NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

抗体

Fibronectin Monoclonal Antibody (FN-3), eBioscience™

14-9869-37

2毫克

1200.00美元

单克隆

小鼠

未共轭

Fn-3

免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片

Fibronectin Monoclonal Antibody (FN-3), eBioscience™

14-9869-37

2毫克

1200.00美元

单克隆

亲和色谱

小鼠

人类

Immunocytochemistry: 0.025 µg/mL, Immunofluorescence: 0.025 µg/mL, Immunohistochemistry (Paraffin): 10 µg/mL, Western Blot: 0.5 µg/mL

人类

FN-3

IgG1

4° C

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.

液体

Immunocytochemistry: 0.025 µg/mL, Immunofluorescence: 0.025 µg/mL, Immunohistochemistry (Paraffin): 10 µg/mL, Western Blot: 0.5 µg/mL

Anastellin; CIG; Cold-insoluble globulin; cumulus cell-specific fibronectin 1 transcript; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; E330027I09; ED-B; embryo-specific fibronectin 1 transcript; ferritin L subunit; ferritin L-chain; FIBNEC; Fibronectin; fibronectin 1; fibronectin ED-A- region; fibronectin ED-B+ region; fibronectin variable region; FINC; Fn; FN1; fn-1; FNZ; GFND; GFND2; LETS; LOW QUALITY PROTEIN: fibronectin; migration-stimulating factor; MSF; Ugl-Y1; Ugl-Y2; Ugl-Y3