产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscience
目录 :
16-0037-85
规格 :
500微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
鼠单克隆抗体-CD3
反应物种 :
人类, 猕猴
应用 :
流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 537
出版应用/物种/样本/稀释参考文献
  • 抑制或激活实验; 人类; 0.25 ug/ml; 图 5d
Pinkert J, Boehm H, Trautwein M, Doecke W, Wessel F, Ge Y, et al. T cell-mediated elimination of cancer cells by blocking CEACAM6-CEACAM1 interaction. Oncoimmunology. 2022;11:2008110 pubmed 出版商
  • 抑制或激活实验; 人类; 2 ug/ml; 图 4b
Thakkar D, Paliwal S, Dharmadhikari B, Guan S, Liu L, Kar S, et al. Rationally targeted anti-VISTA antibody that blockades the C-C' loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner. J Immunother Cancer. 2022;10: pubmed 出版商
  • 抑制或激活实验; 人类; 2 ug/ml; 图 4a
Han L, Hu J, Ma B, Wen D, Zhang T, Lu Z, et al. IL-17A increases MHC class I expression and promotes T cell activation in papillary thyroid cancer patients with coexistent Hashimoto's thyroiditis. Diagn Pathol. 2019;14:52 pubmed 出版商
  • 流式细胞仪; 人类; 图 1a
Banki Z, Krabbendam L, Klaver D, Leng T, Kruis S, Mehta H, et al. Antibody opsonization enhances MAIT cell responsiveness to bacteria via a TNF-dependent mechanism. Immunol Cell Biol. 2019;97:538-551 pubmed 出版商
  • 流式细胞仪; 人类; 图 1b
Pizzolla A, Nguyen T, Sant S, Jaffar J, Loudovaris T, Mannering S, et al. Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles. J Clin Invest. 2018;128:721-733 pubmed 出版商
  • 流式细胞仪; 人类; 图 2c
Meng Y, Zhou W, Jin L, Liu L, Chang K, Mei J, et al. RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization. Cell Death Dis. 2017;8:e3105 pubmed 出版商
  • 抑制或激活实验; 人类; 1 ug/ml; 图 6d
Kruglova N, Meshkova T, Kopylov A, Mazurov D, Filatov A. Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP). PLoS ONE. 2017;12:e0182468 pubmed 出版商
  • 抑制或激活实验; 人类; 表 1
Zheng C, Zheng L, Yoo J, Guo H, Zhang Y, Guo X, et al. Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing. Cell. 2017;169:1342-1356.e16 pubmed 出版商
  • 流式细胞仪; 人类; 图 3a
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed 出版商
  • 流式细胞仪; 人类; 图 2a
Su S, Zou Z, Chen F, Ding N, Du J, Shao J, et al. CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer. Oncoimmunology. 2017;6:e1249558 pubmed 出版商
  • 流式细胞仪; 人类; 图 1
Zhen A, Rezek V, Youn C, Lam B, Chang N, Rick J, et al. Targeting type I interferon-mediated activation restores immune function in chronic HIV infection. J Clin Invest. 2017;127:260-268 pubmed 出版商
  • 流式细胞仪; 人类; 图 2c
Tomic A, Varanasi P, Golemac M, Malic S, Riese P, Borst E, et al. Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand. PLoS Pathog. 2016;12:e1006015 pubmed 出版商
  • 抑制或激活实验; 人类; 2.5 ug/ml; 图 7d
Guillou L, Babataheri A, Saitakis M, Bohineust A, Dogniaux S, Hivroz C, et al. T-lymphocyte passive deformation is controlled by unfolding of membrane surface reservoirs. Mol Biol Cell. 2016;27:3574-3582 pubmed
  • 抑制或激活实验; 人类; 图 6a
Pageon S, Nicovich P, Mollazade M, Tabarin T, Gaus K. Clus-DoC: a combined cluster detection and colocalization analysis for single-molecule localization microscopy data. Mol Biol Cell. 2016;27:3627-3636 pubmed
  • 抑制或激活实验; 人类; 图 1
Pageon S, Tabarin T, Yamamoto Y, Ma Y, Nicovich P, Bridgeman J, et al. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proc Natl Acad Sci U S A. 2016;113:E5454-63 pubmed 出版商
  • 流式细胞仪; 人类
