产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD178 (Fas Ligand) Monoclonal Antibody (MFL3), Functional Grade, eBioscience
目录 :
16-5911-85
规格 :
500微克
价格 :
美国397
克隆性 :
单克隆
宿主 :
仓鼠
共轭标签 :
未共轭
克隆名称 :
MFL3
反应物种 :
小鼠
应用 :
中和反应, 免疫沉淀, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 42
出版应用/物种/样本/稀释 | 参考文献 |
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| Nakae S, Iwakura Y, Suto H, Galli S. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol. 2007;81:1258-68 pubmed
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Frenzel L, Abdullah Z, Kriegeskorte A, Dieterich R, Lange N, Busch D, et al. Role of natural-killer group 2 member D ligands and intercellular adhesion molecule 1 in natural killer cell-mediated lysis of murine embryonic stem cells and embryonic stem cell-derived cardiomyocytes. Stem Cells. 2009;27:307-16 pubmed 出版商
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Ruffell B, Johnson P. Hyaluronan induces cell death in activated T cells through CD44. J Immunol. 2008;181:7044-54 pubmed
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Brincks E, Katewa A, Kucaba T, Griffith T, Legge K. CD8 T cells utilize TRAIL to control influenza virus infection. J Immunol. 2008;181:4918-25 pubmed
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Zhang Y, Xu G, Zhang L, Roberts A, Shi Y. Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-gamma. J Immunol. 2008;181:190-6 pubmed
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McKinstry K, Golech S, Lee W, Huston G, Weng N, Swain S. Rapid default transition of CD4 T cell effectors to functional memory cells. J Exp Med. 2007;204:2199-211 pubmed
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Priatel J, Chen X, Zenewicz L, Shen H, Harder K, Horwitz M, et al. Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion. J Immunol. 2007;179:2143-52 pubmed
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Li M, Wang Y, Guo R, Bai Y, Yu Z. Glucocorticoids impair microglia ability to induce T cell proliferation and Th1 polarization. Immunol Lett. 2007;109:129-37 pubmed
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Zhang J, Gong Y, Shao X, Zhang R, Xu W, Chu Y, et al. Asynchronism of thymocyte development in vivo and in vitro. DNA Cell Biol. 2007;26:19-27 pubmed
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Buhtoiarov I, Sondel P, Eickhoff J, Rakhmilevich A. Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides. Immunology. 2007;120:412-23 pubmed
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Ishiyama K, Ohdan H, Tokita D, Shishida M, Tanaka Y, Irei T, et al. Induction of endotoxin tolerance inhibits alloimmune responses. Transpl Immunol. 2006;16:158-65 pubmed
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Tokita D, Shishida M, Ohdan H, Onoe T, Hara H, Tanaka Y, et al. Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity. J Immunol. 2006;177:3615-24 pubmed
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Onoe T, Ohdan H, Tokita D, Shishida M, Tanaka Y, Hara H, et al. Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice. J Immunol. 2005;175:139-46 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
CD178 (Fas Ligand) Monoclonal Antibody (MFL3), Functional Grade, eBioscience
目录# :
16-5911-85
规格 :
500微克
价格 :
美国397
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
亚美尼亚仓鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent
物种 :
小鼠
克隆 :
MFL3
抗体亚型 :
IgG
储存 :
4° C
描述 :
CD178 (Fas ligand, FasL) is a type-II-membrane protein, whose N-terminus is in the cytoplasm and its C-terminal region extends into the extracellular space. Its receptor, FasR, is a cell-surface-type-I-membrane protein and a member of the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family. As a member of the TNF-cytokine family CD178 induces apoptosis when interacting with FasR. CD178 may exist as either membrane bound (45 kD) or soluble forms (26 kD). The soluble protein can be released from cells upon cleavage by metalloproteinases. Binding of CD178 to Fas leads to oligomerization of the receptor and triggers apoptotic cell death through the interaction of other proteins. CD178 is predominantly expressed in activated T-lymphocytes and natural killer (NK) cells also it is expressed in the tissues of immune-privilege sites such as testis and eye. CD178 expression is also reported in various tissues as thymus, liver, ovary, lung, heart and kidney. It is assumed that induction of apoptosis through CD178 is predominantly involved in anti-viral immune responses. CD178 is a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis. Various cells express FAS, where CD178 is expressed predominantly on activated T cells. FAS and CD178 are involved in the down-regulation of immune reactions as well as T cell-mediated cytotoxicity. CD178 concentration has also been shown to be associated with atherosclerosis and inflammatory disease, in patients with hypertension. The Fas/ CD178 system has been shown to play a role in a number of human diseases, for example AIDS, hepatitis or cancer.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent
别名 :
ADAM10-processed FasL form; ALPS1B; APL; Apoptosis (APO 1) antigen ligand 1; apoptosis (APO-1) antigen ligand 1; Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand); apoptosis antigen ligand; APT1LG1; APTL; CD178; CD178 antigen; CD95 ligand; CD95 ligand protein;Generalized lymphoproliferative disease (Gld); Cd95l; CD95-L; CD95L protein; fas antigen ligand; Fas ligand; Fas ligand (TNF superfamily, member 6); Fasl; Fas-L; FasL ICD; FasL intracellular domain; Faslg; Fas-LG; generalized lymphoproliferative disease; gld; mutant tumor necrosis factor family member 6; Receptor-binding FasL ectodomain; sFasL; Soluble Fas ligand; soluble form; SPA; SPPL2A-processed FasL form; TNFL; Tnfsf6; TNLG1A; Tumor necrosis factor (ligand) superfamily member 6; Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand); Tumor necrosis factor ligand; tumor necrosis factor ligand 1A; tumor necrosis factor ligand superfamily member 6; Tumor necrosis factor ligand superfamily member 6 (TNFL6 / TNFSF6); Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form
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