产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD154 (CD40 Ligand) Monoclonal Antibody (MR1), Functional Grade, eBioscience™
目录 :
16-1541-85
规格 :
500微克
价格 :
美国378
克隆性 :
单克隆
宿主 :
仓鼠
共轭标签 :
未共轭
克隆名称 :
MR1
反应物种 :
小鼠
应用 :
中和反应, 流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 6a
Ferdinand J, Richard A, Meylan F, Al Shamkhani A, Siegel R. Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells. J Immunol. 2018;200:1360-1369 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Werner J, Busl E, Farkas S, Schlitt H, Geissler E, Hornung M. DX5+NKT cells display phenotypical and functional differences between spleen and liver as well as NK1.1-Balb/c and NK1.1+ C57Bl/6 mice. BMC Immunol. 2011;12:26 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 2
Nakae S, Iwakura Y, Suto H, Galli S. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol. 2007;81:1258-68 pubmed
Bartleson J, Viehmann Milam A, Donermeyer D, Horvath S, Xia Y, Egawa T, et al. Strength of tonic T cell receptor signaling instructs T follicular helper cell-fate decisions. Nat Immunol. 2020;21:1384-1396 pubmed 出版商
Orr M, Khandhar A, Seydoux E, Liang H, Gage E, Mikasa T, et al. Reprogramming the adjuvant properties of aluminum oxyhydroxide with nanoparticle technology. NPJ Vaccines. 2019;4:1 pubmed 出版商
Shan Q, Zeng Z, Xing S, Li F, Hartwig S, Gullicksrud J, et al. The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol. 2017;18:931-939 pubmed 出版商
Noelle R, Roy M, Shepherd D, Stamenkovico I, Ledbetter J, Aruffo A. Pillars Article: A 39-kDa Protein on Activated Helper T Cells Binds CD40 and Transduces the Signal for Cognate Activation of B Cells. Proc. Natl. Acad. Sci. 1992. 89: 6550-6554. J Immunol. 2016;197:4195-4199 pubmed
Lee Chang C, Bodogai M, Moritoh K, Chen X, Wersto R, Sen R, et al. Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers. J Immunol. 2016;196:3385-97 pubmed 出版商
Pascutti M, Geerman S, Slot E, van Gisbergen K, Boon L, Arens R, et al. Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection. PLoS Pathog. 2015;11:e1004675 pubmed 出版商
Song L, Yang M, Knoff J, Wu T, Hung C. Cancer immunotherapy employing an innovative strategy to enhance CD4+ T cell help in the tumor microenvironment. PLoS ONE. 2014;9:e115711 pubmed 出版商
Shaw P, Weidinger C, Vaeth M, Luethy K, Kaech S, Feske S. CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2. J Clin Invest. 2014;124:4549-63 pubmed 出版商
Shimizuhira C, Otsuka A, Honda T, Kitoh A, Egawa G, Nakajima S, et al. Natural killer T cells are essential for the development of contact hypersensitivity in BALB/c mice. J Invest Dermatol. 2014;134:2709-2718 pubmed 出版商
Llopiz D, Huarte E, Ruiz M, Bezunartea J, Belsue V, Zabaleta A, et al. Helper cell-independent antitumor activity of potent CD8+ T cell epitope peptide vaccines is dependent upon CD40L. Oncoimmunology. 2013;2:e27009 pubmed
Shugart J, Bambina S, Alice A, Montler R, Bahjat K. A self-help program for memory CD8+ T cells: positive feedback via CD40-CD40L signaling as a critical determinant of secondary expansion. PLoS ONE. 2013;8:e64878 pubmed 出版商
Bolduc A, Long E, Stapler D, Cascalho M, Tsubata T, Koni P, et al. Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas. J Immunol. 2010;185:220-30 pubmed 出版商
Noris M, Cassis P, Azzollini N, Cavinato R, Cugini D, Casiraghi F, et al. The Toll-IL-1R member Tir8/SIGIRR negatively regulates adaptive immunity against kidney grafts. J Immunol. 2009;183:4249-60 pubmed 出版商
Zaheen A, Boulianne B, Parsa J, Ramachandran S, Gommerman J, Martin A. AID constrains germinal center size by rendering B cells susceptible to apoptosis. Blood. 2009;114:547-54 pubmed 出版商
Lesley R, Kelly L, Xu Y, Cyster J. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc Natl Acad Sci U S A. 2006;103:10717-22 pubmed
Hausl C, Ahmad R, Schwarz H, Muchitsch E, Turecek P, Dorner F, et al. Preventing restimulation of memory B cells in hemophilia A: a potential new strategy for the treatment of antibody-dependent immune disorders. Blood. 2004;104:115-22 pubmed
de Vinuesa C, Cook M, Ball J, Drew M, Sunners Y, Cascalho M, et al. Germinal centers without T cells. J Exp Med. 2000;191:485-94 pubmed
Roy M, Waldschmidt T, Aruffo A, Ledbetter J, Noelle R. The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells. J Immunol. 1993;151:2497-510 pubmed
van den Eertwegh A, Noelle R, Roy M, Shepherd D, Aruffo A, Ledbetter J, et al. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions. J Exp Med. 1993;178:1555-65 pubmed
Roy M, Aruffo A, Ledbetter J, Linsley P, Kehry M, Noelle R. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Eur J Immunol. 1995;25:596-603 pubmed
Yellin M, Sippel K, Inghirami G, Covey L, Lee J, Sinning J, et al. CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function. J Immunol. 1994;152:598-608 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD154 (CD40 Ligand) Monoclonal Antibody (MR1), Functional Grade, eBioscience™
目录# :
16-1541-85
规格 :
500微克
价格 :
美国378
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
亚美尼亚仓鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent
物种 :
小鼠
克隆 :
MR1
抗体亚型 :
IgG
储存 :
4° C
描述 :
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent
别名 :
CD154; CD40 antigen ligand; CD40 ligand; CD40 ligand CD154; CD40 ligand, membrane form; CD40 ligand, soluble form; Cd40l; CD40-L; CD40LG; gp39; hCD40L; H-CD-40-L; HIGM1; IGM; IMD3; Ly62; Ly-62; M-CD-40-L; RP23-153G22.3; T-B cell-activating molecule; T-BAM; T-cell antigen Gp39; TNF-related activation protein; Tnfsf5; TRAP; tumor necrosis factor (ligand) superfamily member 5; tumor necrosis factor (ligand) superfamily, member 5; tumor necrosis factor ligand superfamily member 5
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国