产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-10 Monoclonal Antibody (JES3-9D7), Functional Grade, eBioscience
目录 :
16-7108-81
规格 :
50微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
JES3-9D7
反应物种 :
African green monkey, 人类
应用 :
酶联免疫吸附测定, 免疫细胞化学, 中和反应, 流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 72
出版应用/物种/样本/稀释参考文献
  • 酶联免疫吸附测定; 人类; 图 5c
Otsuka Y, Watanabe E, Shinya E, Okura S, Saeki H, Geijtenbeek T, et al. Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22-Specific Th Cells. J Immunol. 2018;201:3006-3016 pubmed 出版商
  • 流式细胞仪; 人类; 图 3b
Pizzolla A, Nguyen T, Sant S, Jaffar J, Loudovaris T, Mannering S, et al. Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles. J Clin Invest. 2018;128:721-733 pubmed 出版商
  • 流式细胞仪; 人类; 图 7
Scottà C, Fanelli G, Hoong S, Romano M, Lamperti E, Sukthankar M, et al. Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells. Haematologica. 2016;101:91-100 pubmed 出版商
  • 流式细胞仪; 人类
Lee J, Jeong I, Joh J, Jung Y, Sim S, Choi B, et al. Differential expression of CD57 in antigen-reactive CD4+ T cells between active and latent tuberculosis infection. Clin Immunol. 2015;159:37-46 pubmed 出版商
  • 流式细胞仪; 人类
Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, et al. CD26-mediated induction of EGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway. J Immunol. 2015;194:960-72 pubmed 出版商
  • 免疫细胞化学; 人类
Touzot M, Cacoub P, Bodaghi B, Soumelis V, Saadoun D. IFN-α induces IL-10 production and tilt the balance between Th1 and Th17 in Behçet disease. Autoimmun Rev. 2015;14:370-5 pubmed 出版商
  • 流式细胞仪; 人类
Cousens L, Najafian N, Martin W, De Groot A. Tregitope: Immunomodulation powerhouse. Hum Immunol. 2014;75:1139-46 pubmed 出版商
  • 流式细胞仪; 人类
Mohanty S, Joshi S, Ueda I, Wilson J, Blevins T, Siconolfi B, et al. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. J Infect Dis. 2015;211:1174-84 pubmed 出版商
  • 抑制或激活实验; 人类; 20 ug/ml
Preciado Llanes L, Wing J, Foster R, Carlring J, Lees A, Read R, et al. Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking. Immunology. 2014;: pubmed 出版商
  • 抑制或激活实验; African green monkey; 10 ug/ml; 图 s4
Park S, Veerapu N, Shin E, Biancotto A, McCoy J, Capone S, et al. Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection. Nat Med. 2013;19:1638-42 pubmed 出版商
  • 流式细胞仪; African green monkey; 图 3
de Campos S, Souza Lemos C, Teva A, Porrozzi R, Grimaldi G. Systemic and compartmentalised immune responses in a Leishmania braziliensis-macaque model of self-healing cutaneous leishmaniasis. Vet Immunol Immunopathol. 2010;137:149-54 pubmed 出版商
Volodarsky I, Shimoni S, Haberman D, Mirkin V, Fabrikant Y, Yoskovich Mashriki T, et al. Circulating Regulatory B-Lymphocytes in Patients with Acute Myocardial Infarction: A Pilot Study. J Cardiovasc Dev Dis. 2022;10: pubmed 出版商
Simanullang R, Situmorang P, Herlina M, Noradina -, Silalahi B, Manurung S. Histological changes of cervical tumours following Zanthoxylum acanthopodium DC treatment, and its impact on cytokine expression. Saudi J Biol Sci. 2022;29:2706-2718 pubmed 出版商
Fan X, Zhang Y, Ouyang R, Luo B, Li L, He W, et al. Cysticercus cellulosae Regulates T-Cell Responses and Interacts With the Host Immune System by Excreting and Secreting Antigens. Front Cell Infect Microbiol. 2021;11:728222 pubmed 出版商
Eriksen L, Nielsen M, Laursen T, Deleuran B, Vilstrup H, St xf8 y S. Early loss of T lymphocyte 4-1BB receptor expression is associated with higher short-term mortality in alcoholic hepatitis. PLoS ONE. 2021;16:e0255574 pubmed 出版商
