产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
FOXP3 Monoclonal Antibody (NRRF-30), eBioscience
目录 :
14-4771-80
规格 :
25微克
价格 :
美国169
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
NRRF-30
反应物种 :
小鼠
应用 :
免疫印迹, 免疫组化, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, mass cytometry
更多信息或购买 :
文章摘录数: 49
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 3b
Zhou S, Wu W, Wang Z, Wang Z, Su Q, Li X, et al. RelB regulates the homeostatic proliferation but not the function of Tregs. BMC Immunol. 2020;21:37 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1b
Bergmann B, Fei Y, Jirholt P, Hu Z, Bergquist M, Ali A, et al. Pre-treatment with IL2 gene therapy alleviates Staphylococcus aureus arthritis in mice. BMC Infect Dis. 2020;20:185 pubmed 出版商
  • mass cytometry; 小鼠; 6 ug/ml; 图 5d
Guo C, Allen B, Hiam K, Dodd D, Van Treuren W, Higginbottom S, et al. Depletion of microbiome-derived molecules in the host using Clostridium genetics. Science. 2019;366: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 e5c
  • 流式细胞仪; 小鼠; 图 e5b
Yao W, Rose J, Wang W, Seth S, Jiang H, Taguchi A, et al. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature. 2019;: pubmed 出版商
  • 流式细胞仪; 小鼠; 图 1a
Mailer R, Gisterå A, Polyzos K, Ketelhuth D, Hansson G. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. Sci Rep. 2017;7:15655 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100
  • 流式细胞仪; 小鼠; 1:40
Maneva Radicheva L, Amatya C, Parker C, Ellefson J, Radichev I, Raghavan A, et al. Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1. PLoS ONE. 2014;9:e107213 pubmed 出版商
Boccasavia V, Bovolenta E, Villanueva A, Borroto A, Oeste C, van Santen H, et al. Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen. Cell Rep. 2021;34:108861 pubmed 出版商
Weinberg S, Singer B, Steinert E, Martinez C, Mehta M, Martínez Reyes I, et al. Mitochondrial complex III is essential for suppressive function of regulatory T cells. Nature. 2019;565:495-499 pubmed 出版商
Lee S, Park H, Cheon J, Wu L, Van Kaer L, Hong S. iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis. Front Immunol. 2018;9:2168 pubmed 出版商
He Y, Yuan X, Li Y, Zhong C, Liu Y, Qian H, et al. Loss of Gαq impairs regulatory B-cell function. Arthritis Res Ther. 2018;20:186 pubmed 出版商
Yoshida M, Taguchi A, Kawana K, Ogishima J, Adachi K, Kawata A, et al. Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity. Int J Oncol. 2018;53:1580-1590 pubmed 出版商
Park H, Lee S, Kwon D, Heo S, Park S, Kim S, et al. Oral administration of taheebo (Tabebuia avellanedae Lorentz ex Griseb.) water extract prevents DSS-induced colitis in mice by up-regulating type II T helper immune responses. BMC Complement Altern Med. 2017;17:448 pubmed 出版商
Lundberg V, Berglund M, Skogberg G, Lindgren S, Lundqvist C, Gudmundsdottir J, et al. Thymic exosomes promote the final maturation of thymocytes. Sci Rep. 2016;6:36479 pubmed 出版商
Chen Q, Xu L, Liang C, Wang C, Peng R, Liu Z. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nat Commun. 2016;7:13193 pubmed 出版商
Patel M, Kim J, Theodros D, Tam A, Velarde E, Kochel C, et al. Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma. J Immunother Cancer. 2016;4:28 pubmed 出版商
Pallangyo C, Ziegler P, Greten F. IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. J Exp Med. 2015;212:2253-66 pubmed 出版商
Ahn B, Kohanbash G, Ohkuri T, Kosaka A, Chen X, Ikeura M, et al. Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas. Oncoimmunology. 2015;4:e1047581 pubmed
Sanin D, Prendergast C, Bourke C, Mountford A. Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive. PLoS Pathog. 2015;11:e1004841 pubmed 出版商
Ohkuri T, Ghosh A, Kosaka A, Zhu J, Ikeura M, David M, et al. STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment. Cancer Immunol Res. 2014;2:1199-208 pubmed 出版商
Devaud C, Yong C, John L, Westwood J, Duong C, House C, et al. Foxp3 expression in macrophages associated with RENCA tumors in mice. PLoS ONE. 2014;9:e108670 pubmed 出版商
Surana R, Wang S, Xu W, Jablonski S, Weiner L. IL4 limits the efficacy of tumor-targeted antibody therapy in a murine model. Cancer Immunol Res. 2014;2:1103-12 pubmed 出版商
Kosaka A, Ohkuri T, Okada H. Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells. Cancer Immunol Immunother. 2014;63:847-57 pubmed 出版商
Eneljung T, Tengvall S, Jirholt P, Henningsson L, Holmdahl R, Gustafsson K, et al. Antigen-specific gene therapy after immunisation reduces the severity of collagen-induced arthritis. Clin Dev Immunol. 2013;2013:345092 pubmed 出版商
Wong L, HATFIELD J, Brown M. Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development. J Biol Chem. 2013;288:35170-9 pubmed 出版商
Yolcu E, Kaminitz A, Mizrahi K, Ash S, Yaniv I, Stein J, et al. Immunomodulation with donor regulatory T cells armed with Fas-ligand alleviates graft-versus-host disease. Exp Hematol. 2013;41:903-11 pubmed 出版商
Kaminitz A, Yolcu E, Mizrahi K, Shirwan H, Askenasy N. Killer Treg cells ameliorate inflammatory insulitis in non-obese diabetic mice through local and systemic immunomodulation. Int Immunol. 2013;25:485-94 pubmed 出版商
