产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Ubiquitin Monoclonal Antibody (Ubi-1)
目录 :
13-1600
规格 :
100微克
价格 :
美国375.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Ubi-1
反应物种 :
酵母菌目, African green monkey, 人类, 小鼠, 大鼠, 鸡, 牛, fruit fly , 非洲爪蛙, domestic rabbit, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 83
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:2000; 图 6b
Signes A, Cerutti R, Dickson A, Benincá C, Hinchy E, Ghezzi D, et al. APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS. EMBO Mol Med. 2019;11: pubmed 出版商
  • 免疫印迹; 大鼠; 图 4d
Aukrust I, Rosenberg L, Ankerud M, Bertelsen V, Hollås H, Saraste J, et al. Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes. FEBS Open Bio. 2017;7:160-173 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 s7a
Oh E, Kim J, Kim J, Kim S, Lee J, Hong S, et al. NQO1 inhibits proteasome-mediated degradation of HIF-1α. Nat Commun. 2016;7:13593 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Ding X, Barodia S, Ma L, Goldberg M. Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity. Neurobiol Dis. 2017;98:122-136 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3f
Hu Z, Wang J, Yu D, Soon J, de Kleijn D, Foo R, et al. Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy. Sci Rep. 2016;6:35247 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:1000; 图 2
Bayram Weston Z, Jones L, Dunnett S, Brooks S. Comparison of mHTT Antibodies in Huntington's Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease Development. PLoS ONE. 2016;11:e0155834 pubmed 出版商
  • 免疫细胞化学; fruit fly ; 1:20; 图 2
Bouché V, Espinosa A, Leone L, Sardiello M, Ballabio A, Botas J. Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway. Autophagy. 2016;12:484-98 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 s1
Slowicka K, Vereecke L, Mc Guire C, Sze M, Maelfait J, Kolpe A, et al. Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling. Eur J Immunol. 2016;46:971-80 pubmed 出版商
  • 免疫印迹; 人类; 图 5e
Phan L, Chou P, Velazquez Torres G, Samudio I, Parreno K, Huang Y, et al. The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming. Nat Commun. 2015;6:7530 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
  • 免疫细胞化学; 人类
Lee S, Lee T, Lee E, Kang S, Park A, Kim S, et al. Identification of a subnuclear body involved in sequence-specific cytokine RNA processing. Nat Commun. 2015;6:5791 pubmed 出版商
  • 免疫印迹; 人类
Chen J, Shin J, Zhao R, Phan L, Wang H, Xue Y, et al. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun. 2014;5:5384 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Naudin C, Sirvent A, Leroy C, Larive R, Simon V, Pannequin J, et al. SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2. Nat Commun. 2014;5:3159 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Brouxhon S, Kyrkanides S, Teng X, Raja V, O Banion M, Clarke R, et al. Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: involvement of the HER/PI3K/Akt/mTOR and IAP pathways. Clin Cancer Res. 2013;19:3234-46 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Choudhury S, Kolukula V, Preet A, Albanese C, Avantaggiati M. Dissecting the pathways that destabilize mutant p53: the proteasome or autophagy?. Cell Cycle. 2013;12:1022-9 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫组化; 人类
  • 免疫印迹; 人类
  • 免疫细胞化学; African green monkey
  • 免疫印迹; African green monkey
Kirilyuk A, Shimoji M, Catania J, Sahu G, Pattabiraman N, Giordano A, et al. An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation. PLoS ONE. 2012;7:e48243 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I. Analysis of nuclear factor-?B (NF-?B) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-?B. J Biol Chem. 2012;287:23626-34 pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 1
