产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-4 Monoclonal Antibody (MP4-25D2), eBioscience™
目录 :
14-7048-85
规格 :
500µg
价格 :
美国247
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
MP4-25D2
反应物种 :
人类
应用 :
流式细胞仪, 抑制或激活实验
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 37
出版应用/物种/样本/稀释参考文献
  • 抑制或激活实验; 人类; 10 ug/ml
Deng N, Weaver J, Mosmann T. Cytokine diversity in the Th1-dominated human anti-influenza response caused by variable cytokine expression by Th1 cells, and a minor population of uncommitted IL-2+IFN?- Thpp cells. PLoS ONE. 2014;9:e95986 pubmed 出版商
  • 流式细胞仪; 人类; 图 7b
Svajger U, Obermajer N, Jeras M. IFN-?-rich environment programs dendritic cells toward silencing of cytotoxic immune responses. J Leukoc Biol. 2014;95:33-46 pubmed 出版商
  • 流式细胞仪; 人类
Gironi M, Saresella M, Rovaris M, Vaghi M, Nemni R, Clerici M, et al. A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis. Immun Ageing. 2013;10:1 pubmed 出版商
  • 流式细胞仪; 人类; 图 1C
Yamada H, Nakashima Y, Okazaki K, Mawatari T, Fukushi J, Kaibara N, et al. Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis. Ann Rheum Dis. 2008;67:1299-304 pubmed
  • 抑制或激活实验; 人类; 5 ug/ml
De Fanis U, Mori F, Kurnat R, Lee W, Bova M, Adkinson N, et al. GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. Blood. 2007;109:4343-50 pubmed
Doh K, Kim B, Kim K, Chung B, Yang C. Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression. BMC Complement Altern Med. 2019;19:54 pubmed 出版商
Anuradha R, Munisankar S, Bhootra Y, Dolla C, Kumaran P, Nutman T, et al. Modulation of CD4+ and CD8+ T Cell Function and Cytokine Responses in Strongyloides stercoralis Infection by Interleukin-27 (IL-27) and IL-37. Infect Immun. 2017;85: pubmed 出版商
Massoud A, Charbonnier L, Lopez D, Pellegrini M, Phipatanakul W, Chatila T. An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells. Nat Med. 2016;22:1013-22 pubmed 出版商
Bharadwaj A, Schewitz Bowers L, Wei L, Lee R, Smith J. Intercellular adhesion molecule 1 mediates migration of Th1 and Th17 cells across human retinal vascular endothelium. Invest Ophthalmol Vis Sci. 2013;54:6917-25 pubmed 出版商
Blom L, Poulsen L. In vitro Th1 and Th2 cell polarization is severely influenced by the initial ratio of naïve and memory CD4+ T cells. J Immunol Methods. 2013;397:55-60 pubmed 出版商
Sato T, Kitawaki T, Fujita H, Iwata M, Iyoda T, Inaba K, et al. Human CD1c? myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D?. J Immunol. 2013;191:3152-60 pubmed 出版商
Asgari E, Le Friec G, Yamamoto H, Perucha E, Sacks S, Köhl J, et al. C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. Blood. 2013;122:3473-81 pubmed 出版商
Yan R, Zhong W, Zhu Y, Zhang X. Trichosanthin-stimulated dendritic cells induce a type 2 helper T lymphocyte response through the OX40 ligand. J Investig Allergol Clin Immunol. 2012;22:491-500 pubmed
Blom L, Poulsen L. IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures. J Immunol. 2012;189:4331-7 pubmed 出版商
Chung B, Kim K, Kim B, Piao S, Lim S, Choi B, et al. Dysregulation of Th17 cells during the early post-transplant period in patients under calcineurin inhibitor based immunosuppression. PLoS ONE. 2012;7:e42011 pubmed 出版商
Gaspar Ramírez O, Pérez Vázquez F, Pruneda Álvarez L, Orta García S, Gonzalez Amaro R, Pérez Maldonado I. Effect of polychlorinated biphenyls 118 and 153 on Th1/Th2 cells differentiation. Immunopharmacol Immunotoxicol. 2012;34:627-32 pubmed 出版商
Hansmann L, Schmidl C, Kett J, Steger L, Andreesen R, Hoffmann P, et al. Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression. J Immunol. 2012;188:1275-82 pubmed 出版商
Simhadri V, Mariano J, Zhou Q, DeBell K, Borrego F. Differential expression of CD300a/c on human TH1 and TH17 cells. BMC Immunol. 2011;12:62 pubmed 出版商
Divekar A, Khanna D, Abtin F, Maranian P, Saggar R, Saggar R, et al. Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosis. Clin Immunol. 2011;141:293-303 pubmed 出版商
