产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
E钙粘蛋白单克隆抗体(HECD-1)
目录 :
13-1700
规格 :
100微克
价格 :
425美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
HECD-1
反应物种 :
仓鼠, 豚鼠, 人类, 小鼠, 大鼠, 犬, 牛, domestic rabbit
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 抑制或激活实验
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 287
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 5g
Benedicto I, Lehmann G, Ginsberg M, Nolan D, Bareja R, Elemento O, et al. Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors. Nat Commun. 2017;8:15374 pubmed 出版商
  • 免疫组化; 人类; 图 1c
Gibier J, Hemon B, Fanchon M, Gaudelot K, Pottier N, Ringot B, et al. Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1336-1349 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200
  • 免疫印迹; 人类; 图 3c
Day K, Lorenzatti Hiles G, Kozminsky M, Dawsey S, Paul A, Broses L, et al. HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone. Cancer Res. 2017;77:74-85 pubmed 出版商
  • 免疫组化; 人类; 1:1000; 图 1a
Varga E, Nemes C, Táncos Z, Bock I, Berzsenyi S, Lévay G, et al. Establishment of EHMT1 mutant induced pluripotent stem cell (iPSC) line from a 11-year-old Kleefstra syndrome (KS) patient with autism and normal intellectual performance. Stem Cell Res. 2016;17:531-533 pubmed 出版商
  • 免疫细胞化学; 人类; 2 ug/ml; 图 4e
  • 免疫印迹; 人类; 图 4b
Matos M, Lapyckyj L, Rosso M, Besso M, Mencucci M, Briggiler C, et al. Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events. J Cell Physiol. 2017;232:1368-1386 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Runge T, Shaheen N, Djukic Z, Hallquist S, Orlando R. Cleavage of E-Cadherin Contributes to Defective Barrier Function in Neosquamous Epithelium. Dig Dis Sci. 2016;61:3169-3175 pubmed
  • 免疫细胞化学; 人类; 1:1000; 图 1A
Tancos Z, Varga E, Kovacs E, Dinnyes A, Kobolak J. Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Res. 2016;17:81-83 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 1A
Chandrasekaran A, Varga E, Nemes C, Tancos Z, Kobolak J, Dinnyes A. Establishment of induced pluripotent stem cell (iPSC) line from a 63-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Res. 2016;17:78-80 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 1A
Tancos Z, Varga E, Kovacs E, Dinnyes A, Kobolak J. Establishment of induced pluripotent stem cell (iPSC) line from an 84-year old patient with late onset Alzheimer's disease (LOAD). Stem Cell Res. 2016;17:75-77 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 1A
Ochalek A, Nemes C, Varga E, Tancos Z, Kobolak J, Dinnyes A. Establishment of induced pluripotent stem cell (iPSC) line from a 57-year old patient with sporadic Alzheimer's disease. Stem Cell Res. 2016;17:72-74 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Morton P, Hicks A, Ortiz Zapater E, Raghavan S, Pike R, Noble A, et al. TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers. Sci Rep. 2016;6:26321 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
  • 免疫组化; 人类; 1:500; 图 5
  • 免疫印迹; 人类; 图 2
Teo W, Merino V, Cho S, Korangath P, Liang X, Wu R, et al. HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24. Oncogene. 2016;35:5539-5551 pubmed 出版商
  • 免疫细胞化学; 人类; 1:300; 图 2
Bell C, Hendriks D, Moro S, Ellis E, Walsh J, Renblom A, et al. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Sci Rep. 2016;6:25187 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 s2
Nummela P, Leinonen H, Järvinen P, Thiel A, Jarvinen H, Lepistö A, et al. Expression of CEA, CA19-9, CA125, and EpCAM in pseudomyxoma peritonei. Hum Pathol. 2016;54:47-54 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:7000; 图 2
  • 免疫印迹; 人类; 图 4
Wang O, Azizian N, Guo M, Capello M, Deng D, Zang F, et al. Prognostic and Functional Significance of MAP4K5 in Pancreatic Cancer. PLoS ONE. 2016;11:e0152300 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:7000; 图 7
Huo L, Wang Y, Gong Y, Krishnamurthy S, Wang J, Diao L, et al. MicroRNA expression profiling identifies decreased expression of miR-205 in inflammatory breast cancer. Mod Pathol. 2016;29:330-46 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 4
Tato Costa J, Casimiro S, Pacheco T, Pires R, Fernandes A, Alho I, et al. Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer. Clin Colorectal Cancer. 2016;15:170-178.e3 pubmed 出版商
  • 免疫细胞化学; 人类
Lizalek J, McKenna T, Huegel K, Marsh S, Carolan A, Kobliska A, et al. Lysophosphatidic Acid Stimulates Urokinase Receptor (uPAR/CD87) in Ovarian Epithelial Cancer Cells. Anticancer Res. 2015;35:5263-70 pubmed
  • 免疫印迹; 小鼠
Wei Q, Chen Z, Wang L, Zhang T, Duan L, Behrens C, et al. LZTFL1 suppresses lung tumorigenesis by maintaining differentiation of lung epithelial cells. Oncogene. 2016;35:2655-63 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 3
Ko A, Bekaii Saab T, Van Ziffle J, Mirzoeva O, Joseph N, Talasaz A, et al. A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma. Clin Cancer Res. 2016;22:61-8 pubmed 出版商
  • 免疫细胞化学; 人类
Burkhalter R, Westfall S, Liu Y, Stack M. Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma. J Biol Chem. 2015;290:22143-54 pubmed 出版商
  • 免疫印迹; 小鼠
Barber A, Castillo Martin M, Bonal D, Jia A, Rybicki B, Christiano A, et al. PI3K/AKT pathway regulates E-cadherin and Desmoglein 2 in aggressive prostate cancer. Cancer Med. 2015;4:1258-71 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 表 2
Savci Heijink C, Halfwerk H, Hooijer G, Horlings H, Wesseling J, van de Vijver M. Retrospective analysis of metastatic behaviour of breast cancer subtypes. Breast Cancer Res Treat. 2015;150:547-57 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
  • 免疫印迹; 人类; 1:500
Nguyen D, Rubinstein L, Takebe N, Miele L, Tomaszewski J, Ivy P, et al. Notch1 phenotype and clinical stage progression in non-small cell lung cancer. J Hematol Oncol. 2015;8:9 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1
Nykopp T, Pasonen Seppänen S, Tammi M, Tammi R, Kosma V, Anttila M, et al. Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer. Gynecol Oncol. 2015;137:152-9 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:3000
Davidson B, Holth A, Hellesylt E, Tan T, Huang R, Tropé C, et al. The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions. Hum Pathol. 2015;46:1-8 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 4
Akoury E, Zhang L, Ao A, Slim R. NLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton. Hum Reprod. 2015;30:159-69 pubmed 出版商
  • 免疫细胞化学; 人类
Hagos Y, Wegner W, Kuehne A, Floerl S, Marada V, Burckhardt G, et al. HNF4α induced chemosensitivity to oxaliplatin and 5-FU mediated by OCT1 and CNT3 in renal cell carcinoma. J Pharm Sci. 2014;103:3326-34 pubmed 出版商
  • 免疫组化; 人类; 1:3000
Wennerström A, Lothe I, Sandhu V, Kure E, Myklebost O, Munthe E. Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines. PLoS ONE. 2014;9:e103873 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:2500; 表 3
Lindström A, Hellberg D. Immunohistochemical LRIG3 expression in cervical intraepithelial neoplasia and invasive squamous cell cervical cancer: association with expression of tumor markers, hormones, high-risk HPV-infection, smoking and patient outcome. Eur J Histochem. 2014;58:2227 pubmed 出版商
  • 免疫组化; 小鼠
Costales M, Lopez F, García Inclán C, Fernandez S, Marcos C, Llorente J, et al. Establishment and characterization of an orthotopic sinonasal squamous cell carcinoma mouse model. Head Neck. 2015;37:1769-75 pubmed 出版商
  • 免疫印迹; 人类; 图 3
McEwen A, Maher M, Mo R, Gottardi C. E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion. Mol Biol Cell. 2014;25:2365-74 pubmed 出版商
  • 流式细胞仪; 人类; 1:50
