产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
HELIOS Monoclonal Antibody (22F6), FITC, eBioscience™
目录 :
11-9883-82
规格 :
100微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
仓鼠
共轭标签 :
异硫氰酸荧光素
克隆名称 :
22F6
反应物种 :
人类, 小鼠,
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 37
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 s2a
Amodio D, Cotugno N, Macchiarulo G, Rocca S, Dimopoulos Y, Castrucci M, et al. Quantitative Multiplexed Imaging Analysis Reveals a Strong Association between Immunogen-Specific B Cell Responses and Tonsillar Germinal Center Immune Dynamics in Children after Influenza Vaccination. J Immunol. 2018;200:538-550 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2b
Chien C, Yu H, Chen S, Chiang B. Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells. Sci Rep. 2017;7:46348 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s3e
Ansa Addo E, Zhang Y, Yang Y, Hussey G, Howley B, Salem M, et al. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. J Clin Invest. 2017;127:1321-1337 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:400; 图 4a
Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, et al. CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. Nat Commun. 2017;8:14715 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1c
He R, Hou S, Liu C, Zhang A, Bai Q, Han M, et al. Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection. Nature. 2016;537:412-428 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s4
Saha A, O Connor R, Thangavelu G, Lovitch S, Dandamudi D, Wilson C, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016;126:2642-60 pubmed 出版商
Jhala G, Chee J, Trivedi P, Selck C, Gurzov E, Graham K, et al. Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes. JCI Insight. 2016;1:e86065 pubmed 出版商
Sebastian M, Lopez Ocasio M, Metidji A, RIEDER S, Shevach E, Thornton A. Helios Controls a Limited Subset of Regulatory T Cell Functions. J Immunol. 2016;196:144-55 pubmed 出版商
Dilek N, Poirier N, Hulin P, Coulon F, Mary C, Ville S, et al. Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells. PLoS ONE. 2013;8:e83139 pubmed 出版商
Eneljung T, Tengvall S, Jirholt P, Henningsson L, Holmdahl R, Gustafsson K, et al. Antigen-specific gene therapy after immunisation reduces the severity of collagen-induced arthritis. Clin Dev Immunol. 2013;2013:345092 pubmed 出版商
Dingle B, Liu Y, Fatheree N, Min J, Rhoads J, Tran D. FoxP3? regulatory T cells attenuate experimental necrotizing enterocolitis. PLoS ONE. 2013;8:e82963 pubmed 出版商
van der Merwe M, Abdelsamed H, Seth A, Ong T, Vogel P, Pillai A. Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation. J Immunol. 2013;191:5764-76 pubmed 出版商
Yamamoto Taguchi N, Satou Y, Miyazato P, Ohshima K, Nakagawa M, Katagiri K, et al. HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression. PLoS Pathog. 2013;9:e1003630 pubmed 出版商
Peters J, Koenen H, Fasse E, Tijssen H, Ijzermans J, Groenen P, et al. Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells. Blood. 2013;122:2213-23 pubmed 出版商
Tsai S, Serra P, Clemente Casares X, Slattery R, Santamaria P. Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II. J Immunol. 2013;191:70-82 pubmed 出版商
Podojil J, Liu L, Marshall S, Chiang M, Goings G, Chen L, et al. B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms. J Autoimmun. 2013;44:71-81 pubmed 出版商
Macdonald K, Han J, Himmel M, Huang Q, Kan B, Campbell A, et al. Response to comment on "helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans". J Immunol. 2013;190:4440-1 pubmed 出版商
Stumpf M, Zhou X, Bluestone J. The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes. J Immunol. 2013;190:961-9 pubmed 出版商
Baine I, Basu S, Ames R, Sellers R, Macian F. Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells. J Immunol. 2013;190:1008-16 pubmed 出版商
