产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD117 (c-Kit) Monoclonal Antibody (ACK2), eBioscience
目录 :
14-1172-81
规格 :
50微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
ACK2
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 157
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠
Ricci B, Tycksen E, Celik H, Belle J, Fontana F, Civitelli R, et al. Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics. elife. 2020;9: pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Zhang C, Yi W, Li F, Du X, Wang H, Wu P, et al. Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis. Cell Res. 2018;28:323-335 pubmed 出版商
  • 流式细胞仪; 人类; 图 3c
Freire A, Waghray A, Soares da Silva F, Resende T, Lee D, Pereira C, et al. Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate. Stem Cell Reports. 2017;9:136-148 pubmed 出版商
  • 流式细胞仪; 小鼠
Le Q, Yao W, Chen Y, Yan B, Liu C, Yuan M, et al. GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal. Cell Death Dis. 2016;7:e2478 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2d
Adachi E, Sakai K, Nishiuchi T, Imamura R, Sato H, Matsumoto K. Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma. Oncotarget. 2016;7:70779-70793 pubmed 出版商
  • 流式细胞仪; 人类
  • 流式细胞仪; 小鼠
Henry E, Sy C, Inclan Rico J, Espinosa V, Ghanny S, Dwyer D, et al. Carbonic anhydrase enzymes regulate mast cell-mediated inflammation. J Exp Med. 2016;213:1663-73 pubmed 出版商
  • 流式细胞仪; 小鼠
Lasigliè D, Boero S, Bauer I, Morando S, Damonte P, Cea M, et al. Sirt6 regulates dendritic cell differentiation, maturation, and function. Aging (Albany NY). 2016;8:34-49 pubmed
  • 流式细胞仪; 人类; 表 5
Hayashi Y, Bardsley M, Toyomasu Y, Milosavljevic S, Gajdos G, Choi K, et al. Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1. Gastroenterology. 2015;149:420-32.e16 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Wensveen F, Jelenčić V, Valentić S, Å estan M, Wensveen T, Theurich S, et al. NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 2015;16:376-85 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Krysiak K, Tibbitts J, Shao J, Liu T, Ndonwi M, Walter M. Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells. Exp Hematol. 2015;43:319-30.e10 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1
Wu X, Satpathy A, Kc W, Liu P, Murphy T, Murphy K. Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo. PLoS ONE. 2013;8:e64800 pubmed 出版商
  • 流式细胞仪; 小鼠
Velaga S, Herbrand H, Friedrichsen M, Jiong T, Dorsch M, Hoffmann M, et al. Chemokine receptor CXCR5 supports solitary intestinal lymphoid tissue formation, B cell homing, and induction of intestinal IgA responses. J Immunol. 2009;182:2610-9 pubmed 出版商
  • 流式细胞仪; 小鼠
Sheng H, Wang Y, Jin Y, Zhang Q, Zhang Y, Wang L, et al. A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res. 2008;18:846-57 pubmed 出版商
  • 流式细胞仪; 小鼠
Jeannet G, Scheller M, Scarpellino L, Duboux S, Gardiol N, Back J, et al. Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin. Blood. 2008;111:142-9 pubmed
  • 流式细胞仪; 小鼠; 1 ug/ml
Chen H, ORDOG T, Chen J, YOUNG D, Bardsley M, Redelman D, et al. Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine. Physiol Genomics. 2007;31:492-509 pubmed
  • 流式细胞仪; 小鼠; 1 ug/ml
Chen H, Redelman D, Ro S, Ward S, ORDOG T, Sanders K. Selective labeling and isolation of functional classes of interstitial cells of Cajal of human and murine small intestine. Am J Physiol Cell Physiol. 2007;292:C497-507 pubmed
