产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
MERTK Monoclonal Antibody (DS5MMER), Functional Grade, eBioscience
目录 :
16-5751-050
规格 :
50毫克
价格 :
美国12850
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
DS5MMER
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 10
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 s3d
Bhattacharjee O, Ayyangar U, Kurbet A, Lakshmanan V, Palakodeti D, Ginhoux F, et al. Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin. Front Immunol. 2021;12:718005 pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 1c
Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4c
Manils J, Webb L, Howes A, Janzen J, Boeing S, Bowcock A, et al. CARD14E138A signalling in keratinocytes induces TNF-dependent skin and systemic inflammation. elife. 2020;9: pubmed 出版商
  • 流式细胞仪; 小鼠
Wang S, Li R, Ng T, Luthria G, Oudin M, Prytyskach M, et al. Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. Sci Adv. 2020;6:eaaz8521 pubmed 出版商
  • 流式细胞仪; 小鼠
Te H, Perlman D, Shenoy C, Steinberger D, Cogswell R, Roukoz H, et al. Clinical characteristics and organ system involvement in sarcoidosis: comparison of the University of Minnesota Cohort with other cohorts. BMC Pulm Med. 2020;20:155 pubmed 出版商
  • 流式细胞仪; 小鼠
Lee K, Zhang Z, Achuthan A, Fleetwood A, Smith J, Hamilton J, et al. IL-23 in arthritic and inflammatory pain development in mice. Arthritis Res Ther. 2020;22:123 pubmed 出版商
  • 流式细胞仪; 小鼠
Woo Y, Lim J, Oh J, Lee J, Kim J. Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice. Antioxidants (Basel). 2020;9: pubmed 出版商
Waterborg C, Beermann S, Broeren M, Bennink M, Koenders M, van Lent P, et al. Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models. Front Immunol. 2018;9:742 pubmed 出版商
Barnette D, Cahill T, Gunadasa Rohling M, Carr C, Freeman M, Riley P. iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction. JCI Insight. 2018;3: pubmed 出版商
Dransfield I, Zagórska A, Lew E, Michail K, Lemke G. Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells. Cell Death Dis. 2015;6:e1646 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
MERTK Monoclonal Antibody (DS5MMER), Functional Grade, eBioscience
目录# :
16-5751-050
规格 :
50毫克
价格 :
美国12850
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: Assay-Dependent, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): 5 µg/mL, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent
物种 :
小鼠
克隆 :
DS5MMER
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-Dependent, Functional assay: Assay-Dependent, Immunohistochemistry (Frozen): 5 µg/mL, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent
别名 :
c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国