产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-17A Monoclonal Antibody (eBio64DEC17), eBioscience™
目录 :
14-7179-95
规格 :
10毫克
价格 :
3000.00美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
eBio64DEC17
反应物种 :
人类
应用 :
酶联免疫吸附测定, 免疫组化, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 45
参考文献
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Rainard P, Cunha P, Ledresseur M, Staub C, Touzé J, Kempf F, et al. Antigen-Specific Mammary Inflammation Depends on the Production of IL-17A and IFN-γ by Bovine CD4+ T Lymphocytes. PLoS ONE. 2015;10:e0137755 pubmed 出版商
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Wang W, Yen M, Liu K, Hsu P, Lin M, Chen P, et al. Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses. Stem Cell Reports. 2015;5:392-404 pubmed 出版商
van Meijgaarden K, Haks M, Caccamo N, Dieli F, Ottenhoff T, Joosten S. Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset. PLoS Pathog. 2015;11:e1004671 pubmed 出版商
Van Eyck L, De Somer L, Pombal D, Bornschein S, Frans G, Humblet Baron S, et al. Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency. Arthritis Rheumatol. 2015;67:1592-7 pubmed 出版商
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Zhong H, Bao W, Friedman D, Yazdanbakhsh K. Hemin controls T cell polarization in sickle cell alloimmunization. J Immunol. 2014;193:102-10 pubmed 出版商
Macleod A, Rudolph R, Corriden R, Ye I, Garijo O, Havran W. Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. J Immunol. 2014;192:5695-702 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
IL-17A Monoclonal Antibody (eBio64DEC17), eBioscience™
目录# :
14-7179-95
规格 :
10毫克
价格(美元) :
3000.00美元
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA:依实验方法而定, 免疫组化(冷冻):依实验方法而定
物种 :
人类
克隆 :
eBio64DEC17
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
格式 :
液体
应用w/稀释 :
ELISA:依实验方法而定, 免疫组化(冷冻):依实验方法而定
别名 :
CTLA8; Ctla-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; Il17a; IL-17A; ILN; Interleukin; interleukin 17; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin 17A-like; interleukin-17; Interleukin17A; interleukin-17A; LOC100339322; R-IL-17-A
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国