产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD4 Monoclonal Antibody (4SM95), eBioscience™
目录 :
14-9766-80
规格 :
25µg
价格 :
美国109
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
4SM95
反应物种 :
小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 37
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 5a
Schreiber L, Urbiola C, Das K, Spiesschaert B, Kimpel J, Heinemann F, et al. The lytic activity of VSV-GP treatment dominates the therapeutic effects in a syngeneic model of lung cancer. Br J Cancer. 2019;121:647-658 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 7e
Rühl J, Citterio C, Engelmann C, Haigh T, Dzionek A, Dreyer J, et al. Heterologous prime-boost vaccination protects against EBV antigen-expressing lymphomas. J Clin Invest. 2019;129:2071-2087 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 s4
Sato Y, Bolzenius J, Eteleeb A, Su X, Maher C, Sehn J, et al. CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blockade. JCI Insight. 2018;3: pubmed 出版商
  • 免疫组化; 小鼠; 1:40; 图 5a
Kanneganti A, Malireddi R, Saavedra P, Vande Walle L, Van Gorp H, Kambara H, et al. GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever. J Exp Med. 2018;215:1519-1529 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5c
Ubil E, Caskey L, Holtzhausen A, Hunter D, Story C, Earp H. Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest. 2018;128:2356-2369 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:600; 图 s11e
Zhang Z, Zi Z, Lee E, Zhao J, Contreras D, South A, et al. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nat Med. 2018;24:617-627 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 3k
Jin Z, Liang F, Yang J, Mei W. hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer. PLoS Genet. 2017;13:e1006672 pubmed 出版商
  • 免疫组化; 小鼠; 图 s7b
Pishesha N, Bilate A, Wibowo M, Huang N, Li Z, Deshycka R, et al. Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease. Proc Natl Acad Sci U S A. 2017;114:3157-3162 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50; 图 3
Liu Y, Wang Z, De La Torre R, Barling A, Tsujikawa T, Hornick N, et al. Trim32 Deficiency Enhances Th2 Immunity and Predisposes to Features of Atopic Dermatitis. J Invest Dermatol. 2017;137:359-366 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:20; 图 3b
Hirai Yuki A, Hensley L, McGivern D, Gonzalez Lopez O, Das A, Feng H, et al. MAVS-dependent host species range and pathogenicity of human hepatitis A virus. Science. 2016;353:1541-1545 pubmed
  • 免疫组化; 小鼠; 图 3
Seo J, Bang M, Kim G, Cho S, Park D. Erythronium japonicum attenuates histopathological lung abnormalities in a mouse model of ovalbumin-induced asthma. Int J Mol Med. 2016;37:1221-8 pubmed 出版商
  • 免疫组化; 小鼠; 图 5
Bang M, Seo J, Seo J, Jo G, Jung S, Yu R, et al. Bacillus subtilis KCTC 11782BP-produced alginate oligosaccharide effectively suppresses asthma via T-helper cell type 2-related cytokines. PLoS ONE. 2015;10:e0117524 pubmed 出版商
  • 免疫细胞化学; 小鼠
Hirayama T, Asano Y, Iida H, Watanabe T, Nakamura T, Goitsuka R. Meis1 is required for the maintenance of postnatal thymic epithelial cells. PLoS ONE. 2014;9:e89885 pubmed 出版商
Morrison M, Verschuren L, Salic K, Verheij J, Menke A, Wielinga P, et al. Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice. Hepatol Commun. 2018;2:1513-1532 pubmed 出版商
Simula L, Pacella I, Colamatteo A, Procaccini C, Cancila V, Bordi M, et al. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming. Cell Rep. 2018;25:3059-3073.e10 pubmed 出版商
Messenger Z, Hall J, Jima D, House J, Tam H, Tokarz D, et al. C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event. Cell Death Dis. 2018;9:1054 pubmed 出版商
Mi Y, Smith C, Yang F, Qi Y, Roche K, Serody J, et al. A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy. Adv Mater. 2018;30:e1706098 pubmed 出版商
Suárez López L, Sriram G, Kong Y, Morandell S, Merrick K, Hernandez Y, et al. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Proc Natl Acad Sci U S A. 2018;115:E4236-E4244 pubmed 出版商
