产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD27 Monoclonal Antibody (O323), APC, eBioscience™
目录 :
17-0279-41
规格 :
25试验
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
APC
克隆名称 :
O323
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 88
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 2a
Sullivan N, Reuter Monslow M, Sei J, Durr E, Davis C, Chang C, et al. Breadth and Functionality of Varicella-Zoster Virus Glycoprotein-Specific Antibodies Identified after Zostavax Vaccination in Humans. J Virol. 2018;92: pubmed 出版商
  • 流式细胞仪; 人类; 1:100; 图 7
Brown P, Gascoyne D, Lyne L, Spearman H, Felce S, McFadden N, et al. N-terminally truncated FOXP1 protein expression and alternate internal FOXP1 promoter usage in normal and malignant B cells. Haematologica. 2016;101:861-71 pubmed 出版商
  • 流式细胞仪; 人类; 图 1a
Flint S, Gibson A, Lucas G, Nandigam R, Taylor L, Provan D, et al. A distinct plasmablast and naïve B-cell phenotype in primary immune thrombocytopenia. Haematologica. 2016;101:698-706 pubmed 出版商
  • 流式细胞仪; 人类; 图 5
Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, et al. Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. J Exp Med. 2015;212:939-51 pubmed 出版商
  • 流式细胞仪; 人类; 表 2
Chovancová J, Bernard T, Stehlíková O, Sálek D, Janíková A, Mayer J, et al. Detection of Minimal Residual Disease in Mantle Cell Lymphoma. Establishment of Novel 8-Color Flow Cytometry Approach. Cytometry B Clin Cytom. 2014;: pubmed 出版商
  • 流式细胞仪; 人类
Randall K, Chan S, Ma C, Fung I, Mei Y, Yabas M, et al. DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med. 2011;208:2305-20 pubmed 出版商
  • 流式细胞仪; 人类; 图 1
Cummings J, Cairo C, Armstrong C, Davis C, Pauza C. Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS. J Leukoc Biol. 2008;84:371-9 pubmed 出版商
  • 流式细胞仪; 人类; 图 7
Infantino S, Moepps B, Thelen M. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. J Immunol. 2006;176:2197-207 pubmed
  • 流式细胞仪; 人类
Viguier M, Lemaitre F, Verola O, Cho M, Gorochov G, Dubertret L, et al. Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells. J Immunol. 2004;173:1444-53 pubmed
Eggers E, Michel B, Wu H, Wang S, Bevan C, Abounasr A, et al. Clonal relationships of CSF B cells in treatment-naive multiple sclerosis patients. JCI Insight. 2017;2: pubmed 出版商
Ezeonyeji A, Baldwin H, Vukmanovic Stejic M, Ehrenstein M. CD4 T-Cell Dysregulation in Psoriatic Arthritis Reveals a Regulatory Role for IL-22. Front Immunol. 2017;8:1403 pubmed 出版商
Meraviglia S, Lo Presti E, Tosolini M, La Mendola C, Orlando V, Todaro M, et al. Distinctive features of tumor-infiltrating ?? T lymphocytes in human colorectal cancer. Oncoimmunology. 2017;6:e1347742 pubmed 出版商
Nguyen T, Sant S, Bird N, Grant E, Clemens E, Koutsakos M, et al. Perturbed CD8+ T cell immunity across universal influenza epitopes in the elderly. J Leukoc Biol. 2017;: pubmed 出版商
Kong F, Feng B, Zhang H, Rao H, Wang J, Cong X, et al. Abnormal phenotypic features of IgM+B cell subsets in patients with chronic hepatitis C virus infection. Exp Ther Med. 2017;14:1846-1852 pubmed 出版商
Van Caeneghem Y, De Munter S, Tieppo P, Goetgeluk G, Weening K, Verstichel G, et al. Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities. Oncoimmunology. 2017;6:e1283460 pubmed 出版商
Lo Presti E, Toia F, Oieni S, Buccheri S, Turdo A, Mangiapane L, et al. Squamous Cell Tumors Recruit γδ T Cells Producing either IL17 or IFNγ Depending on the Tumor Stage. Cancer Immunol Res. 2017;5:397-407 pubmed 出版商
Zhu H, Hu F, Sun X, Zhang X, Zhu L, Liu X, et al. CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus. Front Immunol. 2016;7:512 pubmed
