy M, Partida D, Eguren M, et al. Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis. Blood. 2014;124:2380-90 pubmed 出版商
Bestas B, Moreno P, Blomberg K, Mohammad D, Saleh A, Sutlu T, et al. Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model. J Clin Invest. 2014;124:4067-81 pubmed 出版商
Wang H, Yang Y, Zhang H, Yan H, Wu X, Zhang C. Administration of the resveratrol analogues isorhapontigenin and heyneanol-A protects mice hematopoietic cells against irradiation injuries. Biomed Res Int. 2014;2014:282657 pubmed 出版商
Madhu V, Li C, Dighe A, Balian G, Cui Q. BMP-non-responsive Sca1+ CD73+ CD44+ mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation. PLoS ONE. 2014;9:e103060 pubmed 出版商
Au Yeung B, Melichar H, Ross J, Cheng D, Zikherman J, Shokat K, et al. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol. 2014;15:687-94 pubmed 出版商
Hu Z, Wang J, Wan Y, Zhu L, Ren X, Qiu S, et al. Boosting functional avidity of CD8+ T cells by vaccinia virus vaccination depends on intrinsic T-cell MyD88 expression but not the inflammatory milieu. J Virol. 2014;88:5356-68 pubmed 出版商
D Cruz L, Stradner M, Yang C, Goldrath A. E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation. J Immunol. 2014;192:2227-36 pubmed 出版商
Rubinstein M, Salem M, Doedens A, Moore C, Chiuzan C, Rivell G, et al. G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses. J Hematol Oncol. 2013;6:75 pubmed 出版商
Lee P, Puppi M, Schluns K, Yu Lee L, Dong C, Lacorazza H. The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage. J Immunol. 2014;192:178-88 pubmed 出版商
Campaner S, Viale A, De Fazio S, Doni M, De Franco F, D Artista L, et al. A non-redundant function of cyclin E1 in hematopoietic stem cells. Cell Cycle. 2013;12:3663-72 pubmed 出版商
Yu Y, Wang D, Kaosaard K, Liu C, Fu J, Haarberg K, et al. c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice. Eur J Immunol. 2013;43:2327-37 pubmed 出版商
Grosselin J, Sii Felice K, Payen E, Chretien S, Tronik Le Roux D, Leboulch P. Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics. Stem Cells. 2013;31:2162-71 pubmed 出版商
Reis B, Rogoz A, Costa Pinto F, Taniuchi I, Mucida D. Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4? T cell immunity. Nat Immunol. 2013;14:271-80 pubmed 出版商
Ma D, Suthar M, Kasahara S, Gale M, Clark E. CD22 is required for protection against West Nile virus Infection. J Virol. 2013;87:3361-75 pubmed 出版商
Burton O, Darling A, Zhou J, Noval Rivas M, Jones T, Gurish M, et al. Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. Mucosal Immunol. 2013;6:740-50 pubmed 出版商
Serre K, Cunningham A, Coughlan R, Lino A, Rot A, Hub E, et al. CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines. Blood. 2012;120:4552-9 pubmed 出版商
Tang F, Wu Q, Ikenoue T, Guan K, Liu Y, Zheng P. A critical role for Rictor in T lymphopoiesis. J Immunol. 2012;189:1850-7 pubmed 出版商
Goncharova V, Serobyan N, Iizuka S, Schraufstatter I, de Ridder A, Povaliy T, et al. Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis. J Biol Chem. 2012;287:25419-33 pubmed 出版商
Shakhov A, Singh V, Bone F, Cheney A, Kononov Y, Krasnov P, et al. Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2). PLoS ONE. 2012;7:e33044 pubmed 出版商
Taylor J, Pape K, Jenkins M. A germinal center-independent pathway generates unswitched memory B cells early in the primary response. J Exp Med. 2012;209:597-606 pubmed 出版商
Wisor J, Clegern W, Schmidt M. Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss. Sleep. 2011;34:1335-45 pubmed 出版商
Yu Y, Wang D, Liu C, Kaosaard K, Semple K, Anasetti C, et al. Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and ROR?t in mice. Blood. 2011;118:5011-20 pubmed 出版商
Rybtsov S, Sobiesiak M, Taoudi S, Souilhol C, Senserrich J, Liakhovitskaia A, et al. Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region. J Exp Med. 2011;208:1305-15 pubmed 出版商
Flutter B, Edwards N, Fallah Arani F, Henderson S, Chai J, Sivakumaran S, et al. Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation. J Clin Invest. 2010;120:3855-68 pubmed 出版商
Herrera Merchan A, Cerrato C, Luengo G, Dominguez O, Piris M, Serrano M, et al. miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal. Cell Cycle. 2010;9:3277-85 pubmed 出版商
Skarica M, Wang T, McCadden E, Kardian D, Calabresi P, Small D, et al. Signal transduction inhibition of APCs diminishes th17 and Th1 responses in experimental autoimmune encephalomyelitis. J Immunol. 2009;182:4192-9 pubmed 出版商
Barnes M, Krebs P, Harris N, Eidenschenk C, Gonzalez Quintial R, Arnold C, et al. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol. 2009;7:e51 pubmed 出版商
Glanville S, Bekiaris V, Jenkinson E, Lane P, Anderson G, Withers D. Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization. Eur J Immunol. 2009;39:280-9 pubmed 出版商
Ryan C, STAVELEY O CARROLL K, Schell T. Combined anti-CD40 conditioning and well-timed immunization prolongs CD8+ T cell accumulation and control of established brain tumors. J Immunother. 2008;31:906-20 pubmed 出版商
Rubinstein M, Lind N, Purton J, Filippou P, Best J, McGhee P, et al. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood. 2008;112:3704-12 pubmed 出版商
Lucas J, Menke J, Rabacal W, Schoen F, Sharpe A, Kelley V. Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. J Immunol. 2008;181:2513-21 pubmed
Shi Z, Rifa i M, Lee Y, Shiku H, Isobe K, Suzuki H. Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Immunology. 2008;124:121-8 pubmed 出版商
Laky K, Fowlkes B. Presenilins regulate alphabeta T cell development by modulating TCR signaling. J Exp Med. 2007;204:2115-29 pubmed
Cho J, Boyman O, Kim H, Hahm B, Rubinstein M, Ramsey C, et al. An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2. J Exp Med. 2007;204:1787-801 pubmed
Rifa i M, Kawamoto Y, Nakashima I, Suzuki H. Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis. J Exp Med. 2004;200:1123-34 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD45.1 Monoclonal Antibody (A20), FITC, eBioscience™
目录# :
11-0453-82
规格 :
100微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: 0.5 µg/test
物种 :
小鼠
克隆 :
A20
抗体亚型 :
IgG2a, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.5 µg/test
别名 :
B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; Leukocyte common antigen; loc; LY5; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国