Bassagañas S, Carvalho S, Dias A, Pérez Garay M, Ortiz M, Figueras J, et al. Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of ?2?1 integrin and E-cadherin function. PLoS ONE. 2014;9:e98595 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Moiola C, De Luca P, Zalazar F, Cotignola J, Rodríguez Seguí S, Gardner K, et al. Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice. Clin Cancer Res. 2014;20:4086-95 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Zhang C, Zhang H, Yu L, Cao Y. Helicobacter pylori dwelling on the apical surface of gastrointestinal epithelium damages the mucosal barrier through direct contact. Helicobacter. 2014;19:330-42 pubmed 出版商
  • 免疫印迹; 人类
Wojtalewicz N, Sadeqzadeh E, Weiß J, Tehrani M, Klein Scory S, Hahn S, et al. A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding. PLoS ONE. 2014;9:e90461 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:2000
Agoston A, Odze R. Evidence that gastric pit dysplasia-like atypia is a neoplastic precursor lesion. Hum Pathol. 2014;45:446-55 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 7
Hesami P, Holzapfel B, Taubenberger A, Roudier M, Fazli L, Sieh S, et al. A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone. Clin Exp Metastasis. 2014;31:435-46 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 5
Grivas P, Day K, Karatsinides A, Paul A, Shakir N, Owainati I, et al. Evaluation of the antitumor activity of dacomitinib in models of human bladder cancer. Mol Med. 2013;19:367-76 pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 9
Haisler W, Timm D, Gage J, Tseng H, Killian T, Souza G. Three-dimensional cell culturing by magnetic levitation. Nat Protoc. 2013;8:1940-9 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Shields M, Ebine K, Sahai V, Kumar K, Siddiqui K, Hwang R, et al. Snail cooperates with KrasG12D to promote pancreatic fibrosis. Mol Cancer Res. 2013;11:1078-87 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Tsai Y, Disson O, Bierne H, Lecuit M. Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses. PLoS Pathog. 2013;9:e1003381 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 1
Shi Y, Wu H, Zhang M, Ding L, Meng F, Fan X. Expression of the epithelial-mesenchymal transition-related proteins and their clinical significance in lung adenocarcinoma. Diagn Pathol. 2013;8:89 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 1
Rakha E, Teoh T, Lee A, Nolan C, Ellis I, Green A. Further evidence that E-cadherin is not a tumour suppressor gene in invasive ductal carcinoma of the breast: an immunohistochemical study. Histopathology. 2013;62:695-701 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 3
Majewski I, Kluijt I, Cats A, Scerri T, de Jong D, Kluin R, et al. An ?-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. J Pathol. 2013;229:621-9 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Gordon K, Kochkodan J, Blatt H, Lin S, Kaplan N, Johnston A, et al. Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis. J Invest Dermatol. 2013;133:712-722 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 4
de Toledo M, Anguille C, Roger L, Roux P, Gadea G. Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity. PLoS ONE. 2012;7:e48344 pubmed 出版商
  • 免疫印迹; 人类; 2 ug/ml
Visciano P, Schirone M, Tofalo R, Berti M, Luciani M, Ferri N, et al. Detection of yessotoxin by three different methods in Mytilus galloprovincialis of Adriatic Sea, Italy. Chemosphere. 2013;90:1077-82 pubmed 出版商
  • 免疫组化; 人类; 图 s3
Takahashi Y, Kupferman M, Bell D, Jiffar T, Lee J, Xie T, et al. Establishment and characterization of novel cell lines from sinonasal undifferentiated carcinoma. Clin Cancer Res. 2012;18:6178-87 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Langer M, Duggan E, Booth J, Patel V, Zander R, Silasi Mansat R, et al. Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infect Immun. 2012;80:4374-87 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 6
Piao Y, Liang J, Holmes L, Zurita A, Henry V, Heymach J, et al. Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype. Neuro Oncol. 2012;14:1379-92 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 4
Peramo A, Marcelo C. Visible effects of rapamycin (sirolimus) on human skin explants in vitro. Arch Dermatol Res. 2013;305:163-71 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1
Veschi S, Lattanzio R, Aceto G, Curia M, Magnasco S, Angelucci D, et al. Alterations of MEN1 and E-cadherin/?-catenin complex in sporadic pulmonary carcinoids. Int J Oncol. 2012;41:1221-8 pubmed 出版商
  • 免疫组化-石蜡切片; 犬; 图 2
Mackowiak I, Gentile L, Chaible L, Nagamine M, Guerra J, Mota E, et al. E-cadherin in canine mast cell tumors: decreased expression and altered subcellular localization in Grade 3 tumors. Vet J. 2012;194:405-11 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Stamp L, Braxton D, Wu J, Akopian V, Hasegawa K, Chandrasoma P, et al. The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin. Stem Cells. 2012;30:1999-2009 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 表 1
Jang S, Han H, Jun Y, Jang S, Min K, Sim J, et al. Clinicopathological significance of CADM4 expression, and its correlation with expression of E-cadherin and Ki-67 in colorectal adenocarcinomas. J Clin Pathol. 2012;65:902-6 pubmed
  • 免疫细胞化学; 人类; 图 4
  • 免疫印迹; 人类; 图 2
Raiko L, Siljamäki E, Mahoney M, Putaala H, Suominen E, Peltonen J, et al. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes. Exp Dermatol. 2012;21:586-91 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1
Liu Y, Burkhalter R, Symowicz J, Chaffin K, Ellerbroek S, Stack M. Lysophosphatidic Acid disrupts junctional integrity and epithelial cohesion in ovarian cancer cells. J Oncol. 2012;2012:501492 pubmed 出版商
  • 免疫细胞化学; 人类; 1:2500; 表 1
Karlsson H, Fryknäs M, Larsson R, Nygren P. Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system. Exp Cell Res. 2012;318:1577-85 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:100
Simões Correia J, Figueiredo J, Lopes R, Stricher F, Oliveira C, Serrano L, et al. E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer. PLoS ONE. 2012;7:e33783 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1
DesRochers T, Shamis Y, Alt Holland A, Kudo Y, Takata T, Wang G, et al. The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma. Epigenetics. 2012;7:34-46 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 图 3
Nguyen Hoang A, Chen P, Juarez J, Sachamitr P, Billing B, Bosnjak L, et al. Dendritic cell functional properties in a three-dimensional tissue model of human lung mucosa. Am J Physiol Lung Cell Mol Physiol. 2012;302:L226-37 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:2500; 表 3
Samir R, Asplund A, Tot T, Pekar G, Hellberg D. Oral contraceptive and progestin-only use correlates to tissue tumor marker expression in women with cervical intraepithelial neoplasia. Contraception. 2012;85:288-93 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Grabowska M, Sandhu B, Day M. EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells. Cell Signal. 2012;24:532-8 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 5
Schneider D, Wu M, Le T, Cho S, Brenner M, Blackburn M, et al. Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-? production and epithelial to mesenchymal transition. FASEB J. 2012;26:503-12 pubmed 出版商
  • 免疫组化; 小鼠; 图 1
Nikitas G, Deschamps C, Disson O, Niault T, Cossart P, Lecuit M. Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin. J Exp Med. 2011;208:2263-77 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 6
  • 免疫印迹; 人类; 1:500; 图 3
Sigurdsson V, Hilmarsdottir B, Sigmundsdottir H, Fridriksdottir A, Ringner M, Villadsen R, et al. Endothelial induced EMT in breast epithelial cells with stem cell properties. PLoS ONE. 2011;6:e23833 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
de Wit M, Jimenez C, Carvalho B, Belien J, Delis van Diemen P, Mongera S, et al. Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression. Gut. 2012;61:855-64 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:300; 表 1
