产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-1 beta (Pro-form) Monoclonal Antibody (NJTEN3), PE, eBioscience
目录 :
12-7114-82
规格 :
100微克
价格 :
美国411
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
PE
克隆名称 :
NJTEN3
反应物种 :
小鼠
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 33
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠
Yang C, Kwon D, Kim M, Im S, Lee Y. Commensal Microbiome Expands Tγδ17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia. Front Immunol. 2021;12:645741 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 7d
Huang L, Nazarova E, Tan S, Liu Y, Russell D. Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny. J Exp Med. 2018;215:1135-1152 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4
Kim J, Phan T, Nguyen V, Dinh Vu H, Zheng J, Yun M, et al. Salmonella typhimurium Suppresses Tumor Growth via the Pro-Inflammatory Cytokine Interleukin-1β. Theranostics. 2015;5:1328-42 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:50; 图 3
Elahy M, Jackaman C, Mamo J, Lam V, Dhaliwal S, Giles C, et al. Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment. Immun Ageing. 2015;12:2 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Fontana M, Baccarella A, Pancholi N, Pufall M, Herbert D, Kim C. JUNB is a key transcriptional modulator of macrophage activation. J Immunol. 2015;194:177-86 pubmed 出版商
Luo Y, Guo J, Jia W, Wu M, Yin F, Niu G, et al. TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization. Oxid Med Cell Longev. 2021;2021:3877617 pubmed 出版商
Guo X, Xu X, Li T, Yu Q, Wang J, Chen Y, et al. NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis. Front Immunol. 2021;12:749979 pubmed 出版商
Duan R, Yang C, Du T, Liu A, Wang A, Sun W, et al. Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway. J Neuroinflammation. 2021;18:145 pubmed 出版商
Shao L, He Q, Wang J, He F, Lin S, Wu L, et al. MicroRNA-326 attenuates immune escape and prevents metastasis in lung adenocarcinoma by targeting PD-L1 and B7-H3. Cell Death Discov. 2021;7:145 pubmed 出版商
Jones N, Blagih J, Zani F, Rees A, Hill D, Jenkins B, et al. Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation. Nat Commun. 2021;12:1209 pubmed 出版商
Ding L, Sontz E, Saqui Salces M, Merchant J. Interleukin-1β Suppresses Gastrin via Primary Cilia and Induces Antral Hyperplasia. Cell Mol Gastroenterol Hepatol. 2021;11:1251-1266 pubmed 出版商
Reverchon F, de Concini V, Larrigaldie V, Benmerzoug S, Briault S, Togbe D, et al. Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments. J Neuroinflammation. 2020;17:268 pubmed 出版商
Castoldi A, Monteiro L, van Teijlingen Bakker N, Sanin D, Rana N, Corrado M, et al. Triacylglycerol synthesis enhances macrophage inflammatory function. Nat Commun. 2020;11:4107 pubmed 出版商
Kitamoto S, Nagao Kitamoto H, Jiao Y, Gillilland M, Hayashi A, Imai J, et al. The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis. Cell. 2020;182:447-462.e14 pubmed 出版商
Di Gioia M, Spreafico R, Springstead J, Mendelson M, Joehanes R, Levy D, et al. Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. Nat Immunol. 2020;21:42-53 pubmed 出版商
Wasnik S, Rundle C, Baylink D, Yazdi M, Carreon E, Xu Y, et al. 1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites. JCI Insight. 2018;3: pubmed 出版商
Lee S, Charmoy M, Romano A, Paun A, Chaves M, Cope F, et al. Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment. J Exp Med. 2018;215:357-375 pubmed 出版商
Varol D, Mildner A, Blank T, Shemer A, Barashi N, Yona S, et al. Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain. Immunity. 2017;46:1030-1044.e8 pubmed 出版商
Kimball A, Joshi A, Boniakowski A, Schaller M, Chung J, ALLEN R, et al. Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing. Front Immunol. 2017;8:635 pubmed 出版商
Westerterp M, Gautier E, Ganda A, Molusky M, Wang W, Fotakis P, et al. Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity. Cell Metab. 2017;25:1294-1304.e6 pubmed 出版商
Jin W, Shi S, Li Z, Li M, Wood K, Gonzales R, et al. Depletion of microglia exacerbates postischemic inflammation and brain injury. J Cereb Blood Flow Metab. 2017;37:2224-2236 pubmed 出版商
. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1603-1658 pubmed 出版商
Ravindran R, Loebbermann J, Nakaya H, Khan N, Ma H, Gama L, et al. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. 2016;531:523-527 pubmed 出版商
Blaisdell A, Crequer A, Columbus D, Daikoku T, Mittal K, Dey S, et al. Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells. Cancer Cell. 2015;28:785-799 pubmed 出版商
Patankar Y, Mabaera R, Berwin B. Differential ASC requirements reveal a key role for neutrophils and a noncanonical IL-1β response to Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol. 2015;309:L902-13 pubmed 出版商
Torres I, Patankar Y, Shabaneh T, Dolben E, Hogan D, Leib D, et al. Acidosis potentiates the host proinflammatory interleukin-1β response to Pseudomonas aeruginosa infection. Infect Immun. 2014;82:4689-97 pubmed 出版商
Asrat S, Dugan A, Isberg R. The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines. PLoS Pathog. 2014;10:e1004229 pubmed 出版商
Berod L, Stüve P, Swallow M, Arnold Schrauf C, Kruse F, Gentilini M, et al. MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection. Eur J Immunol. 2014;44:1399-409 pubmed 出版商
Sun B, Hu X, Liu G, Ma B, Xu Y, Yang T, et al. Phosphatase Wip1 negatively regulates neutrophil migration and inflammation. J Immunol. 2014;192:1184-95 pubmed 出版商
Kim H, Lee H, Chang Y, Pichavant M, Shore S, Fitzgerald K, et al. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med. 2014;20:54-61 pubmed 出版商
Gower R, Boehler R, Azarin S, Ricci C, Leonard J, Shea L. Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression. Biomaterials. 2014;35:2024-31 pubmed 出版商
Enzler T, Sano Y, Choo M, Cottam H, Karin M, Tsao H, et al. Cell-selective inhibition of NF-?B signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discov. 2011;1:496-507 pubmed 出版商
Mayer Barber K, Andrade B, Barber D, Hieny S, Feng C, Caspar P, et al. Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity. 2011;35:1023-34 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
IL-1 beta (Pro-form) Monoclonal Antibody (NJTEN3), PE, eBioscience
目录# :
12-7114-82
规格 :
100微克
价格 :
美国411
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: 0.06 µg/test
物种 :
小鼠
克隆 :
NJTEN3
抗体亚型 :
IgG1, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is instead secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions.IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. These cytokines play important roles in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. Their activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions, giving IL-RA or IL-1 beta neutralizing antibodies potential therapeutical value.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.06 µg/test
别名 :
il 1b; IL 1ß; IL-1 beta; Il1b; Il-1b; IL-1beta; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin1 beta; interleukin-1 beta; Interleukin-1b
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国