Sullivan K, Lewis H, Hill A, Pandey A, Jackson L, Cabral J, et al. Trisomy 21 consistently activates the interferon response. elife. 2016;5: pubmed 出版商
  • 抑制或激活实验; 人类; 图 1
Hahn S, Neuhoff A, Landsberg J, Schupp J, Eberts D, Leukel P, et al. A key role of GARP in the immune suppressive tumor microenvironment. Oncotarget. 2016;7:42996-43009 pubmed 出版商
  • 抑制或激活实验; 人类; 图 8
Hu H, Wang H, Xiao Y, Jin J, Chang J, Zou Q, et al. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016;213:399-414 pubmed 出版商
  • 流式细胞仪; 人类; 图 4
Su S, Hu B, Shao J, Shen B, Du J, Du Y, et al. CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. Sci Rep. 2016;6:20070 pubmed 出版商
  • 抑制或激活实验; 人类; 图 2
Vivar O, Masi G, Carpier J, Magalhaes J, Galgano D, Pazour G, et al. IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo. Proc Natl Acad Sci U S A. 2016;113:386-91 pubmed 出版商
  • 流式细胞仪; 人类; 图 s1a
Schulz A, Mälzer J, Domingo C, Jürchott K, Grützkau A, Babel N, et al. Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans. J Immunol. 2015;195:4699-711 pubmed 出版商
  • 抑制或激活实验; 人类; 图 1
Silacci M, Lembke W, Woods R, Attinger Toller I, Baenziger Tobler N, Batey S, et al. Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases. MAbs. 2016;8:141-9 pubmed 出版商
  • 抑制或激活实验; 人类; 1 ug/ml; 图 6c
Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, et al. The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells. Nat Immunol. 2015;16:1077-84 pubmed 出版商
  • 流式细胞仪; 人类; 图 1
Japp A, Kursunel M, Meier S, Mälzer J, Li X, Rahman N, et al. Dysfunction of PSA-specific CD8+ T cells in prostate cancer patients correlates with CD38 and Tim-3 expression. Cancer Immunol Immunother. 2015;64:1487-94 pubmed 出版商
  • 抑制或激活实验; 人类; 图 s5
Klammt C, Novotná L, Li D, Wolf M, Blount A, Zhang K, et al. T cell receptor dwell times control the kinase activity of Zap70. Nat Immunol. 2015;16:961-9 pubmed 出版商
  • 流式细胞仪; 人类; 图 1b
Wang Y, Zhong H, Xie X, Chen C, Huang D, Shen L, et al. Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection. Proc Natl Acad Sci U S A. 2015;112:E3883-92 pubmed 出版商
  • 流式细胞仪; 人类; 图 s3
Mende N, Kuchen E, Lesche M, Grinenko T, Kokkaliaris K, Hanenberg H, et al. CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo. J Exp Med. 2015;212:1171-83 pubmed 出版商
  • 抑制或激活实验; 人类; 0.01 ug/ml; 图 1
Tsai P, Chang Y, Lee Y, Ko Y, Yang Y, Lin C, et al. Differentiation of blood T cells: Reprogramming human induced pluripotent stem cells into neuronal cells. J Chin Med Assoc. 2015;78:353-9 pubmed 出版商
  • 抑制或激活实验; 人类; 5 ug/ml
Vassena L, Giuliani E, Koppensteiner H, Bolduan S, Schindler M, Doria M. HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes. J Virol. 2015;89:5687-700 pubmed 出版商
  • 抑制或激活实验; 人类; 图 3
Severson J, Serracino H, Mateescu V, Raeburn C, McIntyre R, Sams S, et al. PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer. Cancer Immunol Res. 2015;3:620-30 pubmed 出版商
  • 抑制或激活实验; 人类; 0.5 ug/ml
Chauhan A, Chen C, Moore T, DiPaolo R. Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset. J Biol Chem. 2015;290:5127-40 pubmed 出版商
  • 抑制或激活实验; 人类
Caramalho I, Nunes Silva V, Pires A, Mota C, Pinto A, Nunes Cabaço H, et al. Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus. J Autoimmun. 2015;56:98-110 pubmed 出版商
  • 流式细胞仪; 人类