Menard L, Habte S, Gonsiorek W, Lee D, Banas D, Holloway D, et al. B cells from African American lupus patients exhibit an activated phenotype. JCI Insight. 2016;1:e87310 pubmed 出版商
Horvath S, Gurven M, Levine M, Trumble B, Kaplan H, Allayee H, et al. An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biol. 2016;17:171 pubmed 出版商
Nguyen T, Bird N, Grant E, Miles J, Thomas P, Kotsimbos T, et al. Maintenance of the EBV-specific CD8+ TCR?? repertoire in immunosuppressed lung transplant recipients. Immunol Cell Biol. 2017;95:77-86 pubmed 出版商
Klarenbeek P, Doorenspleet M, Esveldt R, van Schaik B, Lardy N, van Kampen A, et al. Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction. PLoS ONE. 2015;10:e0140815 pubmed 出版商
Volk T, Pannicke U, Reisli I, Bulashevska A, Ritter J, Björkman A, et al. DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency. Hum Mol Genet. 2015;24:7361-72 pubmed 出版商
Li L, Honda Okubo Y, Li C, Sajkov D, Petrovsky N. Delta Inulin Adjuvant Enhances Plasmablast Generation, Expression of Activation-Induced Cytidine Deaminase and B-Cell Affinity Maturation in Human Subjects Receiving Seasonal Influenza Vaccine. PLoS ONE. 2015;10:e0132003 pubmed 出版商
McGowan I, Anton P, Elliott J, Cranston R, Duffill K, Althouse A, et al. Exploring the feasibility of multi-site flow cytometric processing of gut associated lymphoid tissue with centralized data analysis for multi-site clinical trials. PLoS ONE. 2015;10:e0126454 pubmed 出版商
Subramaniam K, Skinner J, Ivan E, Mutimura E, Kim R, Feintuch C, et al. HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults. PLoS ONE. 2015;10:e0124412 pubmed 出版商
Rickabaugh T, Baxter R, Sehl M, Sinsheimer J, Hultin P, Hultin L, et al. Acceleration of age-associated methylation patterns in HIV-1-infected adults. PLoS ONE. 2015;10:e0119201 pubmed 出版商
Corsiero E, Sutcliffe N, Pitzalis C, Bombardieri M. Accumulation of self-reactive naïve and memory B cell reveals sequential defects in B cell tolerance checkpoints in Sjögren's syndrome. PLoS ONE. 2014;9:e114575 pubmed 出版商
Workalemahu G, Wang H, Puan K, Nada M, Kuzuyama T, Jones B, et al. Metabolic engineering of Salmonella vaccine bacteria to boost human V?2V?2 T cell immunity. J Immunol. 2014;193:708-21 pubmed 出版商
Alcena D, Kobie J, Kaminski D, Rosenberg A, Mattiacio J, Brewer M, et al. 9G4+ antibodies isolated from HIV-infected patients neutralize HIV-1 and have distinct autoreactivity profiles. PLoS ONE. 2013;8:e85098 pubmed 出版商
Thomas M, Demberg T, Vargas Inchaustegui D, Xiao P, Tuero I, Venzon D, et al. Rhesus macaque rectal and duodenal tissues exhibit B-cell sub-populations distinct from peripheral blood that continuously secrete antigen-specific IgA in short-term explant cultures. Vaccine. 2014;32:872-80 pubmed 出版商
Baker J, Hullsiek K, Singh A, Wilson E, Henry K, Lichtenstein K, et al. Immunologic predictors of coronary artery calcium progression in a contemporary HIV cohort. AIDS. 2014;28:831-40 pubmed 出版商
Xu X, Tan C, Li P, Zhang S, Pang X, Liu H, et al. Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest. PLoS ONE. 2013;8:e77401 pubmed 出版商
Lee D, Waschbisch A, Lämmer A, Doerfler A, Schwab S, Linker R. Immunological and clinical consequences of splenectomy in a multiple sclerosis patient treated with natalizumab. J Neuroinflammation. 2013;10:123 pubmed 出版商
Ndungu F, Lundblom K, Rono J, Illingworth J, Eriksson S, Farnert A. Long-lived Plasmodium falciparum specific memory B cells in naturally exposed Swedish travelers. Eur J Immunol. 2013;43:2919-29 pubmed 出版商