Chung B, Kim K, Sun I, Choi S, Park H, Jeon E, et al. Increased interleukin-17 producing effector memory T cells in the end-stage renal disease patients. Immunol Lett. 2012;141:181-9 pubmed 出版商
Blom L, Poulsen B, Jensen B, Hansen A, Poulsen L. IL-33 induces IL-9 production in human CD4+ T cells and basophils. PLoS ONE. 2011;6:e21695 pubmed 出版商
Tjin E, Konijnenberg D, Krebbers G, Mallo H, Drijfhout J, Franken K, et al. T-cell immune function in tumor, skin, and peripheral blood of advanced stage melanoma patients: implications for immunotherapy. Clin Cancer Res. 2011;17:5736-47 pubmed 出版商
Kalache S, Dinavahi R, Pinney S, Mehrotra A, Cunningham M, Heeger P. Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients. J Immunol. 2011;187:1023-30 pubmed 出版商
Stephens G, Swerdlow B, Benjamin E, Coyle A, Humbles A, Kolbeck R, et al. IL-9 is a Th17-derived cytokine that limits pathogenic activity in organ-specific autoimmune disease. Eur J Immunol. 2011;41:952-62 pubmed 出版商
James E, Van Haren S, Ettinger R, Fijnvandraat K, Liberman J, Kwok W, et al. T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site. J Thromb Haemost. 2011;9:689-99 pubmed 出版商
Saresella M, Calabrese E, Marventano I, Piancone F, Gatti A, Alberoni M, et al. Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer's disease. Brain Behav Immun. 2011;25:539-47 pubmed 出版商
Yadav M, Liebau E, Haldar C, Rathaur S. Identification of major antigenic peptide of filarial glutathione-S-transferase. Vaccine. 2011;29:1297-303 pubmed 出版商
Narayanan S, Silva R, Peruzzi G, Alvarez Y, Simhadri V, DeBell K, et al. Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. PLoS ONE. 2010;5:e10636 pubmed 出版商
Colin E, Asmawidjaja P, van Hamburg J, Mus A, van Driel M, Hazes J, et al. 1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum. 2010;62:132-42 pubmed 出版商
Wang J, Huizinga T, Toes R. De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid. J Immunol. 2009;183:4119-26 pubmed 出版商
Jain P, Manuel S, Khan Z, Ahuja J, Quann K, Wigdahl B. DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells. J Virol. 2009;83:10908-21 pubmed 出版商
Kaminuma O, Kitamura F, Miyatake S, Yamaoka K, Miyoshi H, Inokuma S, et al. T-box 21 transcription factor is responsible for distorted T(H)2 differentiation in human peripheral CD4+ T cells. J Allergy Clin Immunol. 2009;123:813-23.e3 pubmed 出版商
Suzukawa M, Iikura M, Koketsu R, Nagase H, Tamura C, Komiya A, et al. An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor. J Immunol. 2008;181:5981-9 pubmed
Hartigan O Connor D, Abel K, McCune J. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med. 2007;204:2679-92 pubmed
Soler D, Chapman T, Poisson L, Wang L, Cote Sierra J, Ryan M, et al. CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J Immunol. 2006;177:6940-51 pubmed
Ramanathan L, Ingram R, Sullivan L, Greenberg R, Reim R, Trotta P, et al. Immunochemical mapping of domains in human interleukin 4 recognized by neutralizing monoclonal antibodies. Biochemistry. 1993;32:3549-56 pubmed
Abrams J, Roncarolo M, Yssel H, Andersson U, Gleich G, Silver J. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol Rev. 1992;127:5-24 pubmed
产品信息
产品类型 :
抗体
产品名称 :
IL-4 Monoclonal Antibody (MP4-25D2), eBioscience™
目录# :
14-7048-85
规格 :
500µg
价格 :
美国247
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
人类
应用 :
Flow Cytometry: Assay-Dependent
物种 :
人类
克隆 :
MP4-25D2
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-Dependent
别名 :
B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; Binetrakin; BOS_7769; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; Il4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; Interleukin4; Interleukin-4; interleukin-4 precursor; Lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国