Sadeghlar F, Vogt A, Mohr R, Mahn R, van Beekum K, Kornek M, et al. Induction of cytotoxic effector cells towards cholangiocellular, pancreatic, and colorectal tumor cells by activation of the immune checkpoint CD40/CD40L on dendritic cells. Cancer Immunol Immunother. 2021;70:1451-1464 pubmed 出版商
Huang B, Liu Y, Lai S, Lin H, Shen C, Yang L, et al. CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions. Int J Mol Sci. 2020;21: pubmed 出版商
Imura Y, Ando M, Kondo T, Ito M, Yoshimura A. CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD. JCI Insight. 2020;5: pubmed 出版商
Cekanaviciute E, Pröbstel A, Thomann A, Runia T, CASACCIA P, Katz Sand I, et al. Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria. mSystems. 2018;3: pubmed 出版商
Shi Y, Zhang P, Wang G, Liu X, Sun X, Zhang X, et al. Description of organ-specific phenotype, and functional characteristics of tissue resident lymphocytes from liver transplantation donor and research on immune tolerance mechanism of liver. Oncotarget. 2018;9:15552-15565 pubmed 出版商
Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, et al. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype. Nat Commun. 2018;9:873 pubmed 出版商
Roux C, Saviane G, Pini J, Belaïd N, Dhib G, Voha C, et al. Immunosuppressive Mesenchymal Stromal Cells Derived from Human-Induced Pluripotent Stem Cells Induce Human Regulatory T Cells In Vitro and In Vivo. Front Immunol. 2017;8:1991 pubmed 出版商
Vargas Hernandez A, Mace E, Zimmerman O, Zerbe C, Freeman A, Rosenzweig S, et al. Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations. J Allergy Clin Immunol. 2018;141:2142-2155.e5 pubmed 出版商
Powell R, Lissauer D, Tamblyn J, Beggs A, Cox P, Moss P, et al. Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN. J Immunol. 2017;199:3406-3417 pubmed 出版商
Schwerd T, Twigg S, Aschenbrenner D, Manrique S, Miller K, Taylor I, et al. A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis. J Exp Med. 2017;214:2547-2562 pubmed 出版商
Sulzer D, Alcalay R, Garretti F, Cote L, Kanter E, Agin Liebes J, et al. T cells from patients with Parkinson's disease recognize α-synuclein peptides. Nature. 2017;546:656-661 pubmed 出版商
Fan H, Li L, Zhang Y, Yang J, Li M, Zeng F, et al. PKC? in prostate cancer cells represses the recruitment and M2 polarization of macrophages in the prostate cancer microenvironment. Tumour Biol. 2017;39:1010428317701442 pubmed 出版商
Miles B, Miller S, Folkvord J, Levy D, Rakasz E, Skinner P, et al. Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection. PLoS Pathog. 2016;12:e1005924 pubmed 出版商
Mariuzzi L, Domenis R, Orsaria M, Marzinotto S, Londero A, Bulfoni M, et al. Functional expression of aryl hydrocarbon receptor on mast cells populating human endometriotic tissues. Lab Invest. 2016;96:959-971 pubmed 出版商
Hussain K, Letley D, Greenaway A, Kenefeck R, Winter J, Tomlinson W, et al. Helicobacter pylori-Mediated Protection from Allergy Is Associated with IL-10-Secreting Peripheral Blood Regulatory T Cells. Front Immunol. 2016;7:71 pubmed 出版商
Wang Y, Yi J, Chen X, Zhang Y, Xu M, Yang Z. The regulation of cancer cell migration by lung cancer cell-derived exosomes through TGF-β and IL-10. Oncol Lett. 2016;11:1527-1530 pubmed
Singh S, Vedi S, Samrat S, Li W, Kumar R, Agrawal B. Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines. PLoS ONE. 2016;11:e0146404 pubmed 出版商
Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed 出版商
Keating P, Munim A, Hartmann J. Effect of vitamin D on T-helper type 9 polarized human memory cells in chronic persistent asthma. Ann Allergy Asthma Immunol. 2014;112:154-62 pubmed 出版商
