产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscience™
目录 :
16-0289-85
规格 :
500微克
价格 :
351美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CD28.2
反应物种 :
食蟹猴, 人类, 小鼠, 猕猴
应用 :
免疫沉淀, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 120
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 4a
Liu G, Yu Y, Feng F, Zhu P, Zhang H, Zhang D, et al. Human CD8+CD28- T suppressor cells expanded by common gamma chain (γc) cytokines retain steady allospecific suppressive capacity in vivo. BMC Immunol. 2020;21:23 pubmed 出版商
  • 抑制或激活实验; 人类; 2 ug/ml; 图 4a
Han L, Hu J, Ma B, Wen D, Zhang T, Lu Z, et al. IL-17A increases MHC class I expression and promotes T cell activation in papillary thyroid cancer patients with coexistent Hashimoto's thyroiditis. Diagn Pathol. 2019;14:52 pubmed 出版商
  • 免疫沉淀; 人类; 图 6f
Zhao Y, Harrison D, Song Y, Ji J, Huang J, Hui E. Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Rep. 2018;24:379-390.e6 pubmed 出版商
  • 流式细胞仪; 人类; 1 ug/ml; 图 2c
Meng Y, Zhou W, Jin L, Liu L, Chang K, Mei J, et al. RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization. Cell Death Dis. 2017;8:e3105 pubmed 出版商
  • 抑制或激活实验; 人类; 表 1
Zheng C, Zheng L, Yoo J, Guo H, Zhang Y, Guo X, et al. Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing. Cell. 2017;169:1342-1356.e16 pubmed 出版商
  • 抑制或激活实验; 小鼠; 图 6e
He W, Wang C, Mu R, Liang P, Huang Z, Zhang J, et al. MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles. Oncogene. 2017;36:4212-4223 pubmed 出版商
  • 流式细胞仪; 人类; 图 s2
Su S, Zou Z, Chen F, Ding N, Du J, Shao J, et al. CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer. Oncoimmunology. 2017;6:e1249558 pubmed 出版商
  • 抑制或激活实验; 人类; 图 6a
Pageon S, Nicovich P, Mollazade M, Tabarin T, Gaus K. Clus-DoC: a combined cluster detection and colocalization analysis for single-molecule localization microscopy data. Mol Biol Cell. 2016;27:3627-3636 pubmed
  • 抑制或激活实验; 人类; 图 1
Hahn S, Neuhoff A, Landsberg J, Schupp J, Eberts D, Leukel P, et al. A key role of GARP in the immune suppressive tumor microenvironment. Oncotarget. 2016;7:42996-43009 pubmed 出版商
  • 抑制或激活实验; 人类; 图 8
Hu H, Wang H, Xiao Y, Jin J, Chang J, Zou Q, et al. Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016;213:399-414 pubmed 出版商
  • 流式细胞仪; 人类; 图 5
Su S, Hu B, Shao J, Shen B, Du J, Du Y, et al. CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. Sci Rep. 2016;6:20070 pubmed 出版商
  • 流式细胞仪; 猕猴; 图 4
Bolton D, Pegu A, Wang K, McGinnis K, Nason M, Foulds K, et al. Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs. J Virol. 2016;90:1321-32 pubmed 出版商
  • 抑制或激活实验; 人类; 图 1
Silacci M, Lembke W, Woods R, Attinger Toller I, Baenziger Tobler N, Batey S, et al. Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases. MAbs. 2016;8:141-9 pubmed 出版商
  • 抑制或激活实验; 人类; 1 ug/ml; 图 6c
Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, et al. The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells. Nat Immunol. 2015;16:1077-84 pubmed 出版商
  • 抑制或激活实验; 人类; 图 3
Severson J, Serracino H, Mateescu V, Raeburn C, McIntyre R, Sams S, et al. PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer. Cancer Immunol Res. 2015;3:620-30 pubmed 出版商
  • 抑制或激活实验; 人类; 1 ug/ml
Chauhan A, Chen C, Moore T, DiPaolo R. Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset. J Biol Chem. 2015;290:5127-40 pubmed 出版商
  • 抑制或激活实验; 人类
Caramalho I, Nunes Silva V, Pires A, Mota C, Pinto A, Nunes Cabaço H, et al. Human regulatory T-cell development is dictated by Interleukin-2 and -15 expressed in a non-overlapping pattern in the thymus. J Autoimmun. 2015;56:98-110 pubmed 出版商
