产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
连接蛋白单克隆抗体(CX-1B1)
目录 :
13-8300
规格 :
100微克
价格 :
美国456.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CX-1B1
反应物种 :
仓鼠, 人类, 小鼠, 大鼠, 犬, 牛, pigs
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片, 抑制或激活实验, mass cytometry
更多信息或购买 :
文章摘录数: 126
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| Förster T, Rausch V, Zhang Y, Isayev O, Heilmann K, Schoensiegel F, et al. Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication. Oncotarget. 2014;5:1621-34 pubmed
|
| |
| |
| |
| |
| |
| Liu W, Glueckert R, Linthicum F, Rieger G, Blumer M, Bitsche M, et al. Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons : A comparative study with clinical implications. Cell Tissue Res. 2014;355:267-78 pubmed 出版商
|
| |
| Novo R, Freire C, Felisbino S, Minicucci M, Azevedo P, Zornoff L, et al. Smoking is associated with remodeling of gap junction in the rat heart: smoker's paradox explanation?. Arq Bras Cardiol. 2013;100:274-80 pubmed
|
| |
| |
| Wu W, Li Y, Lu Z, Hu X. Increased susceptibility to ischemia-induced ventricular tachyarrhythmias in depressed rats: Involvement of reduction of connexin 43. Exp Ther Med. 2012;3:192-194 pubmed
|
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| Shintani Ishida K, Unuma K, Yoshida K. Ischemia enhances translocation of connexin43 and gap junction intercellular communication, thereby propagating contraction band necrosis after reperfusion. Circ J. 2009;73:1661-8 pubmed
|
| |
| |
| Berisha B, Bridger P, Toth A, Kliem H, Meyer H, Schams D, et al. Expression and localization of gap junctional connexins 26 and 43 in bovine periovulatory follicles and in corpus luteum during different functional stages of oestrous cycle and pregnancy. Reprod Domest Anim. 2009;44:295-302 pubmed 出版商
|
| |
| |
| |
| |
| |
| |
| |
| |
| |
| Sundset R, Ytrehus K, Zhang Y, Saffitz J, Yamada K. Repeated simulated ischemia and protection against gap junctional uncoupling. Cell Commun Adhes. 2007;14:239-49 pubmed
|
| Leinonen P, Aaltonen V, Koskela S, Lehenkari P, Korkiamäki T, Peltonen J. Impaired gap junction formation and intercellular calcium signaling in urinary bladder cancer cells can be improved by Gö6976. Cell Commun Adhes. 2007;14:125-36 pubmed
|
| Meilleur M, Akpovi C, Pelletier R, Vitale M. Tumor necrosis factor-alpha-induced anterior pituitary folliculostellate TtT/GF cell uncoupling is mediated by connexin 43 dephosphorylation. Endocrinology. 2007;148:5913-24 pubmed
|
| Zhang S, Liu Y, Huang G, Liu L. Aconitine alters connexin43 phosphorylation status and [Ca2+] oscillation patterns in cultured ventricular myocytes of neonatal rats. Toxicol In Vitro. 2007;21:1476-85 pubmed
|
| Wang R, Zhang C, Ruan Y, Liu N, Wang L. Changes in phosphorylation of connexin43 in rats during acute myocardial hypoxia and effects of antiarrhythmic peptide on the phosphorylation. J Huazhong Univ Sci Technolog Med Sci. 2007;27:241-4 pubmed
|
| Malone P, Miao H, Parker A, Juarez S, Hernandez M. Pressure induces loss of gap junction communication and redistribution of connexin 43 in astrocytes. Glia. 2007;55:1085-98 pubmed
|
| Girao H, Pereira P. The proteasome regulates the interaction between Cx43 and ZO-1. J Cell Biochem. 2007;102:719-28 pubmed
|
| Goubaeva F, Mikami M, Giardina S, Ding B, Abe J, Yang J. Cardiac mitochondrial connexin 43 regulates apoptosis. Biochem Biophys Res Commun. 2007;352:97-103 pubmed
|
| Chung T, Wang S, Chang Y, Chen Y, Wu J. 18beta-glycyrrhetinic acid promotes src interaction with connexin43 in rat cardiomyocytes. J Cell Biochem. 2007;100:653-64 pubmed
|
| Rucker Martin C, Milliez P, Tan S, Decrouy X, Recouvreur M, Vranckx R, et al. Chronic hemodynamic overload of the atria is an important factor for gap junction remodeling in human and rat hearts. Cardiovasc Res. 2006;72:69-79 pubmed
|
| Larre I, Ponce A, Fiorentino R, Shoshani L, Contreras R, Cereijido M. Contacts and cooperation between cells depend on the hormone ouabain. Proc Natl Acad Sci U S A. 2006;103:10911-6 pubmed
|
| Choi Y, Stamm C, Hammer P, Kwaku K, Marler J, Friehs I, et al. Cardiac conduction through engineered tissue. Am J Pathol. 2006;169:72-85 pubmed
|
| Rouach N, Pebay A, Meme W, Cordier J, Ezan P, Etienne E, et al. S1P inhibits gap junctions in astrocytes: involvement of G and Rho GTPase/ROCK. Eur J Neurosci. 2006;23:1453-64 pubmed
