产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Bcl-2 Monoclonal Antibody (10C4), eBioscience
目录 :
14-6992-82
规格 :
100微克
价格 :
美国219
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
10C4
反应物种 :
小鼠, 大鼠
应用 :
免疫印迹, 免疫沉淀, 流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 13
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 6d
Visekruna A, Hartmann S, Sillke Y, Glauben R, Fischer F, Raifer H, et al. Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. J Clin Invest. 2019;129:1972-1983 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 5e
Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed 出版商
Rudak P, Choi J, Parkins K, Summers K, Jackson D, Foster P, et al. Chronic stress physically spares but functionally impairs innate-like invariant T cells. Cell Rep. 2021;35:108979 pubmed 出版商
Hosking M, Flynn C, Botten J, Whitton J. CD8+ memory T cells appear exhausted within hours of acute virus infection. J Immunol. 2013;191:4211-22 pubmed 出版商
Bezman N, Kim C, Sun J, Min oo G, Hendricks D, Kamimura Y, et al. Molecular definition of the identity and activation of natural killer cells. Nat Immunol. 2012;13:1000-9 pubmed 出版商
McFarland H, Puig M, Grajkowska L, Tsuji K, Lee J, Mason K, et al. Regulatory T cells in ? irradiation-induced immune suppression. PLoS ONE. 2012;7:e39092 pubmed 出版商
Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S. Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors. J Immunol. 2012;188:4838-45 pubmed 出版商
Wang X, Szymczak Workman A, Gravano D, Workman C, Green D, Vignali D. Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis. Cell Death Dis. 2012;3:e270 pubmed 出版商
Lawlor K, Smith S, van Nieuwenhuijze A, Huang D, Wicks I. Evaluation of the Bcl-2 family antagonist ABT-737 in collagen-induced arthritis. J Leukoc Biol. 2011;90:819-29 pubmed 出版商
Yewdall A, DRUTMAN S, Jinwala F, Bahjat K, Bhardwaj N. CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells. PLoS ONE. 2010;5:e11144 pubmed 出版商
Sgouroudis E, Albanese A, Piccirillo C. Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. J Immunol. 2008;181:6283-92 pubmed
GRATIOT DEANS J, Ding L, Turka L, Nunez G. bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation. J Immunol. 1993;151:83-91 pubmed
Hockenbery D, Nunez G, Milliman C, Schreiber R, Korsmeyer S. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature. 1990;348:334-6 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Bcl-2 Monoclonal Antibody (10C4), eBioscience
目录# :
14-6992-82
规格 :
100微克
价格 :
美国219
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
小鼠, 大鼠
应用 :
Flow Cytometry: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 0.5-10 µg/mL
物种 :
小鼠, 大鼠
克隆 :
10C4
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: 0.5-10 µg/mL
别名 :
apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国