产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45R (B220) Monoclonal Antibody (RA3-6B2), eBioscience™
目录 :
14-0452-85
规格 :
500µg
价格 :
美国223
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
RA3-6B2
反应物种 :
人类, 小鼠
应用 :
免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 其他
更多信息或购买 :
文章摘录数: 968
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠; 图 1b
Nagai M, Noguchi R, Takahashi D, Morikawa T, Koshida K, Komiyama S, et al. Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses. Cell. 2019;178:1072-1087.e14 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1a
Zhang J, Supakorndej T, Krambs J, Rao M, Abou Ezzi G, Ye R, et al. Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking. J Clin Invest. 2019;129:2920-2931 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:400; 图 e2j, 4g
Jacome Galarza C, Percin G, Muller J, Mass E, Lazarov T, Eitler J, et al. Developmental origin, functional maintenance and genetic rescue of osteoclasts. Nature. 2019;568:541-545 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6b
Marcandalli J, Fiala B, Ols S, Perotti M, De van der Schueren W, Snijder J, et al. Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus. Cell. 2019;176:1420-1431.e17 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1c
Rowe R, Lummertz da Rocha E, Sousa P, Missios P, Morse M, Marion W, et al. The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia. J Exp Med. 2019;216:527-538 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s3b
Nayar S, Campos J, Smith C, Iannizzotto V, Gardner D, Colafrancesco S, et al. Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome. Ann Rheum Dis. 2019;78:249-260 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 ev2c
Er J, Koean R, Ding J. Loss of T-bet confers survival advantage to influenza-bacterial superinfection. EMBO J. 2019;38: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 1e
Percin G, Eitler J, Kranz A, Fu J, Pollard J, Naumann R, et al. CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages. Nat Commun. 2018;9:5279 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5i
Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, et al. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol. 2018;19:189 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 2e
Bahmani B, Uehara M, Jiang L, Ordikhani F, Banouni N, Ichimura T, et al. Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival. J Clin Invest. 2018;128:4770-4786 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6c
Stephens J, Bailey J, Hang H, Rittell V, Dietrich M, Mynatt R, et al. Adipose Tissue Dysfunction Occurs Independently of Obesity in Adipocyte-Specific Oncostatin Receptor Knockout Mice. Obesity (Silver Spring). 2018;26:1439-1447 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 1c
Cao A, Alluqmani N, Buhari F, Wasim L, Smith L, Quaile A, et al. Galectin-9 binds IgM-BCR to regulate B cell signaling. Nat Commun. 2018;9:3288 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1c
Webster B, Werneke S, Zafirova B, This S, Coléon S, Decembre E, et al. Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses. elife. 2018;7: pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1e
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s5d
Donaldson G, Ladinsky M, Yu K, Sanders J, Yoo B, Chou W, et al. Gut microbiota utilize immunoglobulin A for mucosal colonization. Science. 2018;360:795-800 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Georgiev H, Ravens I, Papadogianni G, Halle S, Malissen B, Loots G, et al. Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches. Front Immunol. 2018;9:714 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3e
Harker J, Wong K, Dallari S, Bao P, Dolgoter A, Jo Y, et al. Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection. J Virol. 2018;92: pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1a
Kawano Y, Zavidij O, Park J, Moschetta M, Kokubun K, Mouhieddine T, et al. Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression. J Clin Invest. 2018;128:2487-2499 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s3
Safya H, Mellouk A, Legrand J, Le Gall S, Benbijja M, Kanellopoulos Langevin C, et al. Variations in Cellular Responses of Mouse T Cells to Adenosine-5'-Triphosphate Stimulation Do Not Depend on P2X7 Receptor Expression Levels but on Their Activation and Differentiation Stage. Front Immunol. 2018;9:360 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Bröker K, Figge J, Magnusen A, Manz R, Köhl J, Karsten C. A Novel Role for C5a in B-1 Cell Homeostasis. Front Immunol. 2018;9:258 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 1a
