产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD3 Monoclonal Antibody (OKT3), eBioscience™
目录 :
14-0037-82
规格 :
100微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
鼠单克隆抗体-CD3
反应物种 :
人类, 猕猴
应用 :
流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 584
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 1:200; 图 2s1b
Zumaquero E, Stone S, Scharer C, Jenks S, Nellore A, Mousseau B, et al. IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation. elife. 2019;8: pubmed 出版商
  • 流式细胞仪; 人类; 图 1a
Banki Z, Krabbendam L, Klaver D, Leng T, Kruis S, Mehta H, et al. Antibody opsonization enhances MAIT cell responsiveness to bacteria via a TNF-dependent mechanism. Immunol Cell Biol. 2019;97:538-551 pubmed 出版商
  • 流式细胞仪; 人类; 图 1b
Pizzolla A, Nguyen T, Sant S, Jaffar J, Loudovaris T, Mannering S, et al. Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles. J Clin Invest. 2018;128:721-733 pubmed 出版商
  • 抑制或激活实验; 人类; 1 ug/ml; 图 6d
Kruglova N, Meshkova T, Kopylov A, Mazurov D, Filatov A. Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP). PLoS ONE. 2017;12:e0182468 pubmed 出版商
  • 抑制或激活实验; 人类; 30 ng/ml; 图 s9
Khodadoust M, Olsson N, Wagar L, Haabeth O, Chen B, Swaminathan K, et al. Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens. Nature. 2017;543:723-727 pubmed 出版商
  • 流式细胞仪; 人类; 图 3a
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed 出版商
  • 流式细胞仪; 人类; 图 2a
Su S, Zou Z, Chen F, Ding N, Du J, Shao J, et al. CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer. Oncoimmunology. 2017;6:e1249558 pubmed 出版商
  • 流式细胞仪; 人类; 图 1
Zhen A, Rezek V, Youn C, Lam B, Chang N, Rick J, et al. Targeting type I interferon-mediated activation restores immune function in chronic HIV infection. J Clin Invest. 2017;127:260-268 pubmed 出版商
  • 流式细胞仪; 人类; 图 2c
Tomic A, Varanasi P, Golemac M, Malic S, Riese P, Borst E, et al. Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand. PLoS Pathog. 2016;12:e1006015 pubmed 出版商
  • 流式细胞仪; 人类
Sullivan K, Lewis H, Hill A, Pandey A, Jackson L, Cabral J, et al. Trisomy 21 consistently activates the interferon response. elife. 2016;5: pubmed 出版商
  • 抑制或激活实验; 人类; 图 1
Hahn S, Neuhoff A, Landsberg J, Schupp J, Eberts D, Leukel P, et al. A key role of GARP in the immune suppressive tumor microenvironment. Oncotarget. 2016;7:42996-43009 pubmed 出版商
  • 流式细胞仪; 人类; 图 4
Su S, Hu B, Shao J, Shen B, Du J, Du Y, et al. CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. Sci Rep. 2016;6:20070 pubmed 出版商
  • 抑制或激活实验; 人类
Kobayashi S, Watanabe T, Suzuki R, Furu M, Ito H, Ito J, et al. TGF-β induces the differentiation of human CXCL13-producing CD4(+) T cells. Eur J Immunol. 2016;46:360-71 pubmed 出版商
  • 流式细胞仪; 人类; 图 s1a
Schulz A, Mälzer J, Domingo C, Jürchott K, Grützkau A, Babel N, et al. Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans. J Immunol. 2015;195:4699-711 pubmed 出版商
  • 抑制或激活实验; 人类; 1 ug/ml; 图 6c
Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, et al. The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells. Nat Immunol. 2015;16:1077-84 pubmed 出版商
  • 流式细胞仪; 人类; 图 1
Japp A, Kursunel M, Meier S, Mälzer J, Li X, Rahman N, et al. Dysfunction of PSA-specific CD8+ T cells in prostate cancer patients correlates with CD38 and Tim-3 expression. Cancer Immunol Immunother. 2015;64:1487-94 pubmed 出版商
  • 流式细胞仪; 人类; 图 1b
Wang Y, Zhong H, Xie X, Chen C, Huang D, Shen L, et al. Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection. Proc Natl Acad Sci U S A. 2015;112:E3883-92 pubmed 出版商
  • 流式细胞仪; 人类; 图 s3
Mende N, Kuchen E, Lesche M, Grinenko T, Kokkaliaris K, Hanenberg H, et al. CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo. J Exp Med. 2015;212:1171-83 pubmed 出版商
  • 抑制或激活实验; 人类; 10 ng/ml; 图 1