Holbrook E, Wu E, Curry W, Lin D, Schwob J. Immunohistochemical characterization of human olfactory tissue. Laryngoscope. 2011;121:1687-701 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Lacher M, Shiina M, Chang P, Keller D, Tiirikainen M, Korn W. ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor. Mol Cancer. 2011;10:91 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:2500; 表 1
Lindström A, Asplund A, Hellberg D. Correlation between LRIG1 and LRIG2 expressions and expression of 11 tumor markers, with special reference to tumor suppressors, in CIN and normal cervical epithelium. Gynecol Oncol. 2011;122:372-6 pubmed 出版商
  • 免疫组化; 人类; 图 4
Jovov B, Que J, Tobey N, Djukic Z, Hogan B, Orlando R. Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol. 2011;106:1039-47 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Diehl H, Stühler K, Klein Scory S, Volmer M, Schöneck A, Bieling C, et al. A catalogue of proteins released by colorectal cancer cells in vitro as an alternative source for biomarker discovery. Proteomics Clin Appl. 2007;1:47-61 pubmed 出版商
  • 免疫细胞化学; 人类; 表 1
Ingthorsson S, Halldorsson T, Sigurdsson V, Friðriksdottir A, Bodvarsdottir S, Steinarsdottir M, et al. Selection for EGFR gene amplification in a breast epithelial cell line with basal-like phenotype and hereditary background. In Vitro Cell Dev Biol Anim. 2011;47:139-48 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1
  • 免疫组化; 人类; 图 1
Ye Y, Tellez J, Durazo M, Belcher M, Yearsley K, Barsky S. E-cadherin accumulation within the lymphovascular embolus of inflammatory breast cancer is due to altered trafficking. Anticancer Res. 2010;30:3903-10 pubmed
  • 免疫组化; 人类; 1:200; 图 1
Rakha E, Patel A, Powe D, Benhasouna A, Green A, Lambros M, et al. Clinical and biological significance of E-cadherin protein expression in invasive lobular carcinoma of the breast. Am J Surg Pathol. 2010;34:1472-9 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 s1
Loessner D, Stok K, Lutolf M, Hutmacher D, Clements J, Rizzi S. Bioengineered 3D platform to explore cell-ECM interactions and drug resistance of epithelial ovarian cancer cells. Biomaterials. 2010;31:8494-506 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Dangi Garimella S, Redig A, Shields M, Siddiqui M, Munshi H. Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes. J Biol Chem. 2010;285:28363-72 pubmed 出版商
  • 免疫组化; 人类; 0.2 ug/ul; 图 1
Brusevold I, Husvik C, Schreurs O, Schenck K, Bryne M, Søland T. Induction of invasion in an organotypic oral cancer model by CoCl2, a hypoxia mimetic. Eur J Oral Sci. 2010;118:168-76 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Maher M, Mo R, Flozak A, Peled O, Gottardi C. Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling. PLoS ONE. 2010;5:e10184 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Wen T, Zhang Z, Yu Y, Qu H, Koch M, Aumailley M. Integrin alpha3 subunit regulates events linked to epithelial repair, including keratinocyte migration and protein expression. Wound Repair Regen. 2010;18:325-34 pubmed 出版商
  • 免疫细胞化学; 人类; 图 7
Blank F, Wehrli M, Lehmann A, Baum O, Gehr P, von Garnier C, et al. Macrophages and dendritic cells express tight junction proteins and exchange particles in an in vitro model of the human airway wall. Immunobiology. 2011;216:86-95 pubmed 出版商
  • 免疫组化; 人类; 1:100; 表 1
Flatmark K, Davidson B, Kristian A, Stavnes H, Førsund M, Reed W. Exploring the peritoneal surface malignancy phenotype--a pilot immunohistochemical study of human pseudomyxoma peritonei and derived animal models. Hum Pathol. 2010;41:1109-19 pubmed 出版商
  • 流式细胞仪; 人类; 1:100
Ghosh S, Koblinski J, Johnson J, Liu Y, Ericsson A, Davis J, et al. Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression. Mol Cancer Res. 2010;8:145-58 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:300; 表 2
Kaarteenaho R, Sormunen R, Paakko P. Variable expression of tenascin-C, osteopontin and fibronectin in inflammatory myofibroblastic tumour of the lung. APMIS. 2010;118:91-100 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:2500; 表 1
Samir R, Asplund A, Tot T, Pekar G, Hellberg D. Tissue tumor marker expression in smokers, including serum cotinine concentrations, in women with cervical intraepithelial neoplasia or normal squamous cervical epithelium. Am J Obstet Gynecol. 2010;202:579.e1-7 pubmed 出版商
  • 抑制或激活实验; 人类
Morales J, Alpaugh M. Gain in cellular organization of inflammatory breast cancer: A 3D in vitro model that mimics the in vivo metastasis. BMC Cancer. 2009;9:462 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 图 2
  • 免疫印迹; 人类; 图 1
Maher M, Flozak A, Stocker A, Chenn A, Gottardi C. Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion. J Cell Biol. 2009;186:219-28 pubmed 出版商
  • 免疫细胞化学; 人类
Kim J, Kushiro K, Graham N, Asthagiri A. Tunable interplay between epidermal growth factor and cell-cell contact governs the spatial dynamics of epithelial growth. Proc Natl Acad Sci U S A. 2009;106:11149-53 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4a
Agnarsson B, Ingthorsson S, Gudjonsson T, Leosson K. Evanescent-wave fluorescence microscopy using symmetric planar waveguides. Opt Express. 2009;17:5075-82 pubmed
  • 免疫细胞化学; 人类; 图 1b
Sarrio D, Palacios J, Hergueta Redondo M, Gomez Lopez G, Cano A, Moreno Bueno G. Functional characterization of E- and P-cadherin in invasive breast cancer cells. BMC Cancer. 2009;9:74 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Rogers S, Box C, Chambers P, Barbachano Y, Nutting C, Rhys Evans P, et al. Determinants of response to epidermal growth factor receptor tyrosine kinase inhibition in squamous cell carcinoma of the head and neck. J Pathol. 2009;218:122-30 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 5
  • 免疫印迹; 人类; 1:1000; 图 3
Jiang H, Guan G, Zhang R, Liu G, Cheng J, Hou X, et al. Identification of urinary soluble E-cadherin as a novel biomarker for diabetic nephropathy. Diabetes Metab Res Rev. 2009;25:232-41 pubmed 出版商
  • 免疫印迹; 人类
Li Z, Zhou Z, Welch D, Donahue H. Expressing connexin 43 in breast cancer cells reduces their metastasis to lungs. Clin Exp Metastasis. 2008;25:893-901 pubmed 出版商
  • 免疫细胞化学; 人类; 20 ug/ml; 图 4
  • 免疫印迹; 人类; 图 3
Marín Briggiler C, Veiga M, Matos M, Echeverría M, Furlong L, Vazquez Levin M. Expression of epithelial cadherin in the human male reproductive tract and gametes and evidence of its participation in fertilization. Mol Hum Reprod. 2008;14:561-71 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Klein E, Campbell L, Kothapalli D, Fournier A, Assoian R. Joint requirement for Rac and ERK activities underlies the mid-G1 phase induction of cyclin D1 and S phase entry in both epithelial and mesenchymal cells. J Biol Chem. 2008;283:30911-8 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200
Van Hoof D, Braam S, Dormeyer W, Ward van Oostwaard D, Heck A, Krijgsveld J, et al. Feeder-free monolayer cultures of human embryonic stem cells express an epithelial plasma membrane protein profile. Stem Cells. 2008;26:2777-81 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 流式细胞仪; 人类; 1:200
  • 免疫印迹; 人类; 1:2000
Caberg J, Hubert P, Begon D, Herfs M, Roncarati P, Boniver J, et al. Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes. Carcinogenesis. 2008;29:1441-7 pubmed 出版商
  • 免疫组化; 人类; 1:200; 表 2