  • 流式细胞仪; 小鼠; 图 5b
Nadafi R, Koning J, Veninga H, Stachtea X, Konijn T, Zwiers A, et al. Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude. Front Immunol. 2018;9:206 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 4b
Kanayama M, Kato Y, Tsuji T, Konoeda Y, Hashimoto A, Kanauchi O, et al. Enhancement of immunomodulative effect of lactic acid bacteria on plasmacytoid dendritic cells with sucrose palmitate. Sci Rep. 2018;8:3147 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2d
Guarnerio J, Mendez L, Asada N, Menon A, Fung J, Berry K, et al. A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche. Nat Commun. 2018;9:66 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4c
Matsuo K, Nagakubo D, Yamamoto S, Shigeta A, Tomida S, Fujita M, et al. CCL28-Deficient Mice Have Reduced IgA Antibody-Secreting Cells and an Altered Microbiota in the Colon. J Immunol. 2018;200:800-809 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 3b
Medaglia C, Giladi A, Stoler Barak L, De Giovanni M, Salame T, Biram A, et al. Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq. Science. 2017;358:1622-1626 pubmed 出版商
  • 免疫组化; 小鼠; 图 s3a
Kortlever R, Sodir N, Wilson C, Burkhart D, Pellegrinet L, Brown Swigart L, et al. Myc Cooperates with Ras by Programming Inflammation and Immune Suppression. Cell. 2017;171:1301-1315.e14 pubmed 出版商
  • 流式细胞仪; 人类; 图 s2
Schwartz J, Ma J, Lamprecht T, Walsh M, Wang S, Bryant V, et al. The genomic landscape of pediatric myelodysplastic syndromes. Nat Commun. 2017;8:1557 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 7c
Minguet S, Kläsener K, Schaffer A, Fiala G, Osteso Ibanez T, Raute K, et al. Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance. Nat Immunol. 2017;18:1150-1159 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1c
Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, et al. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017;214:1471-1491 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Huang M, Zhang W, Guo J, Wei X, Phiwpan K, Zhang J, et al. Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation. Sci Rep. 2016;6:33612 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 表 1
  • 免疫细胞化学; 小鼠; 1:200; 表 1
Jackson Jones L, Duncan S, Magalhaes M, Campbell S, Maizels R, McSorley H, et al. Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation. Nat Commun. 2016;7:12651 pubmed 出版商
  • 流式细胞仪; 小鼠
He C, Duan X, Guo N, Chan C, Poon C, Weichselbaum R, et al. Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy. Nat Commun. 2016;7:12499 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1
Pizzolla A, Oh D, Luong S, Prickett S, Henstridge D, Febbraio M, et al. High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance. PLoS ONE. 2016;11:e0160407 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Terashima A, Okamoto K, Nakashima T, Akira S, Ikuta K, Takayanagi H. Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency. Immunity. 2016;44:1434-43 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 6
Goetz B, An W, Mohapatra B, Zutshi N, Iseka F, Storck M, et al. A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells. Oncotarget. 2016;7:51107-51123 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2b
Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, et al. The REGγ-proteasome forms a regulatory circuit with IκBÉ› and NFκB in experimental colitis. Nat Commun. 2016;7:10761 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200
Ludigs K, Jandus C, Utzschneider D, Staehli F, Bessoles S, Dang A, et al. NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nat Commun. 2016;7:10554 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 2
Aloulou M, Carr E, Gador M, Bignon A, Liblau R, Fazilleau N, et al. Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells. Nat Commun. 2016;7:10579 pubmed 出版商
  • 流式细胞仪; 小鼠
Maelfait J, Roose K, Vereecke L, Mc Guire C, Sze M, Schuijs M, et al. A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection. PLoS Pathog. 2016;12:e1005410 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 8
Duhan V, Khairnar V, Friedrich S, Zhou F, Gassa A, Honke N, et al. Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8(+) T-cell priming and viral control. Sci Rep. 2016;6:19191 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Caballero Franco C, Guma M, Choo M, Sano Y, Enzler T, Karin M, et al. Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38?-Dependent Restraint of NF-?B Signaling. J Immunol. 2016;196:2368-76 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Montufar Solis D, Klein J. Splenic Leukocytes Traffic to the Thyroid and Produce a Novel TSHβ Isoform during Acute Listeria monocytogenes Infection in Mice. PLoS ONE. 2016;11:e0146111 pubmed 出版商