Tsai P, Chang Y, Lee Y, Ko Y, Yang Y, Lin C, et al. Differentiation of blood T cells: Reprogramming human induced pluripotent stem cells into neuronal cells. J Chin Med Assoc. 2015;78:353-9 pubmed 出版商
  • 抑制或激活实验; 人类; 5 ug/ml
Vassena L, Giuliani E, Koppensteiner H, Bolduan S, Schindler M, Doria M. HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes. J Virol. 2015;89:5687-700 pubmed 出版商
  • 抑制或激活实验; 人类; 图 3
Severson J, Serracino H, Mateescu V, Raeburn C, McIntyre R, Sams S, et al. PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer. Cancer Immunol Res. 2015;3:620-30 pubmed 出版商
  • 抑制或激活实验; 人类
Comrie W, Babich A, Burkhardt J. F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse. J Cell Biol. 2015;208:475-91 pubmed 出版商
  • 抑制或激活实验; 人类; 0.5 ug/ml
Chauhan A, Chen C, Moore T, DiPaolo R. Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset. J Biol Chem. 2015;290:5127-40 pubmed 出版商
  • 抑制或激活实验; 人类
Caramalho I, Nunes Silva V, Pires A, Mota C, Pinto A, Nunes Cabaço H, et al. Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus. J Autoimmun. 2015;56:98-110 pubmed 出版商
  • 流式细胞仪; 人类
Lim D, Yawata N, Selva K, Li N, Tsai C, Yeong L, et al. The combination of type I IFN, TNF-α, and cell surface receptor engagement with dendritic cells enables NK cells to overcome immune evasion by dengue virus. J Immunol. 2014;193:5065-75 pubmed 出版商
  • 抑制或激活实验; 人类; 2 ug/ml
O Regan N, Steinfelder S, Venugopal G, Rao G, Lucius R, Srikantam A, et al. Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses. PLoS Negl Trop Dis. 2014;8:e3206 pubmed 出版商
  • 流式细胞仪; 人类; 50 ng/ml
Ramirez L, Arango T, Thompson E, Naji M, Tebas P, Boyer J. High IP-10 levels decrease T cell function in HIV-1-infected individuals on ART. J Leukoc Biol. 2014;96:1055-63 pubmed 出版商
  • 抑制或激活实验; 人类
Kreiser S, Eckhardt J, Kuhnt C, Stein M, Krzyzak L, Seitz C, et al. Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo. Immunobiology. 2015;220:270-9 pubmed 出版商
  • 流式细胞仪; 人类
Tarbox J, Keppel M, Topcagic N, Mackin C, Ben Abdallah M, Baszis K, et al. Elevated double negative T cells in pediatric autoimmunity. J Clin Immunol. 2014;34:594-9 pubmed 出版商
  • 流式细胞仪; 人类
Mao C, Mou X, Zhou Y, Yuan G, Xu C, Liu H, et al. Tumor-activated TCR??? T cells from gastric cancer patients induce the antitumor immune response of TCR??? T cells via their antigen-presenting cell-like effects. J Immunol Res. 2014;2014:593562 pubmed 出版商
  • 流式细胞仪; 人类
Lyngaa R, Pedersen N, Schrama D, Thrue C, Ibrani D, Met O, et al. T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors. Clin Cancer Res. 2014;20:1768-78 pubmed 出版商
  • 抑制或激活实验; 人类; 3 ug/ml
Yang C, Li J, Chiu L, Lan J, Chen D, Chuang H, et al. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J Immunol. 2014;192:1547-57 pubmed 出版商
  • 抑制或激活实验; 人类
Zouk H, d Hennezel E, Du X, Ounissi Benkalha H, Piccirillo C, Polychronakos C. Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus. Clin Exp Immunol. 2014;175:485-97 pubmed 出版商
  • 抑制或激活实验; 人类; 2.5 ug/ml
Magrini E, Szabo I, Doni A, Cibella J, Viola A. Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12. PLoS ONE. 2011;6:e22482 pubmed 出版商
  • 流式细胞仪; 人类; 图 2
Correia M, Costa A, Uhrberg M, Cardoso E, Arosa F. IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion. Immunobiology. 2011;216:604-12 pubmed 出版商
  • 流式细胞仪; 猕猴; 图 4
  • 流式细胞仪; 人类; 图 4
Richardson M, Carroll R, Stremlau M, Korokhov N, Humeau L, Silvestri G, et al. Mode of transmission affects the sensitivity of human immunodeficiency virus type 1 to restriction by rhesus TRIM5alpha. J Virol. 2008;82:11117-28 pubmed 出版商
  • 抑制或激活实验; 人类
Kueng H, Leb V, Haiderer D, Raposo G, Thery C, Derdak S, et al. General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines. J Virol. 2007;81:8666-76 pubmed
  • 抑制或激活实验; 人类; 0.5 ug/ml
