产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45RA Monoclonal Antibody (HI100), FITC, eBioscience™
目录 :
11-0458-42
规格 :
100试验
价格 :
190美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
异硫氰酸荧光素
克隆名称 :
HI100
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 68
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 s5e
Eyquem J, Mansilla Soto J, Giavridis T, van der Stegen S, Hamieh M, Cunanan K, et al. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature. 2017;543:113-117 pubmed 出版商
  • 流式细胞仪; 人类; 图 s7
Tomic A, Varanasi P, Golemac M, Malic S, Riese P, Borst E, et al. Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand. PLoS Pathog. 2016;12:e1006015 pubmed 出版商
  • 流式细胞仪; 人类; 图 S1
LaMere S, Thompson R, Komori H, Mark A, Salomon D. Promoter H3K4 methylation dynamically reinforces activation-induced pathways in human CD4 T cells. Genes Immun. 2016;17:283-97 pubmed 出版商
  • 流式细胞仪; 人类; 图 4
Severson J, Serracino H, Mateescu V, Raeburn C, McIntyre R, Sams S, et al. PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer. Cancer Immunol Res. 2015;3:620-30 pubmed 出版商
  • 流式细胞仪; 人类; 图 s1
Arlehamn C, Seumois G, Gerasimova A, Huang C, Fu Z, Yue X, et al. Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features. J Immunol. 2014;193:2931-40 pubmed 出版商
Lv M, Li Z, Liu J, Lin F, Zhang Q, Li Z, et al. MicroRNA‑155 inhibits the proliferation of CD8+ T cells via upregulating regulatory T cells in vitiligo. Mol Med Rep. 2019;20:3617-3624 pubmed 出版商
Bell C, Fennell K, Chan Y, Rambow F, Yeung M, Vassiliadis D, et al. Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia. Nat Commun. 2019;10:2723 pubmed 出版商
Catakovic K, Gassner F, Ratswohl C, Zaborsky N, Rebhandl S, Schubert M, et al. TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia. Oncoimmunology. 2017;7:e1371399 pubmed 出版商
Tischner D, Grimm M, Kaur H, Staudenraus D, Carvalho J, Looso M, et al. Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation. JCI Insight. 2017;2: pubmed 出版商
Campos Carrascosa L, Klein M, Kitagawa Y, Lückel C, Marini F, König A, et al. Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4. Nat Commun. 2017;8:15366 pubmed 出版商
Cottineau J, Kottemann M, Lach F, Kang Y, Vély F, Deenick E, et al. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest. 2017;127:1991-2006 pubmed 出版商
Sheng S, Gu Y, Lu C, Zou J, Hong H, Wang R. The distribution and function of human memory T cell subsets in lung cancer. Immunol Res. 2017;65:639-650 pubmed 出版商
Knapp D, Hammond C, Aghaeepour N, Miller P, Pellacani D, Beer P, et al. Distinct signaling programs control human hematopoietic stem cell survival and proliferation. Blood. 2017;129:307-318 pubmed 出版商
Hoffmann M, Pantazis N, Martin G, Hickling S, Hurst J, Meyerowitz J, et al. Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection. PLoS Pathog. 2016;12:e1005661 pubmed 出版商
Macdonald K, Hoeppli R, Huang Q, Gillies J, Luciani D, Orban P, et al. Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest. 2016;126:1413-24 pubmed 出版商
Klarenbeek P, Doorenspleet M, Esveldt R, van Schaik B, Lardy N, van Kampen A, et al. Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction. PLoS ONE. 2015;10:e0140815 pubmed 出版商
Hope C, Grace B, Pilkington K, Coates P, Bergmann I, Carroll R. The immune phenotype may relate to cancer development in kidney transplant recipients. Kidney Int. 2014;86:175-83 pubmed 出版商
Wittenbecher F, Rieger K, Dziubianau M, Herholz A, Mensen A, Blau I, et al. Rabbit antithymocyte globulin induces rapid expansion of effector memory CD8 T cells without accelerating acute graft versus host disease. Leuk Res Rep. 2013;2:82-5 pubmed 出版商
Sutavani R, Bradley R, Ramage J, Jackson A, Durrant L, Spendlove I. CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype. J Immunol. 2013;191:5895-903 pubmed 出版商
Ho L, Yit P, Ng L, Linn Y, Zhao Y, Sun L, et al. The road to memory: an early rest for the long journey. J Immunol. 2013;191:5603-14 pubmed 出版商
Kshirsagar S, Binder E, Riedl M, Wechselberger G, Steichen E, Edelbauer M. Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. Arthritis Rheum. 2013;65:2996-3006 pubmed 出版商
Liu X, Gao N, Li M, Xu D, Hou Y, Wang Q, et al. Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction. PLoS ONE. 2013;8:e64531 pubmed 出版商
Jenks J, Seki S, Kanai T, Huang J, Morgan A, Scalco R, et al. Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells. Clin Immunol. 2013;148:227-36 pubmed 出版商
Hannon M, Lechanteur C, Lucas S, Somja J, Seidel L, Belle L, et al. Infusion of clinical-grade enriched regulatory T cells delays experimental xenogeneic graft-versus-host disease. Transfusion. 2014;54:353-63 pubmed 出版商