  • 流式细胞仪; 人类; 图 s1a
Schulz A, Mälzer J, Domingo C, Jürchott K, Grützkau A, Babel N, et al. Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans. J Immunol. 2015;195:4699-711 pubmed 出版商
  • 免疫组化-冰冻切片; 人类
Sewald X, Ladinsky M, Uchil P, Beloor J, Pi R, Herrmann C, et al. Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Science. 2015;350:563-567 pubmed 出版商
  • 流式细胞仪; 小鼠
Pohar J, Lainšček D, Fukui R, Yamamoto C, Miyake K, Jerala R, et al. Species-Specific Minimal Sequence Motif for Oligodeoxyribonucleotides Activating Mouse TLR9. J Immunol. 2015;195:4396-405 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5b
Guo L, Huang Y, Chen X, Hu Li J, Urban J, Paul W. Innate immunological function of TH2 cells in vivo. Nat Immunol. 2015;16:1051-9 pubmed 出版商
  • 流式细胞仪; 小鼠
Yoon K, Byun S, Kwon E, Hwang S, Chu K, Hiraki M, et al. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015;349:1261669 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Fujimura N, Xu B, Dalman J, Deng H, Aoyama K, Dalman R. CCR2 inhibition sequesters multiple subsets of leukocytes in the bone marrow. Sci Rep. 2015;5:11664 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Saulep Easton D, Vincent F, Quah P, Wei A, Ting S, Croce C, et al. The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells. Leukemia. 2016;30:163-72 pubmed 出版商
  • 流式细胞仪; 小鼠
Zhang J, Li L, Baldwin A, Friedman A, Paz Priel I. Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells. PLoS ONE. 2015;10:e0130441 pubmed 出版商
  • 流式细胞仪; 小鼠
Xu G, Wu H, Zhang J, Li D, Wang Y, Wang Y, et al. Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med. 2015;87:15-25 pubmed 出版商
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Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523:337-41 pubmed 出版商
  • 流式细胞仪; 小鼠
Jacque E, Schweighoffer E, Tybulewicz V, Ley S. BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival. J Exp Med. 2015;212:883-92 pubmed 出版商
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Berent Maoz B, Montecino Rodriguez E, Fice M, Casero D, Seet C, Crooks G, et al. The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2). PLoS ONE. 2015;10:e0125414 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s1
Opata M, Carpio V, Ibitokou S, Dillon B, Obiero J, Stephens R. Early effector cells survive the contraction phase in malaria infection and generate both central and effector memory T cells. J Immunol. 2015;194:5346-54 pubmed 出版商
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Povinelli B, Kokolus K, Eng J, Dougher C, Curtin L, Capitano M, et al. Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells. PLoS ONE. 2015;10:e0120078 pubmed 出版商
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Wiesner D, Specht C, Lee C, Smith K, Mukaremera L, Lee S, et al. Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection. PLoS Pathog. 2015;11:e1004701 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s2
Hu W, Dooley J, Chung S, Chandramohan D, Cimmino L, Mukherjee S, et al. miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a. Blood. 2015;125:2206-16 pubmed 出版商
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Du J, Shen X, Hu X, Sun B, Guan W, Li S, et al. Wip1-deficient neutrophils significantly promote intestinal ischemia/reperfusion injury in mice. Curr Mol Med. 2015;15:100-8 pubmed
  • 流式细胞仪; 小鼠; 图 3
Cabrera Perez J, Condotta S, James B, Kashem S, Brincks E, Rai D, et al. Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. J Immunol. 2015;194:1609-20 pubmed 出版商
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Sullivan B, Teijaro J, de la Torre J, Oldstone M. Early virus-host interactions dictate the course of a persistent infection. PLoS Pathog. 2015;11:e1004588 pubmed 出版商
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Vettermann C, Timblin G, Lim V, Lai E, Schlissel M. The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination. PLoS ONE. 2015;10:e0113824 pubmed 出版商
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Tusi B, Deng C, Salz T, Zeumer L, Li Y, So C, et al. Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement. FASEB J. 2015;29:1505-15 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Krysiak K, Tibbitts J, Shao J, Liu T, Ndonwi M, Walter M. Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells. Exp Hematol. 2015;43:319-30.e10 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Karamitros D, Patmanidi A, Kotantaki P, Potocnik A, Bähr Ivacevic T, Benes V, et al. Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors. Development. 2015;142:70-81 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Guo X, Tanaka Y, Kondo M. Thymic precursors of TCRαβ(+)CD8αα(+) intraepithelial lymphocytes are negative for CD103. Immunol Lett. 2015;163:40-8 pubmed 出版商
