产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-17F Monoclonal Antibody (H17F10A7), eBioscience™
目录 :
14-7479-82
规格 :
100微克
价格 :
美国450
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
H17F10A7
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 3
参考文献
Igyarto B, Haley K, Ortner D, Bobr A, Gerami Nejad M, Edelson B, et al. Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses. Immunity. 2011;35:260-72 pubmed 出版商
Chen Z, Tato C, Muul L, Laurence A, O Shea J. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 2007;56:2936-46 pubmed
Wright J, Guo Y, Quazi A, Luxenberg D, Bennett F, Ross J, et al. Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells. J Biol Chem. 2007;282:13447-55 pubmed
产品信息
产品类型 :
抗体
产品名称 :
IL-17F Monoclonal Antibody (H17F10A7), eBioscience™
目录# :
14-7479-82
规格 :
100微克
价格 :
美国450
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Western Blot: 1-2 µg/mL
物种 :
人类
克隆 :
H17F10A7
抗体亚型 :
IgG1
储存 :
4° C
描述 :
IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production. IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells. IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.
格式 :
液体
应用w/稀释 :
Western Blot: 1-2 µg/mL
别名 :
C87042;CANDF6;细胞因子毫升-1;IL17F;IL-17F;IL-24;ILN;白细胞介素;白细胞介素17F;Interleukin17F;白细胞介素17F;白细胞介素24;ML1;毫升-1;突变体IL-17F
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国