产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
PKC丙单克隆抗体(PKC66)
目录 :
13-3800
规格 :
200微克
价格 :
375美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
PKC66
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 15
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 1a
Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, et al. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017;31:685-696.e6 pubmed 出版商
  • 免疫细胞化学; 小鼠
Zhang F, Fang Z, Wang J. Hint1 knockout results in a compromised activation of protein kinase C gamma in the brain. Brain Res. 2015;1622:196-203 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Schubert M, Panja D, Haugen M, Bramham C, Vedeler C. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol. 2014;128:835-52 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1:100; 图 1
Nitzan Luques A, Minert A, Devor M, Tal M. Dynamic genotype-selective "phenotypic switching" of CGRP expression contributes to differential neuropathic pain phenotype. Exp Neurol. 2013;250:194-204 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:50; 图 4
Fleming M, Ramos D, Han S, Zhao J, Son Y, Luo W. The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons. Mol Pain. 2012;8:52 pubmed 出版商
  • 免疫组化; 大鼠; 1:100; 图 1
Nitzan Luques A, Devor M, Tal M. Genotype-selective phenotypic switch in primary afferent neurons contributes to neuropathic pain. Pain. 2011;152:2413-26 pubmed 出版商
Antal C, Hudson A, Kang E, Zanca C, Wirth C, Stephenson N, et al. Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell. 2015;160:489-502 pubmed 出版商
Takanami K, Sakamoto H, Matsuda K, Satoh K, Tanida T, Yamada S, et al. Distribution of gastrin-releasing peptide in the rat trigeminal and spinal somatosensory systems. J Comp Neurol. 2014;522:1858-73 pubmed 出版商
Giaroni C, Zanetti E, Pascale A, Oldrini R, Canciani L, Giuliani D, et al. Involvement of Ca2+-dependent PKCs in the adaptive changes of mu-opioid pathways to sympathetic denervation in the guinea pig colon. Biochem Pharmacol. 2009;78:1233-41 pubmed 出版商
Lim G, Wang S, Zeng Q, Sung B, Yang L, Mao J. Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptor. J Neurosci. 2005;25:11145-54 pubmed
Cejas P, Carlson L, Zhang J, Padmanabhan S, Kolonias D, Lindner I, et al. Protein kinase C betaII plays an essential role in dendritic cell differentiation and autoregulates its own expression. J Biol Chem. 2005;280:28412-23 pubmed
Trojanowski J, Mantione J, Lee J, Seid D, You T, Inge L, et al. Neurons derived from a human teratocarcinoma cell line establish molecular and structural polarity following transplantation into the rodent brain. Exp Neurol. 1993;122:283-94 pubmed
Li Y, Woodruff Pak D, Trojanowski J. Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites. Neurobiol Aging. 1994;15:1-9 pubmed
Clark E, Leach K, Trojanowski J, Lee V. Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains. Lab Invest. 1991;64:35-44 pubmed
Trojanowski J, Newman P, Hill W, Lee V. Human olfactory epithelium in normal aging, Alzheimer's disease, and other neurodegenerative disorders. J Comp Neurol. 1991;310:365-76 pubmed
产品信息
产品类型 :
抗体
产品名称 :
PKC丙单克隆抗体(PKC66)
目录# :
13-3800
规格 :
200微克
价格 :
375美元
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunohistochemistry: Assay Dependent, Western Blot: 2-5 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
PKC66
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC gamma is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
免疫原 :
纯化大鼠大脑PKC
格式 :
液体
应用w/稀释 :
Immunohistochemistry: Assay Dependent, Western Blot: 2-5 µg/mL
别名 :
PKC; Pkcc; PKCG; PKCgamma; PKC-gamma; PKCI; Prkc; Prkcc; Prkcg; protein kinase C gamma; protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma; RATPKCI; SCA14
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国