  • 流式细胞仪; 猕猴
Fujita T, Burwitz B, Chew G, Reed J, Pathak R, Seger E, et al. Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques. J Immunol. 2014;193:5576-83 pubmed 出版商
  • 流式细胞仪; 猕猴
Mylvaganam G, Velu V, Hong J, Sadagopal S, Kwa S, Basu R, et al. Diminished viral control during simian immunodeficiency virus infection is associated with aberrant PD-1hi CD4 T cell enrichment in the lymphoid follicles of the rectal mucosa. J Immunol. 2014;193:4527-36 pubmed 出版商
  • 流式细胞仪; 人类
Mao C, Mou X, Zhou Y, Yuan G, Xu C, Liu H, et al. Tumor-activated TCR??? T cells from gastric cancer patients induce the antitumor immune response of TCR??? T cells via their antigen-presenting cell-like effects. J Immunol Res. 2014;2014:593562 pubmed 出版商
  • 流式细胞仪; 人类
Peguillet I, Milder M, Louis D, Vincent Salomon A, Dorval T, Piperno Neumann S, et al. High numbers of differentiated effector CD4 T cells are found in patients with cancer and correlate with clinical response after neoadjuvant therapy of breast cancer. Cancer Res. 2014;74:2204-16 pubmed 出版商
  • 抑制或激活实验; 人类; 1 ug/ml
Rodriguez M, Loyd C, Ding X, Karim A, MCDONALD D, Canaday D, et al. Mycobacterial phosphatidylinositol mannoside 6 (PIM6) up-regulates TCR-triggered HIV-1 replication in CD4+ T cells. PLoS ONE. 2013;8:e80938 pubmed 出版商
  • 流式细胞仪; 猕猴
Demberg T, Brocca Cofano E, Kuate S, Aladi S, Vargas Inchaustegui D, Venzon D, et al. Impact of antibody quality and anamnestic response on viremia control post-challenge in a combined Tat/Env vaccine regimen in rhesus macaques. Virology. 2013;440:210-21 pubmed 出版商
  • 流式细胞仪; 猕猴; 图 2a
Reuter M, Yuan S, Marx P, Kutzler M, Weiner D, Betts M. DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells. Hum Vaccin Immunother. 2012;8:1648-53 pubmed 出版商
  • 抑制或激活实验; 人类
Qi Y, Operario D, Georas S, Mosmann T. The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin. PLoS ONE. 2012;7:e39072 pubmed 出版商
  • 流式细胞仪; 人类; 图 3
Brucklacher Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E. Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. J Immunol. 2009;183:5494-501 pubmed 出版商
  • 流式细胞仪; 猕猴
  • 流式细胞仪; 食蟹猴
Hokey D, Johnson F, Smith J, Weber J, Yan J, Hirao L, et al. Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques. Eur J Immunol. 2008;38:1435-45 pubmed 出版商
  • 抑制或激活实验; 人类
Hoves S, Krause S, Schutz C, Halbritter D, Scholmerich J, Herfarth H, et al. Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells. J Immunol. 2006;177:2691-8 pubmed
  • 抑制或激活实验; 人类; 100 ng/ml
Quiroga M, Pasquinelli V, Martinez G, Jurado J, Zorrilla L, Musella R, et al. Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. J Immunol. 2006;176:5965-74 pubmed
Martínez García M, Ojeda Ojeda M, Rodríguez Martín E, Insenser M, Moncayo S, Alvarez Blasco F, et al. TLR2 and TLR4 Surface and Gene Expression in White Blood Cells after Fasting and Oral Glucose, Lipid and Protein Challenges: Influence of Obesity and Sex Hormones. Biomolecules. 2020;10: pubmed 出版商
Pampusch M, Haran K, Hart G, Rakasz E, Rendahl A, Berger E, et al. Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations. Mol Ther Methods Clin Dev. 2020;16:1-10 pubmed 出版商
Tanaskovic O, Verga Falzacappa M, Pelicci P. Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells. PLoS ONE. 2019;14:e0217345 pubmed 出版商
Kim D, Kim H, Choi Y, Kim S, Lee J, Sung K, et al. Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer. Exp Mol Med. 2019;51:94 pubmed 出版商
Serwas N, Hoeger B, Ardy R, Stulz S, Sui Z, Memaran N, et al. Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis. Nat Commun. 2019;10:3106 pubmed 出版商
