产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
STAT5甲单克隆抗体(ST5a-2H2)
目录 :
13-3600
规格 :
100微克
价格 :
375美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
ST5a-2H2
反应物种 :
African green monkey, 人类, 小鼠, 大鼠, 牛
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, EMSA, 染色质免疫沉淀
, 免疫组化-石蜡切片, 免疫组化-自由浮动切片
更多信息或购买 :
文章摘录数: 18
| 出版应用/物种/样本/稀释 | 参考文献 |
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| Kabotyanski E, Huetter M, Xian W, Rijnkels M, Rosen J. Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers. Mol Endocrinol. 2006;20:2355-68 pubmed
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| Aittomaki S, Pesu M, Groner B, Janne O, Palvimo J, Silvennoinen O. Cooperation among Stat1, glucocorticoid receptor, and PU.1 in transcriptional activation of the high-affinity Fc gamma receptor I in monocytes. J Immunol. 2000;164:5689-97 pubmed
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Silver D, Naora H, Liu J, Cheng W, Montell D. Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. Cancer Res. 2004;64:3550-8 pubmed
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Gewinner C, Hart G, Zachara N, Cole R, Beisenherz Huss C, Groner B. The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5. J Biol Chem. 2004;279:3563-72 pubmed
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Chong M, Cornish A, Darwiche R, Stanley E, Purton J, Godfrey D, et al. Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. Immunity. 2003;18:475-87 pubmed
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Saharinen P, Vihinen M, Silvennoinen O. Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain. Mol Biol Cell. 2003;14:1448-59 pubmed
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Cornish A, Chong M, Davey G, Darwiche R, Nicola N, Hilton D, et al. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem. 2003;278:22755-61 pubmed
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Millot B, Montoliu L, Fontaine M, Mata T, Devinoy E. Hormone-induced modifications of the chromatin structure surrounding upstream regulatory regions conserved between the mouse and rabbit whey acidic protein genes. Biochem J. 2003;372:41-52 pubmed
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Xu M, Nie L, Kim S, Sun X. STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta. EMBO J. 2003;22:893-904 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
STAT5甲单克隆抗体(ST5a-2H2)
目录# :
13-3600
规格 :
100微克
价格 :
375美元
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: 0.1-1 µg/mL, Gel Shift: 1-3 µg, Immunocytochemistry: 1-3 µg/mL, Immunofluorescence: 1-3 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: 5 µg, Western Blot: 1-3 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
ST5a-2H2
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.
免疫原 :
A peptide corresponding to the C-terminus of murine Stat5a coupled to a protein carrier.
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1 µg/mL, Gel Shift: 1-3 µg, Immunocytochemistry: 1-3 µg/mL, Immunofluorescence: 1-3 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: 5 µg, Western Blot: 1-3 µg/mL
别名 :
AA959963; Mammary gland factor; mammary gland factor STAT5A; mammary gland factor; transcription factor; Mgf; Mpf; signal transducer and activator of transcription 5; signal transducer and activator of transcription 5a; signal transducer and activator of transcription factor 5A; STAT; STAT5; STAT5A; STAT5A, Mammary Gland Factor; STAT5A/MGF; STAT5B; STATA5
更多信息或购买 :
公司信息
赛默飞世尔