Marchio C, Iravani M, Natrajan R, Lambros M, Savage K, Tamber N, et al. Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast. J Pathol. 2008;215:398-410 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Najy A, Day K, Day M. The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation. J Biol Chem. 2008;283:18393-401 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Rakha E, El Sheikh S, Kandil M, El Sayed M, Green A, Ellis I. Expression of BRCA1 protein in breast cancer and its prognostic significance. Hum Pathol. 2008;39:857-65 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Agarwal S, Lee D, Kiener H, Brenner M. Coexpression of two mesenchymal cadherins, cadherin 11 and N-cadherin, on murine fibroblast-like synoviocytes. Arthritis Rheum. 2008;58:1044-54 pubmed 出版商
  • 免疫组化; 人类; 表 2
McClelland R, Wauthier E, Uronis J, Reid L. Gradients in the liver's extracellular matrix chemistry from periportal to pericentral zones: influence on human hepatic progenitors. Tissue Eng Part A. 2008;14:59-70 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:20; 图 1a
  • 免疫印迹; 人类; 图 3a
Fanelli M, Montt Guevara M, Diblasi A, Gago F, Tello O, Cuello Carrión F, et al. P-cadherin and beta-catenin are useful prognostic markers in breast cancer patients; beta-catenin interacts with heat shock protein Hsp27. Cell Stress Chaperones. 2008;13:207-20 pubmed 出版商
  • 流式细胞仪; 人类; 2.5 ug/ml
Ivascu A, Kubbies M. Diversity of cell-mediated adhesions in breast cancer spheroids. Int J Oncol. 2007;31:1403-13 pubmed
  • 免疫细胞化学; 人类; 图 4
  • 免疫印迹; 人类; 图 6
Akat K, Bleck C, Lee Y, Haselmann Weiss U, Kartenbeck J. Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52. Cell Tissue Res. 2008;331:401-12 pubmed
  • 抑制或激活实验; 人类
  • 免疫印迹; 人类; 1:1000
Haga T, Uchide N, Tugizov S, Palefsky J. Role of E-cadherin in the induction of apoptosis of HPV16-positive CaSki cervical cancer cells during multicellular tumor spheroid formation. Apoptosis. 2008;13:97-108 pubmed
  • 免疫印迹; 人类; 1:5000
Xie J, Haslam S. Extracellular matrix, Rac1 signaling, and estrogen-induced proliferation in MCF-7 breast cancer cells. Breast Cancer Res Treat. 2008;110:257-68 pubmed
  • 免疫细胞化学; 人类; 图 5
Troyanovsky R, Laur O, Troyanovsky S. Stable and unstable cadherin dimers: mechanisms of formation and roles in cell adhesion. Mol Biol Cell. 2007;18:4343-52 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200
Chung Y, Lam A, Luk J, Law S, Chan K, Lee P, et al. Altered E-cadherin expression and p120 catenin localization in esophageal squamous cell carcinoma. Ann Surg Oncol. 2007;14:3260-7 pubmed
  • 免疫组化-石蜡切片; 人类; 图 1
Mahomed F, Altini M, Meer S. Altered E-cadherin/beta-catenin expression in oral squamous carcinoma with and without nodal metastasis. Oral Dis. 2007;13:386-92 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200; 图 1
Canavese G, Bernardi A, Candelaresi G, Lovadina P, Amerio S, Rossetti V, et al. Expression of the E-cadherin-catenins complex in sentinel node is related to tumor morphology but not to spread to nonsentinel nodes. Pathol Res Pract. 2007;203:517-23 pubmed
  • 免疫印迹; 人类; 1:4000; 图 1
Symowicz J, Adley B, Gleason K, Johnson J, Ghosh S, Fishman D, et al. Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res. 2007;67:2030-9 pubmed
  • 免疫细胞化学; 人类
Chang Y, Marlin J, Chance T, Jakobi R. RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. Cancer Res. 2006;66:11700-8 pubmed
  • 免疫组化; 人类; 1:100; 表 1
Rakha E, El Sayed M, Green A, Lee A, Robertson J, Ellis I. Prognostic markers in triple-negative breast cancer. Cancer. 2007;109:25-32 pubmed
  • 免疫组化; 人类; 图 2h
Murao K, Kubo Y, Ohtani N, Hara E, Arase S. Epigenetic abnormalities in cutaneous squamous cell carcinomas: frequent inactivation of the RB1/p16 and p53 pathways. Br J Dermatol. 2006;155:999-1005 pubmed
  • 免疫组化; 人类; 1:100
  • 酶联免疫吸附测定; 人类
  • 免疫印迹; 人类; 1:500
Sonne S, Hoei Hansen C, Nielsen J, Herlihy A, Andersson A, Almstrup K, et al. CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours. APMIS. 2006;114:549-58 pubmed
  • 免疫细胞化学; 人类
Robert G, Gaggioli C, Bailet O, Chavey C, Abbe P, Aberdam E, et al. SPARC represses E-cadherin and induces mesenchymal transition during melanoma development. Cancer Res. 2006;66:7516-23 pubmed
  • 免疫组化-石蜡切片; 人类
Rodriguez Sanjuan J, Fontalba A, Mayorga M, Bordin M, Hyland S, Trugeda S, et al. A novel mutation in the E-cadherin gene in the first family with hereditary diffuse gastric cancer reported in Spain. Eur J Surg Oncol. 2006;32:1110-3 pubmed
  • 免疫细胞化学; 人类; 图 6
  • 免疫组化; 人类; 图 1
Bacani J, Soares M, Zwingerman R, Di Nicola N, Senz J, Riddell R, et al. CDH1/E-cadherin germline mutations in early-onset gastric cancer. J Med Genet. 2006;43:867-72 pubmed
  • 免疫细胞化学; 人类; 20 ug/ml; 图 5
Katso R, Pardo O, Palamidessi A, Franz C, Marinov M, De Laurentiis A, et al. Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. Mol Biol Cell. 2006;17:3729-44 pubmed
  • 免疫沉淀; 人类; 图 5
  • 免疫细胞化学; 人类; 图 4
Troyanovsky R, Sokolov E, Troyanovsky S. Endocytosis of cadherin from intracellular junctions is the driving force for cadherin adhesive dimer disassembly. Mol Biol Cell. 2006;17:3484-93 pubmed
  • 免疫细胞化学; 仓鼠; 图 2
  • 免疫印迹; 仓鼠; 图 2
  • 免疫细胞化学; 人类; 图 1
Fujita Y, Hogan C, Braga V. Regulation of cell-cell adhesion by Rap1. Methods Enzymol. 2006;407:359-72 pubmed
  • 免疫组化-石蜡切片; 人类; 1:300
Rao K, Alper O, Opheim K, Bonnet G, Wolfe K, Bryant E, et al. Cytogenetic characterization and H-ras associated transformation of immortalized human mammary epithelial cells. Cancer Cell Int. 2006;6:15 pubmed
  • 免疫组化-石蜡切片; 人类; 1:600
Lascombe I, Clairotte A, Fauconnet S, Bernardini S, Wallerand H, Kantelip B, et al. N-cadherin as a novel prognostic marker of progression in superficial urothelial tumors. Clin Cancer Res. 2006;12:2780-7 pubmed
  • 免疫印迹; 人类; 1:1000; 图 1
Lombaerts M, van Wezel T, Philippo K, Dierssen J, Zimmerman R, Oosting J, et al. E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Br J Cancer. 2006;94:661-71 pubmed
  • 免疫组化-石蜡切片; 人类; 1:100; 表 2
Voutilainen K, Anttila M, Sillanpää S, Ropponen K, Saarikoski S, Juhola M, et al. Prognostic significance of E-cadherin-catenin complex in epithelial ovarian cancer. J Clin Pathol. 2006;59:460-7 pubmed
  • 免疫组化; 人类; 1:100; 表 7
Rakha E, Putti T, Abd El Rehim D, Paish C, Green A, Powe D, et al. Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation. J Pathol. 2006;208:495-506 pubmed
  • 免疫组化-石蜡切片; 人类; 1:400; 图 1
Harigopal M, Shin S, Murray M, Tickoo S, Brogi E, Rosen P. Aberrant E-cadherin staining patterns in invasive mammary carcinoma. World J Surg Oncol. 2005;3:73 pubmed
  • 免疫细胞化学; 人类; 1:200; 图 4B
  • 免疫印迹; 人类; 1:1000; 图 3B
Taylor D, Watt N, Perera W, Hooper N. Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J Cell Sci. 2005;118:5141-53 pubmed
  • 免疫组化-石蜡切片; 人类; 图 1C
  • 免疫细胞化学; 人类; 图 4Ac
  • 免疫印迹; 人类; 图 3B
Han S, Lee H, Lee J, Kim W, Nam H, Kim H, et al. Modulation of E-cadherin by hepatocyte growth factor induces aggressiveness of gastric carcinoma. Ann Surg. 2005;242:676-83 pubmed
  • 免疫组化-石蜡切片; 人类; 1:1000
Asioli S, Marucci G, Ficarra G, Stephens M, Foschini M, Ellis I, et al. Polymorphous adenocarcinoma of the breast. Report of three cases. Virchows Arch. 2006;448:29-34 pubmed
  • 免疫细胞化学; 人类; 图 5
Veveris Lowe T, Lawrence M, Collard R, Bui L, Herington A, Nicol D, et al. Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells. Endocr Relat Cancer. 2005;12:631-43 pubmed
  • 免疫细胞化学; 人类; 1:400
  • 免疫印迹; 人类; 1:1000
  • 免疫印迹; 大鼠; 1:1000
Schmidt C, Gi Y, Patel T, Coffey R, Beauchamp R, Pearson A. E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. Surgery. 2005;138:306-12 pubmed
  • 免疫组化; 人类; 图 2
Margulis A, Zhang W, Alt Holland A, Pawagi S, Prabhu P, Cao J, et al. Loss of intercellular adhesion activates a transition from low- to high-grade human squamous cell carcinoma. Int J Cancer. 2006;118:821-31 pubmed
  • 免疫印迹; 人类; 图 2
Köbel M, Pohl G, Schmitt W, Hauptmann S, Wang T, Shih I. Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor. Am J Pathol. 2005;167:879-85 pubmed
  • 免疫组化-石蜡切片; 人类; 1:1000
