产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Vinculin Monoclonal Antibody (7F9), eBioscience™
目录 :
14-9777-80
规格 :
25µg
价格 :
美国119
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
7F9
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 5
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 图 7c
Xie X, Almuzzaini B, Drou N, Kremb S, Yousif A, Farrants A, et al. β-Actin-dependent global chromatin organization and gene expression programs control cellular identity. FASEB J. 2018;32:1296-1314 pubmed 出版商
Davis E, Kim J, Menasche B, Sheppard J, Liu X, Tan A, et al. Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins. Cell Rep. 2015;11:1727-36 pubmed 出版商
Peng X, Cuff L, Lawton C, DeMali K. Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J Cell Sci. 2010;123:567-77 pubmed 出版商
Geiger B, Tokuyasu K, Dutton A, Singer S. Vinculin, an intracellular protein localized at specialized sites where microfilament bundles terminate at cell membranes. Proc Natl Acad Sci U S A. 1980;77:4127-31 pubmed
Gilmore A, Jackson P, Waites G, Critchley D. Further characterisation of the talin-binding site in the cytoskeletal protein vinculin. J Cell Sci. 1992;103 ( Pt 3):719-31 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Vinculin Monoclonal Antibody (7F9), eBioscience™
目录# :
14-9777-80
规格 :
25µg
价格 :
美国119
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Frozen): 5 µg/mL, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1-5 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
7F9
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Frozen): 5 µg/mL, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1-5 µg/mL
别名 :
9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; epididymis luminal protein 114; HEL114; Metavinculin; metavinculin {ECO:0000250; MV; MVCL; RP11-178G16.3; UniProtKB:P18206}; VCL; vcl {ECO:0000250; vinc; VINC1; Vinculin; vinculin {ECO:0000250
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国