产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-17A Monoclonal Antibody (eBio64CAP17), eBioscience™
目录 :
14-7178-85
规格 :
500µg
价格 :
美国258
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
eBio64CAP17
反应物种 :
African green monkey, 人类, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 100
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 s4c
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  • 流式细胞仪; 人类; 1:100; 图 5h
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  • 酶联免疫吸附测定; 人类; 图 1
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  • 流式细胞仪; African green monkey; 图 1e
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  • 流式细胞仪; 猕猴; 图 1b
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  • 流式细胞仪; 人类; 图 2
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  • 流式细胞仪; 人类
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  • 流式细胞仪; 人类
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  • 流式细胞仪; 人类; 图 1d
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  • 流式细胞仪; African green monkey; 图 s1c
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  • 流式细胞仪; 人类; 1:50; 图 1
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  • 流式细胞仪; 猕猴
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  • 流式细胞仪; 人类
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Wu Q, Wang Q, Mao G, Dowling C, Lundy S, Mao Draayer Y. Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients. J Immunol. 2017;198:3069-3080 pubmed 出版商
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Liang D, Hou Y, Luo L, Ao L. Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis. Int J Mol Med. 2016;38:131-8 pubmed 出版商
Fu D, Song X, Hu H, Sun M, Li Z, Tian Z. Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis. Mol Med Rep. 2016;13:4606-12 pubmed 出版商
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Jonker M, Wubben J, Haanstra K, Vierboom M, t Hart B. Comparative analysis of inflammatory infiltrates in collagen-induced arthritis, kidney graft rejection and delayed-type hypersensitivity in non-human primates. Inflamm Res. 2013;62:181-94 pubmed 出版商
Jasny E, Geer S, Frank I, Vagenas P, Aravantinou M, Salazar A, et al. Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy. J Acquir Immune Defic Syndr. 2012;61:425-35 pubmed 出版商
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Ryan Payseur B, Frencher J, Shen L, Chen C, Huang D, Chen Z. Multieffector-functional immune responses of HMBPP-specific V?2V?2 T cells in nonhuman primates inoculated with Listeria monocytogenes ?actA prfA*. J Immunol. 2012;189:1285-93 pubmed 出版商
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Hebel K, Rudolph M, Kosak B, Chang H, Butzmann J, Brunner Weinzierl M. IL-1? and TGF-? act antagonistically in induction and differentially in propagation of human proinflammatory precursor CD4+ T cells. J Immunol. 2011;187:5627-35 pubmed 出版商
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Ryan Payseur B, Ali Z, Huang D, Chen C, Yan L, Wang R, et al. Virus infection stages and distinct Th1 or Th17/Th22 T-cell responses in malaria/SHIV coinfection correlate with different outcomes of disease. J Infect Dis. 2011;204:1450-62 pubmed 出版商
Gehring A, Koh S, Chia A, Paramasivam K, Chew V, Ho Z, et al. Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection. PLoS ONE. 2011;6:e23330 pubmed 出版商
Lee J, Chang Y, Lai W, Ko J, Kuo M, Chiang C, et al. Increased prevalence of interleukin-17-producing CD4(+) tumor infiltrating lymphocytes in human oral squamous cell carcinoma. Head Neck. 2011;33:1301-8 pubmed 出版商
Morbach H, Wiegering V, Richl P, Schwarz T, Suffa N, Eichhorn E, et al. Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis. Arthritis Rheum. 2011;63:3458-66 pubmed 出版商
Tjin E, Konijnenberg D, Krebbers G, Mallo H, Drijfhout J, Franken K, et al. T-cell immune function in tumor, skin, and peripheral blood of advanced stage melanoma patients: implications for immunotherapy. Clin Cancer Res. 2011;17:5736-47 pubmed 出版商
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Kalache S, Dinavahi R, Pinney S, Mehrotra A, Cunningham M, Heeger P. Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients. J Immunol. 2011;187:1023-30 pubmed 出版商
Li L, Qiao D, Fu X, Lao S, Zhang X, Wu C. Identification of Mycobacterium tuberculosis-specific Th1, Th17 and Th22 cells using the expression of CD40L in tuberculous pleurisy. PLoS ONE. 2011;6:e20165 pubmed 出版商
Li Z, Wu F, Brant S, Kwon J. IL-23 receptor regulation by Let-7f in human CD4+ memory T cells. J Immunol. 2011;186:6182-90 pubmed 出版商
Furuzawa Carballeda J, Lima G, Jakez Ocampo J, Llorente L. Indoleamine 2,3-dioxygenase-expressing peripheral cells in rheumatoid arthritis and systemic lupus erythematosus: a cross-sectional study. Eur J Clin Invest. 2011;41:1037-46 pubmed 出版商
James E, Van Haren S, Ettinger R, Fijnvandraat K, Liberman J, Kwok W, et al. T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site. J Thromb Haemost. 2011;9:689-99 pubmed 出版商
Dusseaux M, Martin E, Serriari N, Peguillet I, Premel V, Louis D, et al. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood. 2011;117:1250-9 pubmed 出版商
Snyder Cappione J, Tincati C, Eccles James I, Cappione A, Ndhlovu L, Koth L, et al. A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-? and MIP1-?, a lack of IL-17, and a Th1-bias in males. PLoS ONE. 2010;5:e15412 pubmed 出版商
