产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD40 Monoclonal Antibody (HM40-3), eBioscience
目录 :
14-0402-81
规格 :
50微克
价格 :
美国86.75
克隆性 :
单克隆
宿主 :
仓鼠
共轭标签 :
未共轭
克隆名称 :
HM40-3
反应物种 :
小鼠, 大鼠
应用 :
免疫组化, 流式细胞仪, 免疫组化-石蜡切片, 抑制或激活实验
更多信息或购买 :
文章摘录数: 76
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 s1b
Leonardi I, Li X, Semon A, Li D, Doron I, Putzel G, et al. CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi. Science. 2018;359:232-236 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3
Sun H, Zhang J, Chen F, Chen X, Zhou Z, Wang H. Activation of RAW264.7 macrophages by the polysaccharide from the roots of Actinidia eriantha and its molecular mechanisms. Carbohydr Polym. 2015;121:388-402 pubmed 出版商
  • 流式细胞仪; 小鼠
Sheng K, Herrero L, Taylor A, Hapel A, Mahalingam S. IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages. PLoS ONE. 2014;9:e95208 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 图 1
Wang Y, Alexander S. DNA vaccination as a treatment for chronic kidney disease. Methods Mol Biol. 2014;1143:297-303 pubmed 出版商
  • 抑制或激活实验; 小鼠; 1 ug/ml; 图 3
Vuong B, Lee M, Kabir S, Irimia C, Macchiarulo S, McKnight G, et al. Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol. 2009;10:420-6 pubmed 出版商
Holloway O, King A, Ziebell J. Microglia Demonstrate Local Mixed Inflammation and a Defined Morphological Shift in an APP/PS1 Mouse Model. J Alzheimers Dis. 2020;77:1765-1781 pubmed 出版商
Lazarević M, Battaglia G, Jevtic B, Đedović N, Bruno V, Cavalli E, et al. Upregulation of Tolerogenic Pathways by the Hydrogen Sulfide Donor GYY4137 and Impaired Expression of H2S-Producing Enzymes in Multiple Sclerosis. Antioxidants (Basel). 2020;9: pubmed 出版商
Yang D, Sun Y, Chen J, Zhang Y, Fan S, Huang M, et al. REV7 is required for processing AID initiated DNA lesions in activated B cells. Nat Commun. 2020;11:2812 pubmed 出版商
Schoeler K, Aufschnaiter A, Messner S, Derudder E, Herzog S, Villunger A, et al. TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells. FEBS J. 2019;286:3566-3581 pubmed 出版商
Li Q, Liu C, Yue R, El Ashram S, Wang J, He X, et al. cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection. Int J Mol Sci. 2019;20: pubmed 出版商
Irons E, Lau J. Systemic ST6Gal-1 Is a Pro-survival Factor for Murine Transitional B Cells. Front Immunol. 2018;9:2150 pubmed 出版商
Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam A, Sattentau Q, Meinhart A, et al. RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Mol Cell. 2018;70:650-662.e8 pubmed 出版商
Huang C, Zhang L, Ling F, Wen S, Luo Y, Liu H, et al. Effect of immune tolerance induced by immature dendritic cells and CTLA4-Ig on systemic lupus erythematosus: An in vivo study. Exp Ther Med. 2018;15:2499-2506 pubmed 出版商
Willis S, Tellier J, Liao Y, Trezise S, Light A, O Donnell K, et al. Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB. Nat Commun. 2017;8:1426 pubmed 出版商
Murai N, Ohtaki H, Watanabe J, Xu Z, Sasaki S, Yagura K, et al. Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice. PLoS ONE. 2017;12:e0186637 pubmed 出版商
Wang H, Lin J, Zeng L, Ouyang C, Ran P, Yang P, et al. Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells. Sci Rep. 2017;7:8519 pubmed 出版商
Kreslavsky T, Vilagos B, Tagoh H, Poliakova D, Schwickert T, Wöhner M, et al. Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol. 2017;18:442-455 pubmed 出版商
DiMenna L, Yen W, Nicolás L, Sharma R, Saldanha Z, Chaudhuri J. Cutting Edge: The Transcription Factor Sox2 Regulates AID Expression in Class-Switched B Cells. J Immunol. 2017;198:2244-2248 pubmed 出版商
Wang H, Hu W, Liang Z, Zeng L, Li J, Yan H, et al. Thiol peroxiredoxin, a novel allergen from Bombyx mori, modulates functions of macrophages and dendritic cells. Am J Transl Res. 2016;8:5320-5329 pubmed
