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抗体

RIP3 Polyclonal Antibody, eBioscience™

14-6048-82

100微克

275美元

多克隆

domestic rabbit

未共轭

小鼠, 大鼠

免疫印迹, 免疫组化

RIP3 Polyclonal Antibody, eBioscience™

14-6048-82

100微克

275美元

多克隆

亲和色谱

兔

小鼠, 大鼠

Immunohistochemistry: Assay-Dependent, Western Blot: 0.5-4 µg/mL

小鼠, 大鼠

IgG

4° C

RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.

液体

Immunohistochemistry: Assay-Dependent, Western Blot: 0.5-4 µg/mL

2610528K09Rik; AW107945; Hcyp2; Homocysteine respondent protein HCYP2; mRIP3; receptor interacting protein 3; receptor interacting serine/threonine kinase 3; receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; receptor-interacting serine-threonine kinase 3; Rip3; RIP-3; Ripk3; RIP-like protein kinase 3