Zhou Q, Zhang D, Zhang H, Wan X, Hu B, Zou Q, et al. Effects of Xiao Chengqi Formula on Slow Transit Constipation by Assessing Gut Microbiota and Metabolomics Analysis in vitro and in vivo. Front Pharmacol. 2022;13:864598 pubmed 出版商
Gentle I, Moelter I, Badr M, D xf6 hner K, L xfc bbert M, H xe4 cker G. The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression. Cell Death Dis. 2021;12:675 pubmed 出版商
Zhao R, Zuo Q, Yuan X, Jin K, Jin J, Ding Y, et al. Production of viable chicken by allogeneic transplantation of primordial germ cells induced from somatic cells. Nat Commun. 2021;12:2989 pubmed 出版商
Jin K, Zhou J, Zuo Q, Song J, Zhang Y, Chang G, et al. Transcriptome Sequencing and Comparative Analysis of Amphoteric ESCs and PGCs in Chicken (Gallus gallus). Animals (Basel). 2020;10: pubmed 出版商
Abd Elhafeez H, Abdo W, Kamal B, Soliman S. Fish telocytes and their relation to rodlet cells in ruby-red-fin shark (rainbow shark) Epalzeorhynchos frenatum (Teleostei: Cyprinidae). Sci Rep. 2020;10:18907 pubmed 出版商
Naka K, Ochiai R, Matsubara E, Kondo C, Yang K, Hoshii T, et al. The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2020;11:4681 pubmed 出版商
Jin K, Li D, Jin J, Song J, Zhang Y, Chang G, et al. C1EIP Functions as an Activator of ENO1 to Promote Chicken PGCs Formation via Inhibition of the Notch Signaling Pathway. Front Genet. 2020;11:751 pubmed 出版商
Abd Elhafeez H, Abou Elhamd A, Soliman S. Morphological and immunohistochemical phenotype of TCs in the intestinal bulb of Grass carp and their potential role in intestinal immunity. Sci Rep. 2020;10:14039 pubmed 出版商
Boichuk S, Galembikova A, Mikheeva E, Bikinieva F, Aukhadieva A, Dunaev P, et al. Inhibition of FGF2-Mediated Signaling in GIST-Promising Approach for Overcoming Resistance to Imatinib. Cancers (Basel). 2020;12: pubmed 出版商
Liu B, Xiao X, Zhou X, Zhou J, Lan L, Long X, et al. Effects of Lactobacillus plantarum CQPC01-fermented soybean milk on activated carbon-induced constipation through its antioxidant activity in mice. Food Sci Nutr. 2019;7:2068-2082 pubmed 出版商
Chen L, Zhang J, Suo H, Wang W, Wang H, Zhang Y, et al. Preventive Effects of Different Fermentation Times of Shuidouchi on Diphenoxylate-Induced Constipation in Mice. Foods. 2019;8: pubmed 出版商
Sun T, Li D, Hu S, Huang L, Sun H, Yang S, et al. Aging-dependent decrease in the numbers of enteric neurons, interstitial cells of Cajal and expression of connexin43 in various regions of gastrointestinal tract. Aging (Albany NY). 2018;10:3851-3865 pubmed 出版商
Kobayashi M, Khalil H, Lei N, Wang Q, Wang K, Wu B, et al. Bioengineering functional smooth muscle with spontaneous rhythmic contraction in vitro. Sci Rep. 2018;8:13544 pubmed 出版商
Gamage P, Patel B, Yeoman M, Ranson R, Saffrey M. Interstitial cell network volume is reduced in the terminal bowel of ageing mice. J Cell Mol Med. 2018;22:5160-5164 pubmed 出版商
Zhao J, An J, Liu S. Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1/CXCR4 and mSCF/Kit-ETV1 Pathways in the Stomach of Diabetic Mice. Evid Based Complement Alternat Med. 2018;2018:7878053 pubmed 出版商
Zeng H, Yu M, Tan H, Li Y, Su W, Shi H, et al. Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis. Sci Adv. 2018;4:eaar5701 pubmed 出版商
Chang C, Kuo C, Ito T, Su Y, Jiang S, Chiu M, et al. CK1? ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation. Proc Natl Acad Sci U S A. 2017;114:E8035-E8044 pubmed 出版商
Zhang C, Wang M, He N, Ahmed M, Wang Y, Zhao R, et al. Hsd3b2 associated in modulating steroid hormone synthesis pathway regulates the differentiation of chicken embryonic stem cells into spermatogonial stem cells. J Cell Biochem. 2018;119:1111-1121 pubmed 出版商