Alexander T, Sattler A, Templin L, Kohler S, Groß C, Meisel A, et al. Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. Ann Rheum Dis. 2013;72:1549-58 pubmed 出版商
Sawant D, Sehra S, Nguyen E, Jadhav R, Englert K, Shinnakasu R, et al. Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function. J Immunol. 2012;189:4759-69 pubmed 出版商
Schlenner S, Weigmann B, Ruan Q, Chen Y, von Boehmer H. Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J Exp Med. 2012;209:1529-35 pubmed 出版商
Akhmetzyanova I, Zelinskyy G, Schimmer S, Brandau S, Altenhoff P, Sparwasser T, et al. Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells. Cancer Immunol Immunother. 2013;62:257-71 pubmed 出版商
Reynolds L, Maizels R. Cutting edge: in the absence of TGF-? signaling in T cells, fewer CD103+ regulatory T cells develop, but exuberant IFN-? production renders mice more susceptible to helminth infection. J Immunol. 2012;189:1113-7 pubmed 出版商
McGovern J, Nguyen D, Notley C, Mauri C, Isenberg D, Ehrenstein M. Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy. Arthritis Rheum. 2012;64:3129-38 pubmed 出版商
Wang C, Lee J, Kim C. Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch. PLoS ONE. 2012;7:e30793 pubmed 出版商
Gottschalk R, Corse E, Allison J. Expression of Helios in peripherally induced Foxp3+ regulatory T cells. J Immunol. 2012;188:976-80 pubmed 出版商
Schwele S, Fischer A, Brestrich G, Wlodarski M, Wagner L, Schmueck M, et al. Cytomegalovirus-specific regulatory and effector T cells share TCR clonality--possible relation to repetitive CMV infections. Am J Transplant. 2012;12:669-81 pubmed 出版商
Zeng C, Shi X, Zhang B, Liu H, Zhang L, Ding W, et al. The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications. J Mol Med (Berl). 2012;90:175-86 pubmed 出版商
Wainwright D, Sengupta S, Han Y, Lesniak M. Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors. Neuro Oncol. 2011;13:1308-23 pubmed 出版商
Onoe T, Kalscheuer H, Danzl N, Chittenden M, Zhao G, Yang Y, et al. Human natural regulatory T cell development, suppressive function, and postthymic maturation in a humanized mouse model. J Immunol. 2011;187:3895-903 pubmed 出版商
Weiss K, Christiaansen A, Fulton R, Meyerholz D, Varga S. Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection. J Immunol. 2011;187:3145-54 pubmed 出版商
Penaranda C, Tang Q, Bluestone J. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol. 2011;187:2015-22 pubmed 出版商
Elkord E, Sharma S, Burt D, Hawkins R. Expanded subpopulation of FoxP3+ T regulatory cells in renal cell carcinoma co-express Helios, indicating they could be derived from natural but not induced Tregs. Clin Immunol. 2011;140:218-22 pubmed 出版商
McClymont S, Putnam A, Lee M, Esensten J, Liu W, Hulme M, et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol. 2011;186:3918-26 pubmed 出版商
Bhagwat A. Comment on "Deoxyuridine triphosphate incorporation during somatic hypermutation of mouse VkOx genes after immunization with phenyloxazolone". J Immunol. 2010;185:7130-1; author reply 7131 pubmed 出版商
Verhagen J, Wraith D. Comment on "Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells". J Immunol. 2010;185:7129; author reply 7130 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
HELIOS Monoclonal Antibody (22F6), FITC, eBioscience™
目录# :
11-9883-82
规格 :
100微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
亚美尼亚仓鼠
反应物种 :
狗, 人类, 小鼠
应用 :
Flow Cytometry: 0.125 µg/test
物种 :
狗, 人类, 小鼠
克隆 :
22F6
抗体亚型 :
IgG
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.125 µg/test
别名 :
A730095J18Rik; ANF1A2; Helios; IKAROS family zinc finger 2; IKAROS family zinc finger 2 (Helios); ikaros family zinc finger protein 2; Ikzf2; Zfpn1a2; zinc finger DNA binding protein Helios; zinc finger protein Helios; zinc finger protein, subfamily 1A, 2 (Helios); ZNF1A2; Znfn1a2
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国