Danso Abeam D, Zhang J, Dooley J, Staats K, Van Eyck L, Van Brussel T, et al. Olmsted syndrome: exploration of the immunological phenotype. Orphanet J Rare Dis. 2013;8:79 pubmed 出版商
Macdonald K, Han J, Himmel M, Huang Q, Kan B, Campbell A, et al. Response to comment on "helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans". J Immunol. 2013;190:4440-1 pubmed 出版商
Goudy K, Aydin D, Barzaghi F, Gambineri E, Vignoli M, Ciullini Mannurita S, et al. Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity. Clin Immunol. 2013;146:248-61 pubmed 出版商
Azevedo R, Soares M, Albuquerque A, Tendeiro R, Soares R, Martins M, et al. Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19:703-12 pubmed 出版商
White Y, Yoshimitsu M, Kozako T, Matsushita K, Koriyama C, Uozumi K, et al. Effects of exogenous interleukin-7 on CD8(+) T-cell survival and function in human T-cell lymphotropic virus type 1 infection. Leuk Lymphoma. 2013;54:2243-50 pubmed 出版商
Moos V, Feurle G, Schinnerling K, Geelhaar A, Friebel J, Allers K, et al. Immunopathology of immune reconstitution inflammatory syndrome in Whipple's disease. J Immunol. 2013;190:2354-61 pubmed 出版商
McArthur M, Sztein M. Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans. Clin Immunol. 2013;146:140-52 pubmed 出版商
Hanai H, Iida T, Ikeya K, Abe J, Maruyama Y, Shimura T, et al. A new paradigm in ulcerative colitis: regulatory T cells are key factor which induces/exacerbates UC through an immune imbalance. Mol Immunol. 2013;54:173-80 pubmed 出版商
Eriksson E, Keh C, Deeks S, Martin J, Hecht F, Nixon D. Differential expression of CD96 surface molecule represents CD8? T cells with dissimilar effector function during HIV-1 infection. PLoS ONE. 2012;7:e51696 pubmed 出版商
Alexander T, Sattler A, Templin L, Kohler S, Groß C, Meisel A, et al. Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. Ann Rheum Dis. 2013;72:1549-58 pubmed 出版商
Wong W, Sigvardsson M, Astrand Grundström I, Hogge D, Larsson J, Qian H, et al. Expression of integrin ?2 receptor in human cord blood CD34+CD38-CD90+ stem cells engrafting long-term in NOD/SCID-IL2R?(c) null mice. Stem Cells. 2013;31:360-71 pubmed 出版商
Hayashi Y, Hirai H, Kamio N, Yao H, Yoshioka S, Miura Y, et al. C/EBP? promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion. Leukemia. 2013;27:619-28 pubmed 出版商
Wege A, Florian C, Ernst W, Zimara N, Schleicher U, Hanses F, et al. Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response. PLoS Negl Trop Dis. 2012;6:e1741 pubmed 出版商
Na I, Wittenbecher F, Dziubianau M, Herholz A, Mensen A, Kunkel D, et al. Rabbit antithymocyte globulin (thymoglobulin) impairs the thymic output of both conventional and regulatory CD4+ T cells after allogeneic hematopoietic stem cell transplantation in adult patients. Haematologica. 2013;98:23-30 pubmed 出版商
Garg G, Tyler J, Yang J, Cutler A, Downes K, Pekalski M, et al. Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. J Immunol. 2012;188:4644-53 pubmed 出版商
Khoo A, Koenen H, Chai L, Sweep F, Netea M, van der Ven A, et al. Seasonal variation in vitamin D? levels is paralleled by changes in the peripheral blood human T cell compartment. PLoS ONE. 2012;7:e29250 pubmed 出版商
Cuda C, Li S, Liang S, Yin Y, Potula H, Xu Z, et al. Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans. J Immunol. 2012;188:604-14 pubmed 出版商
McAlpine S, Issekutz T, Marshall J. Virus stimulation of human mast cells results in the recruitment of CD56? T cells by a mechanism dependent on CCR5 ligands. FASEB J. 2012;26:1280-9 pubmed 出版商
Hippen K, Bucher C, Schirm D, Bearl A, Brender T, Mink K, et al. Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes. Blood. 2012;119:619-28 pubmed 出版商
Zeng C, Shi X, Zhang B, Liu H, Zhang L, Ding W, et al. The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications. J Mol Med (Berl). 2012;90:175-86 pubmed 出版商
Landrigan A, Wong M, Utz P. CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism. J Immunol. 2011;187:3033-43 pubmed 出版商
Liu B, Wei L, Meyerle C, Tuo J, Sen H, Li Z, et al. Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. J Transl Med. 2011;9:1-12 pubmed 出版商
Huntington N, Alves N, Legrand N, Lim A, Strick Marchand H, Plet A, et al. Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice. Eur J Immunol. 2011;41:2883-93 pubmed 出版商
Hughson A, Bromberg I, Johnson B, Quataert S, Jospe N, Fowell D. Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes. Diabetes. 2011;60:2125-33 pubmed 出版商
