产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-1 beta Monoclonal Antibody (B122), eBioscience
目录 :
14-7012-81
规格 :
50微克
价格 :
美国122
克隆性 :
单克隆
宿主 :
仓鼠
共轭标签 :
未共轭
克隆名称 :
B122
反应物种 :
小鼠, 大鼠
应用 :
酶联免疫吸附测定, 中和反应
更多信息或购买 :
文章摘录数: 36
出版应用/物种/样本/稀释 | 参考文献 |
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Xiao X, Kroemer A, Gao W, Ishii N, Demirci G, Li X. OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo. J Immunol. 2008;181:3193-201 pubmed
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Popov S, Popova G, Paderin N, Koval O, Ovodova R, Ovodov Y. Preventative antiinflammatory effect of potamogetonan, a pectin from the common pondweed Potamogeton natans L. Phytother Res. 2007;21:609-14 pubmed
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Hogquist K, Nett M, Sheehan K, Pendleton K, Schreiber R, Chaplin D. Generation of monoclonal antibodies to murine IL-1 beta and demonstration of IL-1 in vivo. J Immunol. 1991;146:1534-40 pubmed
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Rogers H, Sheehan K, Brunt L, Dower S, Unanue E, Schreiber R. Interleukin 1 participates in the development of anti-Listeria responses in normal and SCID mice. Proc Natl Acad Sci U S A. 1992;89:1011-5 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
IL-1 beta Monoclonal Antibody (B122), eBioscience
目录# :
14-7012-81
规格 :
50微克
价格 :
美国122
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
亚美尼亚仓鼠
反应物种 :
小鼠, 大鼠
应用 :
ELISA: 1-4 µg/mL, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
物种 :
小鼠, 大鼠
克隆 :
B122
抗体亚型 :
IgG
储存 :
4° C
描述 :
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
格式 :
液体
应用w/稀释 :
ELISA: 1-4 µg/mL, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
别名 :
catabolin; cytokine; Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; IL-1B; IL1B1; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; Interleukin 1 beta precursor; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; interleukin*1*beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1b; interleukin-1beta; interleukin-beta; LAF; lymphocyte proliferation-potentiating factor; Osteoclast activating factor (OAF); preinterleukin 1 beta; Pro interleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta
更多信息或购买 :
公司信息
赛默飞世尔
产品浏览
- IL-1 beta Monoclonal Antibody (B122), eBioscience | 14-7012-85
- IL-1 beta Monoclonal Antibody (CRM56), eBioscience | 14-7018-81
- IL-1 beta Monoclonal Antibody (CRM56), eBioscience | 14-7018-85
- IL-2 Monoclonal Antibody (JES6-5H4), eBioscience | 14-7021-81
- IL-2 Monoclonal Antibody (JES6-5H4), eBioscience | 14-7021-85
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