产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Bcl-2 Monoclonal Antibody (Bcl-2-100)
目录 :
13-8800
规格 :
100微克
价格 :
美国398.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Bcl-2-100
反应物种 :
人类, 大鼠, 鸡
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 51
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:250; 图 1b
Ranjan K, Pathak C. Expression of FADD and cFLIPL balances mitochondrial integrity and redox signaling to substantiate apoptotic cell death. Mol Cell Biochem. 2016;422:135-150 pubmed
  • 免疫印迹; 人类; 1:500; 图 4f
Ranjan K, Pathak C. FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis. Sci Rep. 2016;6:22787 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Ranjan K, Pathak C. Expression of cFLIPL Determines the Basal Interaction of Bcl-2 With Beclin-1 and Regulates p53 Dependent Ubiquitination of Beclin-1 During Autophagic Stress. J Cell Biochem. 2016;117:1757-68 pubmed 出版商
  • 免疫组化; 人类; 1:80; 图 5
Ertoy Baydar D, Kosemehmetoglu K, Aydin O, Bridge J, Buyukeren B, Aki F. Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature. Diagn Pathol. 2015;10:186 pubmed 出版商
  • 免疫印迹; 鸡; 1:1000; 图 7a
Luna Acosta J, Alba Betancourt C, Martínez Moreno C, Ramírez C, Carranza M, Luna M, et al. Direct antiapoptotic effects of growth hormone are mediated by PI3K/Akt pathway in the chicken bursa of Fabricius. Gen Comp Endocrinol. 2015;224:148-59 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200
Song M, Chung J, Lee J, Yang D, Kim I, Shin D, et al. High Ki-67 expression in involved bone marrow predicts worse clinical outcome in diffuse large B cell lymphoma patients treated with R-CHOP therapy. Int J Hematol. 2015;101:140-7 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Choi J, Kang S, Lee S, Bae Y. Prognostic significance of Bcl-2 expression in non-basal triple-negative breast cancer patients treated with anthracycline-based chemotherapy. Tumour Biol. 2014;35:12255-63 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:700
Nicholson A, Guo X, Sullivan C, Cha C. Automated quantitative analysis of tissue microarray of 443 patients with colorectal adenocarcinoma: low expression of Bcl-2 predicts poor survival. J Am Coll Surg. 2014;219:977-87 pubmed 出版商
  • 免疫组化; 大鼠; 1:200
Biaggio V, Alvarez Olmedo D, Pérez Chaca M, Salvetti N, Valdez S, Fanelli M, et al. Cytoprotective mechanisms in rats lung parenchyma with zinc deprivation. Biometals. 2014;27:305-15 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1
Razavi S, Hasheminia D, Mehdizade M, Movahedian B, Keshani F. The relation of pericoronal third molar follicle dimension and bcl-2/ki-67 expression: An immunohistochemical study. Dent Res J (Isfahan). 2012;9:S26-31 pubmed 出版商
  • 免疫沉淀; 人类; 图 2
  • 免疫印迹; 人类; 图 2
Goraczniak R, Wall B, Behlke M, Lennox K, Ho E, Zaphiros N, et al. U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Mol Ther Nucleic Acids. 2013;2:e92 pubmed 出版商
  • 免疫沉淀; 人类; 图 9
Verma Y, Raghav P, Raj H, Tripathi R, Gangenahalli G. Enhanced heterodimerization of Bax by Bcl-2 mutants improves irradiated cell survival. Apoptosis. 2013;18:212-25 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 2
Giaginis C, Politi E, Alexandrou P, Sfiniadakis J, Kouraklis G, Theocharis S. Expression of peroxisome proliferator activated receptor-gamma (PPAR-?) in human non-small cell lung carcinoma: correlation with clinicopathological parameters, proliferation and apoptosis related molecules and patients' survival. Pathol Oncol Res. 2012;18:875-83 pubmed
  • 免疫印迹; 人类; 1:500
Lúcio K, Rocha G, Monção Ribeiro L, Fernandes J, Takiya C, Gattass C. Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo. PLoS ONE. 2011;6:e28596 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 1, 2, 3
Cheuk W, Tam F, Chan A, Luk I, Yuen A, Chan W, et al. Idiopathic cervical fibrosis--a new member of IgG4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma. Am J Surg Pathol. 2010;34:1678-85 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Yang Z, von Ballmoos M, Faessler D, Voelzmann J, Ortmann J, Diehm N, et al. Paracrine factors secreted by endothelial progenitor cells prevent oxidative stress-induced apoptosis of mature endothelial cells. Atherosclerosis. 2010;211:103-9 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 表 2
