产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD44 Monoclonal Antibody (IM7), Biotin, eBioscience™
目录 :
13-0441-82
规格 :
100微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
生物素
克隆名称 :
IM7
反应物种 :
人类, 小鼠
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 89
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 1
Sadri N, Lu J, Badura M, Schneider R. AUF1 is involved in splenic follicular B cell maintenance. BMC Immunol. 2010;11:1 pubmed 出版商
Li X, Strietz J, Bleilevens A, Stickeler E, Maurer J. Chemotherapeutic Stress Influences Epithelial-Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer. Int J Mol Sci. 2020;21: pubmed 出版商
Sun B, Luo X, Yang C, Liu P, Yang Y, Dong X, et al. Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro. Stem Cells Int. 2019;2019:8035076 pubmed 出版商
Alriyami M, Marchand L, Li Q, Du X, Olivier M, Polychronakos C. Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice. Genome Res. 2019;29:1951-1961 pubmed 出版商
Tuladhar S, Kochanowsky J, Bhaskara A, Ghotmi Y, Chandrasekaran S, Koshy A. The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival. PLoS Pathog. 2019;15:e1007856 pubmed 出版商
Ye W, Ni Z, Yicheng S, Pan H, Huang Y, Xiong Y, et al. Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis. Int J Oncol. 2019;55:1296-1312 pubmed 出版商
Fan C, Ji Q, Zhang C, Xu S, Sun H, Li Z. TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production. Mol Med Rep. 2019;20:3123-3130 pubmed 出版商
Gu J, Xu T, Huang Q, Zhang C, Chen H. HMGB3 silence inhibits breast cancer cell proliferation and tumor growth by interacting with hypoxia-inducible factor 1α. Cancer Manag Res. 2019;11:5075-5089 pubmed 出版商
Lee H, Min S, Park J. Effects of demographic factors on adipogenic and chondrogenic differentiation in bone marrow-derived stem cells. Exp Ther Med. 2019;17:3548-3554 pubmed 出版商
Colunga T, Hayworth M, Kreß S, Reynolds D, Chen L, Nazor K, et al. Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair. Cell Rep. 2019;26:2566-2579.e10 pubmed 出版商
Barsoumian H, Batra L, Shrestha P, Bowen W, Zhao H, Egilmez N, et al. A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4+ T and Natural Killer Cells. Cancer Res. 2019;79:783-794 pubmed 出版商
Kanitz A, Syed A, Kaji K, Zavolan M. Conserved regulation of RNA processing in somatic cell reprogramming. BMC Genomics. 2019;20:100 pubmed 出版商
Chiou N, Kageyama R, Ansel K. Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation. Cell Rep. 2018;25:3356-3370.e4 pubmed 出版商
Liu Z, Ge Y, Wang H, Ma C, Feist M, Ju S, et al. Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2. Nat Commun. 2018;9:4682 pubmed 出版商
Li J, Choi P, Chaffer C, Labella K, Hwang J, Giacomelli A, et al. An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer. elife. 2018;7: pubmed 出版商
Huang W, Bei L, Eklund E. Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin. Oncotarget. 2018;9:25891-25902 pubmed 出版商
Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G, et al. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018;9:1241 pubmed 出版商
Li Z, Zhang S, Cao L, Li W, Ye Y, Shi Z, et al. Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43. Exp Ther Med. 2018;15:1847-1854 pubmed 出版商
Le Saout C, Luckey M, Villarino A, Smith M, Hasley R, Myers T, et al. IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion. JCI Insight. 2017;2: pubmed 出版商
Turaj A, Hussain K, Cox K, Rose Zerilli M, Testa J, Dahal L, et al. Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment. Cancer Cell. 2017;32:777-791.e6 pubmed 出版商
Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian T, et al. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Cell Stem Cell. 2017;21:791-805.e9 pubmed 出版商
Deng R, Hurtz C, Song Q, Yue C, Xiao G, Yu H, et al. Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease. Nat Commun. 2017;8:978 pubmed 出版商
Wang Q, Ning H, Peng H, Wei L, Hou R, Hoft D, et al. Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses. Nat Commun. 2017;8:867 pubmed 出版商
