产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
ERK1/ERK2单克隆抗体(ERK-7D8)
目录 :
13-6200
规格 :
200微克
价格 :
美国428
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
ERK-7D8
反应物种 :
人类, 小鼠, 大鼠, 犬, 非洲爪蛙
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 44
出版应用/物种/样本/稀释参考文献
  • 免疫沉淀; 人类; 图 5a
  • 免疫印迹; 人类; 图 5a
Zhang C, Mao H, Cao Y. Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner. Sci Rep. 2017;7:3769 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 3a
Yan X, Zhu Z, Xu S, Yang L, Liao X, Zheng M, et al. MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways. Sci Rep. 2017;7:45915 pubmed 出版商
  • 免疫印迹; 人类; 图 5e
Grugan K, Dorn K, Jarantow S, Bushey B, Pardinas J, Laquerre S, et al. Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cells. MAbs. 2017;9:114-126 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 2a
Aguilera O, Muñoz Sagastibelza M, Torrejón B, Borrero Palacios A, del Puerto Nevado L, Martínez Useros J, et al. Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer. Oncotarget. 2016;7:47954-47965 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Salas E, Roy S, Marsh T, Rubin B, Debnath J. Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Oncogene. 2016;35:2913-22 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 5b
Murrow L, Malhotra R, Debnath J. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol. 2015;17:300-10 pubmed 出版商
  • 免疫印迹; 人类
Bernusso V, Machado Neto J, Pericole F, Vieira K, Duarte A, Traina F, et al. Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells. Biochim Biophys Acta. 2015;1853:388-95 pubmed 出版商
  • 免疫印迹; 小鼠
Janardhan S, Marks R, Gajewski T. Primary murine CD4+ T cells fail to acquire the ability to produce effector cytokines when active Ras is present during Th1/Th2 differentiation. PLoS ONE. 2014;9:e112831 pubmed 出版商
  • 免疫印迹; 人类
Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2500; 表 1
Iio W, Matsukawa N, Tsukahara T, Toyoda A. The effects of oral taurine administration on behavior and hippocampal signal transduction in rats. Amino Acids. 2012;43:2037-46 pubmed 出版商
  • 免疫印迹; 人类
Machado Neto J, Favaro P, Lazarini M, Costa F, Olalla Saad S, Traina F. Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells. Biochim Biophys Acta. 2011;1813:1404-11 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Urbanet R, Pilon C, Giorgino F, Vettor R, Fallo F. Insulin signaling in adipose tissue of patients with primary aldosteronism. J Endocrinol Invest. 2011;34:86-9 pubmed
  • 免疫印迹; 小鼠; 图 2a
Zha Y, Marks R, Ho A, Peterson A, Janardhan S, Brown I, et al. T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha. Nat Immunol. 2006;7:1166-73 pubmed
  • 免疫印迹; 大鼠; 图 6
Zhu M, Feng J, Lucchinetti E, Fischer G, Xu L, Pedrazzini T, et al. Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc Res. 2006;72:152-62 pubmed
  • 免疫印迹; 大鼠; 图 7
Lo I, Shih J, Jiang M. Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration. J Biomed Sci. 2005;12:377-88 pubmed
  • 免疫印迹; 大鼠; 1:5000; 图 2
Tsai M, Jiang M. Extracellular signal-regulated kinase1/2 in contraction of vascular smooth muscle. Life Sci. 2005;76:877-88 pubmed
  • 免疫印迹; 大鼠; 图 5
Usui S, Sugimoto N, Takuwa N, Sakagami S, Takata S, Kaneko S, et al. Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. J Biol Chem. 2004;279:12300-11 pubmed
  • 免疫印迹; 人类; 图 2
Hernandez M, Barrero M, Crespo M, Nieto M. Lysophosphatidic acid inhibits Ca2+ signaling in response to epidermal growth factor receptor stimulation in human astrocytoma cells by a mechanism involving phospholipase C(gamma) and a G(alphai) protein. J Neurochem. 2000;75:1575-82 pubmed
  • 免疫印迹; 大鼠
Chan E, Stang S, Bottorff D, Stone J. Hypothermic stress leads to activation of Ras-Erk signaling. J Clin Invest. 1999;103:1337-44 pubmed
  • 免疫印迹; 小鼠; 图 1, 2
Korneyev A. Stress-induced tau phosphorylation in mouse strains with different brain Erk 1 + 2 immunoreactivity. Neurochem Res. 1998;23:1539-43 pubmed
  • 免疫沉淀; 小鼠
  • 免疫印迹; 小鼠
Webb C, Van Aelst L, Wigler M, Vande Woude G. Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc Natl Acad Sci U S A. 1998;95:8773-8 pubmed
  • 免疫印迹; 非洲爪蛙; 1:1000; 图 1
Duesbery N, Webb C, Leppla S, Gordon V, Klimpel K, Copeland T, et al. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science. 1998;280:734-7 pubmed
  • 免疫印迹; 人类; 图 3
Hidari K, Weyrich A, Zimmerman G, McEver R. Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. J Biol Chem. 1997;272:28750-6 pubmed