Opstelten R, Slot M, Lardy N, Lankester A, Mulder A, Claas F, et al. Determining the extent of maternal-foetal chimerism in cord blood. Sci Rep. 2019;9:5247 pubmed 出版商
Strecker J, Jones S, Koopal B, Schmid Burgk J, Zetsche B, Gao L, et al. Engineering of CRISPR-Cas12b for human genome editing. Nat Commun. 2019;10:212 pubmed 出版商
Rataj F, Jacobi S, Stoiber S, Asang F, Ogonek J, Tokarew N, et al. High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy. Br J Cancer. 2019;120:79-87 pubmed 出版商
Tran H, Herz C, Ruf P, Stetter R, Lamy E. Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes. Front Immunol. 2018;9:2949 pubmed 出版商
Fiore A, Ugel S, De Sanctis F, Sandri S, Fracasso G, Trovato R, et al. Induction of immunosuppressive functions and NF-κB by FLIP in monocytes. Nat Commun. 2018;9:5193 pubmed 出版商
Bethune M, Li X, Yu J, McLaughlin J, Cheng D, Mathis C, et al. Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules. Proc Natl Acad Sci U S A. 2018;115:E10702-E10711 pubmed 出版商
Ding J, Zhou T, Zheng X, Wang X, Tong X, Luo C, et al. The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis. Acta Cardiol Sin. 2018;34:399-408 pubmed 出版商
Yoshitomi H, Kobayashi S, Miyagawa Hayashino A, Okahata A, Doi K, Nishitani K, et al. Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. Nat Commun. 2018;9:3762 pubmed 出版商
Idelson M, Alper R, Obolensky A, Yachimovich Cohen N, Rachmilewitz J, Ejzenberg A, et al. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Stem Cell Reports. 2018;11:681-695 pubmed 出版商
Dijkstra K, Cattaneo C, Weeber F, Chalabi M, van de Haar J, Fanchi L, et al. Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids. Cell. 2018;174:1586-1598.e12 pubmed 出版商
Zhang A, Yoon J, Kim Y, Scott D. Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells. J Immunol. 2018;201:1434-1441 pubmed 出版商
Zhang R, Sun Q, Chen Y, Sun X, Gu Y, Zhao Z, et al. Ts-Hsp70 induces protective immunity against Trichinella spiralis infection in mouse by activating dendritic cells through TLR2 and TLR4. PLoS Negl Trop Dis. 2018;12:e0006502 pubmed 出版商
Cuadrado E, van den Biggelaar M, de Kivit S, Chen Y, Slot M, Doubal I, et al. Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity. Immunity. 2018;48:1046-1059.e6 pubmed 出版商
Dias A, Correia A, Pereira M, Almeida C, Alves I, Pinto V, et al. Metabolic control of T cell immune response through glycans in inflammatory bowel disease. Proc Natl Acad Sci U S A. 2018;115:E4651-E4660 pubmed 出版商
Inoue M, Niki M, Ozeki Y, Nagi S, Chadeka E, Yamaguchi T, et al. High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages. Sci Rep. 2018;8:6736 pubmed 出版商
Compeer E, Kraus F, Ecker M, Redpath G, Amiezer M, Rother N, et al. A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation. Nat Commun. 2018;9:1597 pubmed 出版商
Lee J, Bangayan N, Chai T, Smith B, Pariva T, Yun S, et al. Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer. Proc Natl Acad Sci U S A. 2018;115:E4473-E4482 pubmed 出版商
Shi Y, Zhang P, Wang G, Liu X, Sun X, Zhang X, et al. Description of organ-specific phenotype, and functional characteristics of tissue resident lymphocytes from liver transplantation donor and research on immune tolerance mechanism of liver. Oncotarget. 2018;9:15552-15565 pubmed 出版商
Akuffo A, Alontaga A, Metcalf R, Beatty M, Becker A, McDaniel J, et al. Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon. J Biol Chem. 2018;293:6187-6200 pubmed 出版商
Carisey A, Mace E, Saeed M, Davis D, Orange J. Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells. Curr Biol. 2018;28:489-502.e9 pubmed 出版商