Lim D, Yawata N, Selva K, Li N, Tsai C, Yeong L, et al. The combination of type I IFN, TNF-α, and cell surface receptor engagement with dendritic cells enables NK cells to overcome immune evasion by dengue virus. J Immunol. 2014;193:5065-75 pubmed 出版商
  • 抑制或激活实验; 人类; 2 ug/ml
O Regan N, Steinfelder S, Venugopal G, Rao G, Lucius R, Srikantam A, et al. Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses. PLoS Negl Trop Dis. 2014;8:e3206 pubmed 出版商
  • 流式细胞仪; 人类; 0.05 ug/ml
Ramirez L, Arango T, Thompson E, Naji M, Tebas P, Boyer J. High IP-10 levels decrease T cell function in HIV-1-infected individuals on ART. J Leukoc Biol. 2014;96:1055-63 pubmed 出版商
  • 抑制或激活实验; 人类
Kreiser S, Eckhardt J, Kuhnt C, Stein M, Krzyzak L, Seitz C, et al. Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo. Immunobiology. 2015;220:270-9 pubmed 出版商
  • 流式细胞仪; 人类
Tarbox J, Keppel M, Topcagic N, Mackin C, Ben Abdallah M, Baszis K, et al. Elevated double negative T cells in pediatric autoimmunity. J Clin Immunol. 2014;34:594-9 pubmed 出版商
  • 流式细胞仪; 人类
Mao C, Mou X, Zhou Y, Yuan G, Xu C, Liu H, et al. Tumor-activated TCR??? T cells from gastric cancer patients induce the antitumor immune response of TCR??? T cells via their antigen-presenting cell-like effects. J Immunol Res. 2014;2014:593562 pubmed 出版商
  • 抑制或激活实验; 人类; 3 ug/ml
Yang C, Li J, Chiu L, Lan J, Chen D, Chuang H, et al. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J Immunol. 2014;192:1547-57 pubmed 出版商
  • 抑制或激活实验; 人类
Zouk H, d Hennezel E, Du X, Ounissi Benkalha H, Piccirillo C, Polychronakos C. Functional evaluation of the role of C-type lectin domain family 16A at the chromosome 16p13 locus. Clin Exp Immunol. 2014;175:485-97 pubmed 出版商
  • 抑制或激活实验; 人类; 2.5 ug/ml
Magrini E, Szabo I, Doni A, Cibella J, Viola A. Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12. PLoS ONE. 2011;6:e22482 pubmed 出版商
  • 流式细胞仪; 人类; 图 2
Correia M, Costa A, Uhrberg M, Cardoso E, Arosa F. IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion. Immunobiology. 2011;216:604-12 pubmed 出版商
  • 流式细胞仪; 人类; 图 4
  • 流式细胞仪; 猕猴; 图 4
Richardson M, Carroll R, Stremlau M, Korokhov N, Humeau L, Silvestri G, et al. Mode of transmission affects the sensitivity of human immunodeficiency virus type 1 to restriction by rhesus TRIM5alpha. J Virol. 2008;82:11117-28 pubmed 出版商
  • 抑制或激活实验; 人类
Kueng H, Leb V, Haiderer D, Raposo G, Thery C, Derdak S, et al. General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines. J Virol. 2007;81:8666-76 pubmed
  • 抑制或激活实验; 人类; 0.5 ug/ml
Clarke S, Betts G, Plant A, Wright K, El Shanawany T, Harrop R, et al. CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer. PLoS ONE. 2006;1:e129 pubmed
  • 抑制或激活实验; 人类
Hoves S, Krause S, Schutz C, Halbritter D, Scholmerich J, Herfarth H, et al. Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells. J Immunol. 2006;177:2691-8 pubmed
  • 流式细胞仪; 人类
Quiroga M, Pasquinelli V, Martinez G, Jurado J, Zorrilla L, Musella R, et al. Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. J Immunol. 2006;176:5965-74 pubmed
Liu Y, Xu Q, Deng F, Zheng Z, Luo J, Wang P, et al. HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway. J Exp Clin Cancer Res. 2023;42:38 pubmed 出版商
Rode A, Buus T, Mraz V, Al Jaberi F, Lopez D, Ford S, et al. Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor. Cells. 2022;11: pubmed 出版商
Banerjee A, Li D, Guo Y, Mei Z, Lau C, Chen K, et al. A reengineered common chain cytokine augments CD8+ T cell-dependent immunotherapy. JCI Insight. 2022;7: pubmed 出版商