Jung C, Choi Y, Lee K, Bae J, Kim H, Yoon S, et al. The cytological, clinical, and pathological features of the cribriform-morular variant of papillary thyroid carcinoma and mutation analysis of CTNNB1 and BRAF genes. Thyroid. 2009;19:905-13 pubmed 出版商
  • 免疫印迹; 人类
Thomson S, Cox A, Cuddihy S, Pullar J, Hampton M. Inhibition of receptor-mediated apoptosis upon Bcl-2 overexpression is not associated with increased antioxidant status. Biochem Biophys Res Commun. 2008;375:145-50 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500
Cheuk W, Chan J, Nuovo G, Chan M, Fok M. Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi)?. Int J Surg Pathol. 2007;15:180-6 pubmed
  • 免疫组化-石蜡切片; 人类
Yoo J, Jung J, Lee M, Seo K, Shim B, Kim S, et al. Immunohistochemical analysis of non-small cell lung cancer: correlation with clinical parameters and prognosis. J Korean Med Sci. 2007;22:318-25 pubmed
  • 免疫组化-石蜡切片; 人类; 图 2
Lawson J, Tran D. Localised breast cancers may have systemic influences on skin and hair. J Clin Pathol. 2007;60:180-4 pubmed
  • 免疫组化-石蜡切片; 人类
Luo H, Yu S, Li T. Differential expression of apoptosis-related proteins in various cellular components of ameloblastomas. Int J Oral Maxillofac Surg. 2006;35:750-5 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200
Sun B, Sun Y, Wang J, Zhao X, Wang X, Hao X. Extent, relationship and prognostic significance of apoptosis and cell proliferation in synovial sarcoma. Eur J Cancer Prev. 2006;15:258-65 pubmed
  • 免疫细胞化学; 人类; 表 1
Rivadeneyra Espinoza L, Ruiz Argüelles A. Cell-penetrating anti-native DNA antibodies trigger apoptosis through both the neglect and programmed pathways. J Autoimmun. 2006;26:52-6 pubmed
  • 免疫组化; 大鼠; 表 1
Damron T, Horton J, Naqvi A, Margulies B, Strauss J, Grant W, et al. Decreased proliferation precedes growth factor changes after physeal irradiation. Clin Orthop Relat Res. 2004;:233-42 pubmed
  • 免疫印迹; 人类; 1:1000; 图 3
Sandalova E, Wei C, Masucci M, Levitsky V. Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering. Proc Natl Acad Sci U S A. 2004;101:3011-6 pubmed
  • 免疫组化; 大鼠; 1:100; 图 3
Damron T, Mathur S, Horton J, Strauss J, Margulies B, Grant W, et al. Temporal changes in PTHrP, Bcl-2, Bax, caspase, TGF-beta, and FGF-2 expression following growth plate irradiation with or without radioprotectant. J Histochem Cytochem. 2004;52:157-67 pubmed
  • 免疫组化-石蜡切片; 人类; 表 1
Ng J, Han A, Edelson M, Rosenblum N. Oncoprotein profiles of primary peritoneal malignant mixed müllerian tumors. Int J Gynecol Cancer. 2003;13:870-4 pubmed
  • 免疫组化-石蜡切片; 人类; 1:50; 表 2
Halperin R, Zehavi S, Hadas E, Habler L, Bukovsky I, Schneider D. Simultaneous carcinoma of the endometrium and ovary vs endometrial carcinoma with ovarian metastases: a clinical and immunohistochemical determination. Int J Gynecol Cancer. 2003;13:32-7 pubmed
  • 免疫组化-石蜡切片; 人类
Tran D, Lawson J. Microcysts and breast cancer: a study of biological markers in archival biopsy material. Breast Cancer Res Treat. 2002;75:213-20 pubmed
  • 免疫组化; 人类; 1:20; 表 3
Solomides C, Miller A, Christman R, Talwar J, Simpkins H. Lymphomas of the oral cavity: histology, immunologic type, and incidence of Epstein-Barr virus infection. Hum Pathol. 2002;33:153-7 pubmed
  • 免疫印迹; 人类; 图 5
Desai B, Myers B, Schreiber S. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2002;99:4319-24 pubmed
  • 流式细胞仪; 人类
Tanaka Y, Nomi M, Fujii K, Hubscher S, Maruo A, Matsumoto S, et al. Intercellular adhesion molecule 1 underlies the functional heterogeneity of synovial cells in patients with rheumatoid arthritis: involvement of cell cycle machinery. Arthritis Rheum. 2000;43:2513-22 pubmed
  • 免疫组化-石蜡切片; 人类; 1:20; 图 2, 3, 4
Reis Filho J, Faoro L, Carrilho C, Bleggi Torres L, Schmitt F. Evaluation of cell proliferation, epidermal growth factor receptor, and bcl-2 immunoexpression as prognostic factors for patients with World Health Organization grade 2 oligodendroglioma. Cancer. 2000;88:862-9 pubmed
