产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
GM-CSF Monoclonal Antibody (MP1-22E9), eBioscience™
目录 :
14-7331-81
规格 :
50微克
价格 :
美国114
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
MP1-22E9
反应物种 :
小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 35
出版应用/物种/样本/稀释参考文献
  • 酶联免疫吸附测定; 小鼠; 图 7d
Akgul A, Maddaloni M, Jun S, Nelson A, Odreman V, Hoffman C, et al. Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren's syndrome. Arthritis Res Ther. 2021;23:99 pubmed 出版商
  • 流式细胞仪; 小鼠
Hamminger P, Marchetti L, Preglej T, Platzer R, Zhu C, Kamnev A, et al. Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. J Autoimmun. 2021;119:102610 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠; 图 3D
Arellano B, Hussain R, Miller Little W, Herndon E, Lambracht Washington D, Eagar T, et al. A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB1*03:01 by a Murine TCR. PLoS ONE. 2016;11:e0152720 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
McWilliams I, Rajbhandari R, Nozell S, BENVENISTE E, Harrington L. STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE. J Neuroinflammation. 2015;12:128 pubmed 出版商
Spiljar M, Steinbach K, Rigo D, Su xe1 rez Zamorano N, Wagner I, Hadadi N, et al. Cold exposure protects from neuroinflammation through immunologic reprogramming. Cell Metab. 2021;33:2231-2246.e8 pubmed 出版商
Hauptmann J, Johann L, Marini F, Kitic M, Colombo E, Mufazalov I, et al. Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier. Acta Neuropathol. 2020;140:549-567 pubmed 出版商
Zhou L, Chu C, Teng F, Bessman N, Goc J, Santosa E, et al. Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature. 2019;568:405-409 pubmed 出版商
Giles D, Duncker P, Wilkinson N, Washnock Schmid J, Segal B. CNS-resident classical DCs play a critical role in CNS autoimmune disease. J Clin Invest. 2018;128:5322-5334 pubmed 出版商
Manresa Arraut A, Johansen F, Brakebusch C, Issazadeh Navikas S, Hasseldam H. RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis. Front Immunol. 2018;9:1235 pubmed 出版商
Wildes T, Grippin A, Dyson K, Wummer B, Damiani D, Abraham R, et al. Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma. Clin Cancer Res. 2018;24:3955-3966 pubmed 出版商
Brenot A, Knolhoff B, DeNardo D, Longmore G. SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion. Oncogenesis. 2018;7:32 pubmed 出版商
Meier L, Auger J, Engelson B, Cowan H, Breed E, Gonzalez Torres M, et al. CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis. Circulation. 2018;137:2478-2493 pubmed 出版商
Goldman N, Lomakova Y, Londregan J, Bucknum A, DePierri K, Somerville J, et al. High macrophage PD-L1 expression not responsible for T cell suppression. Cell Immunol. 2018;324:50-58 pubmed 出版商
Duncker P, Stoolman J, Huber A, Segal B. GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System-Infiltrating Cells, but Is Dispensable for Disease Induction. J Immunol. 2018;200:966-973 pubmed 出版商
Rothchild A, Stowell B, Goyal G, Nunes Alves C, Yang Q, Papavinasasundaram K, et al. Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection. MBio. 2017;8: pubmed 出版商
Anzai A, Choi J, He S, Fenn A, Nairz M, Rattik S, et al. The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. J Exp Med. 2017;214:3293-3310 pubmed 出版商
Oh S, Liu M, Nixon B, Kang D, Toure A, Bivona M, et al. Foxp3-independent mechanism by which TGF-? controls peripheral T cell tolerance. Proc Natl Acad Sci U S A. 2017;114:E7536-E7544 pubmed 出版商
Nanjappa S, Hernández Santos N, Galles K, Wuthrich M, Suresh M, Klein B. Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia. PLoS Pathog. 2015;11:e1005161 pubmed 出版商
Huen S, Huynh L, Marlier A, Lee Y, Moeckel G, Cantley L. GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury. J Am Soc Nephrol. 2015;26:1334-45 pubmed 出版商
Whitney P, Bär E, Osorio F, Rogers N, Schraml B, Deddouche S, et al. Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection. PLoS Pathog. 2014;10:e1004276 pubmed 出版商
