产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Amyloid Precursor Protein Monoclonal Antibody (LN27)
目录 :
13-0200
规格 :
100微克
价格 :
美国482
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
LN27
反应物种 :
猪尾猕猴, 人类, 小鼠, 大鼠, 家羊, domestic rabbit, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 55
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:500; 图 3
Hares K, Redondo J, Kemp K, Rice C, Scolding N, Wilkins A. Axonal motor protein KIF5A and associated cargo deficits in multiple sclerosis lesional and normal-appearing white matter. Neuropathol Appl Neurobiol. 2017;43:227-241 pubmed 出版商
  • 免疫组化; 人类; 图 7
Yuan P, Grutzendler J. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. J Neurosci. 2016;36:632-41 pubmed 出版商
  • 免疫印迹; 人类; 1:400
Chun Y, Oh H, Park M, Kim T, Chung S. Increasing Membrane Cholesterol Level Increases the Amyloidogenic Peptide by Enhancing the Expression of Phospholipase C. J Neurodegener Dis. 2013;2013:407903 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4
Lee I, Jung K, Kim I, Lee H, Kim M, Yun S, et al. Human neural stem cells alleviate Alzheimer-like pathology in a mouse model. Mol Neurodegener. 2015;10:38 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100
Reis R, Hennessy E, Murray C, Griffin Ã, Cunningham C. At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei. Neuropathol Appl Neurobiol. 2015;41:780-97 pubmed 出版商
  • 免疫组化; 猕猴; 图 4
Kelly K, Beck S, Metcalf Pate K, Queen S, Dorsey J, Adams R, et al. Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain. AIDS. 2013;27:F21-8 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Kang M, Baek S, Chun Y, Moore A, Landman N, Berman D, et al. Modulation of lipid kinase PI4KII? activity and lipid raft association of presenilin 1 underlies ?-secretase inhibition by ginsenoside (20S)-Rg3. J Biol Chem. 2013;288:20868-82 pubmed 出版商
  • 免疫细胞化学; 人类
Zheng L, Cedazo Minguez A, Hallbeck M, Jerhammar F, Marcusson J, Terman A. Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system. Transl Neurodegener. 2012;1:19 pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Saito Y, Inoue T, Zhu G, Kimura N, Okada M, Nishimura M, et al. Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and A? generation in Alzheimer's disease. Mol Neurodegener. 2012;7:50 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3, 4
Zheng Y, Wang Q, Xiao B, Lu Q, Wang Y, Wang X. Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and ?-amyloid deposition in Alzheimer's disease models. PLoS ONE. 2012;7:e39035 pubmed 出版商
  • 免疫印迹; 人类; 1:250; 图 3
Killian R, Flippin J, Herrera C, Almenar Queralt A, Goldstein L. Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PLoS ONE. 2012;7:e29755 pubmed 出版商
  • 免疫组化; 人类; 表 2
Huizinga R, van der Star B, Kipp M, Jong R, Gerritsen W, Clarner T, et al. Phagocytosis of neuronal debris by microglia is associated with neuronal damage in multiple sclerosis. Glia. 2012;60:422-31 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 1
Zheng L, Terman A, Hallbeck M, Dehvari N, Cowburn R, Benedikz E, et al. Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells. Autophagy. 2011;7:1528-45 pubmed
  • 免疫印迹; 人类; 图 1
Chapuis J, Vingtdeux V, Capiralla H, Davies P, Marambaud P. Gas1 interferes with A?PP trafficking by facilitating the accumulation of immature A?PP in endoplasmic reticulum-associated raft subdomains. J Alzheimers Dis. 2012;28:127-35 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 7
Ranganathan S, Noyes N, Migliorini M, Winkles J, Battey F, Hyman B, et al. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. J Neurosci. 2011;31:10836-46 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Chapuis J, Vingtdeux V, Campagne F, Davies P, Marambaud P. Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein. Hum Mol Genet. 2011;20:2026-36 pubmed 出版商
  • 免疫印迹; 人类
van Noort J, Bsibsi M, Gerritsen W, van der Valk P, Bajramovic J, Steinman L, et al. Alphab-crystallin is a target for adaptive immune responses and a trigger of innate responses in preactive multiple sclerosis lesions. J Neuropathol Exp Neurol. 2010;69:694-703 pubmed 出版商
