IRF3 Monoclonal Antibody (SL-12 (SL12)), eBioscience™ | 赛默飞世尔 14-9947-82 产品信息

产品简要

公司名称 :

赛默飞世尔

其他品牌 :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

产品类型 :

抗体

产品名称 :

IRF3 Monoclonal Antibody (SL-12 (SL12)), eBioscience™

14-9947-82

规格 :

100微克

价格 :

美国420

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

SL-12(SL12)

反应物种 :

人类

应用 :

免疫印迹

更多信息或购买 :

赛默飞世尔产品网页

文章摘录数: 4

参考文献
Hiscott J. Triggering the innate antiviral response through IRF-3 activation. J Biol Chem. 2007;282:15325-9 pubmed
Melroe G, Silva L, Schaffer P, Knipe D. Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction. Virology. 2007;360:305-21 pubmed
Lin R, Heylbroeck C, Genin P, Pitha P, Hiscott J. Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription. Mol Cell Biol. 1999;19:959-66 pubmed
Au W, Moore P, Lowther W, Juang Y, Pitha P. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc Natl Acad Sci U S A. 1995;92:11657-61 pubmed

产品信息

产品类型 :

抗体

产品名称 :

IRF3 Monoclonal Antibody (SL-12 (SL12)), eBioscience™

目录# :

14-9947-82

规格 :

100微克

价格 :

美国420

克隆性 :

单克隆

纯度 :

亲和色谱

宿主 :

小鼠

反应物种 :

人类

应用 :

Western Blot: 2 µg/mL

物种 :

人类

克隆 :

SL-12(SL12)

抗体亚型 :

IgG1

储存 :

4° C

描述 :

IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling. It is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.

格式 :

液体

应用w/稀释 :

Western Blot: 2 µg/mL

别名 :

C920001K05Rik;IIAE7;干扰素调节因子3;Irf3;IRF-3;IRF3(磷酸化S386);IRF3(pS386);IRF3(pSer386);IRF3磷酸化;IRF3磷酸化S386;IRF3磷酸化Ser386;磷酸化IRF3

更多信息或购买 :

赛默飞世尔产品网页

公司信息

赛默飞世尔

上海浦东新金桥路27号7号楼

analyze.cn@thermofisher.com

http://www.thermo.com.cn

1084193588

公司总部: 美国