产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
APP (Amyloid Precursor Protein) Monoclonal Antibody (22C11), eBioscience
目录 :
14-9749-80
规格 :
25微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
22C11
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 20
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:5000; 图 s4b
Marengo L, Armbrust F, Schoenherr C, Storck S, Schmitt U, Zampar S, et al. Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease. Cell Mol Life Sci. 2022;79:168 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:250; 图 6a
Mammone T, Chidlow G, Casson R, Wood J. Improved immunohistochemical detection of phosphorylated mitogen-activated protein kinases in the injured rat optic nerve head. Histochem Cell Biol. 2019;151:435-456 pubmed 出版商
Lee W, Lee H, Yang J, Shin H, Choi S, Kim J, et al. The Potential Neuroprotective Effects of Extracts from Oat Seedlings against Alzheimer's Disease. Nutrients. 2022;14: pubmed 出版商
Kleffman K, Levinson G, Rose I, Blumenberg L, Shadaloey S, Dhabaria A, et al. Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis. Cancer Discov. 2022;12:1314-1335 pubmed 出版商
Cheng X, Shi F, Zhao K, Lin W, Li X, Zhang J, et al. Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner. Aging (Albany NY). 2021;13:23620-23636 pubmed 出版商
Hu Y, Zhang Y, Ren R, Dammer E, Xie X, Chen S, et al. microRNA-425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies. Aging Cell. 2021;20:e13454 pubmed 出版商
Delizannis A, Nonneman A, Tsering W, de Bondt A, van den Wyngaert I, Zhang B, et al. Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice. Acta Neuropathol Commun. 2021;9:150 pubmed 出版商
Xu P, Chang J, Zhou X, Wang W, Bamkole M, Wong E, et al. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. J Exp Med. 2021;218: pubmed 出版商
Habekost M, Qvist P, Denham M, Holm I, Jørgensen A. Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Mol Neurobiol. 2021;: pubmed 出版商
Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis M, Liu C, et al. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nat Commun. 2020;11:5540 pubmed 出版商
Knupp A, Mishra S, Martinez R, Braggin J, Szabó M, Kinoshita C, et al. Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing. Cell Rep. 2020;31:107719 pubmed 出版商
Suh J, Romano D, Nitschke L, Herrick S, DiMarzio B, Dzhala V, et al. Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019;178:1159-1175.e17 pubmed 出版商
Hashimoto S, Ishii A, Kamano N, Watamura N, Saito T, Ohshima T, et al. Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm. J Biol Chem. 2018;293:3118-3125 pubmed 出版商
Liebsch F, Aurousseau M, Bethge T, McGuire H, Scolari S, Herrmann A, et al. Full-length cellular ?-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. J Biol Chem. 2017;292:13258-13270 pubmed 出版商
Kleinberger G, Brendel M, Mracskó É, Wefers B, Groeneweg L, Xiang X, et al. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO J. 2017;36:1837-1853 pubmed 出版商
Chapuis J, Flaig A, Grenier Boley B, Eysert F, Pottiez V, Deloison G, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathol. 2017;133:955-966 pubmed 出版商
Ubelmann F, Burrinha T, Salavessa L, Gomes R, Ferreira C, Moreno N, et al. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep. 2017;18:102-122 pubmed 出版商
White A, Zheng H, Galatis D, Maher F, Hesse L, Multhaup G, et al. Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress. J Neurosci. 1998;18:6207-17 pubmed
Hilbich C, Mönning U, Grund C, Masters C, Beyreuther K. Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11. J Biol Chem. 1993;268:26571-7 pubmed
Kawai M, Cras P, Richey P, Tabaton M, Lowery D, Gonzalez DeWhitt P, et al. Subcellular localization of amyloid precursor protein in senile plaques of Alzheimer's disease. Am J Pathol. 1992;140:947-58 pubmed
产品信息
产品类型 :
抗体
产品名称 :
APP (Amyloid Precursor Protein) Monoclonal Antibody (22C11), eBioscience
目录# :
14-9749-80
规格 :
25微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 2.5 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 2 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
22C11
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer's disease. Abnormal regulation and processing of APP also plays a role in Down's syndrome, early onset familial Alzheimer's disease, and cerebral hemorrhage.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 2.5 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 2 µg/mL
别名 :
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid A4; Amyloid b precursor protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid ß precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国