Amoah S, Holbrook B, Yammani R, Alexander Miller M. High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion. J Immunol. 2013;190:5020-9 pubmed 出版商
Kim M, Kim T. R-phycoerythrin-conjugated antibodies are inappropriate for intracellular staining of murine plasma cells. Cytometry A. 2013;83:452-60 pubmed 出版商
Tasso R, Ilengo C, Quarto R, Cancedda R, Caspi R, Pennesi G. Mesenchymal stem cells induce functionally active T-regulatory lymphocytes in a paracrine fashion and ameliorate experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2012;53:786-93 pubmed 出版商
Yarkoni S, Prigozhina T, Slavin S, Askenasy N. IL-2-targeted therapy ameliorates the severity of graft-versus-host disease: ex vivo selective depletion of host-reactive T cells and in vivo therapy. Biol Blood Marrow Transplant. 2012;18:523-35 pubmed 出版商
Whitehead G, Wilson R, Nakano K, Burch L, Nakano H, Cook D. IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease. J Allergy Clin Immunol. 2012;129:207-15.e1-5 pubmed 出版商
EGHTESAD S, Jhunjhunwala S, Little S, Clemens P. Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle. Mol Med. 2011;17:917-24 pubmed 出版商
Gupta G, Majumdar S, Adhikari A, Bhattacharya P, Mukherjee A, Majumdar S, et al. Treatment with IP-10 induces host-protective immune response by regulating the T regulatory cell functioning in Leishmania donovani-infected mice. Med Microbiol Immunol. 2011;200:241-53 pubmed 出版商
Kaminitz A, Yolcu E, Stein J, Yaniv I, Shirwan H, Askenasy N. Killer Treg restore immune homeostasis and suppress autoimmune diabetes in prediabetic NOD mice. J Autoimmun. 2011;37:39-47 pubmed 出版商
Fujita M, Kohanbash G, Fellows Mayle W, Hamilton R, Komohara Y, Decker S, et al. COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells. Cancer Res. 2011;71:2664-74 pubmed 出版商
Libregts S, van Olffen R, Van Der Sluijs K, van Lier R, Nolte M. Function of CD27 in helper T cell differentiation. Immunol Lett. 2011;136:177-86 pubmed 出版商
McCarl C, Khalil S, Ma J, Oh Hora M, Yamashita M, Roether J, et al. Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection. J Immunol. 2010;185:5845-58 pubmed 出版商
EGHTESAD S, Zheng H, Nakai H, Epperly M, Clemens P. Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity. Gene Ther. 2010;17:1181-90 pubmed 出版商
Batsalova T, Dzhambazov B, Klaczkowska D, Holmdahl R. Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis. J Immunol. 2010;185:2701-9 pubmed 出版商
Kaminitz A, Mizrahi K, Yaniv I, Stein J, Askenasy N. Immunosuppressive therapy exacerbates autoimmunity in NOD mice and diminishes the protective activity of regulatory T cells. J Autoimmun. 2010;35:145-52 pubmed 出版商
Fujita M, Scheurer M, Decker S, McDonald H, Kohanbash G, Kastenhuber E, et al. Role of type 1 IFNs in antiglioma immunosurveillance--using mouse studies to guide examination of novel prognostic markers in humans. Clin Cancer Res. 2010;16:3409-19 pubmed 出版商
Ueda R, Fujita M, Zhu X, Sasaki K, Kastenhuber E, Kohanbash G, et al. Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines. Clin Cancer Res. 2009;15:6551-9 pubmed 出版商
Sagiv Y, Kaminitz A, Lorberboum Galski H, Askenasy N, Yarkoni S. A fusion protein composed of IL-2 and caspase-3 ameliorates the outcome of experimental inflammatory colitis. Ann N Y Acad Sci. 2009;1173:791-7 pubmed 出版商
O Gorman W, Dooms H, Thorne S, Kuswanto W, Simonds E, Krutzik P, et al. The initial phase of an immune response functions to activate regulatory T cells. J Immunol. 2009;183:332-9 pubmed 出版商
van Olffen R, Koning N, van Gisbergen K, Wensveen F, Hoek R, Boon L, et al. GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo. J Immunol. 2009;182:7490-500 pubmed 出版商
Verhagen J, Gabrysová L, Minaee S, Sabatos C, Anderson G, Sharpe A, et al. Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease. Proc Natl Acad Sci U S A. 2009;106:3306-11 pubmed 出版商
Atarashi K, Mori T, Yoshiki R, Kabashima K, Kuma H, Tokura Y. Skin application of ketoprofen systemically suppresses contact hypersensitivity by inducing CD4(+) CD25(+) regulatory T cells. J Dermatol Sci. 2009;53:216-21 pubmed 出版商
de Zoeten E, Lee I, Wang L, Chen C, Ge G, Wells A, et al. Foxp3 processing by proprotein convertases and control of regulatory T cell function. J Biol Chem. 2009;284:5709-16 pubmed 出版商
Toubaji A, Hill S, Terabe M, Qian J, Floyd T, Simpson R, et al. The combination of GM-CSF and IL-2 as local adjuvant shows synergy in enhancing peptide vaccines and provides long term tumor protection. Vaccine. 2007;25:5882-91 pubmed
产品信息
产品类型 :
抗体
产品名称 :
FOXP3 Monoclonal Antibody (NRRF-30), eBioscience
目录# :
14-4771-80
规格 :
25微克
价格 :
美国169
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Immunohistochemistry (Frozen): 10 µg/mL, Western Blot: 10 µg/mL
物种 :
小鼠
克隆 :
NRRF-30
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Frozen): 10 µg/mL, Western Blot: 10 µg/mL
别名 :
AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国