产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-17A Monoclonal Antibody (eBio17B7), PE, eBioscience
目录 :
12-7177-81
规格 :
50微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
PE
克隆名称 :
eBio17B7
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 流式细胞仪
更多信息或购买 :
文章摘录数: 330
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 4o
Kim G, Kim W, Lim S, Lee H, Koo J, Nam K, et al. In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse. Adv Sci (Weinh). 2021;8:2004973 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3b, 5b
Chen J, Yang F, Shi S, Liu X, Qin F, Wei X, et al. The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice. Mediators Inflamm. 2021;2021:5551578 pubmed 出版商
  • 流式细胞仪; 小鼠
Tyagi A, Darby T, Hsu E, Yu M, Pal S, Dar H, et al. The gut microbiota is a transmissible determinant of skeletal maturation. elife. 2021;10: pubmed 出版商
  • 流式细胞仪; 小鼠; 1:100
Sanmarco L, Wheeler M, Gutiérrez Vázquez C, Polonio C, Linnerbauer M, Pinho Ribeiro F, et al. Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021;: pubmed 出版商
  • 流式细胞仪; 小鼠; 1:100; 图 s3d
Wheeler M, Jaronen M, Covacu R, Zandee S, Scalisi G, Rothhammer V, et al. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019;176:581-596.e18 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4c
Mikolajczyk T, Nosalski R, Skiba D, Koziol J, Mazur M, Justo Junior A, et al. 1,2,3,4,6-Penta-O-galloyl-β-d-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension. Br J Pharmacol. 2019;176:1951-1965 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3d
Kiyohara H, Sujino T, Teratani T, Miyamoto K, Arai M, Nomura E, et al. Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells. Cell Mol Gastroenterol Hepatol. 2019;7:135-156 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6b
Han L, Wang L, Tang S, Yuan L, Wu S, Du X, et al. ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior. J Neuroinflammation. 2018;15:246 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4d
Cheng Y, Zhu X, Wang X, Zhuang Q, Huyan X, Sun X, et al. Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation. Front Immunol. 2018;9:1566 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2a
Linehan J, Harrison O, Han S, Byrd A, Vujkovic Cvijin I, Villarino A, et al. Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair. Cell. 2018;172:784-796.e18 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2b
Zhang H, Qi Y, Yuan Y, Cai L, Xu H, Zhang L, et al. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. Sci Rep. 2017;7:41887 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3f
Hammer A, Yang G, Friedrich J, Kovacs A, Lee D, Grave K, et al. Role of the receptor Mas in macrophage-mediated inflammation in vivo. Proc Natl Acad Sci U S A. 2016;113:14109-14114 pubmed
  • 流式细胞仪; 小鼠; 图 3
Vigeland C, Collins S, Chan Li Y, Hughes A, Oh M, Powell J, et al. Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells. PLoS ONE. 2016;11:e0163288 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3
Gu L, Deng W, Sun X, Zhou H, Xu Q. Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance. Mol Med Rep. 2016;14:1153-61 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Qi X, Gurung P, Malireddi R, Karmaus P, Sharma D, Vogel P, et al. Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunol. 2017;10:128-138 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6
Tosiek M, Fiette L, El Daker S, Eberl G, Freitas A. IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease. Nat Commun. 2016;7:10888 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Woo J, Srikanth S, Nishi M, Ping P, Takeshima H, Gwack Y. Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells. Proc Natl Acad Sci U S A. 2016;113:2762-7 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Hu H, Wang H, Xiao Y, Jin J, Chang J, Zou Q, et al. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016;213:399-414 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s8
Traka M, Podojil J, McCarthy D, Miller S, Popko B. Oligodendrocyte death results in immune-mediated CNS demyelination. Nat Neurosci. 2016;19:65-74 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1c