|
| Lee M, Kim J, Lee S, Sasaki H, Lunny D, Lane E, et al. Association of Shh and Ptc with keratin localization in the initiation of the formation of circumvallate papilla and von Ebner's gland. Cell Tissue Res. 2006;325:253-61 pubmed
|
| Ripplinger C, Krinsky V, Nikolski V, Efimov I. Mechanisms of unpinning and termination of ventricular tachycardia. Am J Physiol Heart Circ Physiol. 2006;291:H184-92 pubmed
|
| Chen Z, Evans W, Pflugfelder S, Li D. Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Stem Cells. 2006;24:1265-73 pubmed
|
| Gorbe A, Becker D, Dux L, Krenacs L, Krenacs T. In differentiating prefusion myoblasts connexin43 gap junction coupling is upregulated before myoblast alignment then reduced in post-mitotic cells. Histochem Cell Biol. 2006;125:705-16 pubmed
|
| Sundset R, Cooper M, Mikalsen S, Ytrehus K. Ischemic preconditioning protects against gap junctional uncoupling in cardiac myofibroblasts. Cell Commun Adhes. 2004;11:51-66 pubmed
|
| King T, Lampe P. Temporal regulation of connexin phosphorylation in embryonic and adult tissues. Biochim Biophys Acta. 2005;1719:24-35 pubmed
|
| Gorbe A, Becker D, Dux L, Stelkovics E, Krenacs L, Bagdi E, et al. Transient upregulation of connexin43 gap junctions and synchronized cell cycle control precede myoblast fusion in regenerating skeletal muscle in vivo. Histochem Cell Biol. 2005;123:573-83 pubmed
|
| Kim J, Cho S, Lee M, Hwang H, Lee J, Lee S, et al. Inhibition of connexin 43 alters Shh and Bmp-2 expression patterns in embryonic mouse tongue. Cell Tissue Res. 2005;320:409-15 pubmed
|
| Leite A, Carvalho C, Furtado A, Barbosa H, Boschero A, Collares Buzato C. Co-expression and regulation of connexins 36 and 43 in cultured neonatal rat pancreatic islets. Can J Physiol Pharmacol. 2005;83:142-51 pubmed
|
| Li W, Hertzberg E, Spray D. Regulation of connexin43-protein binding in astrocytes in response to chemical ischemia/hypoxia. J Biol Chem. 2005;280:7941-8 pubmed
|
| Chung T, Wang S, Wu J. 17beta-estradiol reduces the effect of metabolic inhibition on gap junction intercellular communication in rat cardiomyocytes via the estrogen receptor. J Mol Cell Cardiol. 2004;37:1013-22 pubmed
|
| Altevogt B, Paul D. Four classes of intercellular channels between glial cells in the CNS. J Neurosci. 2004;24:4313-23 pubmed
|
| Cruciani V, Leithe E, Mikalsen S. Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport. Exp Cell Res. 2003;287:130-42 pubmed
|
| Zahs K, Kofuji P, Meier C, Dermietzel R. Connexin immunoreactivity in glial cells of the rat retina. J Comp Neurol. 2003;455:531-46 pubmed
|
| Jahromi S, Wentlandt K, Piran S, Carlen P. Anticonvulsant actions of gap junctional blockers in an in vitro seizure model. J Neurophysiol. 2002;88:1893-902 pubmed
|
| Rucker Martin C, Pecker F, Godreau D, Hatem S. Dedifferentiation of atrial myocytes during atrial fibrillation: role of fibroblast proliferation in vitro. Cardiovasc Res. 2002;55:38-52 pubmed
|
| Bruzzone S, Franco L, Guida L, Zocchi E, Contini P, Bisso A, et al. A self-restricted CD38-connexin 43 cross-talk affects NAD+ and cyclic ADP-ribose metabolism and regulates intracellular calcium in 3T3 fibroblasts. J Biol Chem. 2001;276:48300-8 pubmed
|
| Verderio C, Bruzzone S, Zocchi E, Fedele E, Schenk U, De Flora A, et al. Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes. J Neurochem. 2001;78:646-57 pubmed
|
| Hentula M, Peltonen J, Peltonen S. Expression profiles of cell-cell and cell-matrix junction proteins in developing human epidermis. Arch Dermatol Res. 2001;293:259-67 pubmed
|
| Mercier F, Hatton G. Connexin 26 and basic fibroblast growth factor are expressed primarily in the subpial and subependymal layers in adult brain parenchyma: roles in stem cell proliferation and morphological plasticity?. J Comp Neurol. 2001;431:88-104 pubmed
|
| Nagy J, Li W. A brain slice model for in vitro analyses of astrocytic gap junction and connexin43 regulation: actions of ischemia, glutamate and elevated potassium. Eur J Neurosci. 2000;12:4567-72 pubmed
|
| Li W, Nagy J. Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition. Eur J Neurosci. 2000;12:2644-50 pubmed
|
| Li W, Nagy J. Activation of fibres in rat sciatic nerve alters phosphorylation state of connexin-43 at astrocytic gap junctions in spinal cord: evidence for junction regulation by neuronal-glial interactions. Neuroscience. 2000;97:113-23 pubmed