Géraud C, Koch P, Zierow J, Klapproth K, Busch K, Olsavszky V, et al. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017;127:1099-1114 pubmed 出版商
Tian L, Zhu B, Liu S. Electroacupuncture at ST36 Protects ICC Networks via mSCF/Kit-ETV1 Signaling in the Stomach of Diabetic Mice. Evid Based Complement Alternat Med. 2017;2017:3980870 pubmed 出版商
Qu J, Do D, Zhou Y, Luczak E, Mitzner W, Anderson M, et al. Oxidized CaMKII promotes asthma through the activation of mast cells. JCI Insight. 2017;2:e90139 pubmed 出版商
Shirai C, White B, Tripathi M, Tapia R, Ley J, Ndonwi M, et al. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun. 2017;8:14060 pubmed 出版商
Astuti Y, Kramer A, Blake A, Blazar B, Tolar J, Taisto M, et al. A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing. Stem Cell Reports. 2017;8:177-190 pubmed 出版商
Malysz J, Gibbons S, Saravanaperumal S, Du P, Eisenman S, Cao C, et al. Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca2+ transients and slow waves in adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2017;312:G228-G245 pubmed 出版商
Zhou Y, Copeland B, Otto Duessel M, He M, Markel S, Synold T, et al. Low Testosterone Alters the Activity of Mouse Prostate Stem Cells. Prostate. 2017;77:530-541 pubmed 出版商
Eisenman S, Gibbons S, Verhulst P, Cipriani G, Saur D, Farrugia G. Tumor necrosis factor alpha derived from classically activated "M1" macrophages reduces interstitial cell of Cajal numbers. Neurogastroenterol Motil. 2017;29: pubmed 出版商
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Zhu Y, Wang X, Parsons S, Huizinga J. Stimulus-induced pacemaker activity in interstitial cells of Cajal associated with the deep muscular plexus of the small intestine. Neurogastroenterol Motil. 2016;28:1064-74 pubmed 出版商
Cipriani G, Gibbons S, Verhulst P, Choi K, Eisenman S, Hein S, et al. Diabetic Csf1op/op mice lacking macrophages are protected against the development of delayed gastric emptying. Cell Mol Gastroenterol Hepatol. 2016;2:40-47 pubmed
Napier R, Norris B, Swimm A, Giver C, Harris W, Laval J, et al. Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity. PLoS Pathog. 2015;11:e1004770 pubmed 出版商
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Seifi M, Brown J, Mills J, Bhandari P, Belelli D, Lambert J, et al. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. J Neurosci. 2014;34:10361-78 pubmed 出版商
Male V, Nisoli I, Kostrzewski T, Allan D, Carlyle J, Lord G, et al. The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression. J Exp Med. 2014;211:635-42 pubmed 出版商
Kim T, Cavnar M, Cohen N, Sorenson E, Greer J, Seifert A, et al. Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor. Clin Cancer Res. 2014;20:2350-62 pubmed 出版商
Huizinga J, Chen J, Zhu Y, Pawelka A, McGinn R, Bardakjian B, et al. The origin of segmentation motor activity in the intestine. Nat Commun. 2014;5:3326 pubmed 出版商
Shin J, Hu W, Naramura M, Park C. High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias. J Exp Med. 2014;211:217-31 pubmed 出版商
Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun K, et al. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med. 2014;211:209-15 pubmed 出版商
Huang Z, Ruan H, Zhang Z, Chen W, Lin Z, Zeng H, et al. Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice. Am J Pathol. 2014;184:122-32 pubmed 出版商
Li X, Xue H, Kang Q, Sun H, Yang S, Zhang G, et al. Alterations of the interstitial cells of Cajal and the microstructure of the gastrointestinal tract in KIT distal kinase mutant mice. Cell Tissue Res. 2014;355:49-58 pubmed 出版商