Müller A, Florek M, Kohrt H, Küpper N, Filatenkov A, Linderman J, et al. Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning. J Immunol. 2016;197:4151-4162 pubmed
Visekruna A, Linnerz T, Martinic V, Vachharajani N, Hartmann S, Harb H, et al. Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis. Mucosal Immunol. 2015;8:307-15 pubmed 出版商
Ha N, Pham D, Shahsafaei A, Naruse C, Asano M, Thai T. HP-1? Controls High-Affinity Antibody Response to T-Dependent Antigens. Front Immunol. 2014;5:271 pubmed 出版商
Matthews A, Husain S, Chaudhuri J. Binding of AID to DNA does not correlate with mutator activity. J Immunol. 2014;193:252-7 pubmed 出版商
Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, et al. OX40 ligand regulates splenic CD8? dendritic cell-induced Th2 responses in vivo. Biochem Biophys Res Commun. 2014;444:235-40 pubmed 出版商
Murakami R, Denda Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T. A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS ONE. 2013;8:e73270 pubmed 出版商
Seillet C, Rouquié N, Foulon E, Douin Echinard V, Krust A, Chambon P, et al. Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor ?. J Immunol. 2013;190:5459-70 pubmed 出版商
Rehman A, Hemmert K, Ochi A, Jamal M, Henning J, Barilla R, et al. Role of fatty-acid synthesis in dendritic cell generation and function. J Immunol. 2013;190:4640-9 pubmed 出版商
Innes C, Hesse J, Palii S, Helmink B, Holub A, Sleckman B, et al. DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs. BMC Genomics. 2013;14:163 pubmed 出版商
Masani S, Han L, Yu K. Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination. Mol Cell Biol. 2013;33:1468-73 pubmed 出版商
Wang Y, Wang Y, Wang Y, Zheng G, Zhang G, Zhou J, et al. DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney Int. 2013;83:223-32 pubmed 出版商
Weinberger E, Himly M, Myschik J, Hauser M, Altmann F, Isakovic A, et al. Generation of hypoallergenic neoglycoconjugates for dendritic cell targeted vaccination: a novel tool for specific immunotherapy. J Control Release. 2013;165:101-9 pubmed 出版商
Arcipowski K, Bishop G. TRAF binding is required for a distinct subset of in vivo B cell functions of the oncoprotein LMP1. J Immunol. 2012;189:5165-70 pubmed 出版商
Ramon S, Bancos S, Thatcher T, Murant T, Moshkani S, Sahler J, et al. Peroxisome proliferator-activated receptor ? B cell-specific-deficient mice have an impaired antibody response. J Immunol. 2012;189:4740-7 pubmed 出版商
Chu Y, Soberon V, Glockner L, Beyaert R, Massoumi R, Van Loo G, et al. A20 and CYLD do not share significant overlapping functions during B cell development and activation. J Immunol. 2012;189:4437-43 pubmed 出版商
Sander S, Calado D, Srinivasan L, Köchert K, Zhang B, Rosolowski M, et al. Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell. 2012;22:167-79 pubmed 出版商
Arcipowski K, Bishop G. Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1. PLoS ONE. 2012;7:e42478 pubmed 出版商
Lehmann F, Feicht S, Helm F, Maurberger A, Ladinig C, Zimber Strobl U, et al. Humanized c-Myc mouse. PLoS ONE. 2012;7:e42021 pubmed 出版商
de Andres B, Prado C, Palacios B, Alía M, Jagtap S, Serrano N, et al. Dynamics of the splenic innate-like CD19?CD45Rlo cell population from adult mice in homeostatic and activated conditions. J Immunol. 2012;189:2300-8 pubmed 出版商
Kamphuis T, Meijerhof T, Stegmann T, Lederhofer J, Wilschut J, de Haan A. Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice. PLoS ONE. 2012;7:e36812 pubmed 出版商
Jounai K, Ikado K, Sugimura T, Ano Y, Braun J, Fujiwara D. Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via TLR9-dependent crosstalk with myeloid dendritic cells. PLoS ONE. 2012;7:e32588 pubmed 出版商
Vilagos B, Hoffmann M, Souabni A, Sun Q, Werner B, Medvedovic J, et al. Essential role of EBF1 in the generation and function of distinct mature B cell types. J Exp Med. 2012;209:775-92 pubmed 出版商