May S, Owen H, Phesse T, Greenow K, Jones G, Blackwood A, et al. Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation. J Pathol. 2018;245:270-282 pubmed 出版商
Luo N, Nixon M, Gonzalez Ericsson P, Sanchez V, Opalenik S, Li H, et al. DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer. Nat Commun. 2018;9:248 pubmed 出版商
Kwak J, Laskowski J, Li H, McSharry M, Sippel T, Bullock B, et al. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018;78:143-156 pubmed 出版商
Yan X, Wang L, Zhang R, Pu X, Wu S, Yu L, et al. Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy. Oncoimmunology. 2017;7:e1376156 pubmed 出版商
Tani C, Vagnani S, Carli L, Querci F, Kuhl A, Spieckermann S, et al. Treatment with Allogenic Mesenchymal Stromal Cells in a Murine Model of Systemic Lupus Erythematosus. Int J Stem Cells. 2017;10:160-168 pubmed 出版商
Unver N, Delgado O, Zeleke K, Cumpian A, Tang X, Caetano M, et al. Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol. Int J Cancer. 2017;: pubmed 出版商
Lee S, Bae C, Seo J, Cho S, Bae M, Oh D, et al. Mycoleptodonoides aitchisonii suppresses asthma via Th2 and Th1 cell regulation in an ovalbumin?induced asthma mouse model. Mol Med Rep. 2017;: pubmed 出版商
Beigier Bompadre M, Montagna G, Kuhl A, Lozza L, Weiner J, Kupz A, et al. Mycobacterium tuberculosis infection modulates adipose tissue biology. PLoS Pathog. 2017;13:e1006676 pubmed 出版商
Schmid P, Bouazzaoui A, Schmid K, Birner C, Schach C, Maier L, et al. Acute Renal Graft-Versus-Host Disease in a Murine Model of Allogeneic Bone Marrow Transplantation. Cell Transplant. 2017;26:1428-1440 pubmed 出版商
Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw A, et al. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017;127:3136-3151 pubmed 出版商
Jaini R, Loya M, Eng C. Immunotherapeutic target expression on breast tumors can be amplified by hormone receptor antagonism: a novel strategy for enhancing efficacy of targeted immunotherapy. Oncotarget. 2017;8:32536-32549 pubmed 出版商
Lhotak S, Gyulay G, Cutz J, Al Hashimi A, Trigatti B, Richards C, et al. Characterization of Proliferating Lesion-Resident Cells During All Stages of Atherosclerotic Growth. J Am Heart Assoc. 2016;5: pubmed 出版商
Kroon P, Gadiot J, Peeters M, Gasparini A, Deken M, Yagita H, et al. Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma. Cancer Immunol Immunother. 2016;65:753-63 pubmed 出版商
Marek I, Lichtneger T, Cordasic N, Hilgers K, Volkert G, Fahlbusch F, et al. Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover. PLoS ONE. 2016;11:e0150471 pubmed 出版商
Xiao J, Lu Z, Sheng J, Song Y, Jiang W, Liu F, et al. 5-fluorouracil attenuates dextran sodium sulfate-induced acute colitis in mice. Mol Med Rep. 2016;13:2821-8 pubmed 出版商
Wang D, Mou H, Li S, Li Y, Hough S, Tran K, et al. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Hum Gene Ther. 2015;26:432-42 pubmed 出版商
Foti M, Phelouzat M, Holm A, Rasmusson B, Carpentier J. p56Lck anchors CD4 to distinct microdomains on microvilli. Proc Natl Acad Sci U S A. 2002;99:2008-13 pubmed
Dialynas D, Quan Z, Wall K, Pierres A, Quintans J, Loken M, et al. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J Immunol. 1983;131:2445-51 pubmed
Wilde D, Marrack P, Kappler J, Dialynas D, Fitch F. Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. J Immunol. 1983;131:2178-83 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD4 Monoclonal Antibody (4SM95), eBioscience™
目录# :
14-9766-80
规格 :
25µg
价格 :
美国109
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 5 µg/mL
物种 :
小鼠
克隆 :
4SM95
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 5 µg/mL, Western Blot: 5 µg/mL
别名 :
BOS_5959; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 receptor; cd4a; CD4mut; cell surface glycoprotein CD4; fCD4; L3T4; Leu-3; Ly-4; lymphocyte antigen CD4; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); W3/25; W3/25 antigen
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国