产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (T46)
目录 :
13-6400
规格 :
100微克
价格 :
美国482
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
T46
反应物种 :
人类, 小鼠, 大鼠, 鸡, 牛, fruit fly , domestic rabbit
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 35
出版应用/物种/样本/稀释 | 参考文献 |
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| López de Maturana R, Lang V, Zubiarrain A, Sousa A, Vázquez N, Gorostidi A, et al. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons. J Neuroinflammation. 2016;13:295 pubmed
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| Melis V, Zabke C, Stamer K, Magbagbeolu M, Schwab K, Marschall P, et al. Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration. Cell Mol Life Sci. 2015;72:2199-222 pubmed 出版商
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Audrain M, Haure Mirande J, Wang M, Kim S, Fanutza T, Chakrabarty P, et al. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Mol Psychiatry. 2018;: pubmed 出版商
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Guo J, Arai T, Miklossy J, McGeer P. Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. Proc Natl Acad Sci U S A. 2006;103:1953-8 pubmed
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Mendes S, Henkemeyer M, Liebl D. Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain. J Neurosci. 2006;26:882-92 pubmed
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Yu W, Ko M, Yanagisawa K, Michikawa M. Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy. J Biol Chem. 2005;280:27296-302 pubmed
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Arai T, Guo J, McGeer P. Proteolysis of non-phosphorylated and phosphorylated tau by thrombin. J Biol Chem. 2005;280:5145-53 pubmed
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Zamora Leon S, Bresnick A, Backer J, Shafit Zagardo B. Fyn phosphorylates human MAP-2c on tyrosine 67. J Biol Chem. 2005;280:1962-70 pubmed
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Rissman R, Poon W, Blurton Jones M, Oddo S, Torp R, Vitek M, et al. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004;114:121-30 pubmed
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Clark L, Poorkaj P, Wszolek Z, Geschwind D, Nasreddine Z, Miller B, et al. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17. Proc Natl Acad Sci U S A. 1998;95:13103-7 pubmed
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Reed L, Schmidt M, Wszolek Z, Balin B, Soontornniyomkij V, Lee V, et al. The neuropathology of a chromosome 17-linked autosomal dominant parkinsonism and dementia ("pallido-ponto-nigral degeneration"). J Neuropathol Exp Neurol. 1998;57:588-601 pubmed
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Lieberman A, Trojanowski J, Lee V, Balin B, Ding X, Greenberg J, et al. Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease. Ann Neurol. 1998;43:259-65 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (T46)
目录# :
13-6400
规格 :
100微克
价格 :
美国482
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
牛, 鸡, 人类, 小鼠, 兔, 大鼠, 非洲爪蛙
应用 :
ELISA: 0.1-0.5 µg/mL, Immunocytochemistry: 1:250, Immunohistochemistry (Frozen): Assay-dependent, Immunomicroscopy: Assay-dependent, Immunoprecipitation: 2-5 µg, Western Blot: 0.5-1.0 µg/mL
物种 :
牛, 鸡, 人类, 小鼠, 兔, 大鼠, 非洲爪蛙
克隆 :
T46
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Bovine Tau.
格式 :
液体
应用w/稀释 :
ELISA: 0.1-0.5 µg/mL, Immunocytochemistry: 1:250, Immunohistochemistry (Frozen): Assay-dependent, Immunomicroscopy: Assay-dependent, Immunoprecipitation: 2-5 µg, Western Blot: 0.5-1.0 µg/mL
别名 :
AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)
更多信息或购买 :
公司信息
赛默飞世尔