  • 免疫细胞化学; 小鼠
Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon J, et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem. 2010;285:9100-13 pubmed 出版商
  • 免疫印迹; 人类
Portelius E, Brinkmalm G, Tran A, Andreasson U, Zetterberg H, Westman Brinkmalm A, et al. Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid. Exp Neurol. 2010;223:351-8 pubmed 出版商
  • 免疫组化-石蜡切片; 猕猴; 图 1
Mankowski J, Queen S, Fernandez C, Tarwater P, Karper J, Adams R, et al. Natural host genetic resistance to lentiviral CNS disease: a neuroprotective MHC class I allele in SIV-infected macaques. PLoS ONE. 2008;3:e3603 pubmed 出版商
  • 免疫组化; 人类; 图 1
Moeller J, Macaulay R, Valdmanis P, Weston L, Rouleau G, Dupre N. Autosomal dominant sensory ataxia: a neuroaxonal dystrophy. Acta Neuropathol. 2008;116:331-6 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Ryoo S, Cho H, Lee H, Jeong H, Radnaabazar C, Kim Y, et al. Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease. J Neurochem. 2008;104:1333-44 pubmed
  • 免疫组化-石蜡切片; 大鼠; 1:200
Ai J, Liu E, Wang J, Chen Y, Yu J, Baker A. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J Neurotrauma. 2007;24:960-78 pubmed
  • 酶联免疫吸附测定; 人类; 0.5 ug/ml
Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch M, et al. Expression of APP pathway mRNAs and proteins in Alzheimer's disease. Brain Res. 2007;1161:116-23 pubmed
  • 免疫细胞化学; 人类; 1:1000
Nizzari M, Venezia V, Repetto E, Caorsi V, Magrassi R, Gagliani M, et al. Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling. J Biol Chem. 2007;282:13833-44 pubmed
  • 免疫组化-石蜡切片; 小鼠; 1:1500; 图 8
  • 免疫组化-石蜡切片; 人类; 1:1500
German A, Myint K, Mai N, Pomeroy I, Phu N, Tzartos J, et al. A preliminary neuropathological study of Japanese encephalitis in humans and a mouse model. Trans R Soc Trop Med Hyg. 2006;100:1135-45 pubmed
  • 免疫印迹; 大鼠; 图 2
Kirazov L, Kirazovi E, Schliebs R. L-glutamate and phorbol ester stimulate the release of secretory amyloid precursor protein from rat cortical synaptosomes. Acta Biol Hung. 2005;56:177-83 pubmed
  • 免疫组化; 猕猴; 1:10,000
Helke K, Queen S, Tarwater P, Turchan Cholewo J, Nath A, Zink M, et al. 14-3-3 protein in CSF: an early predictor of SIV CNS disease. J Neuropathol Exp Neurol. 2005;64:202-8 pubmed
  • 免疫组化-石蜡切片; 人类; 图 5
Sasaki K, Doh ura K, Wakisaka Y, Tomoda H, Iwaki T. Fatal familial insomnia with an unusual prion protein deposition pattern: an autopsy report with an experimental transmission study. Neuropathol Appl Neurobiol. 2005;31:80-7 pubmed
  • 免疫组化-石蜡切片; 小鼠; 图 2
  • 免疫印迹; 小鼠; 图 2
Lee K, Lee S, Kim H, Song J, Yang S, Paik S, et al. Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein. J Neurosci Res. 2004;76:572-80 pubmed
  • 酶联免疫吸附测定; 人类
Trysberg E, Höglund K, Svenungsson E, Blennow K, Tarkowski A. Decreased levels of soluble amyloid beta-protein precursor and beta-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus. Arthritis Res Ther. 2004;6:R129-36 pubmed
  • 免疫印迹; 人类; 图 1
Richardson J, Kendal C, Anderson R, Priest F, Gower E, Soden P, et al. Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer's disease. Neuroscience. 2003;122:213-28 pubmed
  • 免疫组化-石蜡切片; 家羊; 图 3
Anderson R, Brown C, Blumbergs P, McLean A, Jones N. Impact mechanics and axonal injury in a sheep model. J Neurotrauma. 2003;20:961-74 pubmed
  • 免疫印迹; 人类; 图 3
Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, et al. Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem. 2003;278:49448-58 pubmed
  • 免疫组化; 人类; 表 2
Weed M, Hienz R, Brady J, Adams R, Mankowski J, Clements J, et al. Central nervous system correlates of behavioral deficits following simian immunodeficiency virus infection. J Neurovirol. 2003;9:452-64 pubmed
  • 免疫组化; 猪尾猕猴; 图 1
Mankowski J, Queen S, Tarwater P, Fox K, Perry V. Accumulation of beta-amyloid precursor protein in axons correlates with CNS expression of SIV gp41. J Neuropathol Exp Neurol. 2002;61:85-90 pubmed
  • 免疫印迹; 人类; 图 6
Daugherty B, Green S. Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing. Traffic. 2001;2:908-16 pubmed
  • 酶联免疫吸附测定; 人类
