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抗体

CD45.1 Monoclonal Antibody (A20), PE-Cyanine5, eBioscience™

15-0453-81

50微克

美国194

单克隆

小鼠

PE-Cy5

A20

CD45.1 Monoclonal Antibody (A20), PE-Cyanine5, eBioscience™

15-0453-81

50微克

美国194

单克隆

亲和色谱

小鼠

小鼠

Flow Cytometry: 0.5 µg/test

小鼠

A20

IgG2a, kappa

4° C, store in dark, DO NOT FREEZE!

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.

液体

Flow Cytometry: 0.5 µg/test

B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; Leukocyte common antigen; loc; LY5; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type, C; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein