产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (T46)
目录 :
13-6400
规格 :
100µg
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
T46
反应物种 :
人类, 小鼠, 大鼠, , ,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 20
出版应用/物种/样品/稀释参考文献
  • 免疫沉淀; 人类
  • 免疫印迹; 人类; 1:1000; 图 1b
Trzeciakiewicz H, Tseng J, Wander C, Madden V, Tripathy A, Yuan C, et al. A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy. Sci Rep. 2017;7:44102 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:100; 图 4b
Atasoy İ, Dursun E, Gezen Ak D, Metin Armağan D, Ozturk M, Yilmazer S. Both secreted and the cellular levels of BDNF attenuated due to tau hyperphosphorylation in primary cultures of cortical neurons. J Chem Neuroanat. 2017;80:19-26 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 1b
Hwang A, Trzeciakiewicz H, Friedmann D, Yuan C, Marmorstein R, Lee V, et al. Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members. PLoS ONE. 2016;11:e0168913 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 2c
  • 免疫印迹; 人类; 1:1000; 图 2e
López de Maturana R, Lang V, Zubiarrain A, Sousa A, Vázquez N, Gorostidi A, et al. Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons. J Neuroinflammation. 2016;13:295 pubmed
  • 免疫印迹; 小鼠; 1:1000; 图 7
Peng Y, Kim M, Hullinger R, O Riordan K, Burger C, Pehar M, et al. Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse. Brain. 2016;139:937-52 pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 6
  • 免疫印迹; 人类; 图 2
Taniguchi Watanabe S, Arai T, Kametani F, Nonaka T, Masuda Suzukake M, Tarutani A, et al. Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta Neuropathol. 2016;131:267-280 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, et al. Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia. Brain Pathol. 2016;26:82-94 pubmed 出版商
  • 免疫印迹; 人类
Corbel C, Zhang B, Le Parc A, Baratte B, Colas P, Couturier C, et al. Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation. Chem Biol. 2015;22:472-482 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Melis V, Zabke C, Stamer K, Magbagbeolu M, Schwab K, Marschall P, et al. Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration. Cell Mol Life Sci. 2015;72:2199-222 pubmed 出版商
Zhou Y, Shi J, Chu D, Hu W, Guan Z, Gong C, et al. Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease. Front Aging Neurosci. 2018;10:27 pubmed 出版商
Wang B, Tanaka K, Ji B, Ono M, Fang Y, Ninomiya Y, et al. Total body 100-mGy X-irradiation does not induce Alzheimer's disease-like pathogenesis or memory impairment in mice. J Radiat Res. 2014;55:84-96 pubmed 出版商
Guo J, Arai T, Miklossy J, McGeer P. Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. Proc Natl Acad Sci U S A. 2006;103:1953-8 pubmed
Mendes S, Henkemeyer M, Liebl D. Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain. J Neurosci. 2006;26:882-92 pubmed
Yu W, Ko M, Yanagisawa K, Michikawa M. Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy. J Biol Chem. 2005;280:27296-302 pubmed
Arai T, Guo J, McGeer P. Proteolysis of non-phosphorylated and phosphorylated tau by thrombin. J Biol Chem. 2005;280:5145-53 pubmed
Zamora Leon S, Bresnick A, Backer J, Shafit Zagardo B. Fyn phosphorylates human MAP-2c on tyrosine 67. J Biol Chem. 2005;280:1962-70 pubmed
Rissman R, Poon W, Blurton Jones M, Oddo S, Torp R, Vitek M, et al. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004;114:121-30 pubmed
Clark L, Poorkaj P, Wszolek Z, Geschwind D, Nasreddine Z, Miller B, et al. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17. Proc Natl Acad Sci U S A. 1998;95:13103-7 pubmed
Reed L, Schmidt M, Wszolek Z, Balin B, Soontornniyomkij V, Lee V, et al. The neuropathology of a chromosome 17-linked autosomal dominant parkinsonism and dementia ("pallido-ponto-nigral degeneration"). J Neuropathol Exp Neurol. 1998;57:588-601 pubmed
Lieberman A, Trojanowski J, Lee V, Balin B, Ding X, Greenberg J, et al. Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease. Ann Neurol. 1998;43:259-65 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (T46)
目录# :
13-6400
规格 :
100µg
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
牛, 鸡, 人类, 小鼠, 兔, 大鼠, 非洲爪蛙
应用 :
ELISA: 0.1-0.5 µg/mL, Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Immunohistochemistry: 5-25 µg/mL, Immunomicroscopy: Assay Dependent, Immunoprecipitation: 2-5 µg, Western Blot: 0.5-1.0 µg/mL
物种 :
牛, 鸡, 人类, 小鼠, 兔, 大鼠, 非洲爪蛙
克隆 :
T46
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Bovine Tau.
格式 :
Liquid
应用w/稀释 :
ELISA: 0.1-0.5 µg/mL, Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Immunohistochemistry: 5-25 µg/mL, Immunomicroscopy: Assay Dependent, Immunoprecipitation: 2-5 µg, Western Blot: 0.5-1.0 µg/mL
别名 :
MAPT, Microtubule-associated protein tau, MTBT1, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国