Bassarova A, Torlakovic E, Sedloev T, Hristova S, Trifonov D, Nesland J. Simultaneous bilateral breast carcinoma: Histopathological characteristics and CD44/catenin-cadherin profile. Histol Histopathol. 2005;20:791-9 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 1
Rakha E, Abd El Rehim D, Pinder S, Lewis S, Ellis I. E-cadherin expression in invasive non-lobular carcinoma of the breast and its prognostic significance. Histopathology. 2005;46:685-93 pubmed
  • 免疫组化-石蜡切片; 人类; 图 1
Vongwiwatana A, Tasanarong A, Rayner D, Melk A, Halloran P. Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant. 2005;5:1367-74 pubmed
  • 酶联免疫吸附测定; 人类; 图 1
Kuefer R, Hofer M, Zorn C, Engel O, Volkmer B, Juarez Brito M, et al. Assessment of a fragment of e-cadherin as a serum biomarker with predictive value for prostate cancer. Br J Cancer. 2005;92:2018-23 pubmed
  • 免疫组化; 人类; 1:10-1:20
Abd El Rehim D, Ball G, Pinder S, Rakha E, Paish C, Robertson J, et al. High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer. 2005;116:340-50 pubmed
  • 免疫组化-石蜡切片; 人类; 1:300; 图 1
Bendardaf R, Elzagheid A, Lamlum H, Ristamaki R, Collan Y, Pyrhonen S. E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer. Oncol Rep. 2005;13:831-5 pubmed
  • 免疫细胞化学; 人类
Ivanov A, Hunt D, Utech M, Nusrat A, Parkos C. Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. Mol Biol Cell. 2005;16:2636-50 pubmed
  • 免疫组化-石蜡切片; 人类; 1:400; 表 2
Pelosi G, Scarpa A, Puppa G, Veronesi G, Spaggiari L, Pasini F, et al. Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids. Cancer. 2005;103:1154-64 pubmed
  • 免疫组化; 人类; 1:1000; 图 1
van Velthuysen M, Taal B, van der Hoeven J, Peterse J. Expression of oestrogen receptor and loss of E-cadherin are diagnostic for gastric metastasis of breast carcinoma. Histopathology. 2005;46:153-7 pubmed
  • 免疫细胞化学; 人类; 1:300; 图 3
Rothen Rutishauser B, Kiama S, Gehr P. A three-dimensional cellular model of the human respiratory tract to study the interaction with particles. Am J Respir Cell Mol Biol. 2005;32:281-9 pubmed
  • 免疫组化-石蜡切片; 人类; 1:100; 表 1
Rakha E, Armour J, Pinder S, Paish C, Ellis I. High-resolution analysis of 16q22.1 in breast carcinoma using DNA amplifiable probes (multiplex amplifiable probe hybridization technique) and immunohistochemistry. Int J Cancer. 2005;114:720-9 pubmed
  • 免疫组化-石蜡切片; 人类
Bane A, Tjan S, Parkes R, Andrulis I, O Malley F. Invasive lobular carcinoma: to grade or not to grade. Mod Pathol. 2005;18:621-8 pubmed
  • 免疫细胞化学; 人类; 图 3
  • 免疫印迹; 人类; 图 1
Rios Doria J, Day M. Truncated E-cadherin potentiates cell death in prostate epithelial cells. Prostate. 2005;63:259-68 pubmed
  • 免疫组化-石蜡切片; 人类; 1:600
Eriksen J, Buffa F, Alsner J, Steiniche T, Bentzen S, Overgaard J. Molecular profiles as predictive marker for the effect of overall treatment time of radiotherapy in supraglottic larynx squamous cell carcinomas. Radiother Oncol. 2004;72:275-82 pubmed
  • 免疫组化-冰冻切片; 人类; 1:300
  • 免疫组化-石蜡切片; 人类; 1:300
Honecker F, Kersemaekers A, Molier M, Van Weeren P, Stoop H, de Krijger R, et al. Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development. J Pathol. 2004;204:167-74 pubmed
  • 免疫细胞化学; 人类; 图 3
  • 免疫印迹; 人类; 1:1000; 图 1
Schmidt C, Gi Y, Coffey R, Beauchamp R, Pearson A. Oncogenic Ras dominates overexpression of E-cadherin in malignant transformation of intestinal epithelial cells. Surgery. 2004;136:303-9 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200; 表 1
Marques F, Fonsechi Carvasan G, de Angelo Andrade L, Bottcher Luiz F. Immunohistochemical patterns for alpha- and beta-catenin, E- and N-cadherin expression in ovarian epithelial tumors. Gynecol Oncol. 2004;94:16-24 pubmed
  • 免疫印迹; 人类; 图 4
Kapoor P, Saunders M, Li Z, Zhou Z, Sheaffer N, Kunze E, et al. Breast cancer metastatic potential: correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells. Int J Cancer. 2004;111:693-7 pubmed
  • 免疫组化-石蜡切片; 人类; 1:1000
Andersen K, Nesland J, Holm R, Flørenes V, Fodstad Ø, Maelandsmo G. Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant melanoma. Mod Pathol. 2004;17:990-7 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200; 图 1
Song S, Kim S, Kim D, Son H, Rhee J, Kim Y. Abnormal expression of E-cadherin in early gastric carcinoma: its relationship with macroscopic growth patterns and catenin alpha and beta. J Clin Gastroenterol. 2004;38:252-9 pubmed
  • 免疫组化-石蜡切片; 人类; 图 2A
Graziano F, Arduini F, Ruzzo A, Bearzi I, Humar B, More H, et al. Prognostic analysis of E-cadherin gene promoter hypermethylation in patients with surgically resected, node-positive, diffuse gastric cancer. Clin Cancer Res. 2004;10:2784-9 pubmed
  • 免疫组化; 人类; 1:75; 表 2
Bassarova A, Nesland J, Sedloev T, Danielsen H, Christova S. Pilomatrix carcinoma with lymph node metastases. J Cutan Pathol. 2004;31:330-5 pubmed
  • 免疫组化-石蜡切片; 人类; 1:100
Graziano F, Arduini F, Ruzzo A, Mandolesi A, Bearzi I, Silva R, et al. Combined analysis of E-cadherin gene (CDH1) promoter hypermethylation and E-cadherin protein expression in patients with gastric cancer: implications for treatment with demethylating drugs. Ann Oncol. 2004;15:489-92 pubmed
  • 免疫沉淀; 人类; 图 4
  • 免疫印迹; 人类; 2.0 ug/ml; 图 2
Chunthapong J, Seftor E, Khalkhali Ellis Z, Seftor R, Amir S, Lubaroff D, et al. Dual roles of E-cadherin in prostate cancer invasion. J Cell Biochem. 2004;91:649-61 pubmed
  • 免疫印迹; 人类; 图 1
Chen Q, Lipkina G, Song Q, Kramer R. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun. 2004;315:850-6 pubmed
  • 免疫组化-石蜡切片; domestic rabbit; 图 7
Tobey N, Argote C, Hosseini S, Orlando R. Calcium-switch technique and junctional permeability in native rabbit esophageal epithelium. Am J Physiol Gastrointest Liver Physiol. 2004;286:G1042-9 pubmed
  • 免疫印迹; 人类
Kuefer R, Hofer M, Gschwend J, Pienta K, Sanda M, Chinnaiyan A, et al. The role of an 80 kDa fragment of E-cadherin in the metastatic progression of prostate cancer. Clin Cancer Res. 2003;9:6447-52 pubmed
  • 免疫印迹; 人类
Han S, Kim H, Seong D, Kim Y, Park Y, Bang Y, et al. Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer. Oncogene. 2004;23:1333-41 pubmed
  • 免疫印迹; 人类; 1:10000; 图 3
Gottardi C, Gumbiner B. Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions. Am J Physiol Cell Physiol. 2004;286:C747-56 pubmed
  • 免疫印迹; 人类; 图 2
Troyanovsky R, Sokolov E, Troyanovsky S. Adhesive and lateral E-cadherin dimers are mediated by the same interface. Mol Cell Biol. 2003;23:7965-72 pubmed
  • 免疫组化; 人类; 1:20; 图 1
Ordonez N. Value of E-cadherin and N-cadherin immunostaining in the diagnosis of mesothelioma. Hum Pathol. 2003;34:749-55 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200; 图 1
Palacios J, Sarrio D, García Macias M, Bryant B, Sobel M, Merino M. Frequent E-cadherin gene inactivation by loss of heterozygosity in pleomorphic lobular carcinoma of the breast. Mod Pathol. 2003;16:674-8 pubmed
  • 免疫组化; 人类; 1:200; 表 1
Rocha A, Soares P, Fonseca E, Cameselle Teijeiro J, Oliveira M, Sobrinho Simoes M. E-cadherin loss rather than beta-catenin alterations is a common feature of poorly differentiated thyroid carcinomas. Histopathology. 2003;42:580-7 pubmed
  • 免疫细胞化学; 人类; 图 3a
  • 免疫印迹; 人类; 图 3b
McGuire J, Li Q, Parks W. Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium. Am J Pathol. 2003;162:1831-43 pubmed
  • 免疫印迹; 人类; 1:1000
Kokenyesi R, Murray K, Benshushan A, Huntley E, Kao M. Invasion of interstitial matrix by a novel cell line from primary peritoneal carcinosarcoma, and by established ovarian carcinoma cell lines: role of cell-matrix adhesion molecules, proteinases, and E-cadherin expression. Gynecol Oncol. 2003;89:60-72 pubmed
  • 流式细胞仪; 人类; 表 3
  • 免疫细胞化学; 人类; 图 5
  • 免疫印迹; 人类; 0.5 ug/ml; 图 8
Offterdinger M, Schneider S, Grunt T. Heregulin and retinoids synergistically induce branching morphogenesis of breast cancer cells cultivated in 3D collagen gels. J Cell Physiol. 2003;195:260-75 pubmed
  • 免疫组化-石蜡切片; 人类