Baltazar Lara R, Ávila Mendoza J, Martínez Moreno C, Carranza M, Pech Pool S, Vázquez Martínez O, et al. Neuroprotective Effects of Growth Hormone (GH) and Insulin-Like Growth Factor Type 1 (IGF-1) after Hypoxic-Ischemic Injury in Chicken Cerebellar Cell Cultures. Int J Mol Sci. 2020;22: pubmed 出版商
Masilamani A, Dettmer Monaco V, Monaco G, Cathomen T, Kuckuck I, Schultze Seemann S, et al. An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells. Cancers (Basel). 2020;12: pubmed 出版商
Li N, Cheng C, Wang T. MiR-181c-5p Mitigates Tumorigenesis in Cervical Squamous Cell Carcinoma via Targeting Glycogen Synthase Kinase 3β Interaction Protein (GSKIP). Onco Targets Ther. 2020;13:4495-4505 pubmed 出版商
Ji T, Feng W, Zhang X, Zang K, Zhu X, Shang F. HDAC inhibitors promote pancreatic stellate cell apoptosis and relieve pancreatic fibrosis by upregulating miR-15/16 in chronic pancreatitis. Hum Cell. 2020;33:1006-1016 pubmed 出版商
Ha Y, Fang Y, Romecin Duran P, Tolosa E, Moser C, Fernandez Zapico M, et al. Induction of Lysosome-associated Protein Transmembrane 4 Beta via Sulfatase 2 Enhances Autophagic Flux in Liver Cancer Cells. Hepatol Commun. 2019;3:1520-1543 pubmed 出版商
Kang Y, Anderson A, Jackson T, Palmer C, De Souza D, Fujihara K, et al. Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome. elife. 2019;8: pubmed 出版商
Ishikawa K, Kawano Y, Arihara Y, Kubo T, Takada K, Murase K, et al. BH3 profiling discriminates the anti‑apoptotic status of 5‑fluorouracil‑resistant colon cancer cells. Oncol Rep. 2019;42:2416-2425 pubmed 出版商
Lin J, Shen J, Yue H, Cao Z. miRNA‑183‑5p.1 promotes the migration and invasion of gastric cancer AGS cells by targeting TPM1. Oncol Rep. 2019;42:2371-2381 pubmed 出版商
Martínez Moreno C, Epardo D, Balderas Márquez J, Fleming T, Carranza M, Luna M, et al. Regenerative Effect of Growth Hormone (GH) in the Retina after Kainic Acid Excitotoxic Damage. Int J Mol Sci. 2019;20: pubmed 出版商
Saunders I, Mir H, Kapur N, Singh S. Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways. Cancer Cell Int. 2019;19:98 pubmed 出版商
Mooney R, Majid A, Mota D, He A, Aramburo S, Flores L, et al. Bcl-2 Overexpression Improves Survival and Efficacy of Neural Stem Cell-Mediated Enzyme Prodrug Therapy. Stem Cells Int. 2018;2018:7047496 pubmed 出版商
Klein S, Abraham M, Bulvik B, Dery E, Weiss I, Barashi N, et al. CXCR4 Promotes Neuroblastoma Growth and Therapeutic Resistance through miR-15a/16-1-Mediated ERK and BCL2/Cyclin D1 Pathways. Cancer Res. 2018;78:1471-1483 pubmed 出版商
Cummins N, Sainski Nguyen A, Natesampillai S, Aboulnasr F, Kaufmann S, Badley A. Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition. J Virol. 2017;91: pubmed 出版商
Shan T, Shan T, Liu F, Zheng H, Li G. Effects of Lycium barbarum polysaccharides on the damage to human endometrial stromal cells induced by hydrogen peroxide. Mol Med Rep. 2017;15:879-884 pubmed 出版商
Zhang S, Li Y, He X, Dong S, Huang Y, Li X, et al. Photothermolysis mediated by gold nanorods modified with EGFR monoclonal antibody induces Hep-2 cells apoptosis in vitro and in vivo. Int J Nanomedicine. 2014;9:1931-46 pubmed 出版商
Lecuit M, Nelson D, Smith S, Khun H, Huerre M, Vacher Lavenu M, et al. Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin. Proc Natl Acad Sci U S A. 2004;101:6152-7 pubmed
Pullar J, Thomson S, King M, Turnbull C, Midwinter R, Hampton M. The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis. Carcinogenesis. 2004;25:765-72 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Bcl-2 Monoclonal Antibody (Bcl-2-100)
目录# :
13-8800
规格 :
100微克
价格 :
美国398.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
物种 :
人类
克隆 :
Bcl-2-100
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
免疫原 :
Synthetic peptide corresponding to residues 41-54 of the human Bcl-2 protein. This sequence is not shared by the mouse Bcl-2 protein.
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
别名 :
apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国