Alam M, Gaida M, Debnath S, Tagad H, Miller Jenkins L, Appella E, et al. Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation. PLoS Biol. 2018;16:e2004111 pubmed 出版商
Pizzolla A, Nguyen T, Sant S, Jaffar J, Loudovaris T, Mannering S, et al. Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles. J Clin Invest. 2018;128:721-733 pubmed 出版商
Khan S, Karges W, Cooper C, Crawley A. Hepatitis C virus core protein reduces CD8+ T-cell proliferation, perforin production and degranulation but increases STAT5 activation. Immunology. 2018;154:156-165 pubmed 出版商
Toor S, Syed Khaja A, Alkurd I, Elkord E. In-vitro effect of pembrolizumab on different T regulatory cell subsets. Clin Exp Immunol. 2017;: pubmed 出版商
Berer K, Gerdes L, Cekanaviciute E, Jia X, Xiao L, Xia Z, et al. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2017;114:10719-10724 pubmed 出版商
Hayashi T, Jean M, Huang H, Simpson S, Santoso N, Zhu J. Screening of an FDA-approved compound library identifies levosimendan as a novel anti-HIV-1 agent that inhibits viral transcription. Antiviral Res. 2017;146:76-85 pubmed 出版商
Naik S, Padhi A, Ganguli G, Sengupta S, Pati S, Das D, et al. Mouse Bone Marrow Sca-1+ CD44+ Mesenchymal Stem Cells Kill Avirulent Mycobacteria but Not Mycobacterium tuberculosis through Modulation of Cathelicidin Expression via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway. Infect Immun. 2017;85: pubmed 出版商
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Darboe A, Danso E, Clarke E, Umesi A, Touray E, Wegmüller R, et al. Enhancement of cytokine-driven NK cell IFN-γ production after vaccination of HCMV infected Africans. Eur J Immunol. 2017;47:1040-1050 pubmed 出版商
Xu F, Zhang C, Zou Z, Fan E, Chen L, Li Y, et al. Aging-related Atg5 defect impairs neutrophil extracellular traps formation. Immunology. 2017;151:417-432 pubmed 出版商
Tyler C, McCarthy N, Lindsay J, Stagg A, Moser B, Eberl M. Antigen-Presenting Human γδ T Cells Promote Intestinal CD4+ T Cell Expression of IL-22 and Mucosal Release of Calprotectin. J Immunol. 2017;198:3417-3425 pubmed 出版商
Khodadoust M, Olsson N, Wagar L, Haabeth O, Chen B, Swaminathan K, et al. Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens. Nature. 2017;543:723-727 pubmed 出版商
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Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller A, et al. D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes. Mol Cell Biol. 2017;37: pubmed 出版商
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Cárcamo Orive I, Hoffman G, Cundiff P, Beckmann N, D Souza S, Knowles J, et al. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity. Cell Stem Cell. 2017;20:518-532.e9 pubmed 出版商
Zhu H, Hu F, Sun X, Zhang X, Zhu L, Liu X, et al. CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus. Front Immunol. 2016;7:512 pubmed
Ribeiro S, Tesio M, Ribot J, Macintyre E, Barata J, Silva Santos B. Casein kinase 2 controls the survival of normal thymic and leukemic ?? T cells via promotion of AKT signaling. Leukemia. 2017;31:1603-1610 pubmed 出版商
Wang Y, Ma C, Ling Y, Bousfiha A, Camcioglu Y, Jacquot S, et al. Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations. J Exp Med. 2016;213:2413-2435 pubmed
Pageon S, Tabarin T, Yamamoto Y, Ma Y, Nicovich P, Bridgeman J, et al. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proc Natl Acad Sci U S A. 2016;113:E5454-63 pubmed 出版商
Chen H, Händel N, Ngeow J, Muller J, Huhn M, Yang H, et al. Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells. J Allergy Clin Immunol. 2017;139:607-620.e15 pubmed 出版商
