产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
连接蛋白26单克隆抗体(CX-12H10)
目录 :
13-8100
规格 :
100微克
价格 :
美国399.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CX-12H10
反应物种 :
African green monkey, common marmoset, 人类, 小鼠, 大鼠, 犬
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化基因敲除验证
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 68
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:500; 图 5c
Ohgaki R, Ohmori T, Hara S, Nakagomi S, Kanai Azuma M, Kaneda Nakashima K, et al. Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc. Mol Cell Biol. 2017;37: pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 1a
  • 免疫印迹; 人类; 1:500; 图 6a
Coyle D, Doyle B, Murphy J, O Donnell A, Gillick J, Puri P. Expression of connexin 26 and connexin 43 is reduced in Hirschsprung's disease. J Surg Res. 2016;206:242-251 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 1
de Wolf E, van de Wiel J, Cook J, Dale N. Altered CO2 sensitivity of connexin26 mutant hemichannels in vitro. Physiol Rep. 2016;4: pubmed
  • 免疫组化; 小鼠; 图 6d
Forsberg D, Horn Z, Tserga E, Smedler E, Silberberg G, Shvarev Y, et al. CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture. elife. 2016;5: pubmed 出版商
  • 免疫组化; African green monkey; 1:300; 图 3a
Suzuki N, Hosoya M, Oishi N, Okano H, Fujioka M, Ogawa K. Expression pattern of wolframin, the WFS1 (Wolfram syndrome-1 gene) product, in common marmoset (Callithrix jacchus) cochlea. Neuroreport. 2016;27:833-6 pubmed 出版商
  • 免疫组化-冰冻切片; common marmoset; 1:300; 图 4
Hosoya M, Fujioka M, Kobayashi R, Okano H, Ogawa K. Overlapping expression of anion exchangers in the cochlea of a non-human primate suggests functional compensation. Neurosci Res. 2016;110:1-10 pubmed 出版商
  • 免疫组化; African green monkey; 1:300; 图 1d
Hosoya M, Fujioka M, Ogawa K, Okano H. Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea. Sci Rep. 2016;6:22250 pubmed 出版商
  • 免疫组化; 小鼠; 1:100; 图 3
Palombo R, Porta G, Bruno E, Provero P, Serra V, Neduri K, et al. OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development. Aging (Albany NY). 2015;7:928-36 pubmed
  • 免疫组化基因敲除验证; 小鼠; 1:100; 图 5
Stewart M, Bechberger J, Welch I, Naus C, Laird D. Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer. Oncotarget. 2015;6:37185-99 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Jiang H, Zhao L, Dong X, He A, Zheng C, Johansson M, et al. Tanshinone IIA enhances bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in nuclei and mitochondria. Oncol Rep. 2015;34:1487-93 pubmed 出版商
  • 免疫组化; 大鼠; 1:100; 图 2
Wu X, Wang Y, Sun Y, Chen S, Zhang S, Shen L, et al. Reduced expression of Connexin26 and its DNA promoter hypermethylation in the inner ear of mimetic aging rats induced by d-galactose. Biochem Biophys Res Commun. 2014;452:340-6 pubmed 出版商
  • 免疫组化; 小鼠; 1:500
  • 免疫印迹; 小鼠; 1:500
Bosen F, Schütz M, Beinhauer A, Strenzke N, Franz T, Willecke K. The Clouston syndrome mutation connexin30 A88V leads to hyperproliferation of sebaceous glands and hearing impairments in mice. FEBS Lett. 2014;588:1795-801 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:100
Holzer L, Cor A, Holzer G. Expression of gap junction proteins connexins 26, 30, and 43 in Dupuytren's disease. Acta Orthop. 2014;85:97-101 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:250
  • 免疫印迹; 人类; 1:500
Yu J, Boicea A, Barrett K, James C, Bagchi I, Bagchi M, et al. Reduced connexin 43 in eutopic endometrium and cultured endometrial stromal cells from subjects with endometriosis. Mol Hum Reprod. 2014;20:260-70 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Xiao J, Zhang G, Qiu P, Liu X, Wu Y, Du B, et al. Tanshinone IIA increases the bystander effect of herpes simplex virus thymidine kinase/ganciclovir gene therapy via enhanced gap junctional intercellular communication. PLoS ONE. 2013;8:e67662 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
  • 免疫印迹; 人类; 图 2
  • 免疫组化-石蜡切片; 小鼠; 图 1