Impola U, Toriseva M, Suomela S, Jeskanen L, Hieta N, Jahkola T, et al. Matrix metalloproteinase-19 is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation. Int J Cancer. 2003;103:709-16 pubmed
  • 免疫组化-石蜡切片; 人类
Carpenter P, Al Kuran R, Theuer C. Paranuaclear E-cadherin in gastric adenocarcinoma. Am J Clin Pathol. 2002;118:887-94 pubmed
  • 免疫组化; 人类
Kuijper A, Preisler Adams S, Rahusen F, Gille J, van der Wall E, van Diest P. Multiple fibroadenomas harbouring carcinoma in situ in a woman with a family history of breast/ovarian cancer. J Clin Pathol. 2002;55:795-7 pubmed
  • 免疫组化-石蜡切片; 人类; 1:2000; 表 2
Karbova E, Davidson B, Metodiev K, Trope C, Nesland J. Adenomatous polyposis coli (APC) protein expression in primary and metastatic serous ovarian carcinoma. Int J Surg Pathol. 2002;10:175-80 pubmed
  • 免疫组化-石蜡切片; 人类; 1:1000; 图 6
Damiani S, Eusebi V, Peterse J. Malignant neoplasms infiltrating pseudoangiomatous' stromal hyperplasia of the breast: an unrecognized pathway of tumour spread. Histopathology. 2002;41:208-15 pubmed
  • 免疫印迹; 人类
Jamal S, Schneider R. UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells. J Clin Invest. 2002;110:443-52 pubmed
  • 免疫组化-石蜡切片; 人类; 1:1000; 表 1
  • 免疫印迹; 人类; 表 3
Khorram Manesh A, Ahlman H, Jansson S, Nilsson O. N-cadherin expression in adrenal tumors: upregulation in malignant pheochromocytoma and downregulation in adrenocortical carcinoma. Endocr Pathol. 2002;13:99-110 pubmed
  • 免疫组化-石蜡切片; 人类; 图 3
Elzagheid A, Kuopio T, Ilmen M, Collan Y. Prognostication of invasive ductal breast cancer by quantification of E-cadherin immunostaining: the methodology and clinical relevance. Histopathology. 2002;41:127-33 pubmed
  • 免疫印迹; 人类; 图 4
Tran N, Adams D, Vaillancourt R, Heimark R. Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization. J Biol Chem. 2002;277:32905-14 pubmed
  • 抑制或激活实验; 人类
Kim J, Joo C. Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1. J Biol Chem. 2002;277:31938-48 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200; 图 1
Rocha A, Soares P, Machado J, Máximo V, Fonseca E, Franssila K, et al. Mucoepidermoid carcinoma of the thyroid: a tumour histotype characterised by P-cadherin neoexpression and marked abnormalities of E-cadherin/catenins complex. Virchows Arch. 2002;440:498-504 pubmed
  • 免疫细胞化学; 人类; 1:100; 图 1
  • 免疫印迹; 人类; 1:1000; 图 1
Sahai E, Marshall C. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol. 2002;4:408-15 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200; 图 2
Paredes J, Milanezi F, Viegas L, Amendoeira I, Schmitt F. P-cadherin expression is associated with high-grade ductal carcinoma in situ of the breast. Virchows Arch. 2002;440:16-21 pubmed
  • 免疫组化; 人类
Mert G. National action plan on Breast Cancer Workshop on Multicultural Aspects of Breast Cancer Etiology: recommendations of the workshop. Cancer. 2002;94:2113 pubmed
  • 抑制或激活实验; 人类
Hegerfeldt Y, Tusch M, Brocker E, Friedl P. Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies. Cancer Res. 2002;62:2125-30 pubmed
  • 免疫印迹; 人类; 1:5000
Hajra K, Chen D, Fearon E. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 2002;62:1613-8 pubmed
  • 免疫组化-石蜡切片; 人类
Laskin W, Miettinen M. Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues. Arch Pathol Lab Med. 2002;126:425-31 pubmed
  • 免疫细胞化学; 人类; 图 4
  • 免疫印迹; 人类; 图 2
Schreider C, Peignon G, Thenet S, Chambaz J, Pincon Raymond M. Integrin-mediated functional polarization of Caco-2 cells through E-cadherin--actin complexes. J Cell Sci. 2002;115:543-52 pubmed
  • 免疫细胞化学; 人类; 1:100
Fetsch P, Simsir A, Brosky K, Abati A. Comparison of three commonly used cytologic preparations in effusion immunocytochemistry. Diagn Cytopathol. 2002;26:61-6 pubmed
  • 免疫印迹; 人类; 图 5
Gregoire L, Rabah R, Schmelz E, Munkarah A, Roberts P, Lancaster W. Spontaneous malignant transformation of human ovarian surface epithelial cells in vitro. Clin Cancer Res. 2001;7:4280-7 pubmed
  • 免疫组化-石蜡切片; 人类
Parker C, Rampaul R, Pinder S, Bell J, Wencyk P, Blamey R, et al. E-cadherin as a prognostic indicator in primary breast cancer. Br J Cancer. 2001;85:1958-63 pubmed
  • 免疫组化-石蜡切片; 人类; 图 3
Pummi K, Malminen M, Aho H, Karvonen S, Peltonen J, Peltonen S. Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes. J Invest Dermatol. 2001;117:1050-8 pubmed
  • 免疫组化-冰冻切片; 人类; 1:200
Ascaño J, Frierson H, Moskaluk C, Harper J, Roviello F, Jackson C, et al. Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer. Mod Pathol. 2001;14:942-9 pubmed
  • 免疫组化-石蜡切片; 人类; 1:1000
Kapiteijn E, Liefers G, Los L, Kranenbarg E, Hermans J, Tollenaar R, et al. Mechanisms of oncogenesis in colon versus rectal cancer. J Pathol. 2001;195:171-8 pubmed
  • 免疫组化-石蜡切片; 人类; 1:20; 图 1
  • 免疫印迹; 人类; 图 2
Krill D, Thomas A, Wu S, Dhir R, Becich M. E-cadherin expression and PSA secretion in human prostate epithelial cells. Urol Res. 2001;29:287-92 pubmed
  • 免疫组化-石蜡切片; 人类; 表 1
Wheelock M, Soler A, Knudsen K. Cadherin junctions in mammary tumors. J Mammary Gland Biol Neoplasia. 2001;6:275-85 pubmed
  • 免疫组化; 人类; 1:800
Noci I, Borri P, Bonfirraro G, Chieffi O, Arcangeli A, Cherubini A, et al. Longstanding survival without cancer progression in a patient affected by endometrial carcinoma treated primarily with leuprolide. Br J Cancer. 2001;85:333-6 pubmed
  • 免疫组化-石蜡切片; 人类; 图 1
Rubin M, Mucci N, Figurski J, Fecko A, Pienta K, Day M. E-cadherin expression in prostate cancer: a broad survey using high-density tissue microarray technology. Hum Pathol. 2001;32:690-7 pubmed
  • 免疫组化; 人类; 图 1
Rocha A, Soares P, Seruca R, Máximo V, Matias Guiu X, Cameselle Teijeiro J, et al. Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant. J Pathol. 2001;194:358-66 pubmed
  • 抑制或激活实验; 人类
  • 免疫沉淀; 人类; 图 3d
  • 免疫组化; 人类; 图 3f
  • 免疫印迹; 人类; 图 2
Tomlinson J, Alpaugh M, Barsky S. An intact overexpressed E-cadherin/alpha,beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma. Cancer Res. 2001;61:5231-41 pubmed
  • 免疫组化-冰冻切片; 人类; 1:10
Hentula M, Peltonen J, Peltonen S. Expression profiles of cell-cell and cell-matrix junction proteins in developing human epidermis. Arch Dermatol Res. 2001;293:259-67 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200
Rahn J, Dabbagh L, Pasdar M, Hugh J. The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literature. Cancer. 2001;91:1973-82 pubmed
  • 免疫印迹; 人类
Gottardi C, Wong E, Gumbiner B. E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol. 2001;153:1049-60 pubmed
  • 免疫组化-石蜡切片; 人类; 1:2000; 图 2
Spina D, Vindigni C, Presenti L, Schurfeld K, Stumpo M, Tosi P. Cell proliferation, cell death, E-cadherin, metalloproteinase expression and angiogenesis in gastric cancer precursors and early cancer of the intestinal type. Int J Oncol. 2001;18:1251-8 pubmed
  • 免疫组化; 人类; 1:100
Leong A, Sormunen R, Vinyuvat S, Hamdani R, Suthipintawong C. Biologic markers in ductal carcinoma in situ and concurrent infiltrating carcinoma. A comparison of eight contemporary grading systems. Am J Clin Pathol. 2001;115:709-18 pubmed
  • 免疫组化-石蜡切片; 人类; 1:500
Rieger Christ K, Pezza J, Dugan J, Braasch J, Hughes K, Summerhayes I. Disparate E-cadherin mutations in LCIS and associated invasive breast carcinomas. Mol Pathol. 2001;54:91-7 pubmed
  • 免疫组化-石蜡切片; 人类; 1:1000; 图 1
Etzell J, DeVries S, Chew K, Florendo C, Molinaro A, Ljung B, et al. Loss of chromosome 16q in lobular carcinoma in situ. Hum Pathol. 2001;32:292-6 pubmed
  • 免疫组化; 人类; 1:1000; 表 3
Waldman F, Hwang E, Etzell J, Eng C, DeVries S, Bennington J, et al. Genomic alterations in tubular breast carcinomas. Hum Pathol. 2001;32:222-6 pubmed
  • 免疫印迹; 人类
Rashid M, Sanda M, Vallorosi C, Rios Doria J, Rubin M, Day M. Posttranslational truncation and inactivation of human E-cadherin distinguishes prostate cancer from matched normal prostate. Cancer Res. 2001;61:489-92 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200