Jensen L, Hoh T, Williamson D, Griffi xe9 J, Sage D, Rubin Delanchy P, et al. Correction of multiple-blinking artifacts in photoactivated localization microscopy. Nat Methods. 2022;19:594-602 pubmed 出版商
Saveljeva S, Sewell G, Ramshorn K, Cader M, West J, Clare S, et al. A purine metabolic checkpoint that prevents autoimmunity and autoinflammation. Cell Metab. 2022;34:106-124.e10 pubmed 出版商
Siegemund M, Oak P, Hansbauer E, Allersdorfer A, Utschick K, Winter A, et al. Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains. Front Pharmacol. 2021;12:759337 pubmed 出版商
Geuijen C, Tacken P, Wang L, Klooster R, Van Loo P, Zhou J, et al. A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade. Nat Commun. 2021;12:4445 pubmed 出版商
Puertas M, Bayón Gil Á, Garcia Guerrero M, Salgado M, Urrea V, Morón López S, et al. VIP-SPOT: an Innovative Assay To Quantify the Productive HIV-1 Reservoir in the Monitoring of Cure Strategies. MBio. 2021;12:e0056021 pubmed 出版商
Xun X, Zhang C, Wang S, Hu S, Xiang X, Cheng Q, et al. Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization. Am J Transl Res. 2021;13:4360-4375 pubmed
Szanto C, Cornel A, Tamminga S, Delemarre E, de Koning C, van den Beemt D, et al. Immune Monitoring during Therapy Reveals Activitory and Regulatory Immune Responses in High-Risk Neuroblastoma. Cancers (Basel). 2021;13: pubmed 出版商
Feldman T, Bercovich A, Moskovitz Y, Chapal Ilani N, Mitchell A, Medeiros J, et al. Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining. Nat Commun. 2021;12:2455 pubmed 出版商
Rubio Perez C, Planas Rigol E, Trincado J, Bonfill Teixidor E, Arias A, Marchese D, et al. Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment. Nat Commun. 2021;12:1503 pubmed 出版商
Zehravi M, Wahid M, Ashraf J. Episomal reprogramming of Duchenne muscular dystrophy patients derived CD3+ T cells towards induced pluripotent stem cells. Pak J Med Sci. 2021;37:432-438 pubmed 出版商
Bost P, De Sanctis F, Cane S, Ugel S, Donadello K, Castellucci M, et al. Deciphering the state of immune silence in fatal COVID-19 patients. Nat Commun. 2021;12:1428 pubmed 出版商
Li H, Kuang X, Liang L, Ye Y, Zhang Y, Li J, et al. The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1. Adv Sci (Weinh). 2021;8:2001596 pubmed 出版商
Liu B, Xie Y, Mei X, Sun Y, Shi W, Wu Z. Reciprocal regulation of interleukin-17A and interleukin-22 secretion through aryl hydrocarbon receptor activation in CD4+ T cells of patients with vitiligo. Exp Ther Med. 2021;21:158 pubmed 出版商
Wang T, Zhou Q, Shang Y. Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma. J Innate Immun. 2021;13:38-48 pubmed 出版商
Podojil J, Ifergan I, Chiang M, Meeks J, Miller S. Methodology for in vitro Assessment of Human T Cell Activation and Blockade. Bio Protoc. 2020;10:e3644 pubmed 出版商
Lund M, Howard C, Thurecht K, Campbell D, Mahler S, Walsh B. A bispecific T cell engager targeting Glypican-1 redirects T cell cytolytic activity to kill prostate cancer cells. BMC Cancer. 2020;20:1214 pubmed 出版商
Renavikar P, Sinha S, Brate A, Borcherding N, Crawford M, Steward Tharp S, et al. IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation. Front Immunol. 2020;11:568630 pubmed 出版商
Su Y, Chen D, Yuan D, Lausted C, Choi J, Dai C, et al. Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19. Cell. 2020;183:1479-1495.e20 pubmed 出版商