Alzubi J, Pallant C, Mussolino C, Howe S, Thrasher A, Cathomen T. Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model. Sci Rep. 2017;7:12475 pubmed 出版商
Cao Y, Lin S, WANG Y, Chin Y, Kang L, Mi J. Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling. Theranostics. 2017;7:3021-3033 pubmed 出版商
Sitrin J, Suto E, Wuster A, Eastham Anderson J, Kim J, Austin C, et al. The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice. J Immunol. 2017;199:1238-1249 pubmed 出版商
Gao S, Zheng G, Wang L, Liang Y, Zhang S, Lao X, et al. Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB. PLoS ONE. 2017;12:e0179248 pubmed 出版商
Miao T, Symonds A, Singh R, Symonds J, Ogbe A, Omodho B, et al. Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation. J Exp Med. 2017;214:1787-1808 pubmed 出版商
Cui N, Wang H, Su L, Zhang J, Long Y, Liu D. Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8+ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis. Chin Med J (Engl). 2017;130:1211-1217 pubmed 出版商
Gao Z, Jin Y, Wu W. SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction. Oncotarget. 2017;8:33432-33443 pubmed 出版商
Bierie B, Pierce S, Kroeger C, Stover D, Pattabiraman D, Thiru P, et al. Integrin-?4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. Proc Natl Acad Sci U S A. 2017;114:E2337-E2346 pubmed 出版商
Liao C, Chen L, Luethy A, Kim Y, Kani K, MacLeod A, et al. Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells. Endocr Relat Cancer. 2017;24:157-170 pubmed 出版商
Cruz L, Hashemifar S, Wu C, Cho S, Nguyen D, Lin L, et al. Excessive expression of miR-27 impairs Treg-mediated immunological tolerance. J Clin Invest. 2017;127:530-542 pubmed 出版商
Jerić I, Maurer G, Cavallo A, Raguz J, Desideri E, Tarkowski B, et al. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis. Nat Commun. 2016;7:13781 pubmed 出版商
Suchorska W, Augustyniak E, Richter M, Trzeciak T. Comparison of Four Protocols to Generate Chondrocyte-Like Cells from Human Induced Pluripotent Stem Cells (hiPSCs). Stem Cell Rev. 2017;13:299-308 pubmed 出版商
Monfared M, Minaee B, Rastegar T, Khrazinejad E, Barbarestani M. Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells. Iran J Basic Med Sci. 2016;19:1186-1192 pubmed
Kim B, Van de Laar E, Cabanero M, Tarumi S, Hasenoeder S, Wang D, et al. SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis. PLoS Biol. 2016;14:e1002581 pubmed 出版商
Shao J, Fan W, Ma B, Wu Y. Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics. Mol Med Rep. 2016;14:4991-4998 pubmed 出版商
Hiraga T, Nakamura H. Comparable roles of CD44v8-10 and CD44s in the development of bone metastases in a mouse model. Oncol Lett. 2016;12:2962-2969 pubmed
Greenwood E, Maisel S, Ebertz D, Russ A, Pandey R, SCHROEDER J. Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration. Oncotarget. 2016;7:60776-60792 pubmed 出版商
Camilleri E, Gustafson M, Dudakovic A, Riester S, Garces C, Paradise C, et al. Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production. Stem Cell Res Ther. 2016;7:107 pubmed 出版商
Menendez C, Jinkins J, Carr D. Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency. J Immunol. 2016;197:1262-75 pubmed 出版商
Brinkman C, Iwami D, Hritzo M, Xiong Y, Ahmad S, Simon T, et al. Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration. Nat Commun. 2016;7:12021 pubmed 出版商
Toneff M, Sreekumar A, Tinnirello A, Hollander P, Habib S, Li S, et al. The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biol. 2016;14:47 pubmed 出版商
Zhang Y, Cabarcas S, Zheng J, Sun L, Mathews L, Zhang X, et al. Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression. Oncol Lett. 2016;11:3803-3812 pubmed
Carofino B, Ayanga B, Tracey L, Brooke Bisschop T, Justice M. PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL. Biol Open. 2016;5:645-53 pubmed 出版商
Park J, Park J, Park D, Kim D, Kim H. Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer. Stem Cells. 2016;34:1177-87 pubmed 出版商
Quattrocelli M, Giacomazzi G, Broeckx S, Ceelen L, Bolca S, Spaas J, et al. Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates. Stem Cell Reports. 2016;6:55-63 pubmed 出版商