Baba T, Naka K, Morishita S, Komatsu N, Hirao A, Mukaida N. MIP-1?/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia. J Exp Med. 2013;210:2661-73 pubmed 出版商
Langford Smith K, Sandiford Z, Langford Smith A, Wilkinson F, Jones S, Wraith J, et al. Signal one and two blockade are both critical for non-myeloablative murine HSCT across a major histocompatibility complex barrier. PLoS ONE. 2013;8:e77632 pubmed 出版商
Oh M, Oh S, Lu J, Lou H, Myers A, Zhu Z, et al. TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis. J Immunol. 2013;191:5371-82 pubmed 出版商
Wu C, Lin Y, Gao J, Winston J, Cheng L, Shi X. Are interstitial cells of Cajal involved in mechanical stress-induced gene expression and impairment of smooth muscle contractility in bowel obstruction?. PLoS ONE. 2013;8:e76222 pubmed 出版商
Yoshida A, Kato J, Nakamae I, Yoneda Kato N. COP1 targets C/EBP? for degradation and induces acute myeloid leukemia via Trib1. Blood. 2013;122:1750-60 pubmed 出版商
Xiang F, Lu X, Liu Y, Feng Q. Cardiomyocyte-specific overexpression of human stem cell factor protects against myocardial ischemia and reperfusion injury. Int J Cardiol. 2013;168:3486-94 pubmed 出版商
Fiedler K, Kokai E, Bresch S, Brunner C. MyD88 is involved in myeloid as well as lymphoid hematopoiesis independent of the presence of a pathogen. Am J Blood Res. 2013;3:124-40 pubmed
Michel A, Schuler A, Friedrich P, Döner F, Bopp T, Radsak M, et al. Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells. J Immunol. 2013;190:5534-44 pubmed 出版商
Lee J, Kim S, Kwon Y, Kim B, So I. Characteristics of the cholecystokinin-induced depolarization of pacemaking activity in cultured interstitial cells of Cajal from murine small intestine. Cell Physiol Biochem. 2013;31:542-54 pubmed 出版商
Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel Wahab O, et al. HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J Exp Med. 2013;210:339-53 pubmed 出版商
Cheng L, Hartmann K, Roers A, Krummel M, Locksley R. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013;38:166-75 pubmed 出版商
Viret C, Cresson C, Broccardo C, Guerder S. Retroviral transduction of lineage antigen-negative ((Lin?) cells: a valuable alternative for the generation of T cell receptor (TCR) retrogenic mice. J Immunol Methods. 2012;384:103-10 pubmed 出版商
Hashitani H, Mitsui R, Shimizu Y, Higashi R, Nakamura K. Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder. Br J Pharmacol. 2012;167:1723-36 pubmed 出版商
Smith K, Harcus Y, Garbi N, Hämmerling G, MacDonald A, Maizels R. Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion. Infect Immun. 2012;80:3481-9 pubmed 出版商
Tashiro K, Omori M, Kawabata K, Hirata N, Yamaguchi T, Sakurai F, et al. Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation. Stem Cells Dev. 2012;21:3381-90 pubmed 出版商
Kim B, Chang I, Choi S, Jun J, Jeon J, Xu W, et al. Involvement of Na(+)-leak channel in substance P-induced depolarization of pacemaking activity in interstitial cells of Cajal. Cell Physiol Biochem. 2012;29:501-10 pubmed 出版商
Smith D, Tan X, Raveendran V, Tawfik O, Stechschulte D, Dileepan K. Mast cell deficiency attenuates progression of atherosclerosis and hepatic steatosis in apolipoprotein E-null mice. Am J Physiol Heart Circ Physiol. 2012;302:H2612-21 pubmed 出版商
Ishii K, Kanatsu Shinohara M, Toyokuni S, Shinohara T. FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of Etv5 and Bcl6b through MAP2K1 activation. Development. 2012;139:1734-43 pubmed 出版商