Clarke S, Betts G, Plant A, Wright K, El Shanawany T, Harrop R, et al. CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer. PLoS ONE. 2006;1:e129 pubmed
  • 抑制或激活实验; 人类
Hoves S, Krause S, Schutz C, Halbritter D, Scholmerich J, Herfarth H, et al. Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells. J Immunol. 2006;177:2691-8 pubmed
  • 流式细胞仪; 人类
Quiroga M, Pasquinelli V, Martinez G, Jurado J, Zorrilla L, Musella R, et al. Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. J Immunol. 2006;176:5965-74 pubmed
Moaaz M, Lotfy H, Elsherbini B, Motawea M, Fadali G. TGF-β Enhances the Anti-inflammatory Effect of Tumor- Infiltrating CD33+11b+HLA-DR Myeloid-Derived Suppressor Cells in Gastric Cancer: A Possible Relation to MicroRNA-494. Asian Pac J Cancer Prev. 2020;21:3393-3403 pubmed 出版商
Ma W, Ma J, Lei T, Zhao M, Zhang M. Targeting immunotherapy for bladder cancer by using anti-CD3 × CD155 bispecific antibody. J Cancer. 2019;10:5153-5161 pubmed 出版商
Trovato R, Fiore A, Sartori S, Cane S, Giugno R, Cascione L, et al. Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3. J Immunother Cancer. 2019;7:255 pubmed 出版商
Meng Z, Wu J, Zhou M, Sun S, Miao S, Han H, et al. Peripheral blood CD4+ T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2019;14:1669-1680 pubmed 出版商
Yonekawa M, Shimizu M, Kaneko A, Matsumura J, Takahashi H. Suppression of R5-type of HIV-1 in CD4+ NKT cells by Vδ1+ T cells activated by flavonoid glycosides, hesperidin and linarin. Sci Rep. 2019;9:7506 pubmed 出版商
Ramirez Carrozzi V, Ota N, Sambandam A, Wong K, Hackney J, Martinez Martin N, et al. Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes. J Immunol. 2019;202:1935-1941 pubmed 出版商
Jochems C, Tritsch S, Knudson K, Gameiro S, Rumfield C, Pellom S, et al. The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex. Oncoimmunology. 2019;8:e1532764 pubmed 出版商
Yu Y, Gao Y, Yu Y. "Waltz" of Cell Membrane-Coated Nanoparticles on Lipid Bilayers: Tracking Single Particle Rotation in Ligand-Receptor Binding. ACS Nano. 2018;12:11871-11880 pubmed 出版商
Liu H, Chen G, Chen L, Zhou M, Xiong X, Meng Z, et al. Cytokine-induced alterations of BAMBI mediate the reciprocal regulation of human Th17/Treg cells in response to cigarette smoke extract. Int J Mol Med. 2018;42:3404-3414 pubmed 出版商
Fourcade J, Sun Z, Chauvin J, Ka M, Davar D, Pagliano O, et al. CD226 opposes TIGIT to disrupt Tregs in melanoma. JCI Insight. 2018;3: pubmed 出版商
Kratchmarov R, Magun A, Reiner S. TCF1 expression marks self-renewing human CD8+ T cells. Blood Adv. 2018;2:1685-1690 pubmed 出版商
Pan H, Liu J, Deng W, Xing J, Li Q, Wang Z. Site-specific PEGylation of an anti-CEA/CD3 bispecific antibody improves its antitumor efficacy. Int J Nanomedicine. 2018;13:3189-3201 pubmed 出版商
Quintarelli C, Orlando D, Boffa I, Guercio M, Polito V, Petretto A, et al. Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma. Oncoimmunology. 2018;7:e1433518 pubmed 出版商
Vely F, Barlogis V, Marinier E, Coste M, Dubern B, Dugelay E, et al. Combined Immunodeficiency in Patients With Trichohepatoenteric Syndrome. Front Immunol. 2018;9:1036 pubmed 出版商
Provine N, Binder B, FitzPatrick M, Schuch A, Garner L, Williamson K, et al. Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells. Front Immunol. 2018;9:756 pubmed 出版商
Idorn M, Olsen M, Halldórsdóttir H, Skadborg S, Pedersen M, Høgdall C, et al. Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction. Oncoimmunology. 2018;7:e1412029 pubmed 出版商
Nissen S, Pedersen J, Helleberg M, Kjær K, Thavachelvam K, Obel N, et al. Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors. J Immunol. 2018;200:3372-3382 pubmed 出版商
Orlando D, Miele E, De Angelis B, Guercio M, Boffa I, Sinibaldi M, et al. Adoptive Immunotherapy Using PRAME-Specific T Cells in Medulloblastoma. Cancer Res. 2018;78:3337-3349 pubmed 出版商