Ferretti A, Kula T, Wang Y, Nguyen D, Weinheimer A, Dunlap G, et al. Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein. Immunity. 2020;53:1095-1107.e3 pubmed 出版商
Yang J, Zhang J, Lu R, Tan Y, Du G, Zhou G. T cell-derived exosomes induced macrophage inflammatory protein-1α/β drive the trafficking of CD8+ T cells in oral lichen planus. J Cell Mol Med. 2020;24:14086-14098 pubmed 出版商
Biemann R, Roomp K, Noor F, Krishnan S, Li Z, Shahzad K, et al. Gene expression profile of CD14+ blood monocytes following lifestyle-induced weight loss in individuals with metabolic syndrome. Sci Rep. 2020;10:17855 pubmed 出版商
Lee J, Sheen J, Lim O, Lee Y, Ryu J, Shin D, et al. Abrogation of HLA surface expression using CRISPR/Cas9 genome editing: a step toward universal T cell therapy. Sci Rep. 2020;10:17753 pubmed 出版商
Ye Y, Kuang X, Xie Z, Liang L, Zhang Z, Zhang Y, et al. Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1. Genome Med. 2020;12:83 pubmed 出版商
Sadik A, Somarribas Patterson L, Oztürk S, Mohapatra S, Panitz V, Secker P, et al. IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. Cell. 2020;182:1252-1270.e34 pubmed 出版商
Kuehn H, Bernasconi A, Niemela J, Almejún M, Gallego W, Goel S, et al. A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency. J Clin Immunol. 2020;40:1093-1101 pubmed 出版商
Boshuizen J, Vredevoogd D, Krijgsman O, Ligtenberg M, Blankenstein S, de Bruijn B, et al. Reversal of pre-existing NGFR-driven tumor and immune therapy resistance. Nat Commun. 2020;11:3946 pubmed 出版商
Crawford M, Sinha S, Renavikar P, Borcherding N, Karandikar N. CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression. Proc Natl Acad Sci U S A. 2020;117:19408-19414 pubmed 出版商
Ferrara M, Chialli G, Ferreira L, Ruggieri E, Careccia G, Preti A, et al. Oxidation of HMGB1 Is a Dynamically Regulated Process in Physiological and Pathological Conditions. Front Immunol. 2020;11:1122 pubmed 出版商
Sahin M, Sahin E. Prostaglandin E2 Reverses the Effects of DNA Methyltransferase Inhibitor and TGFB1 on the Conversion of Naive T Cells to iTregs. Transfus Med Hemother. 2020;47:244-253 pubmed 出版商
Wragg K, Tan H, Kristensen A, Nguyen Robertson C, Kelleher A, Parsons M, et al. High CD26 and Low CD94 Expression Identifies an IL-23 Responsive Vδ2+ T Cell Subset with a MAIT Cell-like Transcriptional Profile. Cell Rep. 2020;31:107773 pubmed 出版商
Rollins M, Spartz E, Stromnes I. T Cell Receptor Engineered Lymphocytes for Cancer Therapy. Curr Protoc Immunol. 2020;129:e97 pubmed 出版商
Hu J, Lei B, Wen D, Ma B, Zhang T, Lu Z, et al. IL-2 enhanced MHC class I expression in papillary thyroid cancer with Hashimoto's thyroiditis overcomes immune escape in vitro. J Cancer. 2020;11:4250-4260 pubmed 出版商
Lu Z, Hu J, Liu W, Wen D, Wei W, Wang Y, et al. IL-10 Restores MHC Class I Expression and Interferes With Immunity in Papillary Thyroid Cancer With Hashimoto Thyroiditis. Endocrinology. 2020;161: pubmed 出版商
Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, Antonucci Y, et al. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction. Cell Death Differ. 2020;: pubmed 出版商
Ma Y, Yang Q, Fan M, Zhang L, Gu Y, Jia W, et al. Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation. Cell Prolif. 2020;53:e12802 pubmed 出版商