Vagenas P, Aravantinou M, Williams V, Jasny E, Piatak M, Lifson J, et al. A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation. PLoS ONE. 2010;5:e12891 pubmed 出版商
DeForge L, Loyet K, Delarosa D, Chinn J, Zamanian F, Chuntharapai A, et al. Evaluation of heterophilic antibody blocking agents in reducing false positive interference in immunoassays for IL-17AA, IL-17FF, and IL-17AF. J Immunol Methods. 2010;362:70-81 pubmed 出版商
Harris L, Klatt N, Vinton C, Briant J, Tabb B, Ladell K, et al. Mechanisms underlying ?? T-cell subset perturbations in SIV-infected Asian rhesus macaques. Blood. 2010;116:4148-57 pubmed 出版商
Ikeda U, Wakita D, Ohkuri T, Chamoto K, Kitamura H, Iwakura Y, et al. 1?,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells. Immunol Lett. 2010;134:7-16 pubmed 出版商
Ersvaer E, Liseth K, Skavland J, Gjertsen B, Bruserud Ø. Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. BMC Immunol. 2010;11:38 pubmed 出版商
Kagina B, Abel B, Scriba T, Hughes E, Keyser A, Soares A, et al. Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns. Am J Respir Crit Care Med. 2010;182:1073-9 pubmed 出版商
Oseroff C, Sidney J, Kotturi M, Kolla R, Alam R, Broide D, et al. Molecular determinants of T cell epitope recognition to the common Timothy grass allergen. J Immunol. 2010;185:943-55 pubmed 出版商
Ness Schwickerath K, Jin C, Morita C. Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells. J Immunol. 2010;184:7268-80 pubmed 出版商
von Vietinghoff S, Ouyang H, Ley K. Mycophenolic acid suppresses granulopoiesis by inhibition of interleukin-17 production. Kidney Int. 2010;78:79-88 pubmed 出版商
Klatt N, Harris L, Vinton C, Sung H, Briant J, Tabb B, et al. Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. Mucosal Immunol. 2010;3:387-98 pubmed 出版商
Blatner N, Bonertz A, Beckhove P, Cheon E, Krantz S, Strouch M, et al. In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction. Proc Natl Acad Sci U S A. 2010;107:6430-5 pubmed 出版商
Kawamoto K, Pahuja A, Hering B, Bansal Pakala P. Transforming growth factor beta 1 (TGF-beta1) and rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3+ Tregs. Transpl Immunol. 2010;23:28-33 pubmed 出版商
Yao S, Huang D, Chen C, Halliday L, Zeng G, Wang R, et al. Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis. PLoS Pathog. 2010;6:e1000789 pubmed 出版商
Chaudhary N, Staab J, Marr K. Healthy human T-Cell Responses to Aspergillus fumigatus antigens. PLoS ONE. 2010;5:e9036 pubmed 出版商
Jeffery L, Burke F, Mura M, Zheng Y, Qureshi O, Hewison M, et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol. 2009;183:5458-67 pubmed 出版商
Kap Y, van Meurs M, van Driel N, Koopman G, Melief M, Brok H, et al. A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. J Histochem Cytochem. 2009;57:1159-67 pubmed 出版商
van den Boorn J, Konijnenberg D, Dellemijn T, van der Veen J, Bos J, Melief C, et al. Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients. J Invest Dermatol. 2009;129:2220-32 pubmed 出版商
Agrati C, Cimini E, Sacchi A, Bordoni V, Gioia C, Casetti R, et al. Activated V gamma 9V delta 2 T cells trigger granulocyte functions via MCP-2 release. J Immunol. 2009;182:522-9 pubmed
Kleinewietfeld M, Starke M, Di Mitri D, Borsellino G, Battistini L, Rotzschke O, et al. CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells. Blood. 2009;113:827-36 pubmed 出版商
Roses R, Xu S, Xu M, Koldovsky U, Koski G, Czerniecki B. Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists. J Immunol. 2008;181:5120-7 pubmed
Miyazaki Y, Iwabuchi K, Kikuchi S, Fukazawa T, Niino M, Hirotani M, et al. Expansion of CD4+CD28- T cells producing high levels of interferon-{gamma} in peripheral blood of patients with multiple sclerosis. Mult Scler. 2008;14:1044-55 pubmed 出版商
Jasny E, Eisenblatter M, Mätz Rensing K, Tenner Racz K, Tenbusch M, Schrod A, et al. IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation. J Immunol. 2008;180:6629-39 pubmed
Scriba T, Kalsdorf B, Abrahams D, Isaacs F, Hofmeister J, Black G, et al. Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response. J Immunol. 2008;180:1962-70 pubmed
Coury F, Annels N, Rivollier A, Olsson S, Santoro A, Speziani C, et al. Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. Nat Med. 2008;14:81-7 pubmed
Lim H, Lee J, Hillsamer P, Kim C. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J Immunol. 2008;180:122-9 pubmed
Chen Z, Tato C, Muul L, Laurence A, O Shea J. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 2007;56:2936-46 pubmed
Patel D, King C, Bailey S, Holt J, Venkatachalam K, Agrawal A, et al. Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation. J Biol Chem. 2007;282:27229-38 pubmed
产品信息
产品类型 :
抗体
产品名称 :
IL-17A Monoclonal Antibody (eBio64CAP17), eBioscience™
目录# :
14-7178-85
规格 :
500µg
价格 :
美国258
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: 0.5-2 µg/mL, Flow Cytometry: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay Dependent
物种 :
人类
克隆 :
eBio64CAP17
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
格式 :
液体
应用w/稀释 :
ELISA: 0.5-2 µg/mL, Flow Cytometry: Assay-Dependent, Immunohistochemistry (Frozen): Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay Dependent
别名 :
BOS_21471; CTLA8; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; IL17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A; interleukin 17A-like; interleukin-17; Interleukin17A; Interleukin-17A; LOC100339322; R-IL-17-A
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国