Terrinoni A, Serra V, Bruno E, Strasser A, Valente E, Flores E, et al. Role of p63 and the Notch pathway in cochlea development and sensorineural deafness. Proc Natl Acad Sci U S A. 2013;110:7300-5 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s1
Johnson K, Mitra S, Katoch P, Kelsey L, Johnson K, Mehta P. Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells. Mol Biol Cell. 2013;24:715-33 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 3
  • 免疫印迹; 小鼠; 1:500
Degen J, Schütz M, Dicke N, Strenzke N, Jokwitz M, Moser T, et al. Connexin32 can restore hearing in connexin26 deficient mice. Eur J Cell Biol. 2011;90:817-24 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 5
Schütz M, Auth T, Gehrt A, Bosen F, Körber I, Strenzke N, et al. The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome. Hum Mol Genet. 2011;20:28-39 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 4
Schütz M, Scimemi P, Majumder P, De Siati R, Crispino G, Rodriguez L, et al. The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice. Hum Mol Genet. 2010;19:4759-73 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Ambrosi C, Gassmann O, Pranskevich J, Boassa D, Smock A, Wang J, et al. Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other. J Biol Chem. 2010;285:24420-31 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1
  • 免疫印迹; 人类; 1:500; 图 4
Liu X, Furuya T, Li D, Xu J, Cao X, Li Q, et al. Connexin 26 expression correlates with less aggressive phenotype of intestinal type-gastric carcinomas. Int J Mol Med. 2010;25:709-16 pubmed
  • 免疫细胞化学; 人类; 图 s1
del Castillo F, Cohen Salmon M, Charollais A, Caille D, Lampe P, Chavrier P, et al. Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. Hum Mol Genet. 2010;19:262-75 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Serre Beinier V, Bosco D, Zulianello L, Charollais A, Caille D, Charpantier E, et al. Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression. Hum Mol Genet. 2009;18:428-39 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Schalper K, Palacios Prado N, Retamal M, Shoji K, Martinez A, Saez J. Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses. Mol Biol Cell. 2008;19:3501-13 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
  • 免疫印迹; 人类; 图 3a
Leinonen P, Aaltonen V, Koskela S, Lehenkari P, Korkiamäki T, Peltonen J. Impaired gap junction formation and intercellular calcium signaling in urinary bladder cancer cells can be improved by Gö6976. Cell Commun Adhes. 2007;14:125-36 pubmed
  • 免疫细胞化学; 犬
Larre I, Ponce A, Fiorentino R, Shoshani L, Contreras R, Cereijido M. Contacts and cooperation between cells depend on the hormone ouabain. Proc Natl Acad Sci U S A. 2006;103:10911-6 pubmed
  • 免疫细胞化学; 人类; 1:250
  • 免疫印迹; 人类; 1:500
Gemel J, Lin X, Veenstra R, Beyer E. N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26. J Cell Sci. 2006;119:2258-68 pubmed
  • 免疫细胞化学; 大鼠; 1:100
Gorbe A, Becker D, Dux L, Krenacs L, Krenacs T. In differentiating prefusion myoblasts connexin43 gap junction coupling is upregulated before myoblast alignment then reduced in post-mitotic cells. Histochem Cell Biol. 2006;125:705-16 pubmed
  • 免疫组化-石蜡切片; 人类
Haass N, Wladykowski E, Kief S, Moll I, Brandner J. Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis. J Histochem Cytochem. 2006;54:171-82 pubmed
  • 免疫细胞化学; 人类; 图 6
Wang M, Martinez A, Berthoud V, Seul K, Gemel J, Valiunas V, et al. Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins. Biochem Biophys Res Commun. 2005;333:1185-93 pubmed
  • 免疫组化-冰冻切片; 大鼠; 1:100
Gorbe A, Becker D, Dux L, Stelkovics E, Krenacs L, Bagdi E, et al. Transient upregulation of connexin43 gap junctions and synchronized cell cycle control precede myoblast fusion in regenerating skeletal muscle in vivo. Histochem Cell Biol. 2005;123:573-83 pubmed
  • 免疫细胞化学; 人类; 1:500; 图 4
  • 免疫印迹; 人类; 1:500; 图 5