Basler M, Mundt S, Muchamuel T, Moll C, Jiang J, Groettrup M, et al. Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. EMBO Mol Med. 2014;6:226-38 pubmed 出版商
Sánchez Vallecillo M, Ullio Gamboa G, Palma S, Harman M, Chiodetti A, Moron G, et al. Adjuvant activity of CpG-ODN formulated as a liquid crystal. Biomaterials. 2014;35:2529-42 pubmed 出版商
Samavedam U, Iwata H, Müller S, Schulze F, Recke A, Schmidt E, et al. GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisita. J Immunol. 2014;192:559-71 pubmed 出版商
Othy S, Hegde P, Topçu S, Sharma M, Maddur M, Lacroix Desmazes S, et al. Intravenous gammaglobulin inhibits encephalitogenic potential of pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine-1 phosphate receptor 1-mammalian target of rapamycin axis. J Immunol. 2013;190:4535-41 pubmed 出版商
Kamei A, Wu W, Traficante D, Koh A, Van Rooijen N, Pier G, et al. Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia. J Infect Dis. 2013;207:39-49 pubmed 出版商
Massilamany C, Asojo O, Gangaplara A, Steffen D, Reddy J. Identification of a second mimicry epitope from Acanthamoeba castellanii that induces CNS autoimmunity by generating cross-reactive T cells for MBP 89-101 in SJL mice. Int Immunol. 2011;23:729-39 pubmed 出版商
Yeh W, McWilliams I, Harrington L. Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis. J Immunol. 2011;187:4998-5006 pubmed 出版商
Massilamany C, Gangaplara A, Steffen D, Reddy J. Identification of novel mimicry epitopes for cardiac myosin heavy chain-? that induce autoimmune myocarditis in A/J mice. Cell Immunol. 2011;271:438-49 pubmed 出版商
Khajah M, Millen B, Cara D, Waterhouse C, McCafferty D. Granulocyte-macrophage colony-stimulating factor (GM-CSF): a chemoattractive agent for murine leukocytes in vivo. J Leukoc Biol. 2011;89:945-53 pubmed 出版商
Wu H, Suzuki T, Carey B, Trapnell B, McCormack F. Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophages. J Biol Chem. 2011;286:14932-40 pubmed 出版商
Ganguly S, Manicassamy S, Blackwell J, Pulendran B, Amara R. Adenovirus type 5 induces vitamin A-metabolizing enzymes in dendritic cells and enhances priming of gut-homing CD8 T cells. Mucosal Immunol. 2011;4:528-38 pubmed 出版商
Nijnik A, Madera L, Ma S, Waldbrook M, Elliott M, Easton D, et al. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol. 2010;184:2539-50 pubmed 出版商
Zhu S, Chen M, Jongstra Bilen J, Cybulsky M. GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions. J Exp Med. 2009;206:2141-9 pubmed 出版商
Jiang D, Chen Y, Schwarz H. CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol. 2008;181:3923-32 pubmed
Nagai Y, Garrett K, Ohta S, Bahrun U, Kouro T, Akira S, et al. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity. 2006;24:801-12 pubmed
产品信息
产品类型 :
抗体
产品名称 :
GM-CSF Monoclonal Antibody (MP1-22E9), eBioscience™
目录# :
14-7331-81
规格 :
50微克
价格 :
美国114
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
ELISA: 1-4 µg/mL, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent
物种 :
小鼠
克隆 :
MP1-22E9
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
GM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The active form of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q-syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The ability of recombinant GM-CSF to increase hematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation. Recent studies have investigated GM-CSF in inflammatory and autoimmune diseases such as arthritis, arthritis related interstitial lung disease, nephritis, and psoriasis. In the CNS, GM-CSF depletion or neutralization has been studied in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).
格式 :
液体
应用w/稀释 :
ELISA: 1-4 µg/mL, Immunohistochemistry (Frozen): Assay-Dependent, Western Blot: Assay-Dependent
别名 :
colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; Molgramostin; put. GM-CSF; sargramostim
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国