Hampel F, Ehrenberg S, Hojer C, Draeseke A, Marschall Schröter G, Kühn R, et al. CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling. Blood. 2011;118:6321-31 pubmed 出版商
Ebensen T, Libanova R, Schulze K, Yevsa T, Morr M, Guzman C. Bis-(3',5')-cyclic dimeric adenosine monophosphate: strong Th1/Th2/Th17 promoting mucosal adjuvant. Vaccine. 2011;29:5210-20 pubmed 出版商
Boué J, Blanpied C, Brousset P, Vergnolle N, Dietrich G. Endogenous opioid-mediated analgesia is dependent on adaptive T cell response in mice. J Immunol. 2011;186:5078-84 pubmed 出版商
Nowak U, Matthews A, Zheng S, Chaudhuri J. The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nat Immunol. 2011;12:160-6 pubmed 出版商
Calado D, Zhang B, Srinivasan L, Sasaki Y, Seagal J, Unitt C, et al. Constitutive canonical NF-?B activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma. Cancer Cell. 2010;18:580-9 pubmed 出版商
Yabu M, Shime H, Hara H, Saito T, Matsumoto M, Seya T, et al. IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid. Int Immunol. 2011;23:29-41 pubmed 出版商
Chu Y, Vahl J, Kumar D, Heger K, Bertossi A, Wójtowicz E, et al. B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice. Blood. 2011;117:2227-36 pubmed 出版商
Peters A, Stunz L, Meyerholz D, Mohan C, Bishop G. Latent membrane protein 1, the EBV-encoded oncogenic mimic of CD40, accelerates autoimmunity in B6.Sle1 mice. J Immunol. 2010;185:4053-62 pubmed 出版商
DRUTMAN S, Trombetta E. Dendritic cells continue to capture and present antigens after maturation in vivo. J Immunol. 2010;185:2140-6 pubmed 出版商
Sugita S, Horie S, Yamada Y, Mochizuki M. Inhibition of B-cell activation by retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2010;51:5783-8 pubmed 出版商
Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold C, et al. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci U S A. 2010;107:9759-64 pubmed 出版商
Nesbeth Y, Martinez D, Toraya S, Scarlett U, Cubillos Ruiz J, Rutkowski M, et al. CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. J Immunol. 2010;184:5654-62 pubmed 出版商
Hirata Y, Hamanaka S, Onodera M. Transactivation of the dopamine receptor 3 gene by a single provirus integration results in development of B-cell lymphoma in transgenic mice generated from retrovirally transduced embryonic stem cells. Blood. 2010;115:3930-8 pubmed 出版商
Gulani J, Norbury C, Bonneau R, Beckwith C. The effect of Helicobacter hepaticus infection on immune responses specific to herpes simplex virus type 1 and characteristics of dendritic cells. Comp Med. 2009;59:534-44 pubmed
Gaudenzio N, Espagnolle N, Mars L, Liblau R, Valitutti S, Espinosa E. Cell-cell cooperation at the T helper cell/mast cell immunological synapse. Blood. 2009;114:4979-88 pubmed 出版商
Cao L, Palmer C, Malon J, De Leo J. Critical role of microglial CD40 in the maintenance of mechanical hypersensitivity in a murine model of neuropathic pain. Eur J Immunol. 2009;39:3562-9 pubmed 出版商
Walsh K, Brady M, Finlay C, Boon L, Mills K. Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. J Immunol. 2009;183:1577-86 pubmed 出版商
Turner J, Langley R, Johnston K, Gentil K, Ford L, Wu B, et al. Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis. J Biol Chem. 2009;284:22364-78 pubmed 出版商
Hong Z, Huang X, Yin Z, Zhao W, Wang X. Immunosuppressive function of bone marrow mesenchymal stem cells on acute rejection of liver allografts in rats. Transplant Proc. 2009;41:403-9 pubmed 出版商
Silva Flannery L, Cabrera Mora M, Dickherber M, Moreno A. Polymeric linear Peptide chimeric vaccine-induced antimalaria immunity is associated with enhanced in vitro antigen loading. Infect Immun. 2009;77:1798-806 pubmed 出版商
Babbe H, McMenamin J, Hobeika E, Wang J, Rodig S, Reth M, et al. Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. J Immunol. 2009;182:347-60 pubmed