Guo L, Huang Y, Chen X, Hu Li J, Urban J, Paul W. Innate immunological function of TH2 cells in vivo. Nat Immunol. 2015;16:1051-9 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Wang X, Huang Z, Chen Y, Lu X, Zhu P, Wen K, et al. A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus. PLoS ONE. 2015;10:e0136888 pubmed 出版商
  • 流式细胞仪; 人类; 图 3
Hannani D, Vétizou M, Enot D, Rusakiewicz S, Chaput N, Klatzmann D, et al. Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25. Cell Res. 2015;25:208-24 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat Immunol. 2015;16:178-87 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3c
Wu C, He S, Peng Y, Kushwaha K, Lin J, Dong J, et al. TSLPR deficiency attenuates atherosclerotic lesion development associated with the inhibition of TH17 cells and the promotion of regulator T cells in ApoE-deficient mice. J Mol Cell Cardiol. 2014;76:33-45 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Griffiths K, Stylianou E, Poyntz H, Betts G, Fletcher H, McShane H. Cholera toxin enhances vaccine-induced protection against Mycobacterium tuberculosis challenge in mice. PLoS ONE. 2013;8:e78312 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6
Tousif S, Singh Y, Prasad D, Sharma P, Van Kaer L, Das G. T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection. PLoS ONE. 2011;6:e19864 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3
Werner J, Busl E, Farkas S, Schlitt H, Geissler E, Hornung M. DX5+NKT cells display phenotypical and functional differences between spleen and liver as well as NK1.1-Balb/c and NK1.1+ C57Bl/6 mice. BMC Immunol. 2011;12:26 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3
Mandal M, Marzouk A, Donnelly R, Ponzio N. Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells. Brain Behav Immun. 2011;25:863-71 pubmed 出版商
Gupta S, Simic M, Sagan S, Shepherd C, Duecker J, Sobel R, et al. CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity. Neurol Neuroimmunol Neuroinflamm. 2023;10: pubmed 出版商
Zhou Y, Zhang Z, Sun Y, Zhou D, Zhao Y, Li J, et al. Liangxue Tongyu Prescription Alleviates Brain Damage in Acute Intracerebral Hemorrhage Rats by Regulating Intestinal Mucosal Barrier Function. Evid Based Complement Alternat Med. 2022;2022:2197763 pubmed 出版商
Hu X, Zou Y, Copland D, Schewitz Bowers L, Li Y, Lait P, et al. Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2. EBioMedicine. 2022;86:104333 pubmed 出版商
Liu Y, Zhao N, Xu Q, Deng F, Wang P, Dong L, et al. MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis. J Inflamm Res. 2022;15:4315-4329 pubmed 出版商
Tarke A, Potestà M, Varchetta S, Fenoglio D, Iannetta M, Sarmati L, et al. Early and Polyantigenic CD4 T Cell Responses Correlate with Mild Disease in Acute COVID-19 Donors. Int J Mol Sci. 2022;23: pubmed 出版商
x17b migrodzka M, Witkowska Pi x142 aszewicz O, Pingwara R, Winnicka A. Platelet Extracellular Vesicles Are Taken up by Canine T Lymphocytes but Do Not Play a Role in Their Proliferation, Differentiation and Cytokine Production In Vitro. Int J Mol Sci. 2022;23: pubmed 出版商
Tang T, Wang F, Liu J, Ye W, Zhao T, Li Z. Rhubarb Alleviates Acute Lung Injury by Modulating Gut Microbiota Dysbiosis in Mice. Curr Microbiol. 2022;79:116 pubmed 出版商
Park J, Lee D, Yang S, Jeong H, Na H, Cho K, et al. Methotrexate-loaded nanoparticles ameliorate experimental model of autoimmune arthritis by regulating the balance of interleukin-17-producing T cells and regulatory T cells. J Transl Med. 2022;20:85 pubmed 出版商
Zou Q, Liu C, Hu N, Wang W, Wang H. miR-126 ameliorates multiple organ dysfunction in septic rats by regulating the differentiation of Th17/Treg. Mol Biol Rep. 2022;49:2985-2998 pubmed 出版商
Lin X, Gaudino S, Jang K, Bahadur T, Singh A, Banerjee A, et al. IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment. Immunity. 2022;55:237-253.e8 pubmed 出版商
Mart xed nez Iglesias O, Carrera I, Naidoo V, Cacabelos R. AntiGan: An Epinutraceutical Bioproduct with Antitumor Properties in Cultured Cell Lines. Life (Basel). 2022;12: pubmed 出版商
Chen Y, Liu R, Cui Y, Hettinghouse A, Fu W, Zhang L, et al. Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases. Arthritis Res Ther. 2022;24:27 pubmed 出版商
Sugiura A, Andrejeva G, Voss K, Heintzman D, Xu X, Madden M, et al. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022;55:65-81.e9 pubmed 出版商