Saran N, Pommerencke J, Witzlau K, Regelin M, Krueger A. Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117. PLoS ONE. 2012;7:e30864 pubmed 出版商
He X, Yang W, Wen X, Tang D, Xiao L, Han J, et al. Late embryonic and postnatal development of interstitial cells of cajal in mouse esophagus: distribution, proliferation and kit dependence. Cells Tissues Organs. 2012;196:175-88 pubmed 出版商
Treviño Villarreal J, Cotanche D, Sepúlveda R, Bortoni M, Manneberg O, Udagawa T, et al. Host-derived pericytes and Sca-1+ cells predominate in the MART-1- stroma fraction of experimentally induced melanoma. J Histochem Cytochem. 2011;59:1060-75 pubmed 出版商
Brickshawana A, Shapiro V, Kita H, Pease L. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol. 2011;187:5795-804 pubmed 出版商
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Lowie B, Wang X, White E, Huizinga J. On the origin of rhythmic calcium transients in the ICC-MP of the mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2011;301:G835-45 pubmed 出版商
Glotzbach J, Januszyk M, Vial I, Wong V, Gelbard A, Kalisky T, et al. An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells. PLoS ONE. 2011;6:e21211 pubmed 出版商
Mark Kappeler C, Sen N, Lukefahr A, McKee L, Sipes I, KONHILAS J, et al. Inhibition of ovarian KIT phosphorylation by the ovotoxicant 4-vinylcyclohexene diepoxide in rats. Biol Reprod. 2011;85:755-62 pubmed 出版商
Ding X, Lin Q, Ensenat Waser R, Rose John S, Zenke M. Polycomb group protein Bmi1 promotes hematopoietic cell development from embryonic stem cells. Stem Cells Dev. 2012;21:121-32 pubmed 出版商
Takaki M, Misawa H, Matsuyoshi H, Kawahara I, Goto K, Zhang G, et al. In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT4-receptor activation. Biochem Biophys Res Commun. 2011;406:529-33 pubmed 出版商
Sindrilaru A, Peters T, Wieschalka S, Baican C, Baican A, Peter H, et al. An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest. 2011;121:985-97 pubmed 出版商
Busche A, Schmitz S, Fleige H, Robbins S, Walzer T, Stewart C, et al. Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection. J Immunol. 2011;186:2918-25 pubmed 出版商
Zhou Y, He Y, Chen C, Ji J, Niu J, Wang H, et al. Time-specific blockade of PDGFR with Imatinib (Glivec®) causes cataract and disruption of lens fiber cells in neonatal mice. Virchows Arch. 2011;458:349-56 pubmed 出版商
Sasaki T, Mizuochi C, Horio Y, Nakao K, Akashi K, Sugiyama D. Regulation of hematopoietic cell clusters in the placental niche through SCF/Kit signaling in embryonic mouse. Development. 2010;137:3941-52 pubmed 出版商
Simon L, Ekman G, Garcia T, Carnes K, Zhang Z, Murphy T, et al. ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance. Stem Cells. 2010;28:1882-92 pubmed 出版商
Smith D, Tan X, Tawfik O, Milne G, Stechschulte D, Dileepan K. Increased aortic atherosclerotic plaque development in female apolipoprotein E-null mice is associated with elevated thromboxane A2 and decreased prostacyclin production. J Physiol Pharmacol. 2010;61:309-16 pubmed
Huang Y, Li F, Tong W, Zhang A, He Y, Fu T, et al. Hydrogen sulfide, a gaseous transmitter, stimulates proliferation of interstitial cells of Cajal via phosphorylation of AKT protein kinase. Tohoku J Exp Med. 2010;221:125-32 pubmed
Dixon R, Ramsey K, Schripsema J, Sanders K, Ward S. Time-dependent disruption of oviduct pacemaker cells by Chlamydia infection in mice. Biol Reprod. 2010;83:244-53 pubmed 出版商
