产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
FGFR1单克隆抗体(VBS-7)
目录 :
13-3100
规格 :
100微克
价格 :
375美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
VBS-7
反应物种 :
豚鼠, 人类, 小鼠, 大鼠, 鸡, 牛
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 4
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
Dumon K, Ishii H, Vecchione A, Trapasso F, Baldassarre G, Chakrani F, et al. Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer. Cancer Res. 2001;61:4827-36 pubmed
| |
Panossian V, Liu S, Lane J, Finerman G. Fibroblast growth factor and epidermal growth factor receptors in ligament healing. Clin Orthop Relat Res. 1997;:173-80 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
FGFR1单克隆抗体(VBS-7)
目录# :
13-3100
规格 :
100微克
价格 :
375美元
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
牛, 鸡, 豚鼠, 人类, 小鼠, 大鼠
应用 :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: 2-5 µg, Western Blot: 2 µg/mL
物种 :
牛, 鸡, 豚鼠, 人类, 小鼠, 大鼠
克隆 :
VBS-7
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family containing an Ig-like domain and a tyrosine kinase domain. FGFR1 has multiple isoforms and is a Type I membrane protein. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR1 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR1 binds both acidic and basic fibroblast growth factors and is involved in limb induction. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM. Four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR-1, FGFR-2, FGFR-3 and FGFR-4.FGFRs are members of the tyrosine kinase family of growth factor receptors. At the mRNA level, FGFR1 is highly expressed in developing human tissues including the brain, vascular basement membrane and skin. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
免疫原 :
Bovine FGF Receptor 1 (flg) purified from bovine Coronary Venular Endothelial Cells (CVEC).
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: 2-5 µg, Western Blot: 2 µg/mL
别名 :
2.7.10.1; AW208770; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R; bFGF-R-1; CD331; CD331 antigen; CEK; CEK1; cek1 protein; c-fgr; Eask; ECCL; FGF receptor; FGF receptor-1; FGFBR; fgfr 1; Fgfr1; FGFR-1; FGFR1/PLAG1 fusion; FGFR1IIIC; FGFRI; Fibroblast growth factor receptor 1; fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome); fibroblast growth factor receptor type 1; Flg; FLT2; FLT-2; Fms-like tyrosine kinase 2; fms-related tyrosine kinase 2; HBGFR; heparin-binding growth factor receptor; HH2; HRTFDS; Hspy; hydroxyaryl-protein kinase; KAL2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1; MFR; N-sam; OGD; proto-oncogene c-Fgr; Tyrosine kinase receptor CEK1
更多信息或购买 :
公司信息
赛默飞世尔