Maine C, Aziz N, Chatterjee J, Hayford C, Brewig N, Whilding L, et al. Programmed death ligand-1 over-expression correlates with malignancy and contributes to immune regulation in ovarian cancer. Cancer Immunol Immunother. 2014;63:215-24 pubmed 出版商
Gudbrandsdottir S, Hasselbalch H, Nielsen C. Activated platelets enhance IL-10 secretion and reduce TNF-? secretion by monocytes. J Immunol. 2013;191:4059-67 pubmed 出版商
Voo K, Bover L, Harline M, Vien L, Facchinetti V, Arima K, et al. Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function. J Immunol. 2013;191:3641-50 pubmed 出版商
McCarthy N, Bashir Z, Vossenkamper A, Hedin C, Giles E, Bhattacharjee S, et al. Proinflammatory V?2+ T cells populate the human intestinal mucosa and enhance IFN-? production by colonic ?? T cells. J Immunol. 2013;191:2752-63 pubmed 出版商
Wang H, Brown J, Gao S, Liang S, Jotwani R, Zhou H, et al. The role of JAK-3 in regulating TLR-mediated inflammatory cytokine production in innate immune cells. J Immunol. 2013;191:1164-74 pubmed 出版商
Davtyan T, Poghosyan D, Sukiasyan A, Grant M. The anti-idiotypic antibody 1F7 stimulates monocyte interleukin-10 production and induces endotoxin tolerance. J Inflamm (Lond). 2013;10:14 pubmed 出版商
Olsen I, Sollid L. Pitfalls in determining the cytokine profile of human T cells. J Immunol Methods. 2013;390:106-12 pubmed 出版商
Kwon H, Kim G, Kim Y, Hwang W, Jash A, Sahoo A, et al. Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response. Clin Immunol. 2013;146:217-27 pubmed 出版商
Luger R, Valookaran S, Knapp N, Vizzardelli C, Dohnal A, Felzmann T. Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode. PLoS ONE. 2013;8:e54879 pubmed 出版商
Jaudszus A, Gruen M, Watzl B, Ness C, Roth A, Lochner A, et al. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. J Lipid Res. 2013;54:923-35 pubmed 出版商
Gellatly S, Needham B, Madera L, Trent M, Hancock R. The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation. Infect Immun. 2012;80:3122-31 pubmed 出版商
Belderbos M, Levy O, Stalpers F, Kimpen J, Meyaard L, Bont L. Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors. PLoS ONE. 2012;7:e33419 pubmed 出版商
André M, Gille C, Glemser P, Woiterski J, Hsu H, Spring B, et al. Bacterial reprogramming of PBMCs impairs monocyte phagocytosis and modulates adaptive T cell responses. J Leukoc Biol. 2012;91:977-89 pubmed 出版商
Vohra P, Poxton I. Induction of cytokines in a macrophage cell line by proteins of Clostridium difficile. FEMS Immunol Med Microbiol. 2012;65:96-104 pubmed 出版商
Zhang M, Zheng X, Zhang J, Zhu Y, Zhu X, Liu H, et al. CD19(+)CD1d(+)CD5(+) B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses. Cell Immunol. 2012;274:89-97 pubmed 出版商
Hansmann L, Schmidl C, Kett J, Steger L, Andreesen R, Hoffmann P, et al. Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression. J Immunol. 2012;188:1275-82 pubmed 出版商
Neunkirchner A, Leb Reichl V, Schmetterer K, Mutschlechner S, Kueng H, Haiderer D, et al. Human TCR transgenic Bet v 1-specific Th1 cells suppress the effector function of Bet v 1-specific Th2 cells. J Immunol. 2011;187:4077-87 pubmed 出版商
Sauer U, Domnanich P, Preininger C. Protein chip for the parallel quantification of high and low abundant biomarkers for sepsis. Anal Biochem. 2011;419:46-52 pubmed 出版商
Ma C, Fan R, Ahmad H, Shi Q, Comin Anduix B, Chodon T, et al. A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells. Nat Med. 2011;17:738-43 pubmed 出版商
Liu Y, Zhu T, Cai G, Qin Y, Wang W, Tang G, et al. Elevated circulating CD4+ ICOS+ Foxp3+ T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic lupus erythematosus. Lupus. 2011;20:620-7 pubmed 出版商