Hu G, Zhou X. Gallic Acid Ameliorates Atopic Dermatitis-Like Skin Inflammation Through Immune Regulation in a Mouse Model. Clin Cosmet Investig Dermatol. 2021;14:1675-1683 pubmed 出版商
Chao J, Korzinkin M, Zhavoronkov A, Ozerov I, Walker M, Higgins K, et al. Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma. Cell Rep Med. 2021;2:100399 pubmed 出版商
Huang G, Ge Y, Gui Z, Zhu M, Liu J, Wang H. Toxicity of Melastoma dodecandrum Lour. and its effects on lipopolysaccharide-induced inflammation and oxidative stress. Exp Ther Med. 2021;22:807 pubmed 出版商
Yang X, Zhou F, Yuan P, Dou G, Liu X, Liu S, et al. T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance. Bioact Mater. 2021;6:3150-3163 pubmed 出版商
Ma C, Li S, Hu Y, Ma Y, Wu Y, Wu C, et al. AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis. J Exp Med. 2021;218: pubmed 出版商
Viladomiu M, Metz M, Lima S, Jin W, Chou L, Guo C, et al. Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation. Cell Host Microbe. 2021;29:607-619.e8 pubmed 出版商
Gao T, Huang F, Xie Y, Wang W, Wang L, Mu D, et al. Dynamic changes in the systemic immune responses of spinal cord injury model mice. Neural Regen Res. 2021;16:382-387 pubmed 出版商
O Connor E, Muñoz Wolf N, León G, Lavelle E, Mills K, Walsh P, et al. UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation. PLoS ONE. 2020;15:e0239713 pubmed 出版商
Ge N, Peng J, Yu L, Huang S, Xu L, Su Y, et al. Orthodontic treatment induces Th17/Treg cells to regulate tooth movement in rats with periodontitis. Iran J Basic Med Sci. 2020;23:1315-1322 pubmed 出版商
Li H, Zhou Y, Zhao A, Guo L. Exploring the Mechanism on the Medullary Visceral Zone Inhibiting the Cholinergic Anti-inflammatory Pathway Induced by Sepsis. Mediators Inflamm. 2020;2020:1320278 pubmed 出版商
Medina Rodríguez E, Madorma D, O Connor G, Mason B, Han D, Deo S, et al. Identification of a Signaling Mechanism by Which the Microbiome Regulates Th17 Cell-Mediated Depressive-Like Behaviors in Mice. Am J Psychiatry. 2020;177:974-990 pubmed 出版商
Zhu F, Qiu T, Zhu S, Zhao K, Chen C, Qiao J, et al. TIRC7 inhibits Th1 cells by upregulating the expression of CTLA‑4 and STAT3 in mice with acute graft‑versus‑host disease. Oncol Rep. 2020;44:43-54 pubmed 出版商
Hu F, Jiang X, Guo C, Li Y, Chen S, Zhang W, et al. Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study. Nat Commun. 2020;11:1911 pubmed 出版商
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Iwanaga N, Sandquist I, Wanek A, McCombs J, Song K, Kolls J. Host immunology and rational immunotherapy for carbapenem-resistant Klebsiella pneumoniae infection. JCI Insight. 2020;5: pubmed 出版商
Zhang C, Jin H, Wang Y, Li C, Zhao X, Li Y, et al. Critical role of OX40 in drug-induced acute liver injury. Br J Pharmacol. 2020;177:3183-3196 pubmed 出版商
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Okuyama Y, Nagashima H, Ushio Fukai M, Croft M, Ishii N, So T. IQGAP1 restrains T-cell cosignaling mediated by OX40. FASEB J. 2020;34:540-554 pubmed 出版商
Song Y, Xu J, Wang X, Yang Y, Bai X, Pang J, et al. Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection. Parasite. 2019;26:74 pubmed 出版商
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Zhang H, Carnevale G, Polese B, Simard M, Thurairajah B, Khan N, et al. CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota. Cell Rep. 2019;29:391-405.e5 pubmed 出版商
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Xu Y, Tang X, Yang M, Zhang S, Li S, Chen Y, et al. Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway. Mediators Inflamm. 2019;2019:4652596 pubmed 出版商
Dmitrieva Posocco O, Dzutsev A, Posocco D, Hou V, Yuan W, Thovarai V, et al. Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer. Immunity. 2019;50:166-180.e7 pubmed 出版商
Li Q, Shan Q, Sang X, Zhu R, Chen X, Cao G. Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance. Am J Chin Med. 2019;47:177-201 pubmed 出版商
Scheer S, Ackloo S, Medina T, Schapira M, Li F, Ward J, et al. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat Commun. 2019;10:19 pubmed 出版商
Soriano Romaní L, Contreras Ruiz L, López García A, Diebold Y, Masli S. Topical Application of TGF-β-Activating Peptide, KRFK, Prevents Inflammatory Manifestations in the TSP-1-Deficient Mouse Model of Chronic Ocular Inflammation. Int J Mol Sci. 2018;20: pubmed 出版商