Acs G, Lawton T, Rebbeck T, LiVolsi V, Zhang P. Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications. Am J Clin Pathol. 2001;115:85-98 pubmed
  • 免疫组化; 人类; 1:100; 图 5
Maluf H, Swanson P, Koerner F. Solid low-grade in situ carcinoma of the breast: role of associated lesions and E-cadherin in differential diagnosis. Am J Surg Pathol. 2001;25:237-44 pubmed
  • 免疫组化; 人类; 1:200
Acs G, LiVolsi V. Loss of membrane expression of E-cadherin in leukemic erythroblasts. Arch Pathol Lab Med. 2001;125:198-201 pubmed
  • 免疫组化-石蜡切片; 小鼠; 1:100
Luo Y, Ferreira Cornwell M, Baldwin H, Kostetskii I, Lenox J, Lieberman M, et al. Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin. Development. 2001;128:459-69 pubmed
  • 免疫组化-石蜡切片; 人类
Kolby L, Bernhardt P, Ahlman H, Wangberg B, Johanson V, Wigander A, et al. A transplantable human carcinoid as model for somatostatin receptor-mediated and amine transporter-mediated radionuclide uptake. Am J Pathol. 2001;158:745-55 pubmed
  • 免疫印迹; 人类
Corn P, Smith B, Ruckdeschel E, Douglas D, Baylin S, Herman J. E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia. Clin Cancer Res. 2000;6:4243-8 pubmed
  • 免疫组化; 人类
Rechardt O, Elomaa O, Vaalamo M, Pääkkönen K, Jahkola T, Hook Nikanne J, et al. Stromelysin-2 is upregulated during normal wound repair and is induced by cytokines. J Invest Dermatol. 2000;115:778-87 pubmed
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类; 图 2
Kaida M, Cao F, Skumatz C, Irving P, Burke J. Time at confluence for human RPE cells: effects on the adherens junction and in vitro wound closure. Invest Ophthalmol Vis Sci. 2000;41:3215-24 pubmed
  • 免疫组化-冰冻切片; 牛
  • 免疫组化; 牛
Burke J, Cao F, Irving P. High levels of E-/P-cadherin: correlation with decreased apical polarity of Na/K ATPase in bovine RPE cells in situ. Invest Ophthalmol Vis Sci. 2000;41:1945-52 pubmed
  • 流式细胞仪; 人类
Hsu M, Meier F, Nesbit M, Hsu J, Van Belle P, Elder D, et al. E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors. Am J Pathol. 2000;156:1515-25 pubmed
  • 免疫组化-石蜡切片; 人类; 1:500; 表 1
Bukholm I, Nesland J. Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas. Virchows Arch. 2000;436:224-8 pubmed
  • 免疫组化-石蜡切片; 人类; 图 1
Halachmi S, Demarzo A, Chow N, Halachmi N, Smith A, Linn J, et al. Genetic alterations in urinary bladder carcinosarcoma: evidence of a common clonal origin. Eur Urol. 2000;37:350-7 pubmed
  • 免疫组化-冰冻切片; 人类
Spirin K, Ljubimov A, Castellon R, Wiedoeft O, Marano M, Sheppard D, et al. Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA. Invest Ophthalmol Vis Sci. 1999;40:3108-15 pubmed
  • 免疫组化-石蜡切片; 人类
Huiping C, Sigurgeirsdottir J, Jonasson J, Eiriksdottir G, Johannsdottir J, Egilsson V, et al. Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer. Br J Cancer. 1999;81:1103-10 pubmed
  • 免疫细胞化学; 人类; 1:400
Gomez S, del Mont Llosas M, Verdu J, Roura S, Lloreta J, Fabre M, et al. Independent regulation of adherens and tight junctions by tyrosine phosphorylation in Caco-2 cells. Biochim Biophys Acta. 1999;1452:121-32 pubmed
  • 免疫细胞化学; 人类
Burke J, Cao F, Irving P, Skumatz C. Expression of E-cadherin by human retinal pigment epithelium: delayed expression in vitro. Invest Ophthalmol Vis Sci. 1999;40:2963-70 pubmed
  • 免疫组化-石蜡切片; 人类; 图 3
Peralta Soler A, Knudsen K, Salazar H, Han A, Keshgegian A. P-cadherin expression in breast carcinoma indicates poor survival. Cancer. 1999;86:1263-72 pubmed
  • 免疫组化-冰冻切片; 人类; 图 1
Peltonen S, Hentula M, Hagg P, Ylä Outinen H, Tuukkanen J, Lakkakorpi J, et al. A novel component of epidermal cell-matrix and cell-cell contacts: transmembrane protein type XIII collagen. J Invest Dermatol. 1999;113:635-42 pubmed
  • 免疫沉淀; 人类; 图 2
  • 免疫细胞化学; 人类; 图 3
  • 免疫印迹; 人类; 图 2
Tran N, Nagle R, Cress A, Heimark R. N-Cadherin expression in human prostate carcinoma cell lines. An epithelial-mesenchymal transformation mediating adhesion withStromal cells. Am J Pathol. 1999;155:787-98 pubmed
  • 免疫组化-石蜡切片; 人类; 1:800; 图 1
Blok P, Craanen M, Dekker W, Tytgat G. Loss of E-cadherin expression in early gastric cancer. Histopathology. 1999;34:410-5 pubmed
  • 免疫细胞化学; 人类
Wong A, Maines Bandiera S, Rosen B, Wheelock M, Johnson K, Leung P, et al. Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: influence of family history of ovarian cancer. Int J Cancer. 1999;81:180-8 pubmed
  • 免疫印迹; 人类
Day M, Zhao X, Vallorosi C, Putzi M, Powell C, Lin C, et al. E-cadherin mediates aggregation-dependent survival of prostate and mammary epithelial cells through the retinoblastoma cell cycle control pathway. J Biol Chem. 1999;274:9656-64 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200; 图 2
Montonen O, Ezer S, Laurikkala J, Karjalainen Lindsberg M, Thesleff I, Kere J, et al. Expression of the anhidrotic ectodermal dysplasia gene is reduced in skin cancer coinciding with reduced E-cadherin. Exp Dermatol. 1998;7:168-74 pubmed
  • 免疫细胞化学; 人类
Sancho E, Vila M, Sanchez Pulido L, Lozano J, Paciucci R, Nadal M, et al. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. Mol Cell Biol. 1998;18:576-89 pubmed
  • 流式细胞仪; 人类; 1:1000; 图 2
Laihia J, Jansen C. Up-regulation of human epidermal Langerhans' cell B7-1 and B7-2 co-stimulatory molecules in vivo by solar-simulating irradiation. Eur J Immunol. 1997;27:984-9 pubmed
  • 免疫组化-石蜡切片; 人类
Songun I, van de Velde C, Hermans J, Pals S, Verspaget H, Vis A, et al. Expression of oncoproteins and the amount of eosinophilic and lymphocytic infiltrates can be used as prognostic factors in gastric cancer. Dutch Gastric Cancer Group (DGCG). Br J Cancer. 1996;74:1783-8 pubmed
  • 免疫组化-石蜡切片; 人类; 5 ug/ml
Cheng L, Nagabhushan M, Pretlow T, Amini S, Pretlow T. Expression of E-cadherin in primary and metastatic prostate cancer. Am J Pathol. 1996;148:1375-80 pubmed
  • 流式细胞仪; 人类
Rokhlin O, Cohen M. Expression of cellular adhesion molecules on human prostate tumor cell lines. Prostate. 1995;26:205-12 pubmed
Carneiro P, Moreira A, Figueiredo J, Barros R, Oliveira P, Fernandes M, et al. S100P is a molecular determinant of E-cadherin function in gastric cancer. Cell Commun Signal. 2019;17:155 pubmed 出版商
Palangat M, Anastasakis D, Fei D, Lindblad K, Bradley R, Hourigan C, et al. The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation. Genes Dev. 2019;33:482-497 pubmed 出版商
Saxena S, Purohit A, Varney M, Hayashi Y, Singh R. Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells. BMC Cancer. 2018;18:1283 pubmed 出版商
Song J, Miermont A, Lim C, Kamm R. A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines. Sci Rep. 2018;8:17949 pubmed 出版商
Papoff G, Presutti D, Lalli C, Bolasco G, Santini S, Manelfi C, et al. CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion. Sci Rep. 2018;8:17705 pubmed 出版商
Wolf G, Winter W, Bellile E, Nguyen A, Donnelly C, McHugh J, et al. Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck. Oral Oncol. 2018;87:29-35 pubmed 出版商
Motawea H, Chotani M, Ali M, Ackerman W, Zhao G, Ahmed A, et al. Human Placenta Expresses α2-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction. Am J Pathol. 2018;188:2774-2785 pubmed 出版商
Tang M, Yue P, Ip P, Huang R, Lai H, Cheung A, et al. Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface. Nat Commun. 2018;9:2270 pubmed 出版商
Chang J, Hu S, Wang W, Li Y, Zhi W, Lu S, et al. Matrine inhibits prostate cancer via activation of the unfolded protein response/endoplasmic reticulum stress signaling and reversal of epithelial to mesenchymal transition. Mol Med Rep. 2018;18:945-957 pubmed 出版商
Ottaviani S, Stebbing J, Frampton A, Zagorac S, Krell J, de Giorgio A, et al. TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Nat Commun. 2018;9:1845 pubmed 出版商
