产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45.2 Monoclonal Antibody (104), Biotin, eBioscience
目录 :
13-0454-85
规格 :
500微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
104
反应物种 :
小鼠
应用 :
免疫组化, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 53
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 s4a
Lu Z, Hong C, Kong G, Assumpção A, Ong I, Bresnick E, et al. Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence. Cell Rep. 2018;22:1545-1559 pubmed 出版商
  • 免疫组化; 小鼠; 20 ug/ml
Leus N, Morselt H, Zwiers P, Kowalski P, Ruiters M, Molema G, et al. VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression. Int J Pharm. 2014;469:121-31 pubmed 出版商
  • 流式细胞仪; 小鼠
Sadri N, Lu J, Badura M, Schneider R. AUF1 is involved in splenic follicular B cell maintenance. BMC Immunol. 2010;11:1 pubmed 出版商
Young I, Wu B, Andricovich J, Chuang S, Li R, Tzatsos A, et al. Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling. Cell Rep. 2021;37:110036 pubmed 出版商
Gerber A, Abdi K, Singh N. The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo. Cell Rep. 2021;37:109816 pubmed 出版商
Kawano R, Okamura T, Hashimoto Y, Majima S, Senmaru T, Ushigome E, et al. Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance. Int J Mol Sci. 2021;22: pubmed 出版商
Prasad M, Wojciech L, Brzostek J, Hu J, Chua Y, Tung D, et al. Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice. Front Immunol. 2021;12:644483 pubmed 出版商
Hu X, Dong X, Li G, Chen Y, Chen J, He X, et al. Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages. JCI Insight. 2021;6: pubmed 出版商
Moon S, Park Y, Hyeon S, Kim Y, Kim J, Kim H, et al. Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation. J Exp Med. 2021;218: pubmed 出版商
Rivas M, Meydan C, Chin C, Challman M, Kim D, Bhinder B, et al. Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation. Nat Immunol. 2021;22:240-253 pubmed 出版商
Fu H, Sun Y, Shao Y, Saredy J, Cueto R, Liu L, et al. Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis. Front Immunol. 2020;11:595813 pubmed 出版商
Wilkinson A, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo R, et al. Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation. Nature. 2019;: pubmed 出版商
Moretti F, Klapproth S, Ruppert R, Margraf A, Weber J, Pick R, et al. Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus. elife. 2018;7: pubmed 出版商
Schmidt K, Zhang Q, Tasdogan A, Petzold A, Dahl A, Arneth B, et al. The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice. elife. 2018;7: pubmed 出版商
Wilson K, Ochoa L, Solomon O, Pal R, Cardona S, Carpio V, et al. Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria. J Neuroinflammation. 2018;15:173 pubmed 出版商
Llewellyn R, Gutknecht M, Thomas K, Conaway M, Bouton A. Focal adhesion kinase (FAK) deficiency in mononuclear phagocytes alters murine breast tumor progression. Am J Cancer Res. 2018;8:675-687 pubmed
Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, et al. Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. Cell Stem Cell. 2018;22:713-725.e8 pubmed 出版商
Guo X, Chu L, Ke F, Mu L, Li Z, Cai J, et al. Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells. Oncotarget. 2017;8:108981-108988 pubmed 出版商
Miao T, Symonds A, Singh R, Symonds J, Ogbe A, Omodho B, et al. Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation. J Exp Med. 2017;214:1787-1808 pubmed 出版商
Li Y, Liu X, Duan W, Tian H, Zhu G, He H, et al. Batf3-dependent CD8?+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages. EBioMedicine. 2017;18:188-198 pubmed 出版商
Eddens T, Elsegeiny W, Garcia Hernadez M, Castillo P, Trevejo Nuñez G, Serody K, et al. Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity. Cell Rep. 2017;18:3078-3090 pubmed 出版商
Hérault A, Binnewies M, Leong S, Calero Nieto F, Zhang S, Kang Y, et al. Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. Nature. 2017;544:53-58 pubmed 出版商
Zamarin D, Holmgaard R, Ricca J, Plitt T, Palese P, Sharma P, et al. Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity. Nat Commun. 2017;8:14340 pubmed 出版商
Chudnovskiy A, Mortha A, Kana V, Kennard A, Ramírez J, Rahman A, et al. Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome. Cell. 2016;167:444-456.e14 pubmed 出版商
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed 出版商
Shi Y, Wu W, Chai Q, Li Q, Hou Y, Xia H, et al. LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration. Nat Commun. 2016;7:12369 pubmed 出版商
Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel M, et al. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016;7:292-305 pubmed 出版商
DU Four S, Maenhout S, De Pierre K, Renmans D, Niclou S, Thielemans K, et al. Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model. Oncoimmunology. 2015;4:e998107 pubmed