Ives M, Ma C, Palendira U, Chan A, Bustamante J, Boisson Dupuis S, et al. Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function. J Allergy Clin Immunol. 2013;132:400-11.e9 pubmed 出版商
Thedrez A, Lavoue V, Dessarthe B, Daniel P, Henno S, Jaffre I, et al. A quantitative deficiency in peripheral blood Vγ9Vδ2 cells is a negative prognostic biomarker in ovarian cancer patients. PLoS ONE. 2013;8:e63322 pubmed 出版商
Feuth T, Arends J, Fransen J, Nanlohy N, van Erpecum K, Siersema P, et al. Complementary role of HCV and HIV in T-cell activation and exhaustion in HIV/HCV coinfection. PLoS ONE. 2013;8:e59302 pubmed 出版商
Labuda L, Ateba Ngoa U, Feugap E, Heeringa J, van der Vlugt L, Pires R, et al. Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. PLoS Negl Trop Dis. 2013;7:e2094 pubmed 出版商
Canary L, Vinton C, Morcock D, Pierce J, Estes J, Brenchley J, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol. 2013;190:2959-65 pubmed 出版商
Azevedo R, Soares M, Albuquerque A, Tendeiro R, Soares R, Martins M, et al. Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2013;19:703-12 pubmed 出版商
Slyker J, Lohman Payne B, John Stewart G, Dong T, Mbori Ngacha D, Tapia K, et al. The impact of HIV-1 infection and exposure on natural killer (NK) cell phenotype in Kenyan infants during the first year of life. Front Immunol. 2012;3:399 pubmed 出版商
Qiu Y, Huang Y, Chen J, Qiao D, Zeng G, Cai J. Depletion of IL-22 during culture enhanced antigen-driven IFN-? production by CD4(+)T cells from patients with active TB. Immunol Lett. 2013;150:48-53 pubmed 出版商
Illingworth J, Butler N, Roetynck S, Mwacharo J, Pierce S, Bejon P, et al. Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. J Immunol. 2013;190:1038-47 pubmed 出版商
Mock U, Thiele R, Uhde A, Fehse B, Horn S. Efficient lentiviral transduction and transgene expression in primary human B cells. Hum Gene Ther Methods. 2012;23:408-15 pubmed 出版商
Cairo C, Sagnia B, Cappelli G, Colizzi V, Leke R, Leke R, et al. Human cord blood ?? T cells expressing public V?2 chains dominate the response to bisphosphonate plus interleukin-15. Immunology. 2013;138:346-60 pubmed 出版商
Qiu Y, Chen J, Liao H, Zhang Y, Wang H, Li S, et al. Tim-3-expressing CD4+ and CD8+ T cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions. PLoS Pathog. 2012;8:e1002984 pubmed 出版商
de Vries R, McQuaid S, van Amerongen G, Yüksel S, Verburgh R, Osterhaus A, et al. Measles immune suppression: lessons from the macaque model. PLoS Pathog. 2012;8:e1002885 pubmed 出版商
Wege A, Florian C, Ernst W, Zimara N, Schleicher U, Hanses F, et al. Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response. PLoS Negl Trop Dis. 2012;6:e1741 pubmed 出版商
Na I, Wittenbecher F, Dziubianau M, Herholz A, Mensen A, Kunkel D, et al. Rabbit antithymocyte globulin (thymoglobulin) impairs the thymic output of both conventional and regulatory CD4+ T cells after allogeneic hematopoietic stem cell transplantation in adult patients. Haematologica. 2013;98:23-30 pubmed 出版商
Portugal S, Doumtabe D, Traore B, Miller L, Troye Blomberg M, Doumbo O, et al. B cell analysis of ethnic groups in Mali with differential susceptibility to malaria. Malar J. 2012;11:162 pubmed 出版商
Kawai T, Saito M, Nishikomori R, Yasumi T, Izawa K, Murakami T, et al. Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient. J Clin Immunol. 2012;32:690-7 pubmed 出版商
Boudová S, Li H, Sajadi M, Redfield R, Pauza C. Impact of persistent HIV replication on CD4 negative V?2V?2 T cells. J Infect Dis. 2012;205:1448-55 pubmed 出版商
So N, Ostrowski M, Gray Owen S. Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae. J Immunol. 2012;188:4008-22 pubmed 出版商