Schwab C, Yu S, McGeer P. Optineurin is colocalized with ubiquitin in Marinesco bodies. Acta Neuropathol. 2012;123:289-92 pubmed 出版商
  • 免疫组化; 人类; 图 1
Ginsberg S, Alldred M, Che S. Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease. Neurobiol Dis. 2012;45:99-107 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 5g
Rico Bautista E, Yang C, Lu L, Roth G, Wolf D. Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells. BMC Biol. 2010;8:153 pubmed 出版商
  • 免疫组化; 小鼠; 1:250; 图 4
Duvick L, Barnes J, Ebner B, Agrawal S, ANDRESEN M, Lim J, et al. SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776. Neuron. 2010;67:929-35 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50; 图 4
  • 免疫组化; 人类; 1:50; 图 4
Takahashi Fujigasaki J, Breidert T, Fujigasaki H, Duyckaerts C, Camonis J, Brice A, et al. Amyloid precursor-like protein 2 cleavage contributes to neuronal intranuclear inclusions and cytotoxicity in spinocerebellar ataxia-7 (SCA7). Neurobiol Dis. 2011;41:33-42 pubmed 出版商
  • 免疫组化; fruit fly ; 1:200; 图 6
Nisoli I, Chauvin J, Napoletano F, Calamita P, Zanin V, Fanto M, et al. Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy. Cell Death Differ. 2010;17:1577-87 pubmed 出版商
  • 免疫印迹; 大鼠; 图 6
Guttman M, Betts G, Barnes H, Ghassemian M, van der Geer P, Komives E. Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1. Proteomics. 2009;9:5016-28 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Wiseman R, Chin K, Haynes C, Stanhill A, Xu C, Roguev A, et al. Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle. J Biol Chem. 2009;284:15233-45 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
Zhu H, Rothermel B, Hill J. Autophagy in load-induced heart disease. Methods Enzymol. 2009;453:343-63 pubmed 出版商
  • 免疫印迹; 酵母菌目
den Dulk B, van Eijk P, de Ruijter M, Brandsma J, Brouwer J. The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4. DNA Repair (Amst). 2008;7:858-68 pubmed 出版商
  • 免疫细胞化学; 人类; 4 mg/ml
Marvin Guy L, Duncan P, Wagnière S, Antille N, Porta N, Affolter M, et al. Rapid identification of differentiation markers from whole epithelial cells by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and statistical analysis. Rapid Commun Mass Spectrom. 2008;22:1099-108 pubmed 出版商
  • 免疫印迹; 人类
Nakamura N, Hirose S. Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane. Mol Biol Cell. 2008;19:1903-11 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Tanaka T, Grusby M, Kaisho T. PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. Nat Immunol. 2007;8:584-91 pubmed
  • 免疫印迹; 人类; 1:1000; 图 7
Nomura N, Nomura M, Newcomb E, Zagzag D. Geldanamycin induces G2 arrest in U87MG glioblastoma cells through downregulation of Cdc2 and cyclin B1. Biochem Pharmacol. 2007;73:1528-36 pubmed
  • 免疫印迹; 小鼠; 图 4d
Gallagher E, Enzler T, Matsuzawa A, Anzelon Mills A, Otero D, Holzer R, et al. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol. 2007;8:57-63 pubmed
  • 免疫印迹; 人类
Bloom J, Pagano M. Experimental tests to definitively determine ubiquitylation of a substrate. Methods Enzymol. 2005;399:249-66 pubmed
  • 免疫印迹; 人类; 1:1000; 图 5
Nomura M, Nomura N, Yamashita J. Geldanamycin-induced degradation of Chk1 is mediated by proteasome. Biochem Biophys Res Commun. 2005;335:900-5 pubmed
  • 免疫沉淀; 人类
Lensch M, Tischkowitz M, Christianson T, Reifsteck C, Speckhart S, Jakobs P, et al. Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia. Blood. 2003;102:7-16 pubmed
  • 免疫沉淀; 人类; 图 2