Saito T, Tanaka R, Wataba K, Kudo R, Yamasaki H. Overexpression of estrogen receptor-alpha gene suppresses gap junctional intercellular communication in endometrial carcinoma cells. Oncogene. 2004;23:1109-16 pubmed
  • 免疫细胞化学; 人类; 图 3
Aasen T, Hodgins M, Edward M, Graham S. The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression. Oncogene. 2003;22:7969-80 pubmed
  • 免疫组化-冰冻切片; 大鼠
Nakashima Y, Kohno H, El Assal O, Dhar D, Ono T, Yamanoi A, et al. Sequential changes of connexin32 and connexin26 in ischemia-reperfusion of the liver in rats. Hepatol Res. 2003;27:67-75 pubmed
  • 免疫细胞化学; 人类; 图 4
Nishimura M, Saito T, Yamasaki H, Kudo R. Suppression of gap junctional intercellular communication via 5' CpG island methylation in promoter region of E-cadherin gene in endometrial cancer cells. Carcinogenesis. 2003;24:1615-23 pubmed
  • 免疫组化; 大鼠; 10 ug/ml
Zahs K, Kofuji P, Meier C, Dermietzel R. Connexin immunoreactivity in glial cells of the rat retina. J Comp Neurol. 2003;455:531-46 pubmed
  • 免疫组化; 人类
Rouan F, White T, Brown N, Taylor A, Lucke T, Paul D, et al. trans-dominant inhibition of connexin-43 by mutant connexin-26: implications for dominant connexin disorders affecting epidermal differentiation. J Cell Sci. 2001;114:2105-13 pubmed
  • 免疫印迹; 人类; 图 3
Ko K, Arora P, Lee W, McCulloch C. Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am J Physiol Cell Physiol. 2000;279:C147-57 pubmed
  • 免疫组化-石蜡切片; 小鼠
  • 免疫印迹; 小鼠; 1:300; 图 1
  • 免疫组化-石蜡切片; 人类; 图 5
Ito A, Katoh F, Kataoka T, Okada M, Tsubota N, Asada H, et al. A role for heterologous gap junctions between melanoma and endothelial cells in metastasis. J Clin Invest. 2000;105:1189-97 pubmed
  • 免疫组化-冰冻切片; 大鼠
Madon J, Hagenbuch B, Landmann L, Meier P, Stieger B. Transport function and hepatocellular localization of mrp6 in rat liver. Mol Pharmacol. 2000;57:634-41 pubmed
Hill E, Dale N, Wall M. Detecting CO2-Sensitive Hemichannels in Neurons in Acute Brain Slices. STAR Protoc. 2020;1:100139 pubmed 出版商
Albuloushi A, Lovgren M, Steel A, Yeoh Y, Waters A, Zamiri M, et al. A heterozygous mutation in GJB2 (Cx26F142L) associated with deafness and recurrent skin rashes results in connexin assembly deficiencies. Exp Dermatol. 2020;29:970-979 pubmed 出版商
Beach R, Abitbol J, Allman B, Esseltine J, Shao Q, Laird D. GJB2 Mutations Linked to Hearing Loss Exhibit Differential Trafficking and Functional Defects as Revealed in Cochlear-Relevant Cells. Front Cell Dev Biol. 2020;8:215 pubmed 出版商
Lee M, Wang H, White T, Brooks T, Pittman A, Halai H, et al. Allele-Specific Small Interfering RNA Corrects Aberrant Cellular Phenotype in Keratitis-Ichthyosis-Deafness Syndrome Keratinocytes. J Invest Dermatol. 2020;140:1035-1044.e7 pubmed 出版商
Patodia S, Paradiso B, Ellis M, Somani A, Sisodiya S, Devinsky O, et al. Characterisation of medullary astrocytic populations in respiratory nuclei and alterations in sudden unexpected death in epilepsy. Epilepsy Res. 2019;157:106213 pubmed 出版商
Huebner A, Maier H, Maul A, Nietzsche S, Herrmann T, Praetorius J, et al. Early Hearing Loss upon Disruption of Slc4a10 in C57BL/6 Mice. J Assoc Res Otolaryngol. 2019;20:233-245 pubmed 出版商
Bazzoun D, Adissu H, Wang L, Urazaev A, Tenvooren I, Fostok S, et al. Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epithelium. J Cell Sci. 2019;132: pubmed 出版商
Kim E, Bae Y, Choi M, Hong S. Connexin 43 plays an important role in the transformation of cholangiocytes with Clonochis sinensis excretory-secretory protein and N-nitrosodimethylamine. PLoS Negl Trop Dis. 2019;13:e0006843 pubmed 出版商
Iikawa N, Yamamoto Y, Kawasaki Y, Nishijima Matsunobu A, Suzuki M, Yamada T, et al. Intrinsic Oncogenic Function of Intracellular Connexin26 Protein in Head and Neck Squamous Cell Carcinoma Cells. Int J Mol Sci. 2018;19: pubmed 出版商
Press E, Alaga K, Barr K, Shao Q, Bosen F, Willecke K, et al. Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice. Cell Death Dis. 2017;8:e2845 pubmed 出版商