Liu D, Wang F, Zou Z, Dong S, Wang J, Ran X, et al. Bone marrow derivation of interstitial cells of cajal in small intestine following intestinal injury. J Biomed Biotechnol. 2010;2010:164986 pubmed 出版商
Tong W, Jia H, Zhang L, Li C, Ridolfi T, Liu B. Exogenous stem cell factor improves interstitial cells of Cajal restoration after blockade of c-kit signaling pathway. Scand J Gastroenterol. 2010;45:844-51 pubmed 出版商
Kim B, Park K, Kim H, Choi S, Jun J, Chang I, et al. Identification of TRPM7 channels in human intestinal interstitial cells of Cajal. World J Gastroenterol. 2009;15:5799-804 pubmed
Kim Y, Suzuki H, Xu W, Hashitani H, Choi W, Yun H, et al. Voltage-dependent Ca Current Identified in Freshly Isolated Interstitial Cells of Cajal (ICC) of Guinea-pig Stomach. Korean J Physiol Pharmacol. 2008;12:323-30 pubmed 出版商
Tharayil V, Wouters M, Stanich J, Roeder J, Lei S, Beyder A, et al. Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo. Neurogastroenterol Motil. 2010;22:462-9, e109-10 pubmed 出版商
Onai N, Manz M, Schmid M. Isolation of common dendritic cell progenitors (CDP) from mouse bone marrow. Methods Mol Biol. 2010;595:195-203 pubmed 出版商
Ueda T, Yamada T, Hokuto D, Koyama F, Kasuda S, Kanehiro H, et al. Generation of functional gut-like organ from mouse induced pluripotent stem cells. Biochem Biophys Res Commun. 2010;391:38-42 pubmed 出版商
Han J, SHEN W, Jiang Y, Yu B, He Y, Li N, et al. Distribution, development and proliferation of interstitial cells of Cajal in murine colon: an immunohistochemical study from neonatal to adult life. Histochem Cell Biol. 2010;133:163-75 pubmed 出版商
Gaudenzio N, Espagnolle N, Mars L, Liblau R, Valitutti S, Espinosa E. Cell-cell cooperation at the T helper cell/mast cell immunological synapse. Blood. 2009;114:4979-88 pubmed 出版商
Kim Y, Suzuki H, Xu W, Choi W, Kim S, Lee S. Ca2+-activated K+ current in freshly isolated c-Kit positive cells in guinea-pig stomach. J Korean Med Sci. 2009;24:384-91 pubmed 出版商
Wouters M, Roeder J, Tharayil V, Stanich J, Strege P, Lei S, et al. Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem. 2009;284:21177-84 pubmed 出版商
Astrakhan A, Ochs H, Rawlings D. Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells. J Immunol. 2009;182:7370-80 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
CD117 (c-Kit) Monoclonal Antibody (ACK2), eBioscience
目录# :
14-1172-81
规格 :
50微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Flow Cytometry: 0.125 µg/test, Functional Assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000
物种 :
人类, 小鼠, 大鼠
克隆 :
ACK2
抗体亚型 :
IgG2b, kappa
储存 :
4° C
描述 :
KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.125 µg/test, Functional Assay: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000
别名 :
belly-spot; Bs; CD117; ckit; C-Kit; c-KIT gene1; c-kit protein; c-kit proto-oncogene protein; c-kit receptor; c-kit receptor tyrosine kinase; dominant spotting; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; KIT; kit oncogene; KIT proto-oncogene receptor tyrosine kinase; KIT proto-oncogene, receptor tyrosine kinase; mast cell growth factor receptor; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; MGF; p145 c-kit; PBT; Piebald trait protein; protein kinase; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; receptor tyrosine kinase c-kit; receptor tyrosine kinase type III; SCFR; SCO1; SCO5; Sl; soluble KIT variant 1; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-kit; tyrosine kinase receptor; tyrosine kinase receptor c-KIT; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; W
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国