Alberti S, Demand J, Esser C, Emmerich N, Schild H, Hohfeld J. Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome. J Biol Chem. 2002;277:45920-7 pubmed
  • 免疫印迹; 人类; 图 8
Kassenbrock C, Hunter S, Garl P, Johnson G, Anderson S. Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor. J Biol Chem. 2002;277:24967-75 pubmed
  • 免疫组化; 大鼠; 1:200; 表 1
Tan Z, Sankar R, Tu W, Shin D, Liu H, Wasterlain C, et al. Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus. Brain Res. 2002;929:129-38 pubmed
  • 免疫印迹; 小鼠; 图 2
Floyd Z, Stephens J. Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes. J Biol Chem. 2002;277:4062-8 pubmed
  • 免疫印迹; 人类; 图 2
Ruffner H, Joazeiro C, Hemmati D, Hunter T, Verma I. Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc Natl Acad Sci U S A. 2001;98:5134-9 pubmed
  • 免疫印迹; 猕猴; 图 5
Verdier F, Chretien S, Muller O, Varlet P, Yoshimura A, Gisselbrecht S, et al. Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein. J Biol Chem. 1998;273:28185-90 pubmed
  • 免疫沉淀; domestic rabbit; 图 5d
Nielsen K, Papageorge A, Vass W, Willumsen B, Lowy D. The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1. Mol Cell Biol. 1997;17:7132-8 pubmed
Wu H, Ng D, Cheong I, Matsudaira P. The degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control. PLoS ONE. 2020;15:e0232755 pubmed 出版商
Chan S, Prasad R, Matsudaira P. Genetic Selection Based on a Ste6*C-HA-Ura3 Substrate Identifies New Cytosolic Quality Control Alleles in Saccharomyces cerevisiae. G3 (Bethesda). 2020;10:1879-1891 pubmed 出版商
Jia R, Bonifacino J. Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3. elife. 2019;8: pubmed 出版商
Chai Q, Wang X, Qiang L, Zhang Y, Ge P, Lu Z, et al. A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy. Nat Commun. 2019;10:1973 pubmed 出版商
Kim J, Alavi Naini F, Sun Y, Ma L. Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin. Am J Cancer Res. 2018;8:1823-1836 pubmed
Lei Y, Liu K, Hou L, Ding L, Li Y, Liu L. Small chaperons and autophagy protected neurons from necrotic cell death. Sci Rep. 2017;7:5650 pubmed 出版商
Wei J, Dong S, Bowser R, Khoo A, Zhang L, Jacko A, et al. Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation. Sci Signal. 2017;10: pubmed 出版商
Wang L, Gundelach J, Bram R. Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme. Cell Death Dis. 2017;8:e2807 pubmed 出版商
Dadson K, Hauck L, Hao Z, Grothe D, Rao V, Mak T, et al. The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1. Sci Rep. 2017;7:41490 pubmed 出版商
Fu J, Li S, Feng R, Ma H, Sabeh F, Roodman G, et al. Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease. J Clin Invest. 2016;126:1759-72 pubmed 出版商
Richter B, Sliter D, Herhaus L, Stolz A, Wang C, Beli P, et al. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci U S A. 2016;113:4039-44 pubmed 出版商
Grindheim A, Hollås H, Raddum A, Saraste J, Vedeler A. Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2. J Cell Sci. 2016;129:314-28 pubmed 出版商
Chang J, Zhang W, Yeh H, de Jong E, Jun S, Kim K, et al. mRNA 3'-UTR shortening is a molecular signature of mTORC1 activation. Nat Commun. 2015;6:7218 pubmed 出版商
Christensen H, Trotter C, Hickman M, Edmunds W. Re-evaluating cost effectiveness of universal meningitis vaccination (Bexsero) in England: modelling study. BMJ. 2014;349:g5725 pubmed 出版商
Takeda A, Oberoi Khanuja T, Glatz G, Schulenburg K, Scholz R, Carpy A, et al. Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J. 2014;33:1784-801 pubmed 出版商
Kim M, Park H, Park H, Ro S, Nam S, Reed J, et al. Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging. Autophagy. 2013;9:1201-13 pubmed 出版商