Tang Z, Hao Y, Zhang E, Xu C, Zhou Y, Zheng X, et al. CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade. Mol Med Rep. 2016;14:1107-16 pubmed 出版商
Jones R, Mueller S, O Connor R, Rimpel K, Sloan D, Karel D, et al. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog. 2016;12:e1005545 pubmed 出版商
Kapoor Kaushik N, Hinde E, Compeer E, Yamamoto Y, Kraus F, Yang Z, et al. Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells. Front Immunol. 2016;7:83 pubmed 出版商
Soh K, Tario J, Colligan S, Maguire O, Pan D, Minderman H, et al. Simultaneous, Single-Cell Measurement of Messenger RNA, Cell Surface Proteins, and Intracellular Proteins. Curr Protoc Cytom. 2016;75:7.45.1-7.45.33 pubmed 出版商
Liu C, Jiang J, Gao L, Wang X, Hu X, Wu M, et al. Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways. Arthritis Res Ther. 2015;17:340 pubmed 出版商
Hsu P, Santner Nanan B, Hu M, Skarratt K, Lee C, Stormon M, et al. IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1. J Immunol. 2015;195:3665-74 pubmed 出版商
Elkord E, Abd Al Samid M, Chaudhary B. Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP. Oncotarget. 2015;6:20026-36 pubmed
Choi J, Goh G, Walradt T, Hong B, Bunick C, Chen K, et al. Genomic landscape of cutaneous T cell lymphoma. Nat Genet. 2015;47:1011-9 pubmed 出版商
Kovacsovics Bankowski M, Chisholm L, Vercellini J, Tucker C, Montler R, Haley D, et al. Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities. J Immunother Cancer. 2014;2:38 pubmed 出版商
Bertin S, Aoki Nonaka Y, de Jong P, Nohara L, Xu H, Stanwood S, et al. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014;15:1055-1063 pubmed 出版商
Dang S, Xu H, Xu C, Cai W, Li Q, Cheng Y, et al. Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis. Autophagy. 2014;10:1301-15 pubmed 出版商
Mellergaard M, Skovbakke S, Schneider C, Lauridsen F, Andresen L, Jensen H, et al. N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24. J Biol Chem. 2014;289:20078-91 pubmed 出版商
Kang J, Wang P, Hwang P. Cell-based measurements of mitochondrial function in human subjects. Methods Enzymol. 2014;542:209-21 pubmed 出版商
Hartmann N, Giese N, Giese T, Poschke I, Offringa R, Werner J, et al. Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer. Clin Cancer Res. 2014;20:3422-33 pubmed 出版商
Wang D, Feng X, Lu L, Konkel J, Zhang H, Chen Z, et al. A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus. Arthritis Rheumatol. 2014;66:2234-45 pubmed 出版商
Pankratz S, Bittner S, Herrmann A, Schuhmann M, Ruck T, Meuth S, et al. Human CD4+ HLA-G+ regulatory T cells are potent suppressors of graft-versus-host disease in vivo. FASEB J. 2014;28:3435-45 pubmed 出版商
Guo Y, Riley K, Iwasaki A, Steitz J. Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function. Mol Cell. 2014;54:67-79 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscience™
目录# :
16-0289-85
规格 :
500微克
价格 :
351美元
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent
物种 :
人类
克隆 :
CD28.2
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1 µg/test, Functional assay: Assay-Dependent
别名 :
antigen CD28; Cd28; CD28 antigen; CD28 antigen (Tp44); CD28 isoform; CD28 isoform 2; CD28 molecule; CD28 precursor protein; CD28 protein; CD28 protein precursor; CD28RNA; cell surface protein; CHT28; contains partial extracellular domain; costimulatory molecule B7 receptor CD28; EGK_04709; MGC138290; sCD28; soluble CD28; T44; T-cell costimulatory molecule CD28; T-cell costimulatory molecule Tp44; T-cell-specific surface glycoprotein CD28; T-cell-specific surface glycoprotein CD28 homolog; TP44
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国