  • 免疫组化; 小鼠; 1:400
Dabydeen S, Kang K, Díaz Cruz E, Alamri A, Axelrod M, Bouker K, et al. Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance. Carcinogenesis. 2015;36:122-32 pubmed 出版商
  • 流式细胞仪; 小鼠
Zanotti K, Maul R, Castiblanco D, Yang W, Choi Y, Fox J, et al. ATAD5 deficiency decreases B cell division and Igh recombination. J Immunol. 2015;194:35-42 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200
Peschke K, Dudeck A, Rabenhorst A, Hartmann K, Roers A. Cre/loxP-based mouse models of mast cell deficiency and mast cell-specific gene inactivation. Methods Mol Biol. 2015;1220:403-21 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 5
Morales D, Monte K, Sun L, Struckhoff J, Agapov E, Holtzman M, et al. Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice. J Virol. 2015;89:337-49 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3a
Becker A, Walcheck B, Bhattacharya D. ADAM17 limits the expression of CSF1R on murine hematopoietic progenitors. Exp Hematol. 2015;43:44-52.e1-3 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 3
Nagano T, Edamatsu H, Kobayashi K, Takenaka N, Yamamoto M, Sasaki N, et al. Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma. PLoS ONE. 2014;9:e108373 pubmed 出版商
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Denton A, Roberts E, Linterman M, Fearon D. Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells. Proc Natl Acad Sci U S A. 2014;111:12139-44 pubmed 出版商
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Pisano F, Heine W, Rosenheinrich M, Schweer J, Nuss A, Dersch P. Influence of PhoP and intra-species variations on virulence of Yersinia pseudotuberculosis during the natural oral infection route. PLoS ONE. 2014;9:e103541 pubmed 出版商
  • 流式细胞仪; 人类
Kläsener K, Maity P, Hobeika E, Yang J, Reth M. B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk. elife. 2014;3:e02069 pubmed 出版商
  • 流式细胞仪; 小鼠
Vogelzang A, Perdomo C, Zedler U, Kuhlmann S, Hurwitz R, Gengenbacher M, et al. Central memory CD4+ T cells are responsible for the recombinant Bacillus Calmette-Guérin ?ureC::hly vaccine's superior protection against tuberculosis. J Infect Dis. 2014;210:1928-37 pubmed 出版商
  • 流式细胞仪; 小鼠
Pastille E, Bardini K, Fleissner D, Adamczyk A, Frede A, Wadwa M, et al. Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer. Cancer Res. 2014;74:4258-69 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Alsadeq A, Hobeika E, Medgyesi D, Kläsener K, Reth M. The role of the Syk/Shp-1 kinase-phosphatase equilibrium in B cell development and signaling. J Immunol. 2014;193:268-76 pubmed 出版商
  • 流式细胞仪; 小鼠
Smolarchuk C, Zhu L, Chan W, Anderson C. T cells generated in the absence of a thoracic thymus fail to establish homeostasis. Eur J Immunol. 2014;44:2263-73 pubmed 出版商
  • 流式细胞仪; 小鼠
Vanoaica L, Richman L, Jaworski M, Darshan D, Luther S, Kühn L. Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations. PLoS ONE. 2014;9:e89270 pubmed 出版商
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Behnke M, Fentress S, Mashayekhi M, Li L, Taylor G, Sibley L. The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18. PLoS Pathog. 2012;8:e1002992 pubmed 出版商
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Chevrier S, Genton C, Malissen B, Malissen M, Acha Orbea H. Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells. Front Immunol. 2012;3:27 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
CD45R (B220) Monoclonal Antibody (RA3-6B2), eBioscience™
目录# :
14-0452-85
规格 :
500µg
价格 :
美国223
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
人类, 小鼠
应用 :
Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay-Dependent
物种 :
人类, 小鼠
克隆 :
RA3-6B2
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. Further, these CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. In addition to its role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. Diseases associated with CD45 dysfunction include Severe Combined Immunodeficiency (T-cell negative, B-Cell Negative) and Hepatitis C.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1 µg/test, Immunohistochemistry (Frozen): 5 µg/mL, Immunohistochemistry (Paraffin): 5 µg/mL, Immunoprecipitation: Assay-Dependent
别名 :
B220; BOS_16201; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; leucocyte common antigen; Leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国