Dou C, Zhen G, Dan Y, Wan M, Limjunyawong N, Cao X. Sialylation of TLR2 initiates osteoclast fusion. Bone Res. 2022;10:24 pubmed 出版商
Baschieri F, Le Devedec D, Tettarasar S, Elkhatib N, Montagnac G. Frustration of endocytosis potentiates compression-induced receptor signaling. J Cell Sci. 2020;133: pubmed 出版商
Kim S, Hong K, Kim S, Suh H, Jo K. Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways. Sci Rep. 2020;10:11370 pubmed 出版商
Dong G, Huang X, Jiang S, Ni L, Chen S. Simvastatin Mitigates Apoptosis and Transforming Growth Factor-Beta Upregulation in Stretch-Induced Endothelial Cells. Oxid Med Cell Longev. 2019;2019:6026051 pubmed 出版商
Xuan Z, Wang Y, Xie J. ANO6 promotes cell proliferation and invasion in glioma through regulating the ERK signaling pathway. Onco Targets Ther. 2019;12:6721-6731 pubmed 出版商
Dong G, Lin X, Liu H, Gao D, Cui J, Ren Z, et al. Intermittent hypoxia alleviates increased VEGF and pro-angiogenic potential in liver cancer cells. Oncol Lett. 2019;18:1831-1839 pubmed 出版商
Baschieri F, Dayot S, Elkhatib N, Ly N, Capmany A, Schauer K, et al. Frustrated endocytosis controls contractility-independent mechanotransduction at clathrin-coated structures. Nat Commun. 2018;9:3825 pubmed 出版商
Areiza Mazo N, Robles J, Zamudio Rodriguez J, Giraldez L, Echeverria V, Barrera Bailón B, et al. Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone. Front Chem. 2018;6:276 pubmed 出版商
Araújo A, Araújo L, Medeiros C, Leitao R, Brito G, Costa D, et al. Protective effect of angiotensin II receptor blocker against oxidative stress and inflammation in an oral mucositis experimental model. J Oral Pathol Med. 2018;47:972-984 pubmed 出版商
Blas Rus N, Bustos Morán E, Perez de Castro I, de Carcer G, Borroto A, Camafeita E, et al. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun. 2016;7:11389 pubmed 出版商
Mòdol L, Mancuso R, Alé A, Francos Quijorna I, Navarro X. Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons. Front Cell Neurosci. 2014;8:7 pubmed 出版商
Montenegro L, Leal A, Coutinho D, Valassi H, Nishi M, Arnhold I, et al. Post-receptor IGF1 insensitivity restricted to the MAPK pathway in a Silver-Russell syndrome patient with hypomethylation at the imprinting control region on chromosome 11. Eur J Endocrinol. 2012;166:543-50 pubmed 出版商
Janardhan S, Praveen K, Marks R, Gajewski T. Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells. PLoS ONE. 2011;6:e24931 pubmed 出版商
Driessens G, Zheng Y, Locke F, Cannon J, Gounari F, Gajewski T. Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-?1 phosphorylation. J Immunol. 2011;186:784-90 pubmed 出版商
Yin G, Zheng Q, Yan C, Berk B. GIT1 is a scaffold for ERK1/2 activation in focal adhesions. J Biol Chem. 2005;280:27705-12 pubmed
Michlig S, Mercier A, Doucet A, Schild L, Horisberger J, Rossier B, et al. ERK1/2 controls Na,K-ATPase activity and transepithelial sodium transport in the principal cell of the cortical collecting duct of the mouse kidney. J Biol Chem. 2004;279:51002-12 pubmed
Natalicchio A, Laviola L, De Tullio C, Renna L, Montrone C, Perrini S, et al. Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts. J Biol Chem. 2004;279:43900-9 pubmed
Martinez Quiles N, Ho H, Kirschner M, Ramesh N, Geha R. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol. 2004;24:5269-80 pubmed
Derkinderen P, Valjent E, Toutant M, Corvol J, Enslen H, Ledent C, et al. Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. J Neurosci. 2003;23:2371-82 pubmed
Carraway C, Carvajal M, Carraway K. Association of the Ras to mitogen-activated protein kinase signal transduction pathway with microfilaments. Evidence for a p185(neu)-containing cell surface signal transduction particle linking the mitogenic pathway to a membrane-microfilament associ. J Biol Chem. 1999;274:25659-67 pubmed
Bird T, Sleath P, DeRoos P, Dower S, Virca G. Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases. J Biol Chem. 1991;266:22661-70 pubmed
产品信息
产品类型 :
抗体
产品名称 :
ERK1/ERK2单克隆抗体(ERK-7D8)
目录# :
13-6200
规格 :
200微克
价格 :
美国428
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
狗, 人类, 小鼠, 大鼠
应用 :
ELISA: 0.1-1 mg/mL, Gel Shift: Assay-dependent, Immunocytochemistry: 1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: 2-5 µg, Western Blot: 1 µg/mL
物种 :
狗, 人类, 小鼠, 大鼠
克隆 :
ERK-7D8
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.