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Lee A, Kim M, Cho D, Jang K, Choi S, Kim T. Vibrio vulnificus RtxA Is a Major Factor Driving Inflammatory T Helper Type 17 Cell Responses in vitro and in vivo. Front Immunol. 2018;9:2095 pubmed 出版商
Skalski J, Limon J, Sharma P, Gargus M, Nguyen C, Tang J, et al. Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice. PLoS Pathog. 2018;14:e1007260 pubmed 出版商
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Lee S, Park H, Van Kaer L, Hong S, Hong S. Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model. Sci Rep. 2018;8:10081 pubmed 出版商
Pang P, Zheng K, Wu S, Xü H, Deng L, Shi Y, et al. Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis. Evid Based Complement Alternat Med. 2018;2018:4923062 pubmed 出版商
Lin W, Wang N, Zhou K, Su F, Jiang Y, Shou J, et al. RKIP mediates autoimmune inflammation by positively regulating IL-17R signaling. EMBO Rep. 2018;19: pubmed 出版商
Murera D, Arbogast F, Arnold J, Bouis D, Muller S, Gros F. CD4 T cell autophagy is integral to memory maintenance. Sci Rep. 2018;8:5951 pubmed 出版商
Li H, Yao Q, Mariscal A, Wu X, Hulse J, Pedersen E, et al. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nat Commun. 2018;9:1420 pubmed 出版商
Wang C, Zaheer M, Bian F, Quach D, Swennes A, Britton R, et al. Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci. 2018;19: pubmed 出版商
Liu Y, Sun L, Chen W, Chuai J, Shang Y, Zhang D, et al. Combined treatment with simvastatin and rapamycin attenuates cardiac allograft rejection through the regulation of T helper 17 and regulatory T cells. Exp Ther Med. 2018;15:1941-1949 pubmed 出版商
Li M, Gao J, Tang Y, Liu M, Wu S, Qu K, et al. Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells. Front Pharmacol. 2017;8:959 pubmed 出版商
Emgård J, Kammoun H, García Cassani B, Chesne J, Parigi S, Jacob J, et al. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation. Immunity. 2018;48:120-132.e8 pubmed 出版商
Kumar P, Kolls J. Lymphocyte Isolation, Th17 Cell Differentiation, Activation, and Staining. Bio Protoc. 2016;6: pubmed 出版商
Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, et al. Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease. Nat Commun. 2017;8:978 pubmed 出版商
Zhou H, Wang L, Xu Q, Liu Q, Liu H, Qiu W, et al. ID3 may protect mice from anti?GBM glomerulonephritis by regulating the differentiation of Th17 and Treg cells. Mol Med Rep. 2017;16:9086-9094 pubmed 出版商
Chu F, Hu Y, Zhou Y, Guo M, Lu J, Zheng W, et al. MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway. Clin Exp Immunol. 2017;: pubmed 出版商
Li Y, Li H, Cao Y, Wu F, Ma W, Wang Y, et al. Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance. Mol Med Rep. 2017;16:8137-8145 pubmed 出版商
Soutto M, Saleh M, Arredouani M, Piazuelo B, Belkhiri A, El Rifai W. Loss of Tff1 Promotes Pro-Inflammatory Phenotype with Increase in the Levels of RORγt+ T Lymphocytes and Il-17 in Mouse Gastric Neoplasia. J Cancer. 2017;8:2424-2435 pubmed 出版商
Park H, Lee S, Kwon D, Heo S, Park S, Kim S, et al. Oral administration of taheebo (Tabebuia avellanedae Lorentz ex Griseb.) water extract prevents DSS-induced colitis in mice by up-regulating type II T helper immune responses. BMC Complement Altern Med. 2017;17:448 pubmed 出版商
Minter M, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, et al. Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease. Sci Rep. 2017;7:10411 pubmed 出版商
Tischner D, Grimm M, Kaur H, Staudenraus D, Carvalho J, Looso M, et al. Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation. JCI Insight. 2017;2: pubmed 出版商
Robert R, Ang C, Sun G, Juglair L, Lim E, Mason L, et al. Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice. JCI Insight. 2017;2: pubmed 出版商
Novince C, Whittow C, Aartun J, Hathaway J, Poulides N, Chavez M, et al. Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health. Sci Rep. 2017;7:5747 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
IL-17A Monoclonal Antibody (eBio17B7), PE, eBioscience
目录# :
12-7177-81
规格 :
50微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠, 大鼠
应用 :
Flow Cytometry: 0.125 µg/test
物种 :
小鼠, 大鼠
克隆 :
eBio17B7
抗体亚型 :
IgG2a, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.125 µg/test
别名 :
Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国