Wege A, Ernst W, Eckl J, Frankenberger B, Vollmann Zwerenz A, Männel D, et al. Humanized tumor mice--a new model to study and manipulate the immune response in advanced cancer therapy. Int J Cancer. 2011;129:2194-206 pubmed 出版商
Huntington N, Alves N, Legrand N, Lim A, Strick Marchand H, Mention J, et al. IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo. Proc Natl Acad Sci U S A. 2011;108:6217-22 pubmed 出版商
Zhou X, McElhaney J. Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans. Vaccine. 2011;29:2169-77 pubmed 出版商
Bestard O, Cassis L, Cruzado J, Torras J, Franquesa M, Gil Vernet S, et al. Costimulatory blockade with mTor inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation. Transpl Int. 2011;24:451-60 pubmed 出版商
Bigley V, Haniffa M, Doulatov S, Wang X, Dickinson R, McGovern N, et al. The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. J Exp Med. 2011;208:227-34 pubmed 出版商
Marwaha A, Crome S, Panagiotopoulos C, Berg K, Qin H, Ouyang Q, et al. Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol. 2010;185:3814-8 pubmed 出版商
Shimura C, Satoh T, Igawa K, Aritake K, Urade Y, Nakamura M, et al. Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin. Am J Pathol. 2010;176:227-37 pubmed 出版商
Kvistborg P, Boegh M, Pedersen A, Claesson M, Zocca M. Fast generation of dendritic cells. Cell Immunol. 2009;260:56-62 pubmed 出版商
Han S, Huang Y, Liang Y, Ho Y, Wang Y, Chang L. Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications. J Hematol Oncol. 2009;2:34 pubmed 出版商
Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009;182:7518-26 pubmed 出版商
Matthews K, Lim Z, Afzali B, Pearce L, Abdallah A, Kordasti S, et al. Imbalance of effector and regulatory CD4 T cells is associated with graft-versus-host disease after hematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab. Haematologica. 2009;94:956-66 pubmed 出版商
Lin J, Lineberry N, Kattah M, Su L, Utz P, Fathman C, et al. Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression. J Immunol. 2009;182:5919-28 pubmed 出版商
Varghese J, Kane K. TCR complex-activated CD8 adhesion function by human T cells. J Immunol. 2008;181:6002-9 pubmed
Huarte E, Cubillos Ruiz J, Nesbeth Y, Scarlett U, Martinez D, Engle X, et al. PILAR is a novel modulator of human T-cell expansion. Blood. 2008;112:1259-68 pubmed 出版商
Cummings J, Cairo C, Armstrong C, Davis C, Pauza C. Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS. J Leukoc Biol. 2008;84:371-9 pubmed 出版商
Thakral D, Dobbins J, Devine L, Kavathas P. Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. J Immunol. 2008;180:7431-42 pubmed
van Mierlo G, Scherer H, Hameetman M, Morgan M, Flierman R, Huizinga T, et al. Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J Immunol. 2008;180:2747-51 pubmed
Laudanski K, De A, Miller Graziano C. Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells. Eur J Immunol. 2007;37:2812-24 pubmed
Humblet Baron S, Sather B, Anover S, Becker Herman S, Kasprowicz D, Khim S, et al. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest. 2007;117:407-18 pubmed
Saada J, Pinchuk I, Barrera C, Adegboyega P, Suarez G, Mifflin R, et al. Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosa. J Immunol. 2006;177:5968-79 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD45RA Monoclonal Antibody (HI100), FITC, eBioscience™
目录# :
11-0458-42
规格 :
100试验
价格 :
190美元
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 5 µL (1 µg)/test
物种 :
人类
克隆 :
HI100
抗体亚型 :
IgG2b, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing and these isoforms differ in their extracellular domains, however, they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 is expressed on cells of the human hematopoietic lineage, with the exception of mature red cells and is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Diseases associated with CD45 dysfunction include severe combined immunodeficiency and Hepatitis C.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL (1 µg)/test
别名 :
B220; CD45; CD45 antigen; CD45 antigen isoform 1 precursor; CD45 antigen isoform 2 precursor; CD45 antigen isoform 3 precursor; CD45 antigen isoform 4 precursor; CD45 antigen isoform 5 precursor; CD45 antigen isoform 6 precursor; CD45R; GP180; LCA; L-CA; leucocyte common antigen; Leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; LY5; Ly-5; Lyt-4; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; protein tyrosine phosphatase; alternatively spliced; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T100; T200; T200 glycoprotein; T200 leukocyte common antigen
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国