Traka M, Podojil J, McCarthy D, Miller S, Popko B. Oligodendrocyte death results in immune-mediated CNS demyelination. Nat Neurosci. 2016;19:65-74 pubmed 出版商
Hu Y, Zhang Y, Tian K, Xun C, Wang S, Lv D. Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro. Mol Med Rep. 2016;13:49-58 pubmed 出版商
Quattrocelli M, Swinnen M, Giacomazzi G, Camps J, Barthélemy I, Ceccarelli G, et al. Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle. J Clin Invest. 2015;125:4463-82 pubmed 出版商
Chantzoura E, Skylaki S, Menendez S, Kim S, Johnsson A, Linnarsson S, et al. Reprogramming Roadblocks Are System Dependent. Stem Cell Reports. 2015;5:350-64 pubmed 出版商
Zhou F, Gao S, Wang L, Sun C, Chen L, Yuan P, et al. Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model. Stem Cell Res Ther. 2015;6:92 pubmed 出版商
Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, et al. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nat Cell Biol. 2015;17:569-79 pubmed 出版商
Ali H, Al Yatama M, Abu Farha M, Behbehani K, Al Madhoun A. Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers. PLoS ONE. 2015;10:e0122465 pubmed 出版商
Zhang S, Chung W, Wu G, Egan S, Miele L, Xu K. Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction. Cancer Res. 2015;75:1936-43 pubmed 出版商
Sun Z, Zhang C, Zou X, Jiang G, Xu Z, Li W, et al. Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1. Mol Med Rep. 2015;11:3235-542 pubmed 出版商
Bauderlique Le Roy H, Vennin C, Brocqueville G, Spruyt N, Adriaenssens E, Bourette R. Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19. Stem Cells Dev. 2015;24:1252-62 pubmed 出版商
Samant M, Jackson C, Felix C, Jones A, Goodrich D, Foster B, et al. Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation. Stem Cells Dev. 2015;24:1236-51 pubmed 出版商
Wei H, Nickoloff J, Chen W, Liu H, Lo W, Chang Y, et al. FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells. Oncotarget. 2014;5:9514-29 pubmed
Xiao G, Liu I, Cheng C, Chang C, Lee Y, Cheng W, et al. Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy. PLoS ONE. 2014;9:e106538 pubmed 出版商
Viale A, Pettazzoni P, Lyssiotis C, Ying H, Sánchez N, Marchesini M, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014;514:628-32 pubmed 出版商
Zhang S, Chung W, Wu G, Egan S, Xu K. Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation. Neoplasia. 2014;16:158-67 pubmed 出版商
Ahmed N, Iu J, Brown C, Taylor D, Kandel R. Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction. Tissue Eng Part A. 2014;20:2224-33 pubmed 出版商
Wu T, Chou Y, Chiu P, Tang M, Hu C, Yeh M. Validation of the effects of TGF-?1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties. Cancer Cell Int. 2014;14:20 pubmed 出版商
Driskell R, Lichtenberger B, Hoste E, Kretzschmar K, Simons B, Charalambous M, et al. Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature. 2013;504:277-281 pubmed 出版商
Kaanta A, Virtanen C, Selfors L, Brugge J, Neel B. Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Res. 2013;15:R65 pubmed
Lemaitre F, Moreau H, Vedele L, Bousso P. Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division. J Immunol. 2013;191:1578-85 pubmed 出版商
Yan W, Chen Y, Yao Y, Zhang H, Wang T. Increased invasion and tumorigenicity capacity of CD44+/CD24- breast cancer MCF7 cells in vitro and in nude mice. Cancer Cell Int. 2013;13:62 pubmed 出版商
O MALLEY J, Skylaki S, Iwabuchi K, Chantzoura E, Ruetz T, Johnsson A, et al. High-resolution analysis with novel cell-surface markers identifies routes to iPS cells. Nature. 2013;499:88-91 pubmed 出版商
Sosunov A, Guilfoyle E, Wu X, McKhann G, Goldman J. Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease. J Neurosci. 2013;33:7439-50 pubmed 出版商
Wu S, Ju G, Du T, Zhu Y, Liu G. Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo. PLoS ONE. 2013;8:e61366 pubmed 出版商
Zhang Y, Yang P, Sun T, Li D, Xu X, Rui Y, et al. miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol. 2013;15:284-94 pubmed 出版商