Arbulo Echevarria M, Narbona Sánchez I, Fernandez Ponce C, Vico Barranco I, Rueda Ygueravide M, Dustin M, et al. A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling. Front Immunol. 2018;9:115 pubmed 出版商
Carisey A, Mace E, Saeed M, Davis D, Orange J. Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells. Curr Biol. 2018;28:489-502.e9 pubmed 出版商
Alam M, Gaida M, Debnath S, Tagad H, Miller Jenkins L, Appella E, et al. Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation. PLoS Biol. 2018;16:e2004111 pubmed 出版商
Ahmad S, Martinenaite E, Holmström M, Jørgensen M, Met O, Nastasi C, et al. The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy. Oncoimmunology. 2018;7:e1390641 pubmed 出版商
de Jong A, Pollastro S, Kwekkeboom J, Andersen S, Dorjée A, Bakker A, et al. Functional and phenotypical analysis of IL-6-secreting CD4+ T cells in human adipose tissue. Eur J Immunol. 2018;48:471-481 pubmed 出版商
Majri S, Fritz J, Villarino A, Zheng L, Kanellopoulou C, Chaigne Delalande B, et al. STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells. J Immunol. 2018;200:110-118 pubmed 出版商
Venugopal G, Mueller M, Hartmann S, Steinfelder S. Differential immunomodulation in human monocytes versus macrophages by filarial cystatin. PLoS ONE. 2017;12:e0188138 pubmed 出版商
García González P, Schinnerling K, Sepúlveda Gutiérrez A, Maggi J, Mehdi A, Nel H, et al. Dexamethasone and Monophosphoryl Lipid A Induce a Distinctive Profile on Monocyte-Derived Dendritic Cells through Transcriptional Modulation of Genes Associated With Essential Processes of the Immune Response. Front Immunol. 2017;8:1350 pubmed 出版商
Leitman E, Willberg C, Tsai M, Chen H, Buus S, Chen F, et al. HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection. J Virol. 2017;91: pubmed 出版商
Geisler K, Markwart R, Requardt R, Weigel C, Schubert K, Scherag A, et al. Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis. PLoS ONE. 2017;12:e0183214 pubmed 出版商
Hagner P, Chiu H, ORTIZ M, Apollonio B, Wang M, Couto S, et al. Activity of lenalidomide in mantle cell lymphoma can be explained by NK cell-mediated cytotoxicity. Br J Haematol. 2017;179:399-409 pubmed 出版商
Peng Z, Jiang S, Wu M, Zhou X, Wang Q. Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease. Mol Vis. 2017;23:538-547 pubmed
Kah J, Koh S, Volz T, Ceccarello E, Allweiss L, Lutgehetmann M, et al. Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection. J Clin Invest. 2017;127:3177-3188 pubmed 出版商
Sander F, Nilsson M, Rydström A, Aurelius J, Riise R, Movitz C, et al. Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy. Cancer Immunol Immunother. 2017;66:1473-1484 pubmed 出版商
St Pierre C, Guo J, Shin J, Engstrom L, Lee H, Herbert A, et al. A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system. PLoS ONE. 2017;12:e0180870 pubmed 出版商
Guo X, Zheng H, Luo W, Zhang Q, Liu J, Yao K. 5T4-specific chimeric antigen receptor modification promotes the immune efficacy of cytokine-induced killer cells against nasopharyngeal carcinoma stem cell-like cells. Sci Rep. 2017;7:4859 pubmed 出版商
Bock C, Babu S, Breloer M, Rajamanickam A, Boothra Y, Brunn M, et al. Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells. Front Cell Infect Microbiol. 2017;7:261 pubmed 出版商
Li L, Guo X, Shi X, Li C, Wu W, Yan C, et al. Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling. Proc Natl Acad Sci U S A. 2017;114:E5891-E5899 pubmed 出版商
Pavesi A, Tan A, Koh S, Chia A, Colombo M, Antonecchia E, et al. A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors. JCI Insight. 2017;2: pubmed 出版商
Hernández Del Pino R, Pellegrini J, Rovetta A, Peña D, Álvarez G, Rolandelli A, et al. Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses. Immunol Cell Biol. 2017;95:716-728 pubmed 出版商