|
| Cruciani V, Mikalsen S. Stimulated phosphorylation of intracellular connexin43. Exp Cell Res. 1999;251:285-98 pubmed
|
| Nagy J, Patel D, Ochalski P, Stelmack G. Connexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance. Neuroscience. 1999;88:447-68 pubmed
|
| Krenacs T, Rosendaal M. Gap-junction communication pathways in germinal center reactions. Dev Immunol. 1998;6:111-8 pubmed
|
Polusani S, Kalmykov E, Chandrasekhar A, Zucker S, Nicholson B. Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration. J Cell Sci. 2016;129:4399-4410 pubmed
| |
Radosinska J, Knezl V, Benová T, Urban L, Tribulova N, Slezak J. Alterations of the intercellular coupling protein, connexin-43, during ventricular fibrillation and sinus rhythm restoration demonstrated in male and female rat hearts: A pilot study. Exp Clin Cardiol. 2011;16:116-20 pubmed
| |
Ruan L, Cai W, Chen J, Duan J. Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits. Int J Med Sci. 2010;7:82-9 pubmed
| |
Sosinsky G, Solan J, Gaietta G, Ngan L, Lee G, Mackey M, et al. The C-terminus of connexin43 adopts different conformations in the Golgi and gap junction as detected with structure-specific antibodies. Biochem J. 2007;408:375-85 pubmed
| |
Li J, Patel V, Kostetskii I, Xiong Y, Chu A, Jacobson J, et al. Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circ Res. 2005;97:474-81 pubmed
| |
Boengler K, Dodoni G, Rodriguez Sinovas A, Cabestrero A, Ruiz Meana M, Gres P, et al. Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc Res. 2005;67:234-44 pubmed
| |
Lahlou H, Fanjul M, Pradayrol L, Susini C, Pyronnet S. Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cells. Mol Cell Biol. 2005;25:4034-45 pubmed
| |
Li X, Olson C, Lu S, Kamasawa N, Yasumura T, Rash J, et al. Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1. Eur J Neurosci. 2004;19:2132-46 pubmed
| |
Cowan D, Jones M, Garcia L, Noria S, del Nido P, McGowan F. Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation. Arterioscler Thromb Vasc Biol. 2003;23:1754-60 pubmed
| |
Bruzzone S, Guida L, Zocchi E, Franco L, De Flora A -. Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells. FASEB J. 2001;15:10-12 pubmed
| |
Nagy J, Li W, Roy C, Doble B, Gilchrist J, Kardami E, et al. Selective monoclonal antibody recognition and cellular localization of an unphosphorylated form of connexin43. Exp Cell Res. 1997;236:127-36 pubmed
|
产品信息
产品类型 :
抗体
产品名称 :
连接蛋白单克隆抗体(CX-1B1)
目录# :
13-8300
规格 :
100微克
价格 :
美国456.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
狗, 人类, 小鼠, 大鼠
应用 :
ELISA: 0.1-1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunomicroscopy: Assay-dependent, Western Blot: 1-3 µg/mL
物种 :
狗, 人类, 小鼠, 大鼠
克隆 :
CX-1B1
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate Cx43 to alter gap junction communication. GFAP are membrane-spanning proteins that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is also targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. Mutations in the GFAP gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy, oculodentodigital dysplasia and heart malformations. Alternatively spliced transcript variants of GFAP have been found.
免疫原 :
Synthetic peptide corresponding to a cytoplasmic sequence located near the C-terminus of rat Connexin 43.
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Immunomicroscopy: Assay-dependent, Western Blot: 1-3 µg/mL
别名 :
alpha 1 connexin; AU042049; AVSD3; AW546267; CMDR; Cnx43; connexin 43; connexin43; connexin-43; cx43; Cx-43; cx43 protein; cx43a1; Cx43alpha1; CXA1; Cxn-43; DFNB38; EKVP; etID309742.9; gap junction 43 kDa heart protein; Gap junction alpha-1 protein; gap junction membrane channel protein; gap junction membrane channel protein alpha 1; gap junction protein; gap junction protein alpha 1; gap junction protein connexin 43; gap junction protein, alpha 1; gap junction protein, alpha 1, 43 kD (connexin 43); gap junction protein, alpha 1, 43kDa; gap junction protein, alpha 1, 43kDa (connexin 43); gja1; Gja-1; GJAL; HLHS1; HSS; Npm1; ODD; ODDD; ODOD; PPKCA; SDTY3; shf; Short fin protein; sof; stopsel; stp; Syndactyly type III; vascular smooth muscle connexin43; Vascular smooth muscle connexin-43; zfCx43.3
更多信息或购买 :
公司信息
赛默飞世尔