Chou J, Lin J, Brenot A, Kim J, Provot S, Werb Z. GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol. 2013;15:201-13 pubmed 出版商
Janzen D, Cheng D, Schafenacker A, Paik D, Goldstein A, Witte O, et al. Estrogen and progesterone together expand murine endometrial epithelial progenitor cells. Stem Cells. 2013;31:808-22 pubmed 出版商
Szabo A, Fong S, Yue L, Zhang K, Strachan L, Scalapino K, et al. The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability. Stem Cells. 2013;31:786-99 pubmed 出版商
Yang C, Cao M, Liu H, He Y, Xu J, Du Y, et al. The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering. J Biol Chem. 2012;287:43094-107 pubmed 出版商
Paik D, Janzen D, Schafenacker A, Velasco V, Shung M, Cheng D, et al. Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation. Stem Cells. 2012;30:2487-97 pubmed 出版商
Seedhom M, Mathurin K, Kim S, Welsh R. Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders. J Virol. 2012;86:6010-22 pubmed 出版商
Baumgartner F, Woess C, Pedit V, Tzankov A, Labi V, Villunger A. Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf. Oncogene. 2013;32:621-30 pubmed 出版商
Martinez R, Zhang N, Thomas S, Nandiwada S, Jenkins M, Binstadt B, et al. Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells. J Immunol. 2012;188:170-81 pubmed 出版商
Nadendla S, Hazan A, Ward M, Harper L, Moutasim K, Bianchi L, et al. GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state. PLoS ONE. 2011;6:e20271 pubmed 出版商
Quere R, Andradottir S, Brun A, Zubarev R, Karlsson G, Olsson K, et al. High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event. Leukemia. 2011;25:515-26 pubmed 出版商
Hill R, Calvopina J, Kim C, Wang Y, Dawson D, Donahue T, et al. PTEN loss accelerates KrasG12D-induced pancreatic cancer development. Cancer Res. 2010;70:7114-24 pubmed 出版商
Maddox J, Liao X, Li F, Niyibizi C. Effects of Culturing on the Stability of the Putative Murine Adipose Derived Stem Cells Markers. Open Stem Cell J. 2009;1:54-61 pubmed
Desai V, Wang Y, Simirskii V, Duncan M. CD44 expression is developmentally regulated in the mouse lens and increases in the lens epithelium after injury. Differentiation. 2010;79:111-9 pubmed 出版商
Martin M, Wall E, Sandwith E, Girardin A, Milne K, Watson P, et al. Density of tumour stroma is correlated to outcome after adoptive transfer of CD4+ and CD8+ T cells in a murine mammary carcinoma model. Breast Cancer Res Treat. 2010;121:753-63 pubmed 出版商
Meunier M, Baron C, Perreault C. Two host factors regulate persistence of H7-specific T cells injected in tumor-bearing mice. PLoS ONE. 2009;4:e4116 pubmed 出版商
Anis M, Fulton S, Reba S, Harding C, Boom W. Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection. Infect Immun. 2007;75:2260-8 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD44 Monoclonal Antibody (IM7), Biotin, eBioscience™
目录# :
13-0441-82
规格 :
100微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
人类, 小鼠
应用 :
Flow Cytometry: 0.125 µg/test
物种 :
人类, 小鼠
克隆 :
IM7
抗体亚型 :
IgG2b, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.125 µg/test
别名 :
AU023126; AW121933; AW146109; Bovine CD44; CD44; CD44 antigen; CD44 antigen-like protein; CD44 molecule; CD44 molecule (Indian blood group); CD44 protein; CD44 variant; CD44A; CD44-like protein; CDW44; cell surface glycoprotein CD44; Cell surface glycoprotein CD44 (hyaluronate binding protein); cell-surface glycoprotein; chondroitin sulfate proteoglycan 8; CSPG8; ECMRIII; ECMR-III; Epican; extracellular matrix receptor III; extracellular matrix receptor-III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; HERMES; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; IN; LHR; Ly-24; lymphocyte antigen 24; lymphocyte surface antigen precursor CD44; MC56; MDU2; MDU3; METAA; MIC4; PGP I; Pgp1; PGP-1; PGPI; PGP-I; Phagocytic glycoprotein 1; phagocytic glycoprotein I; putative Bos taurus CD44; RHAMM; sCD 44; sCD44; soluble CD 44; soluble CD44
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国