产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-6 Monoclonal Antibody (MP5-32C11), Biotin, eBioscience
目录 :
13-7062-81
规格 :
50微克
价格 :
美国121
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
生物素
克隆名称 :
MP5-32C11
反应物种 :
小鼠
应用 :
酶联免疫吸附测定
更多信息或购买 :
文章摘录数: 45
出版应用/物种/样本/稀释参考文献
  • 酶联免疫吸附测定; 小鼠; 图 5c
Shutinoski B, Alturki N, Rijal D, Bertin J, Gough P, Schlossmacher M, et al. K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo. Cell Death Differ. 2016;23:1628-37 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠; 图 5a
Raynor J, Karns R, Almanan M, Li K, Divanovic S, Chougnet C, et al. IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. J Immunol. 2015;195:944-52 pubmed 出版商
Lee G, Liao T, Wu J, Wu K, Kuo C. Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE-/- mice fed high fat diet. J Biomed Sci. 2021;28:74 pubmed 出版商
Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother T, Tourtellotte W, et al. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021;54:1463-1477.e11 pubmed 出版商
Alford M, Choi K, Trimble M, Masoudi H, Kalsi P, Pletzer D, et al. Murine Model of Sinusitis Infection for Screening Antimicrobial and Immunomodulatory Therapies. Front Cell Infect Microbiol. 2021;11:621081 pubmed 出版商
Yeh C, Wu J, Lee G, Wen H, Lin P, Kuo C. Vanadium Derivative Exposure Promotes Functional Alterations of VSMCs and Consequent Atherosclerosis via ROS/p38/NF-κB-Mediated IL-6 Production. Int J Mol Sci. 2019;20: pubmed 出版商
Dai D, Yuan J, Wang Y, Xu J, Mao C, Xiao Y. Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation. Sci Rep. 2019;9:8034 pubmed 出版商
Sanchez Lopez E, Zhong Z, Stubelius A, Sweeney S, Booshehri L, Antonucci L, et al. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metab. 2019;29:1350-1362.e7 pubmed 出版商
Martínez López M, Iborra S, Conde Garrosa R, Mastrangelo A, Danne C, Mann E, et al. Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity. Immunity. 2019;50:446-461.e9 pubmed 出版商
Muccioli M, Nandigam H, Loftus T, Singh M, Venkatesh A, Wright J, et al. Modulation of double-stranded RNA pattern recognition receptor signaling in ovarian cancer cells promotes inflammatory queues. Oncotarget. 2018;9:36666-36683 pubmed 出版商
Moreno Fernandez M, Giles D, Stankiewicz T, Sheridan R, Karns R, Cappelletti M, et al. Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. JCI Insight. 2018;3: pubmed 出版商
Ono K, Nimura S, Hideshima Y, Nabeshima K, Nakashima M. Orally administered sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice. Exp Ther Med. 2017;14:5485-5490 pubmed 出版商
Penkert R, Jones B, Hacker H, Partridge J, Hurwitz J. Vitamin A differentially regulates cytokine expression in respiratory epithelial and macrophage cell lines. Cytokine. 2017;91:1-5 pubmed 出版商
Ulland T, Jain N, Hornick E, Elliott E, Clay G, Sadler J, et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016;7:13180 pubmed 出版商
Stemmer K, Kotzbeck P, Zani F, Bauer M, Neff C, Müller T, et al. Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL/6 nude mice. Int J Obes (Lond). 2015;39:791-7 pubmed 出版商
ONTIVEROS E, Halwani A, Stunz L, Kamberos N, Olivier A, Janz S, et al. A new model of LMP1-MYC interaction in B cell lymphoma. Leuk Lymphoma. 2014;55:2917-23 pubmed 出版商
Zhang X, Wu C, Song J, Götte M, Sorokin L. Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis. J Immunol. 2013;191:4551-61 pubmed 出版商
Maldonado M, Kapphahn R, Terluk M, Heuss N, Yuan C, Gregerson D, et al. Immunoproteasome deficiency modifies the alternative pathway of NF?B signaling. PLoS ONE. 2013;8:e56187 pubmed 出版商
Namjoshi D, Martin G, Donkin J, Wilkinson A, Stukas S, Fan J, et al. The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. PLoS ONE. 2013;8:e53529 pubmed 出版商
Park S, Kang S, Min K, Woo Hwang K, Min H. Age-associated changes in microRNA expression in bone marrow derived dendritic cells. Immunol Invest. 2013;42:179-90 pubmed 出版商
Poovassery J, Bishop G. Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms. J Immunol. 2012;189:1757-64 pubmed 出版商
Glowacka W, Alberts P, Ouchida R, Wang J, Rotin D. LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages. J Biol Chem. 2012;287:27691-702 pubmed 出版商
Osterbur J, Sprague L, Muccioli M, Pate M, Mansfield K, McGinty J, et al. Adhesion to substrates induces dendritic cell endothelization and decreases immunological response. Immunobiology. 2013;218:64-75 pubmed 出版商
Freigang S, Ampenberger F, Spohn G, Heer S, Shamshiev A, Kisielow J, et al. Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. Eur J Immunol. 2011;41:2040-51 pubmed 出版商