Steinhilb M, Turner R, Gaut J. The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase. J Biol Chem. 2001;276:4476-84 pubmed
  • 免疫沉淀; 人类; 图 3
  • 免疫印迹; 人类; 图 8
Lefterov I, Koldamova R, Lazo J. Human bleomycin hydrolase regulates the secretion of amyloid precursor protein. FASEB J. 2000;14:1837-47 pubmed
  • 免疫细胞化学; 人类; 图 8
Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, et al. Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. J Biol Chem. 1999;274:2243-54 pubmed
  • 免疫组化-石蜡切片; domestic rabbit; 1:200; 图 1
  • 免疫印迹; domestic rabbit; 1:1000; 图 2
Huang Y, Herman M, Liu J, Katsetos C, Wills M, Savory J. Neurofibrillary lesions in experimental aluminum-induced encephalopathy and Alzheimer's disease share immunoreactivity for amyloid precursor protein, A beta, alpha 1-antichymotrypsin and ubiquitin-protein conjugates. Brain Res. 1997;771:213-20 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200
Sherriff F, Bridges L, Gentleman S, Sivaloganathan S, Wilson S. Markers of axonal injury in post mortem human brain. Acta Neuropathol. 1994;88:433-9 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200
Webster M, Groome N, Francis P, Pearce B, Sherriff F, Thinakaran G, et al. A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. Biochem J. 1995;310 ( Pt 1):95-9 pubmed
Cejas R, Tamaño Blanco M, Blanco J. Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21). Sci Rep. 2021;11:10981 pubmed 出版商
Chai Q, Jovasevic V, Malikov V, Sabo Y, MORHAM S, Walsh D, et al. HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration. Nat Commun. 2017;8:1522 pubmed 出版商
Mbah N, Overmeyer J, Maltese W. Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones. Cell Biol Toxicol. 2017;33:263-282 pubmed 出版商
Yuan P, Condello C, Keene C, Wang Y, Bird T, Paul S, et al. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016;90:724-39 pubmed 出版商
Anjum A, Brathwaite K, Aidley J, Connerton P, Cummings N, Parkhill J, et al. Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168. Nucleic Acids Res. 2016;44:4581-94 pubmed 出版商
Wang J, Lu R, Yang J, Li H, He Z, Jing N, et al. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production. Nat Commun. 2015;6:8876 pubmed 出版商
Cheng X, Gao Y, Zhao Y, Cheng X. Sodium Chloride Increases Aβ Levels by Suppressing Aβ Clearance in Cultured Cells. PLoS ONE. 2015;10:e0130432 pubmed 出版商
Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, et al. Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. PLoS ONE. 2009;4:e7931 pubmed 出版商
Bacher M, Dodel R, Aljabari B, Keyvani K, Marambaud P, Kayed R, et al. CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease. J Exp Med. 2008;205:1593-9 pubmed 出版商
Zambrano N, Gianni D, Bruni P, Passaro F, Telese F, Russo T. Fe65 is not involved in the platelet-derived growth factor-induced processing of Alzheimer's amyloid precursor protein, which activates its caspase-directed cleavage. J Biol Chem. 2004;279:16161-9 pubmed
Sheng J, Price D, Koliatsos V. Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J Neurosci. 2002;22:9794-9 pubmed
Choi Y, Park G, Kim T, Sunwoo I, Steinert P, Kim S. Sporadic inclusion body myositis correlates with increased expression and cross-linking by transglutaminases 1 and 2. J Biol Chem. 2000;275:8703-10 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Amyloid Precursor Protein Monoclonal Antibody (LN27)
目录# :
13-0200
规格 :
100微克
价格 :
美国482
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: 0.1-0.5 µg/mL, Immunohistochemistry: 5-10 µg/mL, Western Blot: 1:250
物种 :
人类
克隆 :
LN27
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer's disease. Abnormal regulation and processing of APP also plays a role in Down's syndrome, early onset familial Alzheimer's disease, and cerebral hemorrhage.
免疫原 :
Rec-beta-amyloid precursor protein (beta-APP 695)
格式 :
液体
应用w/稀释 :
ELISA: 0.1-0.5 µg/mL, Immunohistochemistry: 5-10 µg/mL, Western Blot: 1:250
别名 :
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid A4; Amyloid b precursor protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid ß precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国