产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
TNF alpha Monoclonal Antibody (MAb1), eBioscience™
目录 :
14-7348-81
规格 :
50微克
价格 :
美国102
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
MAb1
反应物种 :
人类
应用 :
酶联免疫吸附测定, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 33
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Stegmann K, Björkström N, Ciesek S, Lunemann S, Jaroszewicz J, Wiegand J, et al. Interferon ?-stimulated natural killer cells from patients with acute hepatitis C virus (HCV) infection recognize HCV-infected and uninfected hepatoma cells via DNAX accessory molecule-1. J Infect Dis. 2012;205:1351-62 pubmed 出版商
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Reske A, Pollara G, Krummenacher C, Katz D, Chain B. Glycoprotein-dependent and TLR2-independent innate immune recognition of herpes simplex virus-1 by dendritic cells. J Immunol. 2008;180:7525-36 pubmed
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Erridge C, Attina T, Spickett C, Webb D. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr. 2007;86:1286-92 pubmed
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Nishikawa H, Tsuji T, Jager E, Briones G, Ritter G, Old L, et al. Induction of regulatory T cell-resistant helper CD4+ T cells by bacterial vector. Blood. 2008;111:1404-12 pubmed
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Kobayashi R, Okamura S, Ohno T, Saito H, Mori M, Ra C, et al. Hyperexpression of FcgammaRI and Toll-like receptor 4 in the intestinal mast cells of Crohn's disease patients. Clin Immunol. 2007;125:149-58 pubmed
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Gorski K, Waller E, Bjornton Severson J, Hanten J, Riter C, Kieper W, et al. Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists. Int Immunol. 2006;18:1115-26 pubmed
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Nagaoka I, Tamura H, Hirata M. An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7. J Immunol. 2006;176:3044-52 pubmed
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Barchet W, Price J, Cella M, Colonna M, MacMillan S, Cobb J, et al. Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood. 2006;107:1497-504 pubmed
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Gavin I, Kukhtin A, Glesne D, Schabacker D, Chandler D. Analysis of protein interaction and function with a 3-dimensional MALDI-MS protein array. Biotechniques. 2005;39:99-107 pubmed
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Danis V, Franic G, Rathjen D, Brooks P. Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-2, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes. Clin Exp Immunol. 1991;85:143-50 pubmed
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Rathjen D, Cowan K, Furphy L, Aston R. Antigenic structure of human tumour necrosis factor: recognition of distinct regions of TNF alpha by different tumour cell receptors. Mol Immunol. 1991;28:79-86 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
TNF alpha Monoclonal Antibody (MAb1), eBioscience™
目录# :
14-7348-81
规格 :
50微克
价格 :
美国102
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA:1-4微克/毫升
物种 :
人类
克隆 :
MAb1
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
格式 :
液体
应用w/稀释 :
ELISA:1-4微克/毫升
别名 :
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
更多信息或购买 :
公司信息
赛默飞世尔
产品浏览
- TNF alpha Monoclonal Antibody (MAb1), eBioscience™ | 14-7348-85
- TNF alpha Monoclonal Antibody (MAb11), eBioscience™ | 14-7349-81
- TNF alpha Monoclonal Antibody (MAb11), eBioscience™ | 14-7349-85
- TNF alpha Monoclonal Antibody (TN3-19.12), eBioscience™ | 14-7423-81
- TNF alpha Monoclonal Antibody (TN3-19.12), eBioscience™ | 14-7423-85
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