van der Vlugt L, Labuda L, Ozir Fazalalikhan A, Lievers E, Gloudemans A, Liu K, et al. Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. PLoS ONE. 2012;7:e30883 pubmed 出版商
Paíno T, Ocio E, Paiva B, San Segundo L, Garayoa M, Gutierrez N, et al. CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype. Haematologica. 2012;97:1110-4 pubmed 出版商
Wrammert J, Onlamoon N, Akondy R, Perng G, Polsrila K, Chandele A, et al. Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans. J Virol. 2012;86:2911-8 pubmed 出版商
Simhadri V, Mariano J, Zhou Q, DeBell K, Borrego F. Differential expression of CD300a/c on human TH1 and TH17 cells. BMC Immunol. 2011;12:62 pubmed 出版商
Biswas S, Chang H, Sarkis P, Fikrig E, Zhu Q, Marasco W. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology. 2011;134:419-33 pubmed 出版商
Duchez S, Rodrigues M, Bertrand F, Valitutti S. Reciprocal polarization of T and B cells at the immunological synapse. J Immunol. 2011;187:4571-80 pubmed 出版商
Kling H, Shipley T, Norris K. Alterations in peripheral blood B-cell populations in SHIV89.6P-infected macaques (Macacca fascicularis). Comp Med. 2011;61:269-77 pubmed
Huntington N, Alves N, Legrand N, Lim A, Strick Marchand H, Plet A, et al. Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice. Eur J Immunol. 2011;41:2883-93 pubmed 出版商
Haufe S, Haug M, Schepp C, Kuemmerle Deschner J, Hansmann S, Rieber N, et al. Impaired suppression of synovial fluid CD4+CD25- T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells. Arthritis Rheum. 2011;63:3153-62 pubmed 出版商
Slyker J, John Stewart G, Dong T, Lohman Payne B, Reilly M, Atzberger A, et al. Phenotypic characterization of HIV-specific CD8+ T cells during early and chronic infant HIV-1 infection. PLoS ONE. 2011;6:e20375 pubmed 出版商
Wege A, Ernst W, Eckl J, Frankenberger B, Vollmann Zwerenz A, Männel D, et al. Humanized tumor mice--a new model to study and manipulate the immune response in advanced cancer therapy. Int J Cancer. 2011;129:2194-206 pubmed 出版商
Monteiro P, Gosselin A, Wacleche V, El Far M, Said E, Kared H, et al. Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin ?7. J Immunol. 2011;186:4618-30 pubmed 出版商
Brocca Cofano E, McKinnon K, Demberg T, Venzon D, Hidajat R, Xiao P, et al. Vaccine-elicited SIV and HIV envelope-specific IgA and IgG memory B cells in rhesus macaque peripheral blood correlate with functional antibody responses and reduced viremia. Vaccine. 2011;29:3310-9 pubmed 出版商
Carotenuto P, Artsen A, Osterhaus A, Pontesilli O. Reciprocal changes of naïve and effector/memory CD8+ T lymphocytes in chronic hepatitis B virus infection. Viral Immunol. 2011;24:27-33 pubmed 出版商
Centlivre M, Legrand N, Steingrover R, van der Sluis R, Grijsen M, Bakker M, et al. Altered dynamics and differential infection profiles of lymphoid and myeloid cell subsets during acute and chronic HIV-1 infection. J Leukoc Biol. 2011;89:785-95 pubmed 出版商
Kuzin I, Sun H, Moshkani S, Feng C, Mantalaris A, Wu J, et al. Long-term immunologically competent human peripheral lymphoid tissue cultures in a 3D bioreactor. Biotechnol Bioeng. 2011;108:1430-40 pubmed 出版商
Libri V, Azevedo R, Jackson S, Di Mitri D, Lachmann R, Fuhrmann S, et al. Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process. Immunology. 2011;132:326-39 pubmed 出版商
Zhao L, Li Y, Smith M, Wang J, Zhang W, Tang F, et al. Expressions of BAFF/BAFF receptors and their correlation with disease activity in Chinese SLE patients. Lupus. 2010;19:1534-49 pubmed 出版商