Rodriguez O, Choudhury S, Kolukula V, Vietsch E, Catania J, Preet A, et al. Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy. Cell Cycle. 2012;11:4436-46 pubmed 出版商
Kageyama Y, Zhang Z, Roda R, Fukaya M, Wakabayashi J, Wakabayashi N, et al. Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J Cell Biol. 2012;197:535-51 pubmed 出版商
Koga H, Martinez Vicente M, Macian F, Verkhusha V, Cuervo A. A photoconvertible fluorescent reporter to track chaperone-mediated autophagy. Nat Commun. 2011;2:386 pubmed 出版商
Mulvihill M, Guttman M, Komives E. Protein interactions among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein. Biochemistry. 2011;50:6208-16 pubmed 出版商
Talbot K, Louneva N, Cohen J, Kazi H, Blake D, Arnold S. Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location. PLoS ONE. 2011;6:e16886 pubmed 出版商
Zhao R, Yeung S, Chen J, Iwakuma T, Su C, Chen B, et al. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest. 2011;121:851-65 pubmed 出版商
Hewawasam G, Shivaraju M, Mattingly M, Venkatesh S, Martin Brown S, Florens L, et al. Psh1 is an E3 ubiquitin ligase that targets the centromeric histone variant Cse4. Mol Cell. 2010;40:444-54 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
Ubiquitin Monoclonal Antibody (Ubi-1)
目录# :
13-1600
规格 :
100微克
价格 :
美国375.00
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
牛, 鸡, 人类, 小鼠, 非洲爪蛙
应用 :
ELISA: 0.1-1 µg/mL, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL
物种 :
牛, 鸡, 人类, 小鼠, 非洲爪蛙
克隆 :
Ubi-1
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.
免疫原 :
Purified bovine ubiquitin conjugated to carrier protein
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1 µg/mL, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL
别名 :
0610006J14Rik; 1810034D23Rik; 2700054O04Rik; 40S ribosomal protein S27a; 40S ribosomal protein S27-like; 40S ribosomal protein S27-like protein; AI194771; AL033289; CEP80; CG5271; CG5271-PA; Chap1; Dmel CG5271; Dmel_CG5271; Dub80; epididymis luminal protein 112; epididymis secretory protein Li 50; HEL112; HEL-S-50; hm:zeh0386; HMG20; hPLIC-2; HRIHFB2157; HUBCEP52; ik:tdsubc_1f2; l(2)04820; l(2)31Ei; LOC100912032; LOC101747587; male female sterile 31; mfs(2)31; mfs(2)48; mfs48; OTTHUMP00000200786; OTTHUMP00000201692; PLIC-2; polyubiquitin; polyubiquitin B; polyubiquitin C; poly-ubiquitin precursor; polyubiquitin-B; Polyubiquitin-C; polyubiquitin-C-like; RE44350p; ribosomal protein S27; ribosomal protein S27 like; ribosomal protein S27A; ribosomal protein S27a L homeolog; ribosomal protein S27a S homeolog; ribosomal protein S27-like; ribosomal protein S27-like protein; RPL40; RpS27; Rps27a; rps27a.L; rps27a.S; RpS27A-PA; RPS27L; S27A; similar to polyubiquitin; similar to ubiquitin-S27a fusion protein; Small ribosomal subunit protein eS27-like; Small ribosomal subunit protein eS31; tdsubc_1f2; TI-225; UB3-D; Uba52; UBA80; UBB; Ubb2; UBC; UBCEP1; UBCEP80; Ubi-f80; Ubi-m; Ubiq; Ubiquilin 2; ubiquitin; ubiquitin (34 AA) (1 is 2nd base in codon); ubiquitin and ribosomal protein S27a; ubiquitin B; ubiquitin C; ubiquitin carboxyl extension protein 80; ubiquitin copy 4; ubiquitin fusion 80; ubiquitin polyprotein (heat shock related); ubiquitin/ribosomal protein; ubiquitin-40S ribosomal protein S27a; ubiquitin-40S ribosomal protein S27a-like; ubiquitin-CEP80; ubiquitin-hybrid protein precursor; Ubiquitin-monomeric; Ubiquitin-related; Ubiquitin-related 1; Ubiquitin-related 2; ubiquitin-S27a fusion protein; Unknown (protein for MGC:127652); unnamed protein product; XELAEV_18028796mg; xx:tdsubc_1f2; zgc:66168; zgc:66168 protein
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