Indra I, Choi J, Chen C, Troyanovsky R, Shapiro L, Honig B, et al. Spatial and temporal organization of cadherin in punctate adherens junctions. Proc Natl Acad Sci U S A. 2018;115:E4406-E4415 pubmed 出版商
Hareza A, Bakun M, Åšwiderska B, Dudkiewicz M, Koscielny A, Bajur A, et al. Phosphoproteomic insights into processes influenced by the kinase-like protein DIA1/C3orf58. Peerj. 2018;6:e4599 pubmed 出版商
Warthan M, Washington S, Franzese S, Ramus R, Kim K, York T, et al. The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma. Biol Reprod. 2018;98:309-322 pubmed 出版商
Li T, Wang L. Riparsaponin isolated from Homonoia riparia Lour induces apoptosis of oral cancer cells. Oncol Lett. 2017;14:6841-6846 pubmed 出版商
Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, et al. Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells in Periodontitis. J Immunol. 2017;199:4023-4035 pubmed 出版商
Aström P, Juurikka K, Hadler Olsen E, Svineng G, Cervigne N, Coletta R, et al. The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma. Br J Cancer. 2017;117:1007-1016 pubmed 出版商
Al Khalaf H, Amir M, Al Mohanna F, Tulbah A, Al Sayed A, Aboussekhra A. Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity. Mol Cell Biol. 2017;37: pubmed 出版商
Bays J, Campbell H, Heidema C, Sebbagh M, DeMali K. Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK. Nat Cell Biol. 2017;19:724-731 pubmed 出版商
Meng J, Zhou P, Liu Y, Liu F, Yi X, Liu S, et al. The development of nasal polyp disease involves early nasal mucosal inflammation and remodelling. PLoS ONE. 2013;8:e82373 pubmed 出版商
Araki K, Shimura T, Suzuki H, Tsutsumi S, Wada W, Yajima T, et al. E/N-cadherin switch mediates cancer progression via TGF-?-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma. Br J Cancer. 2011;105:1885-93 pubmed 出版商
Ferreira A, Suriano G, Mendes N, Gomes B, Wen X, Carneiro F, et al. E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2. Hum Mol Genet. 2012;21:334-43 pubmed 出版商
Yin L, Castagnino P, Assoian R. ABCG2 expression and side population abundance regulated by a transforming growth factor beta-directed epithelial-mesenchymal transition. Cancer Res. 2008;68:800-7 pubmed 出版商
Fournier A, Campbell L, Castagnino P, Liu W, Chung B, Weaver V, et al. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. J Cell Sci. 2008;121:226-33 pubmed 出版商
Villadsen R, Fridriksdottir A, Rønnov Jessen L, Gudjonsson T, Rank F, Labarge M, et al. Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol. 2007;177:87-101 pubmed
Yanagisawa M, Anastasiadis P. p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness. J Cell Biol. 2006;174:1087-96 pubmed
Burke J, Hong J. Fate of E-cadherin in early RPE cultures: transient accumulation of truncated peptides at nonjunctional sites. Invest Ophthalmol Vis Sci. 2006;47:3635-43 pubmed
Liu W, Nelson C, Pirone D, Chen C. E-cadherin engagement stimulates proliferation via Rac1. J Cell Biol. 2006;173:431-41 pubmed
Peignon G, Thenet S, Schreider C, Fouquet S, Ribeiro A, Dussaulx E, et al. E-cadherin-dependent transcriptional control of apolipoprotein A-IV gene expression in intestinal epithelial cells: a role for the hepatic nuclear factor 4. J Biol Chem. 2006;281:3560-8 pubmed
Gottardi C, Gumbiner B. Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. J Cell Biol. 2004;167:339-49 pubmed
Seveau S, Bierne H, Giroux S, Prevost M, Cossart P. Role of lipid rafts in E-cadherin-- and HGF-R/Met--mediated entry of Listeria monocytogenes into host cells. J Cell Biol. 2004;166:743-53 pubmed
Ivanov A, McCall I, Parkos C, Nusrat A. Role for actin filament turnover and a myosin II motor in cytoskeleton-driven disassembly of the epithelial apical junctional complex. Mol Biol Cell. 2004;15:2639-51 pubmed
Tian F, DaCosta Byfield S, Parks W, Yoo S, Felici A, Tang B, et al. Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res. 2003;63:8284-92 pubmed
Conacci Sorrell M, Simcha I, Ben Yedidia T, Blechman J, Savagner P, Ben Ze ev A. Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol. 2003;163:847-57 pubmed
Chan A, Chu K, Lam S, Wong B, Kwok K, Law S, et al. Soluble E-cadherin is an independent pretherapeutic factor for long-term survival in gastric cancer. J Clin Oncol. 2003;21:2288-93 pubmed
Rios Doria J, Day K, Kuefer R, Rashid M, Chinnaiyan A, Rubin M, et al. The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells. J Biol Chem. 2003;278:1372-9 pubmed
Govindarajan R, Zhao S, Song X, Guo R, Wheelock M, Johnson K, et al. Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin. J Biol Chem. 2002;277:50087-97 pubmed
Malminen M, Peltonen S, Koivunen J, Peltonen J. Functional expression of NF1 tumor suppressor protein: association with keratin intermediate filaments during the early development of human epidermis. BMC Dermatol. 2002;2:10 pubmed
Edens H, Levi B, Jaye D, Walsh S, Reaves T, Turner J, et al. Neutrophil transepithelial migration: evidence for sequential, contact-dependent signaling events and enhanced paracellular permeability independent of transjunctional migration. J Immunol. 2002;169:476-86 pubmed
Alpaugh M, Tomlinson J, Kasraeian S, Barsky S. Cooperative role of E-cadherin and sialyl-Lewis X/A-deficient MUC1 in the passive dissemination of tumor emboli in inflammatory breast carcinoma. Oncogene. 2002;21:3631-43 pubmed
Laura R, Witt A, Held H, Gerstner R, Deshayes K, Koehler M, et al. The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J Biol Chem. 2002;277:12906-14 pubmed
Kotelevets L, van Hengel J, Bruyneel E, Mareel M, van Roy F, Chastre E. The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness. J Cell Biol. 2001;155:1129-35 pubmed
Adam L, Vadlamudi R, McCrea P, Kumar R. Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability. J Biol Chem. 2001;276:28443-50 pubmed
Jacobs T, Pliss N, Kouria G, Schnitt S. Carcinomas in situ of the breast with indeterminate features: role of E-cadherin staining in categorization. Am J Surg Pathol. 2001;25:229-36 pubmed
Taraszka K, Higgins J, Tan K, Mandelbrot D, Wang J, Brenner M. Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin. J Exp Med. 2000;191:1555-67 pubmed
Kondo K, Kohno N, Yokoyama A, Hiwada K. Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines. Cancer Res. 1998;58:2014-9 pubmed
Braga V, Machesky L, Hall A, Hotchin N. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol. 1997;137:1421-31 pubmed
Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, et al. Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J Cell Biol. 1995;128:949-57 pubmed
Hirano S, Kimoto N, Shimoyama Y, Hirohashi S, Takeichi M. Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization. Cell. 1992;70:293-301 pubmed
产品信息
产品类型 :
抗体
产品名称 :
E钙粘蛋白单克隆抗体(HECD-1)
目录# :
13-1700
规格 :
100微克
价格 :
425美元
克隆性 :
单克隆
纯度 :
离子交换层析
宿主 :
小鼠
反应物种 :
豚鼠, 人类
应用 :
ELISA: 2-10 µg/mL, Flow Cytometry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunohistochemistry (Frozen): 2-10 µg/mL, Immunohistochemistry (Paraffin): 2-10 µg/mL, Inhibition Assays: 100 µg/mL, Western Blot: 2-10 µg/mL
物种 :
豚鼠, 人类
克隆 :
HECD-1
抗体亚型 :
IgG1
储存 :
4° C
描述 :
E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
免疫原 :
人类乳腺肿瘤细胞株MCF-7
格式 :
冻干
应用w/稀释 :
ELISA: 2-10 µg/mL, Flow Cytometry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunohistochemistry (Frozen): 2-10 µg/mL, Immunohistochemistry (Paraffin): 2-10 µg/mL, Inhibition Assays: 100 µg/mL, Western Blot: 2-10 µg/mL
别名 :
AA960649; Arc-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; Cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-Cadherin phospho; Epithelial cadherin; hab; half baked; LCAM; L-CAM; phospho cadherin 1; phospho E-Cadherin; phospho LCAM; phospho S838; phospho UVO; S840; S840 E-Cadherin; Ser840; Ser840 E-Cadherin; Um; UVO; Uvomorulin
更多信息或购买 :
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公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国