产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IFN gamma Monoclonal Antibody (AN-18), Functional Grade, eBioscience
目录 :
16-7313-85
规格 :
500微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
AN-18
反应物种 :
小鼠
应用 :
酶联免疫吸附测定, 流式细胞仪
更多信息或购买 :
文章摘录数: 67
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 2f, 3c,
Raphael I, Gomez Rivera F, Raphael R, Robinson R, Nalawade S, Forsthuber T. TNFR2 limits proinflammatory astrocyte functions during EAE induced by pathogenic DR2b-restricted T cells. JCI Insight. 2019;4: pubmed 出版商
  • 流式细胞仪; 小鼠; 图 4d
Yang X, Lin Y, Shi Y, Li B, Liu W, Yin W, et al. FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling. Cancer Res. 2016;76:4124-35 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠; 图 3D
Arellano B, Hussain R, Miller Little W, Herndon E, Lambracht Washington D, Eagar T, et al. A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB1*03:01 by a Murine TCR. PLoS ONE. 2016;11:e0152720 pubmed 出版商
Morelli A, Sumpter T, Rojas Canales D, Bandyopadhyay M, Chen Z, Tkacheva O, et al. Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells. Cell Rep. 2020;30:3448-3465.e8 pubmed 出版商
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Sosa R, Murphey C, Ji N, Cardona A, Forsthuber T. The kinetics of myelin antigen uptake by myeloid cells in the central nervous system during experimental autoimmune encephalomyelitis. J Immunol. 2013;191:5848-57 pubmed 出版商
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Jaini R, Rayman P, Cohen P, Finke J, Tuohy V. Combination of sunitinib with anti-tumor vaccination inhibits T cell priming and requires careful scheduling to achieve productive immunotherapy. Int J Cancer. 2014;134:1695-705 pubmed 出版商
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Ryan S, Johnson J, Cobb B. Neutrophils confer T cell resistance to myeloid-derived suppressor cell-mediated suppression to promote chronic inflammation. J Immunol. 2013;190:5037-47 pubmed 出版商
Gilchuk P, Spencer C, Conant S, Hill T, Gray J, Niu X, et al. Discovering naturally processed antigenic determinants that confer protective T cell immunity. J Clin Invest. 2013;123:1976-87 pubmed 出版商
Blum L, Mohanan S, Fabre M, Yafawi R, Appleton J. Intestinal infection with Trichinella spiralis induces distinct, regional immune responses. Vet Parasitol. 2013;194:101-5 pubmed 出版商
Scalfone L, Nel H, Gagliardo L, Cameron J, Al Shokri S, Leifer C, et al. Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis. Infect Immun. 2013;81:1354-63 pubmed 出版商
Kozak K, Wang J, Lye M, Chuh J, Takkar R, Kim N, et al. Micro-volume wall-less immunoassays using patterned planar plates. Lab Chip. 2013;13:1342-50 pubmed 出版商
Hundgeburth L, Wunsch M, Rovituso D, Recks M, Addicks K, Lehmann P, et al. The complement system contributes to the pathology of experimental autoimmune encephalomyelitis by triggering demyelination and modifying the antigen-specific T and B cell response. Clin Immunol. 2013;146:155-64 pubmed 出版商
Monk J, Hou T, Turk H, Weeks B, Wu C, McMurray D, et al. Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis. PLoS ONE. 2012;7:e49739 pubmed 出版商
Young E, Vichaya E, Reusser N, Cook J, Steelman A, Welsh C, et al. Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection. J Neuroimmunol. 2013;254:19-27 pubmed 出版商
Hall A, Beiting D, Tato C, John B, Oldenhove G, Lombana C, et al. The cytokines interleukin 27 and interferon-? promote distinct Treg cell populations required to limit infection-induced pathology. Immunity. 2012;37:511-23 pubmed 出版商
Weinger J, Weist B, Plaisted W, Klaus S, Walsh C, Lane T. MHC mismatch results in neural progenitor cell rejection following spinal cord transplantation in a model of viral-induced demyelination. Stem Cells. 2012;30:2584-95 pubmed 出版商
Kuerten S, Schickel A, Kerkloh C, Recks M, Addicks K, Ruddle N, et al. Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell response. Acta Neuropathol. 2012;124:861-73 pubmed 出版商
Batoulis H, Uhl M, Addicks K, Lehmann P, Kuerten S. The magnitude of the antigen-specific T cell response is separated from the severity of spinal cord histopathology in remitting-relapsing experimental autoimmune encephalomyelitis. Glia. 2012;60:794-805 pubmed 出版商