Ashman R, Goeken J, Latz E, Lenert P. Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding. Int Immunol. 2011;23:203-14 pubmed 出版商
Helmersson S, Stenstrom M, Leanderson T, Ivars F. Specific effect of immunomodulatory quinoline-3-carboxamide ABR-215757 in GM-CSF stimulated bone marrow cell cultures: block of initiation of proliferation of Gr-1+ cells. Int Immunopharmacol. 2011;11:1045-51 pubmed 出版商
Ashman R, Goeken J, Lenert P. Aggregation and secondary loop structure of oligonucleotides do not determine their ability to inhibit TLR9. Int Immunopharmacol. 2011;11:1032-7 pubmed 出版商
Layer T, Steele A, Goeken J, Fleenor S, Lenert P. Engagement of the B cell receptor for antigen differentially affects B cell responses to Toll-like receptor-7 agonists and antagonists in BXSB mice. Clin Exp Immunol. 2011;163:392-403 pubmed 出版商
Hwang W, Jung K, Jeon Y, Yun S, Kim T, Choi I. Knockdown of the interleukin-6 receptor alpha chain of dendritic cell vaccines enhances the therapeutic potential against IL-6 producing tumors. Vaccine. 2010;29:34-44 pubmed 出版商
Nakatsukasa H, Tsukimoto M, Tokunaga A, Kojima S. Repeated gamma irradiation attenuates collagen-induced arthritis via up-regulation of regulatory T cells but not by damaging lymphocytes directly. Radiat Res. 2010;174:313-24 pubmed 出版商
Goeken J, Layer T, Fleenor S, Laccheo M, Lenert P. B-cell receptor for antigen modulates B-cell responses to complex TLR9 agonists and antagonists: implications for systemic lupus erythematosus. Lupus. 2010;19:1290-301 pubmed 出版商
Zha W, Liang G, Xiao J, Studer E, Hylemon P, Pandak W, et al. Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages. PLoS ONE. 2010;5:e9069 pubmed 出版商
Sakai M, Yamashita K, Takemoto N, Ohshima Y, Tsukimoto M, Shinkai Y, et al. Diesel exhaust (DE) aggravates pathology of delayed-type hypersensitivity (DTH) induced by methyl-bovine serum albumin (mBSA) in mice. J Toxicol Sci. 2009;34:483-92 pubmed
Yamashita K, Sakai M, Takemoto N, Tsukimoto M, Uchida K, Yajima H, et al. Attenuation of delayed-type hypersensitivity by fullerene treatment. Toxicology. 2009;261:19-24 pubmed 出版商
Tsukimoto M, Nakatsukasa H, Sugawara K, Yamashita K, Kojima S. Repeated 0.5-Gy gamma irradiation attenuates experimental autoimmune encephalomyelitis with up-regulation of regulatory T cells and suppression of IL17 production. Radiat Res. 2008;170:429-36 pubmed
Sonderegger I, Iezzi G, Maier R, Schmitz N, Kurrer M, Kopf M. GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival. J Exp Med. 2008;205:2281-94 pubmed 出版商
Vanden Bush T, Bishop G. TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation. Eur J Immunol. 2008;38:400-9 pubmed 出版商
Tago F, Tsukimoto M, Nakatsukasa H, Kojima S. Repeated 0.5-Gy gamma irradiation attenuates autoimmune disease in MRL-lpr/lpr mice with suppression of CD3+CD4-CD8-B220+ T-cell proliferation and with up-regulation of CD4+CD25+Foxp3+ regulatory T cells. Radiat Res. 2008;169:59-66 pubmed
Minges Wols H, Ippolito J, Yu Z, Palmer J, White F, Le P, et al. The effects of microenvironment and internal programming on plasma cell survival. Int Immunol. 2007;19:837-46 pubmed
Mutou Y, Ibuki Y, Kojima S. Immunomodulatory effects of ultraviolet B irradiation on atopic dermatitis in NC/Nga mice. Photodermatol Photoimmunol Photomed. 2007;23:135-44 pubmed
Gouze M, Laffitte J, Pinton P, Dedieux G, Galinier A, Thouvenot J, et al. Effect of subacute oral doses of nivalenol on immune and metabolic defence systems in mice. Vet Res. 2007;38:635-46 pubmed
Grigorian A, Lee S, Tian W, Chen I, Gao G, Mendelsohn R, et al. Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis. J Biol Chem. 2007;282:20027-35 pubmed
Le Barillec K, Magalhaes J, Corcuff E, Thuizat A, Sansonetti P, Phalipon A, et al. Roles for T and NK cells in the innate immune response to Shigella flexneri. J Immunol. 2005;175:1735-40 pubmed
Finkelman F, Morris S. Development of an assay to measure in vivo cytokine production in the mouse. Int Immunol. 1999;11:1811-8 pubmed
Sander B, Höidén I, Andersson U, Moller E, Abrams J. Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. Cytokine detection by immunoassay and intracellular immunostaining. J Immunol Methods. 1993;166:201-14 pubmed
产品信息
产品类型 :
抗体
产品名称 :
IL-6 Monoclonal Antibody (MP5-32C11), Biotin, eBioscience
目录# :
13-7062-81
规格 :
50微克
价格 :
美国121
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
ELISA:0.5-2微克/毫升
物种 :
小鼠
克隆 :
MP5-32C11
抗体亚型 :
IgG2a, kappa
储存 :
4° C, 不冻结
描述 :
Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.
格式 :
液体
应用w/稀释 :
ELISA:0.5-2微克/毫升
别名 :
B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国