Burt T, Seu L, Mold J, Kappas A, McCune J. Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin. J Immunol. 2010;185:5279-88 pubmed 出版商
Cairo C, Armstrong C, Cummings J, Deetz C, Tan M, Lu C, et al. Impact of age, gender, and race on circulating ?? T cells. Hum Immunol. 2010;71:968-75 pubmed 出版商
Zuo J, Church J, Belzer M, Kitchen C, Ank B, Schmid I, et al. Short communication: enhanced CD8+ T cell apoptosis in HIV-infected adolescents with virologic failure on protease inhibitor-based therapy. AIDS Res Hum Retroviruses. 2010;26:681-4 pubmed 出版商
Ness Schwickerath K, Jin C, Morita C. Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells. J Immunol. 2010;184:7268-80 pubmed 出版商
Freeman C, Han M, Martinez F, Murray S, Liu L, Chensue S, et al. Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15. J Immunol. 2010;184:6504-13 pubmed 出版商
Moura R, Weinmann P, Pereira P, Caetano Lopes J, Canhao H, Sousa E, et al. Alterations on peripheral blood B-cell subpopulations in very early arthritis patients. Rheumatology (Oxford). 2010;49:1082-92 pubmed 出版商
Oo Y, Weston C, Lalor P, Curbishley S, Withers D, Reynolds G, et al. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol. 2010;184:2886-98 pubmed 出版商
Ali Z, Yan L, Plagman N, Reichenberg A, Hintz M, Jomaa H, et al. Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits. J Immunol. 2009;183:5407-17 pubmed 出版商
Han S, Huang Y, Liang Y, Ho Y, Wang Y, Chang L. Phenotype and functional evaluation of ex vivo generated antigen-specific immune effector cells with potential for therapeutic applications. J Hematol Oncol. 2009;2:34 pubmed 出版商
Riedel D, Sajadi M, Armstrong C, Cummings J, Cairo C, Redfield R, et al. Natural viral suppressors of HIV-1 have a unique capacity to maintain gammadelta T cells. AIDS. 2009;23:1955-64 pubmed 出版商
Agopian J, Navarro J, Gac A, Lecluse Y, Briand M, Grenot P, et al. Agricultural pesticide exposure and the molecular connection to lymphomagenesis. J Exp Med. 2009;206:1473-83 pubmed 出版商
Lages C, Suffia I, Velilla P, Huang B, Warshaw G, Hildeman D, et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol. 2008;181:1835-48 pubmed
Cognasse F, Hamzeh Cognasse H, Lafarge S, Chavarin P, Pozzetto B, Richard Y, et al. Identification of two subpopulations of purified human blood B cells, CD27- CD23+ and CD27high CD80+, that strongly express cell surface Toll-like receptor 9 and secrete high levels of interleukin-6. Immunology. 2008;125:430-7 pubmed 出版商
Ali Z, Shao L, Halliday L, Reichenberg A, Hintz M, Jomaa H, et al. Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2 T cells in macaques. J Immunol. 2007;179:8287-96 pubmed
Hartigan O Connor D, Abel K, McCune J. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med. 2007;204:2679-92 pubmed
Wei C, Anolik J, Cappione A, Zheng B, Pugh Bernard A, Brooks J, et al. A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J Immunol. 2007;178:6624-33 pubmed
Humblet Baron S, Sather B, Anover S, Becker Herman S, Kasprowicz D, Khim S, et al. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest. 2007;117:407-18 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD27 Monoclonal Antibody (O323), APC, eBioscience™
目录# :
17-0279-41
规格 :
25试验
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 5 µL (0.25 µg)/test
物种 :
人类
克隆 :
O323
抗体亚型 :
IgG1, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL (0.25 µg)/test
别名 :
CD antigen 27; CD27; CD27 antigen; CD27 molecule; CD27L receptor; S152; S152. LPFS2; sCD27; soluble CD27; T cell activation antigen S152; T14; T-cell activation antigen CD27; TNFRSF7; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国