Salazar Y, Zheng X, Brunn D, Raifer H, Picard F, Zhang Y, et al. Microenvironmental Th9- and Th17- lymphocytes induce metastatic spreading in lung cancer. J Clin Invest. 2020;: pubmed 出版商
Ko J, Kim H, Jeong H, Lee H, Oh J. Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis. Cell Rep. 2020;30:3806-3820.e6 pubmed 出版商
Li W, Aryal M, Shu S, Smithgall T. HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane. J Biol Chem. 2020;295:5163-5174 pubmed 出版商
Chang Z, Hou A, Chen Y. Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands. Nat Protoc. 2020;15:1507-1524 pubmed 出版商
Janssen A, Villacorta Hidalgo J, Beringer D, van Dooremalen S, Fernando F, van Diest E, et al. γδ T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity. Cancer Immunol Res. 2020;8:530-543 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscience
目录# :
16-0037-85
规格 :
500微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 0.25 µg/test, Functional Assay: Assay-Dependent
物种 :
人类
克隆 :
鼠单克隆抗体-CD3
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.25 µg/test, Functional Assay: Assay-Dependent
别名 :
4930549J05Rik; A430104F18Rik; AI504783; antigen CD3D, delta polypeptide (TiT3 complex); antigen CD3E, epsilon polypeptide (TiT3 complex); antigen CD3G, gamma polypeptide; antigen CD3Z, zeta polypeptide; AW552088; Cd247; CD247 antigen; CD247 antigen, zeta subunit; Cd247 molecule; CD3; CD3 antigen delta chain; CD3 antigen delta polypeptide; CD3 antigen gamma chain; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 antigen, epsilon polypeptide; CD3 antigen, gamma polypeptide; CD3 antigen, zeta polypeptide; CD3 delta; CD3 epsilon; CD3 epsilon chain; CD3 epsilon subunit; CD3 epsilon subunit precursor; CD3 gamma-chain; CD3 glycoprotein; CD3 glycoprotein precursor; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3 molecule, epsilon; CD3 molecule, epsilon polypeptide; CD3 molecule, gamma; CD3 molecule, gamma polypeptide; CD3 protein; CD3 TCR complex; CD3 type I transmembrane glycoprotein; CD3 type I transmembrane glycoprotein precursor; CD3 zeta chain; Cd3d; CD3D antigen delta; CD3D antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; Cd3e; CD3E antigen, epsilon polypeptide; CD3E antigen, epsilon polypeptide (TiT3 complex); CD3e molecule; CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; CD3-epsilon; Cd3-eta; Cd3g; CD3G antigen, gamma polypeptide; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule; CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3-GAMMA; Cd3h; CD3Q; Cd3z; CD3Z antigen, zeta polypeptide (TiT3 complex); Cd3zeta; Cd3-zeta; CD3zeta chain; CD3-zeta/eta; Ctg3; Ctg-3; FLJ18683; IMD17; IMD18; IMD19; IMD25; Leu-4; OKT3, delta chain; T cell antigen receptor complex epsilon subunit of T3; T3/TCR complex; T3d; T3e; T3g; T3Z; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor CD3 epsilon chain; T-cell receptor CD3 epsilon subunit; T-cell receptor CD3 subunit zeta; T-cell receptor CD3, subunit zeta; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell receptor zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T-cell surface protein; TcR CD3 delta-chain; TcR CD3 gamma-chain; TCR zeta chain; TCR zeta chain subunit; TCRE; Tcrk; TCRZ; TCRzeta; TiT3 complex; type I transmembrane protein; T-cell surface molecule CD3
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公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国