Tsao D, Wang S, Lynn B, Nagy J. Immunofluorescence reveals unusual patterns of labelling for connexin43 localized to calbindin-D28K-positive interstitial cells in the pineal gland. Eur J Neurosci. 2017;45:1553-1569 pubmed 出版商
Levi L, Lobo G, Doud M, von Lintig J, Seachrist D, Tochtrop G, et al. Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis. Cancer Res. 2013;73:4770-80 pubmed 出版商
Hostinar C, Stellern S, Schaefer C, Carlson S, Gunnar M. Associations between early life adversity and executive function in children adopted internationally from orphanages. Proc Natl Acad Sci U S A. 2012;109 Suppl 2:17208-12 pubmed 出版商
Martinez A, Maripillan J, Acuña R, Minogue P, Berthoud V, Beyer E. Different domains are critical for oligomerization compatibility of different connexins. Biochem J. 2011;436:35-43 pubmed 出版商
Nomura S, Maeda K, Noda E, Inoue T, Fukunaga S, Nagahara H, et al. Clinical significance of the expression of connexin26 in colorectal cancer. J Exp Clin Cancer Res. 2010;29:79 pubmed 出版商
Sun Y, Tang W, Chang Q, Wang Y, Kong W, Lin X. Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea. J Comp Neurol. 2009;516:569-79 pubmed 出版商
Ezumi K, Yamamoto H, Murata K, Higashiyama M, Damdinsuren B, Nakamura Y, et al. Aberrant expression of connexin 26 is associated with lung metastasis of colorectal cancer. Clin Cancer Res. 2008;14:677-84 pubmed 出版商
Horowitz S, Stamper S, Simmons J. Neuronal connexin expression in the cochlear nucleus of big brown bats. Brain Res. 2008;1197:76-84 pubmed 出版商
Kandyba E, Hodgins M, Martin P. A murine living skin equivalent amenable to live-cell imaging: analysis of the roles of connexins in the epidermis. J Invest Dermatol. 2008;128:1039-49 pubmed
Ikeda Y, Fry C, Hayashi F, Stolz D, Griffiths D, Kanai A. Role of gap junctions in spontaneous activity of the rat bladder. Am J Physiol Renal Physiol. 2007;293:F1018-25 pubmed
Lahlou H, Fanjul M, Pradayrol L, Susini C, Pyronnet S. Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells. Mol Cell Biol. 2005;25:4034-45 pubmed
Gemel J, Valiunas V, Brink P, Beyer E. Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells. J Cell Sci. 2004;117:2469-80 pubmed
Thomas T, Telford D, Laird D. Functional domain mapping and selective trans-dominant effects exhibited by Cx26 disease-causing mutations. J Biol Chem. 2004;279:19157-68 pubmed
Walcott B, Moore L, Birzgalis A, Claros N, Valiunas V, Ott T, et al. Role of gap junctions in fluid secretion of lacrimal glands. Am J Physiol Cell Physiol. 2002;282:C501-7 pubmed
Solomon I, Halat T, El Maghrabi M, O Neal M. Localization of connexin26 and connexin32 in putative CO(2)-chemosensitive brainstem regions in rat. Respir Physiol. 2001;129:101-21 pubmed
Rash J, Yasumura T, Dudek F, Nagy J. Cell-specific expression of connexins and evidence of restricted gap junctional coupling between glial cells and between neurons. J Neurosci. 2001;21:1983-2000 pubmed
Bruzzone S, Guida L, Zocchi E, Franco L, De Flora A -. Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells. FASEB J. 2001;15:10-12 pubmed
产品信息
产品类型 :
抗体
产品名称 :
连接蛋白26单克隆抗体(CX-12H10)
目录# :
13-8100
规格 :
100微克
价格 :
美国399.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: 0.1-1 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry: 1-2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
CX-12H10
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variables (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
免疫原 :
Synthetic peptide corresponding to a segment of the cytoplasmic loop of rat Connexin-26.
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry: 1-2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
AI325222; Cnx26; connexin 26; connexin-26; CX26; CXN-26; DFNA3; DFNA3A; DFNB1; DFNB1A; Gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2; gap junction protein beta 2; gap junction protein, beta 2; gap junction protein, beta 2, 26kDa; GJB2; Gjb-2; HID; KID; mutant gap junction protein beta 2; NSRD1; PPK
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国