Liu B, Groothuismink Z, Janssen H, Boonstra A. Role for IL-10 in inducing functional impairment of monocytes upon TLR4 ligation in patients with chronic HCV infections. J Leukoc Biol. 2011;89:981-8 pubmed 出版商
Pedroza Gonzalez A, Xu K, Wu T, Aspord C, Tindle S, Marches F, et al. Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation. J Exp Med. 2011;208:479-90 pubmed 出版商
Mattila J, Diedrich C, Lin P, Phuah J, Flynn J. Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation. J Immunol. 2011;186:3527-37 pubmed 出版商
Domnanich P, Peña D, Preininger C. Xanthan/chitosan gold chip for metal enhanced protein biomarker detection. Biosens Bioelectron. 2011;26:2559-65 pubmed 出版商
Hovhannisyan Z, Treatman J, Littman D, Mayer L. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011;140:957-65 pubmed 出版商
Yeganegi M, Leung C, Martins A, Kim S, Reid G, Challis J, et al. Lactobacillus rhamnosus GR-1-induced IL-10 production in human placental trophoblast cells involves activation of JAK/STAT and MAPK pathways. Reprod Sci. 2010;17:1043-51 pubmed 出版商
Lim A, Allison C, Price P, Waterer G. Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency. Clin Immunol. 2010;137:296-302 pubmed 出版商
Jeffery L, Burke F, Mura M, Zheng Y, Qureshi O, Hewison M, et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol. 2009;183:5458-67 pubmed 出版商
López M, Pereda C, Segal G, Muñoz L, Aguilera R, González F, et al. Prolonged survival of dendritic cell-vaccinated melanoma patients correlates with tumor-specific delayed type IV hypersensitivity response and reduction of tumor growth factor beta-expressing T cells. J Clin Oncol. 2009;27:945-52 pubmed 出版商
Li H, Han Y, Guo Q, Zhang M, Cao X. Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1. J Immunol. 2009;182:240-9 pubmed
Ma C, Chew G, Simpson N, Priyadarshi A, Wong M, Grimbacher B, et al. Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med. 2008;205:1551-7 pubmed 出版商
Reske A, Pollara G, Krummenacher C, Katz D, Chain B. Glycoprotein-dependent and TLR2-independent innate immune recognition of herpes simplex virus-1 by dendritic cells. J Immunol. 2008;180:7525-36 pubmed
Salhi A, Rodrigues V, Santoro F, Dessein H, Romano A, Castellano L, et al. Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis. J Immunol. 2008;180:6139-48 pubmed
Mueller Y, Do D, Altork S, Artlett C, Gracely E, Katsetos C, et al. IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses. J Immunol. 2008;180:350-60 pubmed
Nowacki T, Kuerten S, Zhang W, Shive C, Kreher C, Boehm B, et al. Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. Cell Immunol. 2007;247:36-48 pubmed
Sendide K, Deghmane A, Pechkovsky D, Av Gay Y, Talal A, Hmama Z. Mycobacterium bovis BCG attenuates surface expression of mature class II molecules through IL-10-dependent inhibition of cathepsin S. J Immunol. 2005;175:5324-32 pubmed
Martin M, Schifferle R, Cuesta N, Vogel S, Katz J, Michalek S. Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J Immunol. 2003;171:717-25 pubmed
Reignat S, Webster G, Brown D, Ogg G, King A, Seneviratne S, et al. Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. J Exp Med. 2002;195:1089-101 pubmed
产品信息
产品类型 :
抗体
产品名称 :
IL-10 Monoclonal Antibody (JES3-9D7), Functional Grade, eBioscience
目录# :
16-7108-81
规格 :
50微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
人类
应用 :
ELISA: Assay-Dependent, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
物种 :
人类
克隆 :
JES3-9D7
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
格式 :
液体
应用w/稀释 :
ELISA: Assay-Dependent, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
别名 :
CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国