Boué J, Blanpied C, Djata Cabral M, Pelletier L, Vergnolle N, Dietrich G. Immune conditions associated with CD4+ T effector-induced opioid release and analgesia. Pain. 2012;153:485-93 pubmed 出版商
Massilamany C, Asojo O, Gangaplara A, Steffen D, Reddy J. Identification of a second mimicry epitope from Acanthamoeba castellanii that induces CNS autoimmunity by generating cross-reactive T cells for MBP 89-101 in SJL mice. Int Immunol. 2011;23:729-39 pubmed 出版商
Massilamany C, Gangaplara A, Steffen D, Reddy J. Identification of novel mimicry epitopes for cardiac myosin heavy chain-? that induce autoimmune myocarditis in A/J mice. Cell Immunol. 2011;271:438-49 pubmed 出版商
Lee D, Kim S, Kang W, Choi Y, Lee S, Lee S, et al. Adjuvant effect of bacterial outer membrane vesicles with penta-acylated lipopolysaccharide on antigen-specific T cell priming. Vaccine. 2011;29:8293-301 pubmed 出版商
Collins E, Jager L, Dabelic R, Benitez P, Holdstein K, Lau K, et al. Inhibition of SOCS1-/- lethal autoinflammatory disease correlated to enhanced peripheral Foxp3+ regulatory T cell homeostasis. J Immunol. 2011;187:2666-76 pubmed 出版商
Paterson A, Brown K, Keir M, Vanguri V, Riella L, Chandraker A, et al. The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo. J Immunol. 2011;187:1097-105 pubmed 出版商
Rottlaender A, Villwock H, Addicks K, Kuerten S. Neuroprotective role of fibroblast growth factor-2 in experimental autoimmune encephalomyelitis. Immunology. 2011;133:370-8 pubmed 出版商
Javeri S, Rodi M, Tary Lehmann M, Lehmann P, Addicks K, Kuerten S. Involvement of brain-derived neurotrophic factor (BDNF) in MP4-induced autoimmune encephalomyelitis. Clin Immunol. 2010;137:181-9 pubmed 出版商
Gürlevik E, Woller N, Strüver N, Schache P, Kloos A, Manns M, et al. Selectivity of oncolytic viral replication prevents antiviral immune response and toxicity, but does not improve antitumoral immunity. Mol Ther. 2010;18:1972-82 pubmed 出版商
Chan P, Liu S, Cheung T, Yeo W, Ngai S, Cheung J, et al. T-cell response to human papillomavirus type 58 L1, E6, And E7 peptides in women with cleared infection, cervical intraepithelial neoplasia, or invasive cancer. Clin Vaccine Immunol. 2010;17:1315-21 pubmed 出版商
Li W, Murthy A, Guentzel M, Chambers J, Forsthuber T, Seshu J, et al. Immunization with a combination of integral chlamydial antigens and a defined secreted protein induces robust immunity against genital chlamydial challenge. Infect Immun. 2010;78:3942-9 pubmed 出版商
Nesbeth Y, Martinez D, Toraya S, Scarlett U, Cubillos Ruiz J, Rutkowski M, et al. CD4+ T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. J Immunol. 2010;184:5654-62 pubmed 出版商
Noor S, Habashy A, Nance J, Clark R, Nemati K, Carson M, et al. CCR7-dependent immunity during acute Toxoplasma gondii infection. Infect Immun. 2010;78:2257-63 pubmed 出版商
Kuerten S, Rodi M, Javeri S, Gruppe T, Tary Lehmann M, Lehmann P, et al. Delineating the impact of neuroantigen vs genetic diversity on MP4-induced EAE of C57BL/6 and B6.129 mice. APMIS. 2009;117:923-35 pubmed 出版商
Narazaki H, Zhu Y, Luo L, Zhu G, Chen L. CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells. Blood. 2010;115:1941-8 pubmed 出版商
Massilamany C, Steffen D, Reddy J. An epitope from Acanthamoeba castellanii that cross-react with proteolipid protein 139-151-reactive T cells induces autoimmune encephalomyelitis in SJL mice. J Neuroimmunol. 2010;219:17-24 pubmed 出版商
Burrows M, Assundani D, Celis E, Tufaro F, Tanaka A, Bradley W. Oral administration of PPC enhances antigen-specific CD8+ T cell responses while reducing IgE levels in sensitized mice. BMC Complement Altern Med. 2009;9:49 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
IFN gamma Monoclonal Antibody (AN-18), Functional Grade, eBioscience
目录# :
16-7313-85
规格 :
500微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Control: Assay-Dependent, Functional Assay: Assay-Dependent, Immunostaining: 1-4 µg/mL
物种 :
小鼠
克隆 :
AN-18
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
格式 :
液体
应用w/稀释 :
Control: Assay-Dependent, Functional Assay: Assay-Dependent, Immunostaining: 1-4 µg/mL
别名 :
BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国