Ali A, Abuelela A, Merzaban J. An Analysis of Trafficking Receptors Shows that CD44 and P-Selectin Glycoprotein Ligand-1 Collectively Control the Migration of Activated Human T-Cells. Front Immunol. 2017;8:492 pubmed 出版商
Silva Cardoso S, Affandi A, Spel L, Cossu M, van Roon J, Boes M, et al. CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells. J Immunol. 2017;199:253-262 pubmed 出版商
Chauhan A. Fc?RIIIa Signaling Modulates Endosomal TLR Responses in Human CD4+ T Cells. J Immunol. 2017;198:4596-4606 pubmed 出版商
Tello Lafoz M, Martínez Martínez G, Rodríguez Rodríguez C, Albar J, Huse M, Gharbi S, et al. Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse. Traffic. 2017;18:491-504 pubmed 出版商
Neuper T, Ellwanger K, Schwarz H, Kufer T, Duschl A, Horejs Hoeck J. NOD1 modulates IL-10 signalling in human dendritic cells. Sci Rep. 2017;7:1005 pubmed 出版商
Tanner M, Tajhya R, Huq R, Gehrmann E, Rodarte K, Atik M, et al. Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. Clin Immunol. 2017;180:45-57 pubmed 出版商
Davey M, Willcox C, Joyce S, Ladell K, Kasatskaya S, McLaren J, et al. Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. Nat Commun. 2017;8:14760 pubmed 出版商
Franchi L, Monteleone I, Hao L, Spahr M, Zhao W, Liu X, et al. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis. J Immunol. 2017;198:2735-2746 pubmed 出版商
Bhattarai N, McLinden J, Xiang J, Mathahs M, Schmidt W, Kaufman T, et al. Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo. PLoS Pathog. 2017;13:e1006232 pubmed 出版商
Schober T, Magg T, Laschinger M, Rohlfs M, Linhares N, Puchalka J, et al. A human immunodeficiency syndrome caused by mutations in CARMIL2. Nat Commun. 2017;8:14209 pubmed 出版商
Chen J, Wang Q, Feng X, Zhang Z, Geng L, Xu T, et al. Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria. Stem Cells Int. 2016;2016:4062789 pubmed 出版商
Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller A, et al. D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes. Mol Cell Biol. 2017;37: pubmed 出版商
Van Puyenbroeck V, Claeys E, Schols D, Bell T, Vermeire K. A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA). Mol Cell Proteomics. 2017;16:157-167 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
CD3 Monoclonal Antibody (OKT3), eBioscience™
目录# :
14-0037-82
规格 :
100微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 0.25 µg/test
物种 :
人类
克隆 :
鼠单克隆抗体-CD3
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.25 µg/test
别名 :
4930549J05Rik; A430104F18Rik; AI504783; antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; CD3; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon; CD3 epsilon chain; CD3 epsilon subunit; CD3 epsilon subunit precursor; CD3 gamma-chain; CD3 glycoprotein; CD3 glycoprotein precursor; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma; CD3 molecule, gamma polypeptide; CD3 protein; CD3 type I transmembrane glycoprotein; CD3 type I transmembrane glycoprotein precursor; CD3 zeta chain; Cd3d; CD3D antigen delta; CD3D antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; Cd3e; CD3E antigen, epsilon polypeptide; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3-epsilon; Cd3-eta; Cd3g; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; Cd3h; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; Ctg3; Ctg-3; FLJ18683; IMD17; IMD18; IMD19; IMD25; Leu-4; OKT3, delta chain; T3/TCR complex; T3d; T3e; T3g; T3Z; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 epsilon chain; T-cell receptor CD3 epsilon subunit; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T-cell surface protein; TcR CD3 delta-chain; TcR CD3 gamma-chain; TCR zeta chain; TCR zeta chain subunit; TCRE; Tcrk; TCRZ; TCRzeta; TiT3 complex; type I transmembrane protein; T-cell surface molecule CD3
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国