Hadeiba H, Sato T, Habtezion A, Oderup C, Pan J, Butcher E. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol. 2008;9:1253-60 pubmed 出版商
Hussain S, He P, Subleski J, Hofseth L, Trivers G, Mechanic L, et al. Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Res. 2008;68:7130-6 pubmed 出版商
Lee J, Dollins C, Boczkowski D, Sullenger B, Nair S. Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen-specific T-cell responses. Immunology. 2008;125:229-40 pubmed 出版商
Li G, Sanders J, Bevard M, Sun Z, Chumley J, Galkina E, et al. CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injury. Am J Pathol. 2008;172:1141-52 pubmed 出版商
Douin Echinard V, Laffont S, Seillet C, Delpy L, Krust A, Chambon P, et al. Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production. J Immunol. 2008;180:3661-9 pubmed
Tenno M, Ohtsubo K, Hagen F, Ditto D, Zarbock A, Schaerli P, et al. Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Mol Cell Biol. 2007;27:8783-96 pubmed
Elftman M, Norbury C, Bonneau R, Truckenmiller M. Corticosterone impairs dendritic cell maturation and function. Immunology. 2007;122:279-90 pubmed
Nabekura T, Nagasawa T, Nakauchi H, Onodera M. An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2. Cancer Immunol Immunother. 2008;57:611-22 pubmed
Munroe M, Bishop G. A costimulatory function for T cell CD40. J Immunol. 2007;178:671-82 pubmed
Ishiyama K, Ohdan H, Tokita D, Shishida M, Tanaka Y, Irei T, et al. Induction of endotoxin tolerance inhibits alloimmune responses. Transpl Immunol. 2006;16:158-65 pubmed
Nishikawa Y, Hikida M, Magari M, Kanayama N, Mori M, Kitamura H, et al. Establishment of lymphotoxin beta receptor signaling-dependent cell lines with follicular dendritic cell phenotypes from mouse lymph nodes. J Immunol. 2006;177:5204-14 pubmed
Rush J, Liu M, Odegard V, Unniraman S, Schatz D. Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc Natl Acad Sci U S A. 2005;102:13242-7 pubmed
Andrade R, Portillo J, Wessendarp M, Subauste C. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun. 2005;73:3115-23 pubmed
Murata K, Ishii N, Takano H, Miura S, Ndhlovu L, Nose M, et al. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J Exp Med. 2000;191:365-74 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD40 Monoclonal Antibody (HM40-3), eBioscience
目录# :
14-0402-81
规格 :
50微克
价格 :
美国86.75
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
亚美尼亚仓鼠
反应物种 :
小鼠, 大鼠
应用 :
Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent, Immunohistochemistry: Assay-Dependent
物种 :
小鼠, 大鼠
克隆 :
HM40-3
抗体亚型 :
IgM, kappa
储存 :
4° C
描述 :
The CD40 antigen is a single chain glycoprotein that is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin's disease associated antigen, CD30. CD40 is present on all B cells except plasma cells and is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of CD40, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of CD40 encoding distinct isoforms have been reported. Diseases associated with CD40 dysfunction include Type 3 Hyper-Igm immunodeficiency and CD40 ligand deficiency.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1 µg/test, Functional Assay: Assay-Dependent, Immunohistochemistry: Assay-Dependent
别名 :
AI326936; B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD antigen CD40; Cd40; CD40 antigen; CD40 antigen (TNF receptor superfamily member 5); CD40 antigen, TNF receptor superfamily member 5; CD40 molecule; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDw40; GP39; HIGM1; I79_006806; IGM; IMD3; Immunoglobulin M; ImmunoglobulinM; membrane protein CD40; MGC9013; p50; receptor for ligand CD154; sCD40; soluble CD40; T-BAM; T-cell differentiation antigen; Tnfrsf5; TRAP; tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国