产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD107a (LAMP-1) Monoclonal Antibody (eBioH4A3), PE, eBioscience™
目录 :
12-1079-41
规格 :
25Tests
价格 :
109.00美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
PE
克隆名称 :
eBioH4A3
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 23
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 s3
Tsai C, Liong K, Gunalan M, Li N, Lim D, Fisher D, et al. Type I IFNs and IL-18 regulate the antiviral response of primary human γδ T cells against dendritic cells infected with Dengue virus. J Immunol. 2015;194:3890-900 pubmed 出版商
  • 流式细胞仪; 人类
Weiskopf D, Angelo M, Bangs D, Sidney J, Paul S, Peters B, et al. The human CD8+ T cell responses induced by a live attenuated tetravalent dengue vaccine are directed against highly conserved epitopes. J Virol. 2015;89:120-8 pubmed 出版商
Arbore G, West E, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, et al. Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. Nat Commun. 2018;9:4186 pubmed 出版商
Lim J, Oh C, Yoon T, Lee J, Lee S, Yoo Y, et al. The effect of propofol and sevoflurane on cancer cell, natural killer cell, and cytotoxic T lymphocyte function in patients undergoing breast cancer surgery: an in vitro analysis. BMC Cancer. 2018;18:159 pubmed 出版商
Singh N, Kulikovskaya I, Barrett D, Binder Scholl G, Jakobsen B, Martinez D, et al. T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma. Oncoimmunology. 2016;5:e1040216 pubmed
Dieckmann N, Hackmann Y, Aricò M, Griffiths G. Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes. Traffic. 2015;16:1330-41 pubmed 出版商
Henault J, Riggs J, Karnell J, Liarski V, Li J, Shirinian L, et al. Self-reactive IgE exacerbates interferon responses associated with autoimmunity. Nat Immunol. 2016;17:196-203 pubmed 出版商
Wang W, Wu F, Cong Z, Liu K, Qin C, Wei Q. The secretion of IL-22 from mucosal NKp44⁺ NK cells is associated with microbial translocation and virus infection in SIV/SHIV-infected Chinese macaques. J Immunol Res. 2014;2014:387950 pubmed 出版商
Amancha P, Hong J, Rogers K, Ansari A, Villinger F. In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit. J Immunol. 2013;191:6060-70 pubmed 出版商
Zhou Q, Gil Krzewska A, Peruzzi G, Borrego F. Matrix metalloproteinases inhibition promotes the polyfunctionality of human natural killer cells in therapeutic antibody-based anti-tumour immunotherapy. Clin Exp Immunol. 2013;173:131-9 pubmed 出版商
McArthur M, Sztein M. Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans. Clin Immunol. 2013;146:140-52 pubmed 出版商
Vargas Inchaustegui D, Xiao P, Tuero I, Patterson L, Robert Guroff M. NK and CD4+ T cell cooperative immune responses correlate with control of disease in a macaque simian immunodeficiency virus infection model. J Immunol. 2012;189:1878-85 pubmed 出版商
Hazeldine J, Hampson P, Lord J. Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity. Aging Cell. 2012;11:751-9 pubmed 出版商
Roat E, De Biasi S, Bertoncelli L, Rompianesi G, Nasi M, Gibellini L, et al. Immunological advantages of everolimus versus cyclosporin A in liver-transplanted recipients, as revealed by polychromatic flow cytometry. Cytometry A. 2012;81:303-11 pubmed 出版商
Kim E, Kim T, Kim N, Kim S, Kumar V, Lee K. Homotypic cell to cell cross-talk among human natural killer cells reveals differential and overlapping roles of 2B4 and CD2. J Biol Chem. 2010;285:41755-64 pubmed 出版商
Canderan G, Gruarin P, Montagna D, Fontana R, Campi G, Melloni G, et al. An efficient strategy to induce and maintain in vitro human T cells specific for autologous non-small cell lung carcinoma. PLoS ONE. 2010;5:e12014 pubmed 出版商
Kim T, Kim N, Kang H, Kim E, Kim S, Ahn H, et al. FK506 causes cellular and functional defects in human natural killer cells. J Leukoc Biol. 2010;88:1089-97 pubmed 出版商
Salerno Goncalves R, Wahid R, Sztein M. Ex Vivo kinetics of early and long-term multifunctional human leukocyte antigen E-specific CD8+ cells in volunteers immunized with the Ty21a typhoid vaccine. Clin Vaccine Immunol. 2010;17:1305-14 pubmed 出版商
Peralta E, Martin B, Edinger A. Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence. J Biol Chem. 2010;285:16814-21 pubmed 出版商
Huynh C, Andrews N. The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis. EMBO Rep. 2005;6:843-7 pubmed
Betts M, Koup R. Detection of T-cell degranulation: CD107a and b. Methods Cell Biol. 2004;75:497-512 pubmed
Grützkau A, Smorodchenko A, Lippert U, Kirchhof L, Artuc M, Henz B. LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells. Cytometry A. 2004;61:62-8 pubmed
Sarafian V, Jadot M, Foidart J, Letesson J, van den Brule F, Castronovo V, et al. Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells. Int J Cancer. 1998;75:105-11 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD107a (LAMP-1) Monoclonal Antibody (eBioH4A3), PE, eBioscience™
目录# :
12-1079-41
规格 :
25Tests
价格(美元) :
109.00美元
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 5 µL (0.125 µg)/test
物种 :
人类
克隆 :
eBioH4A3
抗体亚型 :
IgG1, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
LAMP1 (CD107a, lysosome-associated membrane protein-1) together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. LAMP1 is a heavily glycosylated membrane protein which contains a putative signal peptide, 18 sites for N-linked glycosylation, a single membrane-spanning segment and a short (11 amino acid) cytosolic tail. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. LAMP1 is a type 1 integral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1, and this mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 (and LAMP2) have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore, they are possibly involved in the adhesion of PBMC to the site of inflammation. Increased LAMP1 immunoreactivity is observed in neurons and glial cells surrounding senile plaques in Alzheimer’s Disease (AD) cases, and is localized in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. LAMP1 is a good marker of mast cell activation.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL (0.125 µg)/test
别名 :
120 kDa lysosomal membrane glycoprotein; AI196048; CD107 antigen-like family member A; CD107a; I79_011073; Lamp I; Lamp1; LAMP-1; LAMPA; LGP120; LGP-120; Lgpa; LGP-A; lysosomal associated membrane protein 1; Lysosomal associated membrane protein 1 (120 kDa); lysosomal membrane glycoprotein 1; lysosomal membrane glycoprotein A; lysosomal-associated membrane protein 1; lysosome-associated membrane glycoprotein 1; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B); lysosome-associated membrane protein 1; P2B
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国