产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
p53单克隆抗体(PAB1801)
目录 :
13-4000
规格 :
200µg
价格 :
美国345
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Pab1801
反应物种 :
African green monkey, 人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 14
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:2000; 图 4c
Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Martinez Zapien D, Ruiz F, Poirson J, Mitschler A, Ramirez J, Forster A, et al. Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature. 2016;529:541-5 pubmed 出版商
  • 免疫印迹; 人类
Cao L, Ding J, Dong L, Zhao J, Su J, Wang L, et al. Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability. PLoS ONE. 2015;10:e0137411 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Patwardhan G, Hosain S, Liu D, Khiste S, Zhao Y, Bielawski J, et al. Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells. Biochim Biophys Acta. 2014;1841:1571-80 pubmed 出版商
  • 免疫印迹; 人类; 1:800
Williams R, Barnhill L, Kuo H, Lin W, Batova A, Yu A, et al. Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth. PLoS ONE. 2014;9:e88219 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100
  • 免疫印迹; 人类; 1:500
Hernández Bule M, Trillo M, Ubeda A. Molecular mechanisms underlying antiproliferative and differentiating responses of hepatocarcinoma cells to subthermal electric stimulation. PLoS ONE. 2014;9:e84636 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 3
Frazzi R, Valli R, Tamagnini I, Casali B, Latruffe N, Merli F. Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation. Int J Cancer. 2013;132:1013-21 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Frazzi R, Casali B, Iori M, Nicoli D, Mammi C, Merli F. Increase in clusterin forms part of the stress response in Hodgkin's lymphoma. Int J Oncol. 2011;38:677-84 pubmed 出版商
  • 免疫印迹; African green monkey; 1:2000; 图 3
  • 免疫印迹; 人类; 1:2000; 图 5
Kanezaki R, Toki T, Xu G, Narayanan R, Ito E. Cloning and characterization of the novel chimeric gene p53/FXR2 in the acute megakaryoblastic leukemia cell line CMK11-5. Tohoku J Exp Med. 2006;209:169-80 pubmed
  • 免疫组化-石蜡切片; 小鼠; 图 1
Elso C, Lu X, Culiat C, Rutledge J, Cacheiro N, Generoso W, et al. Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice. Hum Mol Genet. 2004;13:2813-21 pubmed
  • 免疫组化-石蜡切片; 人类
Barshack I, Goldberg I, Chowers Y, Weiss B, Horowitz A, Kopolovic J. Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue. J Clin Pathol. 2001;54:684-8 pubmed
  • 免疫印迹; 人类
Shenk J, Fisher C, Chen S, Zhou X, Tillman K, Shemshedini L. p53 represses androgen-induced transactivation of prostate-specific antigen by disrupting hAR amino- to carboxyl-terminal interaction. J Biol Chem. 2001;276:38472-9 pubmed
  • 免疫印迹; 人类
Evdokiou A, Atkins G, Bouralexis S, Hay S, Raggatt L, Cowled P, et al. Expression of alternatively-spliced MDM2 transcripts in giant cell tumours of bone. Int J Oncol. 2001;19:625-32 pubmed
Levy D, Rodríguez Buño R, Hu T, Moran A. The potential effects of tobacco control in China: projections from the China SimSmoke simulation model. BMJ. 2014;348:g1134 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
p53单克隆抗体(PAB1801)
目录# :
13-4000
规格 :
200µg
价格 :
美国345
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunohistochemistry (Paraffin): 1:50-1:500, Immunoprecipitation: Assay Dependent, Western Blot: 1:1000
物种 :
人类
克隆 :
PAB1801
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
免疫原 :
重组p53肽
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:50-1:500, Immunoprecipitation: Assay Dependent, Western Blot: 1:1000
别名 :
antigen NY-CO-13, cellular tumor antigen p53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, TP53
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国