Wan W, Liu Q, Lionakis M, Marino A, Anderson S, Swamydas M, et al. Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice. Cardiovasc Res. 2015;106:478-87 pubmed 出版商
Habbeddine M, Verbeke P, Karaz S, Bobé P, Kanellopoulos Langevin C. Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface. PLoS ONE. 2014;9:e107267 pubmed 出版商
Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211:2119-34 pubmed 出版商
Dunn J, Qiu H, Kim S, Jjingo D, Hoffman R, Kim C, et al. Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis. J Clin Invest. 2014;124:3187-99 pubmed 出版商
Zamanian Daryoush M, Lindner D, Tallant T, Wang Z, Buffa J, Klipfell E, et al. The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects. J Biol Chem. 2013;288:21237-52 pubmed 出版商
Grosselin J, Sii Felice K, Payen E, Chretien S, Tronik Le Roux D, Leboulch P. Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics. Stem Cells. 2013;31:2162-71 pubmed 出版商
Soehnlein O, Drechsler M, Döring Y, Lievens D, Hartwig H, Kemmerich K, et al. Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes. EMBO Mol Med. 2013;5:471-81 pubmed 出版商
Zhang Y, Yang P, Sun T, Li D, Xu X, Rui Y, et al. miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol. 2013;15:284-94 pubmed 出版商
Reis B, Rogoz A, Costa Pinto F, Taniuchi I, Mucida D. Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4? T cell immunity. Nat Immunol. 2013;14:271-80 pubmed 出版商
Hoshino A, Ueha S, Hanada S, Imai T, Ito M, Yamamoto K, et al. Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts. J Cell Sci. 2013;126:1032-45 pubmed 出版商
Amabile G, Welner R, Nombela Arrieta C, D Alise A, Di Ruscio A, Ebralidze A, et al. In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood. 2013;121:1255-64 pubmed 出版商
Aragon I, Barrington R, Jackowski S, Mori K, Brewer J. The specialized unfolded protein response of B lymphocytes: ATF6?-independent development of antibody-secreting B cells. Mol Immunol. 2012;51:347-55 pubmed 出版商
Nikbakht N, Migone T, Ward C, Manser T. Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments. J Immunol. 2011;187:37-46 pubmed 出版商
Luche H, Ardouin L, Teo P, See P, Henri S, Merad M, et al. The earliest intrathymic precursors of CD8?(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells. Eur J Immunol. 2011;41:2165-75 pubmed 出版商
Vuyyuru R, Mohan C, Manser T, Rahman Z. The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints. J Immunol. 2009;183:5716-27 pubmed 出版商
Zaheen A, Boulianne B, Parsa J, Ramachandran S, Gommerman J, Martin A. AID constrains germinal center size by rendering B cells susceptible to apoptosis. Blood. 2009;114:547-54 pubmed 出版商
Peduto L, Dulauroy S, Lochner M, Späth G, Morales M, Cumano A, et al. Inflammation recapitulates the ontogeny of lymphoid stromal cells. J Immunol. 2009;182:5789-99 pubmed 出版商
Moon J, Chu H, Hataye J, Pagán A, Pepper M, McLachlan J, et al. Tracking epitope-specific T cells. Nat Protoc. 2009;4:565-81 pubmed 出版商
Coffey F, Alabyev B, Manser T. Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles. Immunity. 2009;30:599-609 pubmed 出版商
Kikuchi K, Kasai H, Watanabe A, Lai A, Kondo M. IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression. J Immunol. 2008;181:383-92 pubmed
Lochner M, Peduto L, Cherrier M, Sawa S, Langa F, Varona R, et al. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med. 2008;205:1381-93 pubmed 出版商
Kikuchi K, Kondo M. Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth. Proc Natl Acad Sci U S A. 2006;103:17852-7 pubmed
Veldhoen M, Hocking R, Atkins C, Locksley R, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24:179-89 pubmed
Takizawa H, Kubo Akashi C, Nobuhisa I, Kwon S, Iseki M, Taga T, et al. Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk. Blood. 2006;107:2968-75 pubmed
Hansen D, Loktev A, Ban K, Jackson P. Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. Mol Biol Cell. 2004;15:5623-34 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD45.2 Monoclonal Antibody (104), Biotin, eBioscience
目录# :
13-0454-85
规格 :
500微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Frozen): Assay-Dependent
物种 :
小鼠
克隆 :
104
抗体亚型 :
IgG2a, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
CD45.2 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45.2 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45.2 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45.2 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.5 µg/test, Immunohistochemistry (Frozen): Assay-Dependent
别名 :
B220; Cd45; CD45 antigen; CD45R; GP180; LCA; L-CA; leukocyte common antigen; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type, C; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国