免疫原 :
Synthetic peptide (aa 324-345) corresponding to a segment near the C-terminus of rat ERK1
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1 mg/mL, Gel Shift: Assay-dependent, Immunocytochemistry: 1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: 2-5 µg, Western Blot: 1 µg/mL
别名 :
12559; 9030612K14Rik; AA407128; AU018647; BcDNA:RE08694; C78273; CG12559; CG12559-PA; CG12559-PC; CG12559-PD; CG12559-PE; CG12559-PG; CG12559-PH; CG12559-PI; CG18732; CT34260; CT39192; DERK; D-ERK; DERK-A; Diphospho-ERK; dm-dpERK; Dmel CG12559; Dmel_CG12559; DmErk; DmERKA; DmERK-A; DmMAPK; dpERK; dp-ERK; dpERK1; dpMAPK; drosophila ERK; Dsor2; E(sina)7; EC2-1; EK2-1; enhancer of seven in absentia 7; ERK; Erk MAP kinase; Erk/Map kinase; ERK/rolled; Erk1; Erk-1; erk1 erk2; Erk1/2; ERK1b; ERK2; ERK-2; ERKA; ERK-A; ERT1; ERT2; Esrk1; extracellular signal-regulated kinase; extracellular signal-regulated kinase (ERK2); extracellular signal-regulated kinase 1; Extracellular signal-regulated kinase 2; extracellular signal-regulated kinase A; extracellular signal-regulated kinase-1; extracellular signal-regulated kinase-2; extracellular signal-related kinase 1; Extracellular-regulated kinase A; extracellular-signal-regulated kinase 2; Extracellular-signal-related kinase A; EY2-2; fi06b09; GroupII; HS44KDAP; HUMKER1A; I79_009500; I79_018350; insulin-stimulated MAP2 kinase; l(2)41Ac; l(2R)EMS45-39; M phase MAP kinase; MAP kinase; MAP kinase 1; MAP kinase 2; MAP kinase 3; MAP kinase isoform p42; MAP kinase isoform p44; MapK; MAP-k; MAPK 1; MAPK 2; MAPK 3; MAPK1; mapk1.S; mapk1a; mapk1-a; mapk1-b; mapk2; mapk3; MAP-kinase; MBP kinase; Microtubule-associated protein 2 kinase; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen-activated 3; mitogen-activated protein kinase; mitogen-activated protein kinase 1; mitogen-activated protein kinase 1 S homeolog; mitogen-activated protein kinase 1a; mitogen-activated protein kinase 2; Mitogen-activated protein kinase 3; Mitogen-activated protein kinase ERK-A; MNK1; mpk1; Mtap2k; Myelin basic protein kinase; Myelin xP42 protein kinase; p38; p40; p41; p41mapk; p42; p42 MAP Kinase; P42MAPK; p42-MAPK; p44; p44 MAP kinase; p44erk1; p44-ERK1; p44mapk; p44-MAPK; pERK; p-ERK; phospho-ERK; pMapK; pp42/MAP kinase; Prkm1; PRKM2; Prkm3; protein kinase; Protein rolled; protein tyrosine kinase ERK2; RE08694p; RL; rl/ERK; rl/MAPK; rll; rl-PA; rl-PC; rl-PD; rl-PE; rl-PG; rl-PH; rl-PI; roll; rolled; sem; sevenmaker; SR2-1; Su(Raf)2B; wu:fi06b09; XELAEV_18010534mg; xp42; zERK1; zERK2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国